Isyna1 (inositol-3-phosphate synthase 1)

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Gene: Isyna1 (inositol-3-phosphate synthase 1) Rattus norvegicus

Analyze

Symbol:

Isyna1

Name:

inositol-3-phosphate synthase 1

RGD ID:

1359423

Description:

Enables inositol-3-phosphate synthase activity. Involved in inositol biosynthetic process and negative regulation of inositol biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human ISYNA1 (inositol-3-phosphate synthase 1); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

IPS 1; LOC290651; MI-1-P synthase; MIP synthase; myo-inositol 1-phosphate synthase A1; myo-inositol-1-phosphate synthase; similar to myo-inositol 1-phosphate synthase A1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ISYNA1 (inositol-3-phosphate synthase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Isyna1 (myo-inositol 1-phosphate synthase A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Isyna1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ISYNA1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ISYNA1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Isyna1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ISYNA1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ISYNA1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Isyna1 (inositol-3-phosphate synthase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Isyna1 (myo-inositol 1-phosphate synthase A1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	ISYNA1 (inositol-3-phosphate synthase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	INO1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Inos	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	inos-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	isyna1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	18,839,143 - 18,841,979 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,839,145 - 18,841,979 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,880,839 - 18,883,671 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,013,623 - 20,016,455 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,933,801 - 18,936,633 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,589,497 - 20,592,333 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,589,481 - 20,592,449 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,445,206 - 20,448,042 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,345,305 - 19,348,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,345,311 - 19,348,054 (-)	NCBI
Celera	16	19,030,610 - 19,033,446 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

polycystic ovary syndrome (ISO)

Salivary Gland Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

beta-D-glucosamine (EXP)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (EXP)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumarin (EXP)

coumestrol (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP,ISO)

diclofenac (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

Enterolactone (ISO)

entinostat (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

furan (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

hydrogen cyanide (ISO)

indometacin (ISO)

inulin (ISO)

ivermectin (ISO)

ketamine (EXP)

L-ethionine (EXP)

L-methionine (ISO)

lipopolysaccharide (ISO)

lovastatin (ISO)

naphthalene (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

nimesulide (EXP)

omeprazole (EXP)

ozone (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

potassium cyanide (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

streptozocin (ISO)

tamoxifen (ISO)

temozolomide (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thapsigargin (EXP)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (EXP)

Triptolide (EXP)

trovafloxacin (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vitamin E (ISO)

warfarin (ISO)

zearalenone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inositol biosynthetic process (IBA,IDA,IEA,ISO)

negative regulation of inositol biosynthetic process (IDA)

phospholipid biosynthetic process (IEA)

Cellular Component

cytoplasm (IBA)

Molecular Function

inositol-3-phosphate synthase activity (IBA,IDA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

inositol metabolic pathway (ISO)

inositol phosphate metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Purification, structure, and catalytic properties of L-myo-inositol-1-phosphate synthase from rat testis.	Maeda T and Eisenberg F, J Biol Chem. 1980 Sep 25;255(18):8458-64.
3.	Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein.	Parthasarathy RN, etal., Mol Cell Biochem. 2013 Jun;378(1-2):83-9. doi: 10.1007/s11010-013-1597-7. Epub 2013 Mar 16.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression, and putative role of a 16-kDa gamma(c) isoform.	Seelan RS, etal., J Biol Chem. 2009 Apr 3;284(14):9443-57. doi: 10.1074/jbc.M900206200. Epub 2009 Feb 2.
9.	Incubations of testis myo-inositol-1-phosphate synthase with D-(5-18O)glucose 6-phosphate and with H218O show no evidence of Schiff base formation.	Sherman WR, etal., J Biol Chem. 1977 Aug 25;252(16):5672-6.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8889548	PMID:21841945	PMID:23902760	PMID:30053369

Genomics

Comparative Map Data

Isyna1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	18,839,143 - 18,841,979 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,839,145 - 18,841,979 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,880,839 - 18,883,671 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,013,623 - 20,016,455 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,933,801 - 18,936,633 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,589,497 - 20,592,333 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,589,481 - 20,592,449 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,445,206 - 20,448,042 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,345,305 - 19,348,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,345,311 - 19,348,054 (-)	NCBI
Celera	16	19,030,610 - 19,033,446 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

ISYNA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,434,388 - 18,438,133 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,434,388 - 18,438,167 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,545,198 - 18,548,943 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,406,625 - 18,409,943 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	18,447,020 - 18,450,933 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,108,499 - 18,112,412 (-)	NCBI		HuRef
CHM1_1	19	18,545,346 - 18,549,259 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	18,568,567 - 18,572,312 (-)	NCBI		T2T-CHM13v2.0

Isyna1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,047,131 - 71,049,940 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	71,047,023 - 71,049,940 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,594,481 - 70,597,290 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,594,373 - 70,597,290 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	73,118,380 - 73,121,189 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,523,470 - 73,526,279 (+)	NCBI		MGSCv36	mm8
Celera	8	73,150,596 - 73,153,405 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Isyna1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	3,098,995 - 3,100,454 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	3,099,017 - 3,100,454 (+)	NCBI	ChiLan1.0	ChiLan1.0

ISYNA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	19	22,303,623 - 22,307,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	17,913,400 - 17,916,789 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	18,884,406 - 18,887,931 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	18,884,412 - 18,887,931 (-)	Ensembl	panpan1.1		panPan2

ISYNA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,594,816 - 44,598,495 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,489,219 - 44,598,497 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,509,230 - 44,512,910 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,080,806 - 45,084,487 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,999,052 - 45,085,082 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,318,111 - 44,321,783 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,728,243 - 44,731,923 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,003,669 - 45,007,342 (+)	NCBI		UU_Cfam_GSD_1.0

Isyna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,266,570 - 203,269,890 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,815,821 - 2,819,020 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936596	2,815,782 - 2,819,100 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ISYNA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,363,716 - 59,367,002 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,363,672 - 59,367,003 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ISYNA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,906,724 - 16,910,194 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,905,472 - 16,910,030 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,431,203 - 2,435,020 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Isyna1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,658,512 - 1,661,640 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,658,512 - 1,661,507 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Isyna1
1 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	38
Count of miRNA genes:	37
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000026821
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15726433	21034895	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17696791	82635055	Rat

Markers in Region

RH129421

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	18,839,160 - 18,839,326 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	20,589,515 - 20,589,680	NCBI	Rnor6.0
Rnor_5.0	16	20,445,224 - 20,445,389	UniSTS	Rnor5.0
RGSC_v3.4	16	19,345,323 - 19,345,488	UniSTS	RGSC3.4
Celera	16	19,030,628 - 19,030,793	UniSTS
RH 3.4 Map	16	180.5	UniSTS
Cytogenetic Map	16	p14	UniSTS

RH130875

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	18,838,677 - 18,838,866 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	20,589,032 - 20,589,220	NCBI	Rnor6.0
Rnor_5.0	16	20,444,741 - 20,444,929	UniSTS	Rnor5.0
RGSC_v3.4	16	19,344,840 - 19,345,028	UniSTS	RGSC3.4
Celera	16	19,030,145 - 19,030,333	UniSTS
RH 3.4 Map	16	180.3	UniSTS
Cytogenetic Map	16	p14	UniSTS

UniSTS:498303

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	18,840,324 - 18,840,607 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	20,590,679 - 20,590,961	NCBI	Rnor6.0
Rnor_5.0	16	20,446,388 - 20,446,670	UniSTS	Rnor5.0
RGSC_v3.4	16	19,346,487 - 19,346,769	UniSTS	RGSC3.4
Celera	16	19,031,792 - 19,032,074	UniSTS
Cytogenetic Map	16	p14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	35	34	25	9	25			66	29	41	11
Low		8	23	16	10	16	8	11	8	6			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013880	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BI285489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP490872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA333826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO388828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000026821 ⟹ ENSRNOP00000026821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	18,839,145 - 18,841,979 (-)	Ensembl
Rnor_6.0 Ensembl	16	20,589,481 - 20,592,449 (-)	Ensembl

RefSeq Acc Id:

NM_001013880 ⟹ NP_001013902

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,839,143 - 18,841,979 (-)	NCBI
Rnor_6.0	16	20,589,497 - 20,592,333 (-)	NCBI
Rnor_5.0	16	20,445,206 - 20,448,042 (-)	NCBI
RGSC_v3.4	16	19,345,305 - 19,348,141 (-)	RGD
Celera	16	19,030,610 - 19,033,446 (-)	RGD

Sequence:

show sequence

GCGTGGCCGGGCGTGGCCTCAGCGCTTTTCTTCGCTGCCCCGGGCCTAGGGCCCACGCTGTCGG
CTGCCGCAGTCTGACCCAACTCTTAGTCGCTCGCCGCGATGGAGCCTGCCGCCGAGATCCTGGT
GGACAGCCCGGACGTGATCTTCGGCCCCGAAGCCATCGAGGCGCGCTACGAGTACCGGACAACG
CGCGTCAGCCGCGAGGGCGGCGTGCTGCGGGTGCGGCCCACGGCTACGCGTTTCACCTTCCGCA
CAGCCCGGCAGGTGCCCCGGCTTGGGGTCATGTTAGTCGGCTGGGGCGGGAACAACGGCTCCAC
GCTCACTGCGGCTGTTCTGGCCAACCGGCTACGCCTGACCTGGCCCACGCGCACTGGTCGCAAG
GAGGCAAACTATTATGGCTCGTTGACCCAGGCGGGCACCGTGAACTTGGGTCTGGATGGGGACG
GCCGGGAGGTGTTTGTGCCCTTCAGTGCGCTGCTACCCATGGTGGCACCCAACGACCTGGTGTT
TGACGGCTGGGATATCTCGTCGCTGAACCTGGCGGAGGCGATGCGGCGCGCGCAGGTCCTGGAC
TGCGGTCTGCAGGAGCAGCTGTGGCCCCACATGGAGAGCCTGCGTCCACGGCCCTCAGTCTACA
TTCCTGAGTTCATCGCTGCCAACCAGACAGCACGTGCGGACAACCTCATCCCTGGCACACGCGC
CCAACAGTTGGAGCAGATCCGAAAGGATATTAGAGACTTCCGATCCAGTGCGGGATTGGACAAG
GTCATCGTGCTGTGGACCGCCAATACAGAGCGCTTCTGTGAAGTGGTCCCGGGTCGCAATGACA
CAGCTGAAAACTTGCTGCGTACTATCCAGCTTGGCCTGGAGGTTTCACCATCCACACTTTTTGC
TGTGGCCAGCATCCTGGAGGGCTGCGCCTTCCTCAACGGGTCCCCACAGAACACACTGGTACCC
GGAGCCCTGGAGCTGGCTTCGCAGCGCCATGTGTTCGTAGGTGGCGATGACTTCAAGTCAGGGC
AGACTAAGGTCAAATCTGTTCTGGTCGACTTCCTCATTGGCTCTGGCCTCAAGACCATGTCCAT
CGTGAGCTATAACCACTTGGGCAACAACGATGGGCAGAACCTGTCTGCACCACTGCAGTTCCGC
TCCAAGGAAGTGACAAAGAGCAGTGTGGTGGATGACATGGTTCAGAGCAACCGTGTGCTCTACG
CGCCTGGAGAGGAGCCAGATCACTGTGTGGTGATCAAATATGTACCCTATGTTGGCGACAGCAA
GCGTGCCCTGGATGAGTACACCTCAGAGCTGATGCTGGGTGGGACAAACACTTTGGTGCTCCAT
AACACCTGCGAGGACTCGCTGCTGGCCGCACCCATCATGCTGGACCTAGTGCTGCTCACAGAGC
TGTGTCAGCGTGTGAGCTTCTGCACAGACTCGGACCCAGAGCCTCAGGGCTTCCACCCAGTGCT
GTCGGTGCTCAGCTTCCTCTTTAAGGCACCACTTGTGCCCCCTGGCAGCCCTGTGGTGAATGCC
CTCTTCCGCCAGCGCAGCTGTATTGAGAATATTTTCAGGGCTTGCGTGGGGCTCCCACCCCAGA
ACCACATGCTGTTAGAGCACAAGATGGAGCGCCCTTTCCCAGGCATCAAGCCAGAAGAGGTGAA
GGCCACCAGCCCACTGCCTTGCAAGAAAGAGTCCACACCGGCCACCAATGGCTGCACCGGTGAT
GCCAATGGGCACACACAGGCACCAACACCAGAGCTGTCCACCGCTTAAACCAAGTGCCCAGACC
CTCCTACCCCAATGCCTCCAACCACTGTACTTCAGACCTTGCCAAAGACAATAAAGGGTCCCCC
ACCAAGCAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013902	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90710	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026821
GenBank Protein	Q6AYK3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013902 ⟸ NM_001013880

- UniProtKB:

Q6AYK3 (UniProtKB/Swiss-Prot), A6KA27 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPAAEILVDSPDVIFGPEAIEARYEYRTTRVSREGGVLRVRPTATRFTFRTARQVPRLGVMLV
GWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSLTQAGTVNLGLDGDGREVFVPFSALLP
MVAPNDLVFDGWDISSLNLAEAMRRAQVLDCGLQEQLWPHMESLRPRPSVYIPEFIAANQTARA
DNLIPGTRAQQLEQIRKDIRDFRSSAGLDKVIVLWTANTERFCEVVPGRNDTAENLLRTIQLGL
EVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLI
GSGLKTMSIVSYNHLGNNDGQNLSAPLQFRSKEVTKSSVVDDMVQSNRVLYAPGEEPDHCVVIK
YVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDP
EPQGFHPVLSVLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKMERPF
PGIKPEEVKATSPLPCKKESTPATNGCTGDANGHTQAPTPELSTA

hide sequence

RefSeq Acc Id:

ENSRNOP00000026821 ⟸ ENSRNOT00000026821

Protein Domains

Myo-inositol-1-phosphate synthase GAPDH-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYK3-F1-model_v2	AlphaFold	Q6AYK3	1-557	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700024

Promoter ID:

EPDNEW_R10547

Type:

initiation region

Name:

Isyna1_1

Description:

inositol-3-phosphate synthase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,592,279 - 20,592,339	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359423	AgrOrtholog
BioCyc Gene	G2FUF-11788	BioCyc
BioCyc Pathway	PWY-2301 [myo-inositol biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000019741	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026821	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113337	IMAGE-MGC_LOAD
InterPro	Myo-inos-1-P_Synthase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Myo-inos-1-P_Synthase_GAPDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:290651	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93930	IMAGE-MGC_LOAD
NCBI Gene	290651	ENTREZGENE
PANTHER	INOSITOL-3-PHOSPHATE SYNTHASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MYO-INOSITOL-1 PHOSPHATE SYNTHASE	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	Inos-1-P_synth	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD_binding_5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Isyna1	PhenoGen
PIRSF	Myoinos-ppht_syn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000019741	RatGTEx
Superfamily-SCOP	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-binding Rossmann-fold domains	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6KA27	ENTREZGENE, UniProtKB/TrEMBL
	INO1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-30	Isyna1	inositol-3-phosphate synthase 1	Isyna1	myo-inositol 1-phosphate synthase A1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Isyna1	myo-inositol 1-phosphate synthase A1	LOC290651	similar to myo-inositol 1-phosphate synthase A1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	LOC290651	similar to myo-inositol 1-phosphate synthase A1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)