Palldl1 (palladin-like 1) - Rat Genome Database

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Gene: Palldl1 (palladin-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Palldl1
Name: palladin-like 1
RGD ID: 1359390
Description: Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization and cell migration. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human PALLD (palladin, cytoskeletal associated protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; paracetamol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hypothetical protein LOC364558; LOC108348198; LOC364558; palladin; palladin, cytoskeletal associated protein; Palld; similar to palladin, CGI-151 protein; uncharacterized LOC108348198
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: PalldTn(sb-T2/Bart3)2.341Mcwi  
Genetic Models: F344-PalldTn(sb-T2/Bart3)2.341Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81632,985,252 - 33,154,619 (+)NCBIGRCr8
mRatBN7.21627,981,315 - 28,143,129 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1627,981,354 - 28,621,337 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01631,349,140 - 31,390,340 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1631,349,184 - 31,390,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01631,198,863 - 31,240,064 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41631,144,028 - 31,144,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11631,118,213 - 31,193,638 (-)NCBI
Cytogenetic Map16p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A critical role for palladin in astrocyte morphology and response to injury. Boukhelifa M, etal., Mol Cell Neurosci. 2003 Aug;23(4):661-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. Goicoechea S, etal., J Cell Sci. 2006 Aug 15;119(Pt 16):3316-24. Epub 2006 Jul 25.
4. Isoform-specific upregulation of palladin in human and murine pancreas tumors. Goicoechea SM, etal., PLoS One. 2010 Apr 26;5(4):e10347.
5. Hypoxia inhibits differentiation of lineage-specific Rcho-1 trophoblast giant cells. Gultice AD, etal., Biol Reprod. 2006 Jun;74(6):1041-50. Epub 2006 Feb 15.
6. Palladin mutation causes familial pancreatic cancer and suggests a new cancer mechanism. Pogue-Geile KL, etal., PLoS Med. 2006 Dec;3(12):e516.
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Isoform-specific regulation of the actin-organizing protein palladin during TGF-beta1-induced myofibroblast differentiation. Ronty MJ, etal., J Invest Dermatol. 2006 Nov;126(11):2387-96. Epub 2006 Jun 22.
10. Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells. Salaria SN, etal., Cancer Biol Ther. 2007 Mar;6(3):324-8. Epub 2007 Mar 24.
Additional References at PubMed
PMID:12477932   PMID:20381583   PMID:20877641   PMID:23546604   PMID:29739492  


Genomics

Variants

.
Variants in Palldl1
1568 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat


Genetic Models
This gene Palldl1 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 7 10 7
Low 7 2 2 2 1 1 2 7 7 1
Below cutoff 2 36 30 6 30 2 28 26 1

Sequence


RefSeq Acc Id: ENSRNOT00000064850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1631,349,184 - 31,390,340 (+)Ensembl
RefSeq Acc Id: XM_039095177   ⟹   XP_038951105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,019,697 (+)NCBI
mRatBN7.21627,981,315 - 28,005,846 (+)NCBI
RefSeq Acc Id: XM_039095178   ⟹   XP_038951106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,026,503 (+)NCBI
mRatBN7.21627,981,316 - 28,022,581 (+)NCBI
RefSeq Acc Id: XM_039095179   ⟹   XP_038951107
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,154,619 (+)NCBI
mRatBN7.21627,981,316 - 28,143,129 (+)NCBI
RefSeq Acc Id: XM_039095181   ⟹   XP_038951109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,253 - 33,026,503 (+)NCBI
mRatBN7.21627,981,316 - 28,022,581 (+)NCBI
RefSeq Acc Id: XM_039095182   ⟹   XP_038951110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,253 - 33,026,219 (+)NCBI
mRatBN7.21627,981,316 - 28,019,875 (+)NCBI
RefSeq Acc Id: XM_063275968   ⟹   XP_063132038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,252 - 33,154,619 (+)NCBI
RefSeq Acc Id: XM_063275969   ⟹   XP_063132039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81632,985,253 - 33,026,303 (+)NCBI
RefSeq Acc Id: XP_038951105   ⟸   XM_039095177
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038951107   ⟸   XM_039095179
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038951109   ⟸   XM_039095181
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038951106   ⟸   XM_039095178
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951110   ⟸   XM_039095182
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063132038   ⟸   XM_063275968
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063132039   ⟸   XM_063275969
- Peptide Label: isoform X5
Protein Domains
Ig-like   Immunoglobulin I-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M265-F1-model_v2 AlphaFold F1M265 1-1002 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359390 AgrOrtholog
BioCyc Gene G2FUF-11597 BioCyc
Ensembl Genes ENSRNOG00000010107 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000042312 Ensembl
Ensembl Transcript ENSRNOT00000059673.6 UniProtKB/TrEMBL
  ENSRNOT00000064850.4 UniProtKB/TrEMBL
  ENSRNOT00000067450.3 UniProtKB/TrEMBL
  ENSRNOT00000111769.1 UniProtKB/TrEMBL
  ENSRNOT00000113275.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189104 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Palladin_C UniProtKB/TrEMBL
MGC_CLONE MGC:94544 IMAGE-MGC_LOAD
NCBI Gene 364558 ENTREZGENE
PANTHER CONTACTIN 5 UniProtKB/TrEMBL
  MYOTILIN UniProtKB/TrEMBL
  WRAPPER_REGA-1_KLINGON HOMOLOG UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
PhenoGen Palldl1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010107 RatGTEx
  ENSRNOG00000042312 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I5ZYR4_RAT UniProtKB/TrEMBL
  A0A8I6ADX4_RAT UniProtKB/TrEMBL
  A0A8I6AIC9_RAT UniProtKB/TrEMBL
  A0A8I6GFH4_RAT UniProtKB/TrEMBL
  F1M265_RAT UniProtKB/TrEMBL
  Q5M7W2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Palldl1  palladin-like 1  LOC108348198  uncharacterized LOC108348198  Data merged from RGD:11457236 737654 PROVISIONAL
2016-08-02 LOC108348198  uncharacterized LOC108348198      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-08-01 Palldl1  palladin-like 1  Palld  palladin, cytoskeletal associated protein  Name and Symbol changed 629549 APPROVED
2010-04-20 Palld  palladin, cytoskeletal associated protein  LOC364558  similar to palladin; CGI-151 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC364558  similar to palladin; CGI-151 protein      Symbol and Name status set to provisional 70820 PROVISIONAL