Rpl17l2 (ribosomal protein L17-like 2)

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Gene: Rpl17l2 (ribosomal protein L17-like 2) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Rpl17l2 (Ensembl: RGD1359290)

Name:

ribosomal protein L17-like 2 (Ensembl:Ribosomal_L22 domain containing protein RGD1359290)

RGD ID:

1359290

Description:

Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be part of cytosolic large ribosomal subunit; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

60S ribosomal protein L17; Ac2-210; LOC360649; RGD1359290; Ribosomal_L22 domain containing protein RGD1359290; similar to Ac2-210

RGD Orthologs

Alliance Genes

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	RPL17 (ribosomal protein L17)	HGNC	Treefam
Homo sapiens (human):	GP5 (glycoprotein V platelet)	HGNC	OMA
Alliance orthologs ³
Caenorhabditis elegans (roundworm):	rpl-17	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPL17A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPL17B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RpL17	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	92,373,735 - 92,374,368 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	92,373,775 - 92,389,465 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	95,634,706 - 95,657,977 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	95,642,640 - 95,657,977 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	95,369,356 - 95,392,627 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	96,796,306 - 96,819,928 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	96,810,675 - 96,834,298 (+)	NCBI
Celera	10	91,030,612 - 91,054,228 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

bisphenol A (EXP)

trichloroethene (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic translation (IBA)

translation (IEA)

Cellular Component

cytosolic large ribosomal subunit (IBA)

large ribosomal subunit (IEA)

Molecular Function

structural constituent of ribosome (IBA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

Variants in Rpl17l2
7 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	42
Count of miRNA genes:	40
Interacting mature miRNAs:	42
Transcripts:	ENSRNOT00000029782
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
61419	Cia11	Collagen induced arthritis QTL 11	5.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	3	30356773	98535386	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33703347	104104347	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	41874578	104104347	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	53781112	91609953	Rat
731180	Bp152	Blood pressure QTL 152		0.03	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	53781112	91609953	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat

Markers in Region

D10Mgh4

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	92,369,364 - 92,369,470 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	95,638,234 - 95,638,337	NCBI	Rnor6.0
Rnor_5.0	10	95,372,884 - 95,372,987	UniSTS	Rnor5.0
RGSC_v3.4	10	96,799,833 - 96,799,937	RGD	RGSC3.4
RGSC_v3.4	10	96,799,834 - 96,799,937	UniSTS	RGSC3.4
RGSC_v3.1	10	96,814,203 - 96,814,307	RGD
Celera	10	91,034,140 - 91,034,243	UniSTS
RH 3.4 Map	10	1021.3	UniSTS
RH 3.4 Map	10	1021.3	RGD
RH 2.0 Map	10	1120.3	RGD
SHRSP x BN Map	10	73.41	RGD
FHH x ACI Map	10	76.95	RGD
Cytogenetic Map	10	q32.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	5	31	19	19	19	1	2	34	14	34	10	1
Low		38	26	22		22	7	9	40	21	7	1	7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_056984719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY321338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000029782 ⟹ ENSRNOP00000034767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	92,373,775 - 92,389,465 (+)	Ensembl
Rnor_6.0 Ensembl	10	95,642,640 - 95,657,977 (+)	Ensembl

RefSeq Acc Id:

XM_056984719 ⟹ XP_056840699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	92,373,735 - 92,374,368 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_056840699	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAP86270	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000034767 ⟸ ENSRNOT00000029782

RefSeq Acc Id:	XP_056840699 ⟸ XM_056984719
- UniProtKB:	A0A0H2UHQ1 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7TPJ7-F1-model_v2	AlphaFold	Q7TPJ7	1-220	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359290	AgrOrtholog
BioCyc Gene	G2FUF-22900	BioCyc
Ensembl Genes	ENSRNOG00000018680	UniProtKB/TrEMBL
	ENSRNOG00000027271	Ensembl, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025217	UniProtKB/TrEMBL
	ENSRNOP00000034767.3	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025217	UniProtKB/TrEMBL
	ENSRNOT00000029782.4	UniProtKB/TrEMBL
Gene3D-CATH	3.90.470.10	UniProtKB/TrEMBL
InterPro	Ribosomal_L22	UniProtKB/TrEMBL
	Ribosomal_L22/L17_CS	UniProtKB/TrEMBL
	Ribosomal_L22/L17_euk/arc	UniProtKB/TrEMBL
	Ribosomal_L22/L17_sf	UniProtKB/TrEMBL
KEGG Report	rno:360649	UniProtKB/TrEMBL
NCBI Gene	360649	ENTREZGENE
PANTHER	60S RIBOSOMAL PROTEIN L17	UniProtKB/TrEMBL
	60S RIBOSOMAL PROTEIN L17	UniProtKB/TrEMBL
	Ribosomal_L22/17	UniProtKB/TrEMBL
Pfam	Ribosomal_L22	UniProtKB/TrEMBL
PhenoGen	Rpl17l2	PhenoGen
PROSITE	RIBOSOMAL_L22	UniProtKB/TrEMBL
Superfamily-SCOP	Ribosomal_L22	UniProtKB/TrEMBL
UniProt	A0A0H2UHQ1	ENTREZGENE, UniProtKB/TrEMBL
	Q7TPJ7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-09-19	Rpl17l2	ribosomal protein L17-like 2	RGD1359290	Ribosomal_L22 domain containing protein RGD1359290	Symbol and Name Changed	1299863	APPROVED
2005-11-17	RGD1359290	Ribosomal_L22 domain containing protein RGD1359290	LOC360649	similar to Ac2-210	Symbol and Name updated	1299863	APPROVED
2005-07-29	LOC360649	similar to Ac2-210			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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