Isyna1 (inositol-3-phosphate synthase 1) - Rat Genome Database

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Gene: Isyna1 (inositol-3-phosphate synthase 1) Rattus norvegicus
Analyze
Symbol: Isyna1
Name: inositol-3-phosphate synthase 1
RGD ID: 1359423
Description: Enables inositol-3-phosphate synthase activity. Involved in inositol biosynthetic process and negative regulation of inositol biosynthetic process. Predicted to be active in cytoplasm. Orthologous to human ISYNA1 (inositol-3-phosphate synthase 1); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IPS 1; LOC290651; MI-1-P synthase; MIP synthase; myo-inositol 1-phosphate synthase A1; myo-inositol-1-phosphate synthase; similar to myo-inositol 1-phosphate synthase A1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,873,119 - 18,876,116 (-)NCBIGRCr8
mRatBN7.21618,839,143 - 18,841,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,839,145 - 18,841,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,880,839 - 18,883,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,013,623 - 20,016,455 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,933,801 - 18,936,633 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,589,497 - 20,592,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,589,481 - 20,592,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,445,206 - 20,448,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,345,305 - 19,348,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,345,311 - 19,348,054 (-)NCBI
Celera1619,030,610 - 19,033,446 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
inulin  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-ethionine  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
potassium cyanide  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Purification, structure, and catalytic properties of L-myo-inositol-1-phosphate synthase from rat testis. Maeda T and Eisenberg F, J Biol Chem. 1980 Sep 25;255(18):8458-64.
3. Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein. Parthasarathy RN, etal., Mol Cell Biochem. 2013 Jun;378(1-2):83-9. doi: 10.1007/s11010-013-1597-7. Epub 2013 Mar 16.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Identification of myo-inositol-3-phosphate synthase isoforms: characterization, expression, and putative role of a 16-kDa gamma(c) isoform. Seelan RS, etal., J Biol Chem. 2009 Apr 3;284(14):9443-57. doi: 10.1074/jbc.M900206200. Epub 2009 Feb 2.
9. Incubations of testis myo-inositol-1-phosphate synthase with D-(5-18O)glucose 6-phosphate and with H218O show no evidence of Schiff base formation. Sherman WR, etal., J Biol Chem. 1977 Aug 25;252(16):5672-6.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:21841945   PMID:23902760   PMID:30053369  


Genomics

Comparative Map Data
Isyna1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,873,119 - 18,876,116 (-)NCBIGRCr8
mRatBN7.21618,839,143 - 18,841,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,839,145 - 18,841,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,880,839 - 18,883,671 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,013,623 - 20,016,455 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,933,801 - 18,936,633 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,589,497 - 20,592,333 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,589,481 - 20,592,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,445,206 - 20,448,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,345,305 - 19,348,141 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,345,311 - 19,348,054 (-)NCBI
Celera1619,030,610 - 19,033,446 (-)NCBICelera
Cytogenetic Map16p14NCBI
ISYNA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,434,388 - 18,438,133 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,434,388 - 18,438,167 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,545,198 - 18,548,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,406,625 - 18,409,943 (-)NCBINCBI36Build 36hg18NCBI36
Celera1918,447,020 - 18,450,933 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1918,108,499 - 18,112,412 (-)NCBIHuRef
CHM1_11918,545,346 - 18,549,259 (-)NCBICHM1_1
T2T-CHM13v2.01918,568,567 - 18,572,312 (-)NCBIT2T-CHM13v2.0
Isyna1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,047,131 - 71,049,940 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,047,023 - 71,049,940 (+)EnsemblGRCm39 Ensembl
GRCm38870,594,481 - 70,597,290 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,594,373 - 70,597,290 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,118,380 - 73,121,189 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,523,470 - 73,526,279 (+)NCBIMGSCv36mm8
Celera873,150,596 - 73,153,405 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Isyna1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,098,995 - 3,100,454 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,099,017 - 3,100,454 (+)NCBIChiLan1.0ChiLan1.0
ISYNA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,295,288 - 23,299,230 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,303,623 - 22,307,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,913,400 - 17,916,789 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,884,406 - 18,887,931 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,884,412 - 18,887,931 (-)Ensemblpanpan1.1panPan2
ISYNA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,594,816 - 44,598,495 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,489,219 - 44,598,497 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,509,230 - 44,512,910 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,080,806 - 45,084,487 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,999,052 - 45,085,082 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,318,111 - 44,321,783 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,728,243 - 44,731,923 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,003,669 - 45,007,342 (+)NCBIUU_Cfam_GSD_1.0
Isyna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,266,570 - 203,269,890 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,815,821 - 2,819,020 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,815,782 - 2,819,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISYNA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,363,716 - 59,367,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,363,672 - 59,367,003 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ISYNA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,906,724 - 16,910,194 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,905,472 - 16,910,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,431,203 - 2,435,020 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isyna1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,658,512 - 1,661,640 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,658,512 - 1,661,507 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Isyna1
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000026821
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH129421  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,839,160 - 18,839,326 (+)MAPPERmRatBN7.2
Rnor_6.01620,589,515 - 20,589,680NCBIRnor6.0
Rnor_5.01620,445,224 - 20,445,389UniSTSRnor5.0
RGSC_v3.41619,345,323 - 19,345,488UniSTSRGSC3.4
Celera1619,030,628 - 19,030,793UniSTS
RH 3.4 Map16180.5UniSTS
Cytogenetic Map16p14UniSTS
RH130875  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,838,677 - 18,838,866 (+)MAPPERmRatBN7.2
Rnor_6.01620,589,032 - 20,589,220NCBIRnor6.0
Rnor_5.01620,444,741 - 20,444,929UniSTSRnor5.0
RGSC_v3.41619,344,840 - 19,345,028UniSTSRGSC3.4
Celera1619,030,145 - 19,030,333UniSTS
RH 3.4 Map16180.3UniSTS
Cytogenetic Map16p14UniSTS
UniSTS:498303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,840,324 - 18,840,607 (+)MAPPERmRatBN7.2
Rnor_6.01620,590,679 - 20,590,961NCBIRnor6.0
Rnor_5.01620,446,388 - 20,446,670UniSTSRnor5.0
RGSC_v3.41619,346,487 - 19,346,769UniSTSRGSC3.4
Celera1619,031,792 - 19,032,074UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 34 25 9 25 66 29 41 11
Low 8 23 16 10 16 8 11 8 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000026821   ⟹   ENSRNOP00000026821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,839,145 - 18,841,979 (-)Ensembl
Rnor_6.0 Ensembl1620,589,481 - 20,592,449 (-)Ensembl
RefSeq Acc Id: NM_001013880   ⟹   NP_001013902
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,873,119 - 18,875,955 (-)NCBI
mRatBN7.21618,839,143 - 18,841,979 (-)NCBI
Rnor_6.01620,589,497 - 20,592,333 (-)NCBI
Rnor_5.01620,445,206 - 20,448,042 (-)NCBI
RGSC_v3.41619,345,305 - 19,348,141 (-)RGD
Celera1619,030,610 - 19,033,446 (-)RGD
Sequence:
RefSeq Acc Id: XM_063275161   ⟹   XP_063131231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,873,123 - 18,876,116 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001013902 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90710 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026821
  ENSRNOP00000026821.3
  ENSRNOP00055014121
  ENSRNOP00060012336
  ENSRNOP00065031857
GenBank Protein Q6AYK3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013902   ⟸   NM_001013880
- UniProtKB: Q6AYK3 (UniProtKB/Swiss-Prot),   A6KA27 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000026821   ⟸   ENSRNOT00000026821
RefSeq Acc Id: XP_063131231   ⟸   XM_063275161
- Peptide Label: isoform X1
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYK3-F1-model_v2 AlphaFold Q6AYK3 1-557 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700024
Promoter ID:EPDNEW_R10547
Type:initiation region
Name:Isyna1_1
Description:inositol-3-phosphate synthase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,592,279 - 20,592,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359423 AgrOrtholog
BioCyc Gene G2FUF-11788 BioCyc
BioCyc Pathway PWY-2301 [myo-inositol biosynthesis] BioCyc
BioCyc Pathway Image PWY-2301 BioCyc
Ensembl Genes ENSRNOG00000019741 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010351 UniProtKB/Swiss-Prot
  ENSRNOG00060009375 UniProtKB/Swiss-Prot
  ENSRNOG00065022942 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026821 ENTREZGENE
  ENSRNOT00000026821.6 UniProtKB/Swiss-Prot
  ENSRNOT00055017525 UniProtKB/Swiss-Prot
  ENSRNOT00060015808 UniProtKB/Swiss-Prot
  ENSRNOT00065039218 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113337 IMAGE-MGC_LOAD
InterPro Myo-inos-1-P_Synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Myo-inos-1-P_Synthase_GAPDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290651 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93930 IMAGE-MGC_LOAD
NCBI Gene 290651 ENTREZGENE
PANTHER INOSITOL-3-PHOSPHATE SYNTHASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYO-INOSITOL-1 PHOSPHATE SYNTHASE UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Inos-1-P_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Isyna1 PhenoGen
PIRSF Myoinos-ppht_syn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019741 RatGTEx
  ENSRNOG00055010351 RatGTEx
  ENSRNOG00060009375 RatGTEx
  ENSRNOG00065022942 RatGTEx
Superfamily-SCOP Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KA27 ENTREZGENE, UniProtKB/TrEMBL
  INO1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Isyna1  inositol-3-phosphate synthase 1  Isyna1  myo-inositol 1-phosphate synthase A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Isyna1  myo-inositol 1-phosphate synthase A1  LOC290651  similar to myo-inositol 1-phosphate synthase A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC290651  similar to myo-inositol 1-phosphate synthase A1      Symbol and Name status set to provisional 70820 PROVISIONAL