Rabif (RAB interacting factor) - Rat Genome Database

Name: Rabif
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Rabif (RAB interacting factor) Rattus norvegicus

Analyze

Symbol:

Rabif

Name:

RAB interacting factor

RGD ID:

1359331

Description:

Predicted to enable guanyl-nucleotide exchange factor activity and zinc ion binding activity. Predicted to be involved in post-Golgi vesicle-mediated transport. Predicted to be active in cytosol and membrane. Orthologous to human RABIF (RAB interacting factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

guanine nucleotide exchange factor MSS4; guanine-nucleotide-releasing protein mss4; LOC499636; mammalian suppressor of Sec4; Mss4; RAB-interacting factor; RGD1563962; similar to Mss4 protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RABIF (RAB interacting factor)	RGD	RGD
Mus musculus (house mouse):	Rabif (RAB interacting factor)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Rabif (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RABIF (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RABIF (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rabif (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RABIF (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RABIF (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rabif (RAB interacting factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RABIF (RAB interacting factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rabif (RAB interacting factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rabif (RAB interacting factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK970.8	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	strat	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mdt-9	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	rabif	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	45,936,371 - 45,948,929 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	45,936,369 - 45,949,775 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	48,543,630 - 48,555,085 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,831,698 - 49,843,157 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	47,095,963 - 47,108,882 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	51,317,476 - 51,330,536 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	51,317,460 - 51,331,705 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	165,805,144 - 165,816,697 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	56,374,239 - 56,385,530 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	47,437,336 - 47,448,832 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	47,451,390 - 47,462,864 (+)	NCBI
Celera	13	46,264,113 - 46,275,278 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diethylstilbestrol (ISO)

doxorubicin (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

ivermectin (ISO)

leflunomide (ISO)

methamphetamine (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

sodium arsenite (EXP)

Soman (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

post-Golgi vesicle-mediated transport (IBA)

protein transport (IEA)

small GTPase mediated signal transduction (IEA)

Cellular Component

cytosol (IBA)

membrane (IBA)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA)

protein binding (ISO)

zinc ion binding (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4.	Burton J, etal., Nature 1993 Feb 4;361(6411):464-7.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.	Strick DJ, etal., J Biol Chem 2002 Sep 6;277(36):32722-9. Epub 2002 Jun 24.

Additional References at PubMed

PMID:7619808	PMID:8889548	PMID:12477932	PMID:15277470	PMID:21427360	PMID:25303613

Genomics

Comparative Map Data

Rabif
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	45,936,371 - 45,948,929 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	45,936,369 - 45,949,775 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	48,543,630 - 48,555,085 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	49,831,698 - 49,843,157 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	47,095,963 - 47,108,882 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	51,317,476 - 51,330,536 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	51,317,460 - 51,331,705 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	2	165,805,144 - 165,816,697 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	56,374,239 - 56,385,530 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	47,437,336 - 47,448,832 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	47,451,390 - 47,462,864 (+)	NCBI
Celera	13	46,264,113 - 46,275,278 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

RABIF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	202,878,282 - 202,889,149 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	202,878,282 - 202,889,149 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	202,847,410 - 202,858,277 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	201,114,708 - 201,124,886 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	199,579,744 - 199,589,920	NCBI
Celera	1	175,977,320 - 175,987,480 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	174,013,022 - 174,023,972 (-)	NCBI		HuRef
CHM1_1	1	204,269,659 - 204,280,634 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	202,140,962 - 202,151,831 (-)	NCBI		T2T-CHM13v2.0

Rabif
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	134,422,377 - 134,435,627 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	134,422,386 - 134,436,512 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	134,494,639 - 134,507,889 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	134,494,648 - 134,508,774 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	136,391,237 - 136,404,462 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	136,311,071 - 136,324,296 (+)	NCBI		MGSCv36	mm8
Celera	1	137,101,238 - 137,115,147 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	58.24	NCBI

Rabif
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	38,883,050 - 38,893,251 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	38,883,050 - 38,893,012 (-)	NCBI	ChiLan1.0	ChiLan1.0

RABIF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	46,458,255 - 46,466,967 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	178,479,806 - 178,488,599 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	182,774,480 - 182,783,641 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	182,774,480 - 182,783,647 (-)	Ensembl	panpan1.1		panPan2

RABIF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	286,660 - 295,383 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	286,672 - 293,750 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	341,219 - 350,010 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	296,062 - 304,854 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	296,038 - 306,166 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	284,737 - 293,527 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	393,812 - 402,604 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	416,798 - 425,589 (+)	NCBI		UU_Cfam_GSD_1.0

Rabif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	72,482,128 - 72,492,915 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936567	1,716,753 - 1,726,433 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936567	1,716,804 - 1,726,433 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RABIF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	24,859,385 - 24,867,141 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	24,859,382 - 24,867,141 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	29,219,620 - 29,225,279 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RABIF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	26,516,394 - 26,526,483 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	26,518,124 - 26,526,329 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	27,294,475 - 27,303,898 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rabif
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	7,950,666 - 7,960,596 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	7,950,685 - 7,962,367 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rabif
84 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	5994833	77046787	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7411662	Foco29	Food consumption QTL 29	20.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	13	9313465	54313465	Rat
9589141	Insul28	Insulin level QTL 28	10.82	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	13	9313465	54313465	Rat
2317040	Aia21	Adjuvant induced arthritis QTL 21	2.75		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2317046	Aia8	Adjuvant induced arthritis QTL 8	3.9700000286102295		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	13	9831541	54831541	Rat
2302275	Gluco37	Glucose level QTL 37	3.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	13	11929449	46193066	Rat
631645	Bp121	Blood pressure QTL 121	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	14915655	59915655	Rat
9589164	Gluco66	Glucose level QTL 66	6.67	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	13	15158722	60158722	Rat
1331784	Bp222	Blood pressure QTL 222	2.944		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	17694436	53050594	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
61391	Bp5	Blood pressure QTL 5	5.6		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	22301875	67301875	Rat
70170	Eae14	Experimental allergic encephalomyelitis QTL 14		0.0024	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	23203448	68203448	Rat
6893338	Cm76	Cardiac mass QTL 76	0	0.99	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	23692969	68692969	Rat
1558644	Cm45	Cardiac mass QTL 45	3.6	0.002	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	13	23692969	68692969	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
2301962	Cm72	Cardiac mass QTL 72	4.12		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	13	31241331	58363171	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
2303563	Bw89	Body weight QTL 89	6		body mass (VT:0001259)	body weight (CMO:0000012)	13	32284471	77284471	Rat
61340	Bp25	Blood pressure QTL 25	4.2	0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	34535218	79535218	Rat
12879477	Bp401	Blood pressure QTL 401			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	37262092	82262092	Rat
61349	Bp31	Blood pressure QTL 31	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
70220	Bp55	Blood pressure QTL 55	5.75		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	13	37374509	82374509	Rat
4889861	Pur29	Proteinuria QTL 29	13.8	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	37415584	80753406	Rat
1331750	Bp220	Blood pressure QTL 220	2.98		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	37415584	82415584	Rat
1549897	Stresp12	Stress response QTL 12	3.35		stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	13	38433408	83433408	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	39754544	84754544	Rat
4145117	Mcs27	Mammary carcinoma susceptibility QTL 27		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	13	43437904	47841255	Rat
6893344	Cm79	Cardiac mass QTL 79	1.5	0.04	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	13	43720770	62022792	Rat
12879444	Bp397	Blood pressure QTL 397			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45049404	90049404	Rat
12879472	Bp399	Blood pressure QTL 399			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45228358	47841255	Rat
12879471	Bp398	Blood pressure QTL 398			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45514719	90514719	Rat
12879441	Bp396	Blood pressure QTL 396			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	45699983	90699983	Rat

Markers in Region

RH139414

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,948,488 - 45,948,610 (+)	MAPPER	mRatBN7.2
mRatBN7.2	2	153,447,719 - 153,447,841 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	165,816,282 - 165,816,403	NCBI	Rnor6.0
Rnor_6.0	13	51,330,096 - 51,330,217	NCBI	Rnor6.0
Rnor_5.0	13	56,385,090 - 56,385,211	UniSTS	Rnor5.0
Rnor_5.0	2	185,176,878 - 185,176,999	UniSTS	Rnor5.0
RGSC_v3.4	2	159,207,347 - 159,207,468	UniSTS	RGSC3.4
RGSC_v3.4	13	47,448,392 - 47,448,513	UniSTS	RGSC3.4
Celera	13	46,274,838 - 46,274,959	UniSTS
Celera	2	147,798,108 - 147,798,229	UniSTS
Cytogenetic Map	2	q31	UniSTS
Cytogenetic Map	13	q13	UniSTS

AU046955

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	13	45,945,796 - 45,945,907 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	51,327,404 - 51,327,514	NCBI	Rnor6.0
Rnor_6.0	2	165,813,590 - 165,813,700	NCBI	Rnor6.0
Rnor_5.0	2	185,174,186 - 185,174,296	UniSTS	Rnor5.0
Rnor_5.0	13	56,382,398 - 56,382,508	UniSTS	Rnor5.0
RGSC_v3.4	13	47,445,700 - 47,445,810	UniSTS	RGSC3.4
Celera	13	46,272,146 - 46,272,256	UniSTS
Cytogenetic Map	13	q13	UniSTS
Cytogenetic Map	2	q31	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									4
Low	3	43	55	39	19	39	8	10	70	35	41	11	8
Below cutoff			2	2		2		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM388378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CF977877	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO393618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY319223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005845 ⟹ ENSRNOP00000005845

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	45,936,369 - 45,949,775 (+)	Ensembl
Rnor_6.0 Ensembl	13	51,317,460 - 51,331,705 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000073716 ⟹ ENSRNOP00000066145

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	165,805,144 - 165,816,697 (+)	Ensembl

RefSeq Acc Id:

NM_001007678 ⟹ NP_001007679

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	13	45,936,371 - 45,948,929 (+)	NCBI
Rnor_6.0	13	51,317,476 - 51,330,536 (+)	NCBI
Rnor_5.0	13	56,374,239 - 56,385,530 (+)	NCBI
RGSC_v3.4	13	47,437,336 - 47,448,832 (+)	RGD
Celera	13	46,264,113 - 46,275,278 (+)	RGD

Sequence:

show sequence

CTGTGGCAGCGCGGCAATGGAACCCTGCGAGCTGCAGAACGAGCTAGTGTCAGCCGAAGGCCGG
AACCGGAAGGCGGTGCTGTGCCAGCGTTGTGGCTCTCGGGTGCTGCAGCCAGGGACTGCTCTTT
TCTCTCGCCGGCAGCTTTTCCTCCCCTCCATGAGGAAGAAGCCGGATCTGGTGGACGGCAGCAA
TCCTGATGGTGATGTCCTCGAGGAACACTGGCTGGTTAATGACATGTTCATCTTTGAGAACGTG
GGCTTTACCAAGGACGTGGGCAACGTCAAGTTTCTAGTCTGTGCAGACTGTGAGATTGGACCCA
TTGGCTGGCATTGCCTAGATGACAAGAACAGCTTCTATGTGGCCTTGGAGCGAGTTTCCCACGA
GTAACTGAGGGGTTTGGGACTTGGCTCCACCCTAGCTATAAAGCTCTGCCCACAAGAACCGACA
CTGATGTGTCAGCAGTGCTGGCAGACTTCTTGGTACTAATATAAGCACCGGTGTTTGCCCTTGA
ACTTGCAGAGGGCCGGTCCTGTTTCCTCAGGCCTCAGAGCATGTCTCCTACTTAGTCCTCTCTG
TCACATGTGTCCTAGAGCCCTTTCCCCTGACTTGGAACATGGAAGAACACGCGAGTGCTCTACC
AGTGTAGTCTGGTTCCCGGCACTCTGCCTCCGCACCTCGATGCCAAGCTCTCTTCTTCTCAGCA
AGAACAACATTTATCTTTAGCCATCACGACGGGAACTAAGATGCTAATATTTGAAACTCCACCT
TTCCTCATTCTAGAAGCCAAGTGTGATAGGGTGCACATCTGTAATCCTAGGTCTTGAGTGGGTA
GAGGCAGGAAGATCAGGAGTTCAAGGGCAGCCTTAGCTACATAGACTGGGCCAAGTGAGATGTT
GTCTCAAAAAACATAAAGCATACAAGTATTTGAGAGTAATCTCATTGTATGTGACCTACTTATC
TACAGTAATTTATTCTTTTTAAAAGTAAAACATTTACAGATGTCAGTATTTAAACCTCACTTTA
GATACATTTTTAGTACTGTGTTTGAGAGCCTTTTTTCCGGGTCAATAGTGGCATTTTATAATGA
GGATGAACACGACTCCTCTTCCCTCAGATCTTGATCAGGTTTCTCTTTTTAGTCATTCCTTGCC
CCTGATGTCAACCCTAAGGAAAACTCAGCCCTAGCTGTGTGCCAGACTCTCTTGTAAACCTGTT
CCACGGACATTTCTATTGTTATGGACAAGGTGTTACCTTTTCTTATTATTAGCCAACTTAAATC
TTCAATATGATTTCCAGTTACTCTGTCATTTCTCTTCTGGAGTGACTCAGTAGCTTAAAAGGAC
TCTGTGTAAACAGGTTCAAATACTGTGTCATCATCCCCTCCTCTGAGGGCCTAAATTGAGATAA
GTAGAGACTTCATTATTCCTCATGCCAGAGCTTAGGAAGTGGGGGCAGATCAAGAGTTCAAGGT
CAGCCTCAGTTACTATAATATCAAATTCAAGGCCAGCCTGTACTATGGAGATCTTGTTTCAAAT
GAACAAAACACAAAATAAACAAGTAGGACCTGCAAAAGTGACACGTAGTTAAAAATGTTTGCTG
CTCTTTCAGACGACCTGAGTTCAGGACCTTGCACCCTCATGGGAGGTTTACTCCAGTTCAAGGA
GATCTGCGCCTTCTGGTCCCTGCAGATGCCTTCATGTGTGTGGCACCCATACAAACAAGTGAGC
ACACTCGCGTACACACACACACACGCACGCACGCACGTGAATAAAAATTTTACAAATGAAAAAA
AAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007679	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61807	(Get FASTA)	NCBI Sequence Viewer
	EDM09722	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005845
GenBank Protein	Q08326	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001007679 ⟸ NM_001007678
- UniProtKB:	Q08326 (UniProtKB/Swiss-Prot), B1WBM2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPCELQNELVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLFLPSMRKKPDLVDGSNPDGDV LEEHWLVNDMFIFENVGFTKDVGNVKFLVCADCEIGPIGWHCLDDKNSFYVALERVSHE hide sequence

RefSeq Acc Id:

ENSRNOP00000005845 ⟸ ENSRNOT00000005845

RefSeq Acc Id:

ENSRNOP00000066145 ⟸ ENSRNOT00000073716

Protein Domains

MSS4

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q08326-F1-model_v2	AlphaFold	Q08326	1-123	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698832

Promoter ID:

EPDNEW_R9357

Type:

initiation region

Name:

Rabif_1

Description:

RAB interacting factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	13	51,317,456 - 51,317,516	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359331	AgrOrtholog
BioCyc Gene	G2FUF-18228	BioCyc
Ensembl Genes	ENSRNOG00000004424	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000045814	Ensembl
Ensembl Transcript	ENSRNOT00000005845	ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:9036685	IMAGE-MGC_LOAD
InterPro	Mss4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mss4-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mss4/transl-control_tumour	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:304807	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:187223	IMAGE-MGC_LOAD
NCBI Gene	304807	ENTREZGENE
PANTHER	GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13276	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Mss4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rabif	PhenoGen
PROSITE	MSS4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004424	RatGTEx
	ENSRNOG00000045814	RatGTEx
Superfamily-SCOP	SSF51316	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	B1WBM2	ENTREZGENE, UniProtKB/TrEMBL
	MSS4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Rabif	RAB interacting factor	RGD1563962	similar to Mss4 protein	Data merged from RGD:1563962	737654	PROVISIONAL
2008-04-30	RGD1563962	similar to Mss4 protein	RGD1563962_predicted	similar to Mss4 protein (predicted)	'predicted' is removed	2292626	APPROVED
2008-03-06	Rabif	RAB interacting factor	Mss4	Mss4 protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563962_predicted	similar to Mss4 protein (predicted)	LOC499636	similar to Mss4 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC499636	similar to Mss4 protein			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-07-29	Mss4	Mss4 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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