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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sypl1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of SYPL1 mRNA | CTD | PMID:22206623 | Sypl1 | Rat | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of SYPL1 mRNA | CTD | PMID:32145629 | Sypl1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SYPL1 mRNA | CTD | PMID:19770486 | Sypl1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sypl1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SYPL1 mRNA | CTD | PMID:21570461 | Sypl1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SYPL1 mRNA | CTD | PMID:33387578 | Sypl1 | Rat | 2,6-dimethoxyphenol | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Furaldehyde co-treated with pyrogallol 1 more ... | CTD | PMID:38598786 | Sypl1 | Rat | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of SYPL1 mRNA | CTD | PMID:31881176 | Sypl1 | Rat | actinomycin D | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of SYPL1 protein | CTD | PMID:38460933 | Sypl1 | Rat | alpha-Solamarine | multiple interactions | ISO | Sypl1 (Mus musculus) | 6480464 | alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL1 protein] | CTD | PMID:35350913 | Sypl1 | Rat | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of SYPL1 mRNA | CTD | PMID:30779732 | Sypl1 | Rat | antirheumatic drug | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of SYPL1 mRNA | CTD | PMID:24449571 | Sypl1 | Rat | aristolochic acid A | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of SYPL1 mRNA | CTD | PMID:33212167 | Sypl1 | Rat | arsane | affects methylation | ISO | SYPL1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SYPL1 gene | CTD | PMID:25304211 | Sypl1 | Rat | arsenic atom | affects methylation | ISO | SYPL1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of SYPL1 gene | CTD | PMID:25304211 | Sypl1 | Rat | benzo[a]pyrene | affects methylation | ISO | SYPL1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of SYPL1 promoter | CTD | PMID:27901495 | Sypl1 | Rat | benzo[a]pyrene | multiple interactions | ISO | Sypl1 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to SYPL1 promoter] | CTD | PMID:19654925 | Sypl1 | Rat | benzo[a]pyrene | increases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SYPL1 mRNA | CTD | PMID:22228805 | Sypl1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SYPL1 mRNA | CTD | PMID:25181051 | Sypl1 | Rat | bisphenol A | increases expression | ISO | Sypl1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SYPL1 mRNA | CTD | PMID:33221593 | Sypl1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SYPL1 mRNA | CTD | PMID:34947998 | Sypl1 | Rat | bisphenol F | increases expression | ISO | Sypl1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of SYPL1 mRNA | CTD | PMID:38685157 | Sypl1 | Rat | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of SYPL1 mRNA | CTD | PMID:32479839 | Sypl1 | Rat | cadmium atom | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SYPL1 mRNA | CTD | PMID:35301059 | Sypl1 | Rat | cadmium dichloride | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SYPL1 mRNA | CTD | PMID:38568856 | Sypl1 | Rat | cadmium dichloride | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SYPL1 mRNA | CTD | PMID:35301059 | Sypl1 | Rat | chromium(6+) | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in increased expression of SYPL1 mRNA | CTD | PMID:38479592 | Sypl1 | Rat | copper(II) sulfate | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SYPL1 mRNA | CTD | PMID:19549813 | Sypl1 | Rat | crocidolite asbestos | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of SYPL1 mRNA | CTD | PMID:29523930 | Sypl1 | Rat | cyclosporin A | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of SYPL1 mRNA | CTD | PMID:19770486 | Sypl1 | Rat | deguelin | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | deguelin results in increased expression of SYPL1 mRNA | CTD | PMID:33512557 | Sypl1 | Rat | Dibutyl phosphate | affects expression | ISO | SYPL1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SYPL1 mRNA | CTD | PMID:37042841 | Sypl1 | Rat | dicrotophos | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SYPL1 mRNA | CTD | PMID:28302478 | Sypl1 | Rat | disodium selenite | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Sodium Selenite results in increased expression of SYPL1 mRNA | CTD | PMID:18175754 | Sypl1 | Rat | folic acid | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SYPL1 mRNA | CTD | PMID:25629700 | Sypl1 | Rat | furfural | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Furaldehyde co-treated with pyrogallol 1 more ... | CTD | PMID:38598786 | Sypl1 | Rat | gallic acid | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Gallic Acid results in decreased expression of SYPL1 mRNA | CTD | PMID:34408198 | Sypl1 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of SYPL1 mRNA | CTD | PMID:22061828 | Sypl1 | Rat | haloperidol | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Haloperidol results in decreased expression of SYPL1 mRNA | CTD | PMID:18797397 | Sypl1 | Rat | ivermectin | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SYPL1 protein | CTD | PMID:32959892 | Sypl1 | Rat | lead(0) | affects expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Lead affects the expression of SYPL1 mRNA | CTD | PMID:28903495 | Sypl1 | Rat | methyl methanesulfonate | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of SYPL1 mRNA | CTD | PMID:23649840 | Sypl1 | Rat | Nutlin-3 | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of SYPL1 protein | CTD | PMID:38460933 | Sypl1 | Rat | olanzapine | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Olanzapine results in decreased expression of SYPL1 mRNA | CTD | PMID:18797397 | Sypl1 | Rat | phenobarbital | affects expression | ISO | Sypl1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SYPL1 mRNA | CTD | PMID:23091169 | Sypl1 | Rat | phenytoin | increases expression | EXP | | 6480464 | Phenytoin results in increased expression of SYPL1 mRNA | CTD | PMID:20345932 | Sypl1 | Rat | picoxystrobin | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | picoxystrobin results in increased expression of SYPL1 mRNA | CTD | PMID:33512557 | Sypl1 | Rat | rotenone | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Rotenone results in increased expression of SYPL1 mRNA | CTD | PMID:33512557 | Sypl1 | Rat | sevoflurane | multiple interactions | ISO | Sypl1 (Mus musculus) | 6480464 | alpha-solamargine inhibits the reaction [Sevoflurane results in decreased expression of SYPL1 protein] | CTD | PMID:35350913 | Sypl1 | Rat | sevoflurane | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | Sevoflurane results in decreased expression of SYPL1 protein | CTD | PMID:35350913 | Sypl1 | Rat | sodium arsenate | increases expression | ISO | Sypl1 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of SYPL1 mRNA | CTD | PMID:21795629 | Sypl1 | Rat | sodium arsenite | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SYPL1 mRNA | CTD | PMID:38568856 | Sypl1 | Rat | sodium chloride | multiple interactions | ISO | SYPL1 (Homo sapiens) | 6480464 | [Sodium Chloride co-treated with Furaldehyde] results in decreased expression of and affects the localization of SYPL1 protein more ... | CTD | PMID:38598786 | Sypl1 | Rat | testosterone | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of SYPL1 mRNA | CTD | PMID:33359661 | Sypl1 | Rat | thiram | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Thiram results in decreased expression of SYPL1 mRNA | CTD | PMID:38568856 | Sypl1 | Rat | titanium dioxide | decreases methylation | ISO | Sypl1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SYPL1 promoter | CTD | PMID:35295148 | Sypl1 | Rat | trimellitic anhydride | increases expression | ISO | Sypl1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of SYPL1 mRNA | CTD | PMID:19042947 | Sypl1 | Rat | triptonide | decreases expression | ISO | Sypl1 (Mus musculus) | 6480464 | triptonide results in decreased expression of SYPL1 mRNA | CTD | PMID:33045310 | Sypl1 | Rat | tunicamycin | increases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of SYPL1 mRNA | CTD | PMID:22378314 | Sypl1 | Rat | valproic acid | decreases methylation | ISO | SYPL1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of SYPL1 gene | CTD | PMID:29154799 | Sypl1 | Rat | valproic acid | decreases expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SYPL1 mRNA | CTD | PMID:29154799 | Sypl1 | Rat | valproic acid | affects expression | ISO | SYPL1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SYPL1 mRNA | CTD | PMID:25979313 | |