![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GHITM mRNA | CTD | PMID:36331819 | (S)-nicotine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 1,2-dichloroethane | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of GHITM mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of GHITM mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GHITM mRNA | CTD | PMID:22206623 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | 17alpha-ethynylestradiol | affects expression | ISO | Ghitm (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of GHITM mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GHITM mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | Ethinyl Estradiol results in decreased expression of GHITM mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GHITM mRNA and AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GHITM mRNA] | CTD | PMID:16214954 and PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GHITM mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Ghitm (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of GHITM mRNA | CTD | PMID:21570461 and PMID:24680724 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of GHITM mRNA | CTD | PMID:16214954 | 2,3-dimethoxynaphthalene-1,4-dione | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:17547211 | 2-hydroxypropanoic acid | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of GHITM mRNA | CTD | PMID:30851411 | 3-chloropropane-1,2-diol | increases expression | EXP | | 6480464 | alpha-Chlorohydrin results in increased expression of GHITM protein | CTD | PMID:34915118 | 4,4'-sulfonyldiphenol | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | bis(4-hydroxyphenyl)sulfone results in increased expression of GHITM protein | CTD | PMID:34186270 | acetylsalicylic acid | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Aspirin results in increased expression of GHITM mRNA | CTD | PMID:15928584 | acrylamide | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Acrylamide results in increased expression of GHITM mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | Aflatoxin B1 results in decreased expression of GHITM mRNA | CTD | PMID:19770486 | antimony(0) | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | Antimony results in decreased expression of GHITM mRNA | CTD | PMID:17547211 | Aroclor 1254 | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of GHITM mRNA | CTD | PMID:23650126 | arsenite(3-) | multiple interactions | ISO | GHITM (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to GHITM mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of GHITM mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | GHITM (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of GHITM promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in increased expression of GHITM mRNA | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of GHITM mRNA] | CTD | PMID:19850644 | bisphenol A | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | bisphenol A results in decreased expression of GHITM mRNA | CTD | PMID:26063408 | bisphenol A | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of GHITM protein | CTD | PMID:34186270 | bisphenol A | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | bisphenol A results in increased expression of GHITM mRNA | CTD | PMID:33221593 | bisphenol A | affects expression | ISO | GHITM (Homo sapiens) | 6480464 | bisphenol A affects the expression of GHITM mRNA | CTD | PMID:30903817 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of GHITM mRNA | CTD | PMID:25181051 and PMID:30816183 | butanal | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of GHITM mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | GHITM (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GHITM mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | GHITM (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GHITM mRNA | CTD | PMID:35301059 | caffeine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | carbon nanotube | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of GHITM mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | GHITM (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to GHITM gene] | CTD | PMID:28238834 | chloropicrin | affects expression | ISO | GHITM (Homo sapiens) | 6480464 | chloropicrin affects the expression of GHITM mRNA | CTD | PMID:26352163 | choline | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GHITM gene | CTD | PMID:20938992 | clozapine | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Clozapine results in increased expression of GHITM protein | CTD | PMID:34122009 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of GHITM mRNA | CTD | PMID:24386269 | copper atom | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Copper results in increased expression of GHITM mRNA | CTD | PMID:16629173 | copper(0) | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Copper results in increased expression of GHITM mRNA | CTD | PMID:16629173 | copper(II) sulfate | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of GHITM mRNA | CTD | PMID:19549813 | cyclosporin A | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of GHITM mRNA | CTD | PMID:25562108 | dibenzo[a,l]pyrene | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | dibenzo(a and l)pyrene results in decreased expression of GHITM mRNA | CTD | PMID:25908611 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of GHITM mRNA | CTD | PMID:21266533 | dibutyl phthalate | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of GHITM mRNA | CTD | PMID:21266533 | dicrotophos | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of GHITM mRNA | CTD | PMID:28302478 | dioxygen | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | Oxygen deficiency results in increased expression of GHITM mRNA | CTD | PMID:22629407 | dioxygen | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | Oxygen inhibits the reaction [Oxygen deficiency results in increased expression of GHITM mRNA] | CTD | PMID:22629407 | dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | Antimony Potassium Tartrate results in decreased expression of GHITM mRNA | CTD | PMID:17547211 | doxorubicin | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | Doxorubicin results in decreased expression of GHITM mRNA | CTD | PMID:26873546 | doxorubicin | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of GHITM mRNA | CTD | PMID:29803840 | ethanol | affects splicing | ISO | Ghitm (Mus musculus) | 6480464 | Ethanol affects the splicing of GHITM mRNA | CTD | PMID:30319688 | finasteride | increases expression | EXP | | 6480464 | Finasteride results in increased expression of GHITM mRNA | CTD | PMID:24136188 | fipronil | increases expression | EXP | | 6480464 | fipronil results in increased expression of GHITM mRNA | CTD | PMID:23962444 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of GHITM mRNA | CTD | PMID:24136188 | folic acid | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of GHITM mRNA | CTD | PMID:33387578 | glyphosate | affects methylation | EXP | | 6480464 | glyphosate affects the methylation of GHITM gene | CTD | PMID:35440735 | inulin | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of GHITM mRNA | CTD | PMID:36331819 | isotretinoin | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | Isotretinoin results in decreased expression of GHITM mRNA | CTD | PMID:20436886 | ivermectin | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of GHITM protein | CTD | PMID:32959892 | L-methionine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GHITM gene | CTD | PMID:20938992 | lead diacetate | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | lead acetate results in increased expression of GHITM mRNA | CTD | PMID:25270620 | leflunomide | increases expression | EXP | | 6480464 | leflunomide results in increased expression of GHITM mRNA | CTD | PMID:24136188 | methapyrilene | decreases expression | EXP | | 6480464 | Methapyrilene results in decreased expression of GHITM mRNA | CTD | PMID:30467583 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of GHITM gene | CTD | PMID:33148267 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of GHITM mRNA | CTD | PMID:28801915 | nefazodone | increases expression | EXP | | 6480464 | nefazodone results in increased expression of GHITM mRNA | CTD | PMID:24136188 | nicotine | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1 more ... | CTD | PMID:20230807 | nimesulide | increases expression | EXP | | 6480464 | nimesulide results in increased expression of GHITM mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | GHITM (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of GHITM mRNA | CTD | PMID:35430440 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of GHITM mRNA | CTD | PMID:33387578 | paraquat | increases expression | EXP | | 6480464 | Paraquat results in increased expression of GHITM mRNA | CTD | PMID:32680482 | pentane-2,3-dione | decreases expression | EXP | | 6480464 | 2 and 3-pentanedione results in decreased expression of GHITM mRNA | CTD | PMID:25710175 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Ghitm (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GHITM mRNA more ... | CTD | PMID:36331819 | perfluorooctane-1-sulfonic acid | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in increased expression of GHITM mRNA | CTD | PMID:25812627 | perfluorooctanoic acid | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of GHITM mRNA | CTD | PMID:25812627 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of GHITM gene | CTD | PMID:33148267 | pirinixic acid | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | pirinixic acid results in increased expression of GHITM mRNA | CTD | PMID:18301758 and PMID:23811191 | rac-lactic acid | decreases expression | ISO | GHITM (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of GHITM mRNA | CTD | PMID:30851411 | resveratrol | decreases expression | ISO | Ghitm (Mus musculus) | 6480464 | resveratrol results in decreased expression of GHITM protein | CTD | PMID:25505154 | sulindac | increases expression | EXP | | 6480464 | Sulindac results in increased expression of GHITM mRNA | CTD | PMID:24136188 | sunitinib | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Sunitinib results in increased expression of GHITM mRNA | CTD | PMID:31533062 | T-2 toxin | decreases expression | EXP | | 6480464 | T-2 Toxin results in decreased expression of GHITM mRNA | CTD | PMID:26141394 | tamoxifen | affects expression | ISO | Ghitm (Mus musculus) | 6480464 | Tamoxifen affects the expression of GHITM mRNA | CTD | PMID:17555576 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of GHITM mRNA | CTD | PMID:33387578 | triptonide | increases expression | ISO | Ghitm (Mus musculus) | 6480464 | triptonide results in increased expression of GHITM mRNA | CTD | PMID:33045310 | tunicamycin | increases expression | ISO | GHITM (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of GHITM mRNA | CTD | PMID:22378314 | valproic acid | increases methylation | ISO | GHITM (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of GHITM gene | CTD | PMID:29154799 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of GHITM mRNA | CTD | PMID:23034163 | |