Mocs2 (molybdenum cofactor synthesis 2) - Rat Genome Database

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Gene: Mocs2 (molybdenum cofactor synthesis 2) Rattus norvegicus
Analyze
Symbol: Mocs2
Name: molybdenum cofactor synthesis 2
RGD ID: 1359477
Description: Predicted to enable identical protein binding activity. Predicted to contribute to molybdopterin synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in nuclear speck. Predicted to be part of molybdopterin synthase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2); PARTICIPATES IN molybdenum cofactor biosynthetic pathway; folate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC94220; MOCS2B; molybdenum cofactor synthesis protein 2 large subunit; molybdenum cofactor synthesis protein 2B; molybdopterin synthase; molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2246,504,574 - 46,516,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,504,588 - 46,516,324 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,614,202 - 53,625,948 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0251,672,578 - 51,684,324 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0246,540,417 - 46,552,139 (+)NCBIRnor_WKY
Rnor_6.0246,980,964 - 46,992,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,980,976 - 46,992,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,520,174 - 71,532,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,948,321 - 46,960,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1246,876,587 - 46,888,290 (+)NCBI
Celera242,260,839 - 42,272,490 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cell biology of molybdenum. Mendel RR and Bittner F, Biochim Biophys Acta. 2006 Jul;1763(7):621-35. Epub 2006 May 12.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH. Reiss J and Johnson JL, Hum Mutat 2003 Jun;21(6):569-76.
8. Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. Reiss J, etal., Am J Hum Genet 1999 Mar;64(3):706-11.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames. Sloan J, etal., Nucleic Acids Res 1999 Feb 1;27(3):854-8.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11591653   PMID:12732628   PMID:15073332   PMID:23376485  


Genomics

Comparative Map Data
Mocs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2246,504,574 - 46,516,327 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,504,588 - 46,516,324 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,614,202 - 53,625,948 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0251,672,578 - 51,684,324 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0246,540,417 - 46,552,139 (+)NCBIRnor_WKY
Rnor_6.0246,980,964 - 46,992,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,980,976 - 46,992,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0271,520,174 - 71,532,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,948,321 - 46,960,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1246,876,587 - 46,888,290 (+)NCBI
Celera242,260,839 - 42,272,490 (+)NCBICelera
Cytogenetic Map2q14NCBI
MOCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38553,095,679 - 53,109,757 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl553,095,679 - 53,110,063 (-)EnsemblGRCh38hg38GRCh38
GRCh37552,391,509 - 52,405,587 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,429,649 - 52,441,355 (-)NCBINCBI36Build 36hg18NCBI36
Build 34552,429,653 - 52,441,355NCBI
Celera549,347,470 - 49,359,176 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,363,558 - 49,377,653 (-)NCBIHuRef
CHM1_1552,394,058 - 52,408,152 (-)NCBICHM1_1
T2T-CHM13v2.0553,923,465 - 53,937,543 (-)NCBIT2T-CHM13v2.0
Mocs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,954,707 - 114,965,956 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,954,772 - 114,968,811 (+)EnsemblGRCm39 Ensembl
GRCm3813114,818,160 - 114,829,420 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,818,236 - 114,832,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713115,608,445 - 115,619,628 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,939,164 - 115,949,607 (+)NCBIMGSCv36mm8
Celera13119,161,937 - 119,173,119 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
Mocs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544614,295,737 - 14,307,838 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544614,295,737 - 14,305,735 (+)NCBIChiLan1.0ChiLan1.0
MOCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1562,539,208 - 62,550,926 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl562,539,214 - 62,550,921 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0560,920,268 - 60,931,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MOCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1462,153,828 - 62,164,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl462,153,296 - 62,185,492 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,928,792 - 61,939,117 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,651,866 - 62,662,174 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1462,427,116 - 62,437,429 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,551,658 - 62,561,990 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0463,078,354 - 63,088,687 (+)NCBIUU_Cfam_GSD_1.0
Mocs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,369,033 - 205,380,226 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648014,302,824 - 14,313,265 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOCS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,436,205 - 32,462,521 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,427,783 - 32,462,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,270,548 - 34,290,713 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MOCS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,387,923 - 49,399,902 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,386,487 - 49,399,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,727,742 - 1,739,745 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mocs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247596,261,933 - 6,271,509 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247596,261,970 - 6,272,246 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mocs2
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:165
Count of miRNA genes:126
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000015781
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat

Markers in Region
D5Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,509,113 - 46,509,732 (+)MAPPERmRatBN7.2
Rnor_6.0246,985,503 - 46,986,121NCBIRnor6.0
Rnor_5.0271,524,701 - 71,525,319UniSTSRnor5.0
RGSC_v3.4246,952,847 - 46,953,465UniSTSRGSC3.4
Celera242,265,277 - 42,265,895UniSTS
Cytogenetic Map2q14UniSTS
RH133558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,515,655 - 46,515,860 (+)MAPPERmRatBN7.2
Rnor_6.0246,992,215 - 46,992,419NCBIRnor6.0
Rnor_5.0271,531,413 - 71,531,617UniSTSRnor5.0
RGSC_v3.4246,959,389 - 46,959,593UniSTSRGSC3.4
Celera242,271,819 - 42,272,023UniSTS
RH 3.4 Map2304.4UniSTS
Cytogenetic Map2q14UniSTS
BF404043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,508,124 - 46,508,318 (+)MAPPERmRatBN7.2
Rnor_6.0246,984,514 - 46,984,707NCBIRnor6.0
Rnor_5.0271,523,712 - 71,523,905UniSTSRnor5.0
RGSC_v3.4246,951,858 - 46,952,051UniSTSRGSC3.4
Celera242,264,288 - 42,264,481UniSTS
RH 3.4 Map2292.3UniSTS
Cytogenetic Map2q14UniSTS
AW535104  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,508,195 - 46,508,347 (+)MAPPERmRatBN7.2
Rnor_6.0246,984,585 - 46,984,736NCBIRnor6.0
Rnor_5.0271,523,783 - 71,523,934UniSTSRnor5.0
RGSC_v3.4246,951,929 - 46,952,080UniSTSRGSC3.4
Celera242,264,359 - 42,264,510UniSTS
RH 3.4 Map2294.8UniSTS
Cytogenetic Map2q14UniSTS
RH139819  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,516,084 - 46,516,277 (+)MAPPERmRatBN7.2
Rnor_6.0246,992,644 - 46,992,836NCBIRnor6.0
Rnor_5.0271,531,842 - 71,532,034UniSTSRnor5.0
RGSC_v3.4246,959,818 - 46,960,010UniSTSRGSC3.4
Celera242,272,248 - 42,272,440UniSTS
Cytogenetic Map2q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 36 11 8
Low 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001162413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001395669 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO554692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM123325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000082990   ⟹   ENSRNOP00000073722
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,504,588 - 46,516,324 (+)Ensembl
Rnor_6.0 Ensembl246,981,010 - 46,992,883 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083668   ⟹   ENSRNOP00000069073
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl246,980,976 - 46,992,883 (+)Ensembl
RefSeq Acc Id: NM_001007633   ⟹   NP_001007634
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,588 - 46,516,327 (+)NCBI
Rnor_6.0246,980,976 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
RGSC_v3.4246,948,321 - 46,960,060 (+)RGD
Celera242,260,839 - 42,272,490 (+)RGD
Sequence:
RefSeq Acc Id: NM_001162413   ⟹   NP_001155885
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,588 - 46,516,327 (+)NCBI
Rnor_6.0246,980,976 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
RGSC_v3.4246,948,321 - 46,960,060 (+)RGD
Celera242,260,839 - 42,272,490 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231985   ⟹   XP_006232047
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,608 - 46,516,327 (+)NCBI
Rnor_6.0246,981,010 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231986   ⟹   XP_006232048
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2246,504,574 - 46,516,327 (+)NCBI
Rnor_6.0246,980,986 - 46,992,886 (+)NCBI
Rnor_5.0271,520,174 - 71,532,084 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001007634   ⟸   NM_001007633
- Peptide Label: isoform Mocs2B
- UniProtKB: Q6AY59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001155885   ⟸   NM_001162413
- Peptide Label: isoform Mocs2A
- UniProtKB: Q6AY59 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232048   ⟸   XM_006231986
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006232047   ⟸   XM_006231985
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000073722   ⟸   ENSRNOT00000082990
RefSeq Acc Id: ENSRNOP00000069073   ⟸   ENSRNOT00000083668

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AY59-F1-model_v2 AlphaFold Q6AY59 1-200 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691147
Promoter ID:EPDNEW_R1672
Type:initiation region
Name:Mocs2_1
Description:molybdenum cofactor synthesis 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0246,981,009 - 46,981,069EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359477 AgrOrtholog
BioCyc Gene G2FUF-54327 BioCyc
BioCyc Pathway PWY-6823 [molybdopterin biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000056325 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000073722 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000082990 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.1170.40 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130858 IMAGE-MGC_LOAD
InterPro MoaE_sf UniProtKB/Swiss-Prot
  MOCS2B_euk UniProtKB/Swiss-Prot
  Mopterin_biosynth_MoaE UniProtKB/Swiss-Prot
KEGG Report rno:294753 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94220 IMAGE-MGC_LOAD
NCBI Gene 294753 ENTREZGENE
Pfam MoaE UniProtKB/Swiss-Prot
PhenoGen Mocs2 PhenoGen
Superfamily-SCOP SSF54690 UniProtKB/Swiss-Prot
UniProt MOC2B_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Mocs2  molybdenum cofactor synthesis 2    molybdopterin synthase  Name updated 1299863 APPROVED
2005-07-29 Mocs2  molybdopterin synthase      Symbol and Name status set to provisional 70820 PROVISIONAL