Klf2 (KLF transcription factor 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Klf2 (KLF transcription factor 2) Rattus norvegicus
Symbol: Klf2
Name: KLF transcription factor 2
RGD ID: 1359220
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organonitrogen compound; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of chromatin. Orthologous to human KLF2 (KLF transcription factor 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Krueppel-like factor 2; Kruppel-like factor; Kruppel-like factor 2; Kruppel-like factor 2 (lung); Lklf; lung krueppel-like factor; lung Kruppel-like factor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81617,555,136 - 17,557,768 (-)NCBIGRCr8
mRatBN7.21617,521,107 - 17,523,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,514,552 - 17,523,944 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,587,223 - 17,589,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,720,530 - 18,722,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,640,143 - 17,642,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,223,087 - 19,225,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,223,087 - 19,225,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,084,196 - 19,086,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,941,780 - 17,943,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,941,777 - 17,943,728 (-)NCBI
Celera1617,739,313 - 17,741,263 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
adenine  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
baicalein  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (EXP)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cinacalcet  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumarin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethyl 3,4-dihydroxybenzoate  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
Genipin  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
glyphosate  (EXP)
hexanal  (EXP)
hydroquinone  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
mevalonic acid  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
neomycin  (ISO)
nitrofen  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
phenytoin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
propanal  (ISO)
pterostilbene  (ISO)
pyridaben  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
scopolamine  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfur dioxide  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
triadimefon  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
yoda 1  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
nucleus  (ISO)


References - curated
# Reference Title Reference Citation
1. Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2. Clerk A, etal., Adv Enzyme Regul. 2009;49(1):30-42. Epub 2008 Dec 31.
2. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
3. T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells. Diessenbacher P, etal., Ann N Y Acad Sci 2003 Dec;1010:548-51.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. Wang N, etal., Biochem Biophys Res Commun. 2006 Mar 24;341(4):1244-51. Epub 2006 Jan 30.
9. Lung Kruppel-like factor (LKLF) is a transcriptional activator of the cytosolic phospholipase A2 alpha promoter. Wick MJ, etal., Biochem J. 2005 Apr 1;387(Pt 1):239-46.
Additional References at PubMed
PMID:7565748   PMID:9859212   PMID:15947087   PMID:20551324   PMID:21053160   PMID:21063504   PMID:21768538   PMID:22001906   PMID:22327366   PMID:22482507   PMID:22737924   PMID:22989565  
PMID:23002242   PMID:23043106   PMID:25500203   PMID:26299712   PMID:26416422   PMID:26813466   PMID:27855271   PMID:28167758   PMID:29079188   PMID:30628700   PMID:34147481   PMID:36343159  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81617,555,136 - 17,557,768 (-)NCBIGRCr8
mRatBN7.21617,521,107 - 17,523,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1617,514,552 - 17,523,944 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1617,587,223 - 17,589,173 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01618,720,530 - 18,722,483 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01617,640,143 - 17,642,093 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,223,087 - 19,225,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,223,087 - 19,225,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,084,196 - 19,086,146 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,941,780 - 17,943,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11617,941,777 - 17,943,728 (-)NCBI
Celera1617,739,313 - 17,741,263 (-)NCBICelera
Cytogenetic Map16p14NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381916,324,826 - 16,328,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1916,324,826 - 16,328,685 (+)EnsemblGRCh38hg38GRCh38
GRCh371916,435,637 - 16,439,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,296,651 - 16,299,345 (+)NCBINCBI36Build 36hg18NCBI36
Build 341916,296,650 - 16,299,337NCBI
Celera1916,337,566 - 16,340,260 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1916,006,724 - 16,007,405 (+)NCBIHuRef
CHM1_11916,435,181 - 16,437,875 (+)NCBICHM1_1
T2T-CHM13v2.01916,459,702 - 16,463,562 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39873,072,906 - 73,075,498 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl873,072,877 - 73,075,500 (+)EnsemblGRCm39 Ensembl
GRCm38872,319,062 - 72,321,654 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,319,033 - 72,321,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv37874,842,961 - 74,845,553 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36875,248,022 - 75,250,338 (+)NCBIMGSCv36mm8
Celera876,656,424 - 76,659,017 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.99NCBI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22021,194,451 - 21,197,283 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11920,200,667 - 20,203,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01915,812,506 - 15,815,244 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11916,792,497 - 16,794,143 (+)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12046,182,565 - 46,183,704 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2046,096,492 - 46,098,925 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02046,670,279 - 46,672,712 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2046,670,789 - 46,672,713 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,904,933 - 45,907,365 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02046,316,205 - 46,318,628 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02046,591,720 - 46,594,153 (-)NCBIUU_Cfam_GSD_1.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl261,270,199 - 61,273,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1261,270,733 - 61,273,037 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,903,997 - 60,904,625 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1614,832,013 - 14,834,744 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl614,832,029 - 14,837,462 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660744,637,274 - 4,640,383 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046249081,021,865 - 1,023,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Klf2
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:75
Interacting mature miRNAs:83
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 2 33 1 12 2 2 7 13 11
Low 1 10 56 41 7 41 8 9 72 28 28 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000019052   ⟹   ENSRNOP00000019052
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1619,223,087 - 19,225,037 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112398   ⟹   ENSRNOP00000083422
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1617,514,552 - 17,523,944 (-)Ensembl
RefSeq Acc Id: NM_001007684   ⟹   NP_001007685
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81617,555,136 - 17,557,768 (-)NCBI
mRatBN7.21617,521,107 - 17,523,739 (-)NCBI
Rnor_6.01619,223,087 - 19,225,037 (-)NCBI
Rnor_5.01619,084,196 - 19,086,146 (-)NCBI
RGSC_v3.41617,941,780 - 17,943,730 (-)RGD
Celera1617,739,313 - 17,741,263 (-)RGD
Protein Sequences
Protein RefSeqs NP_001007685 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG02141 (Get FASTA)   NCBI Sequence Viewer  
  EDL90840 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000083422
GenBank Protein Q9ET58 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007685   ⟸   NM_001007684
- UniProtKB: Q9ET58 (UniProtKB/Swiss-Prot),   A6K9P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019052   ⟸   ENSRNOT00000019052
RefSeq Acc Id: ENSRNOP00000083422   ⟸   ENSRNOT00000112398
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ET58-F1-model_v2 AlphaFold Q9ET58 1-351 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699986
Promoter ID:EPDNEW_R10508
Type:single initiation site
Description:Kruppel-like factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,225,053 - 19,225,113EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359220 AgrOrtholog
BioCyc Gene G2FUF-11881 BioCyc
Ensembl Genes ENSRNOG00000014205 Ensembl
  ENSRNOG00000067705 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010222 UniProtKB/Swiss-Prot
  ENSRNOG00060010023 UniProtKB/Swiss-Prot
  ENSRNOG00065021674 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000112398 ENTREZGENE
  ENSRNOT00000112398.1 UniProtKB/Swiss-Prot
  ENSRNOT00055017255 UniProtKB/Swiss-Prot
  ENSRNOT00060016938 UniProtKB/Swiss-Prot
  ENSRNOT00065036847 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:306330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klf2 PhenoGen
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014205 RatGTEx
  ENSRNOG00000067705 RatGTEx
  ENSRNOG00055010222 RatGTEx
  ENSRNOG00060010023 RatGTEx
  ENSRNOG00065021674 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP beta-beta-alpha zinc fingers UniProtKB/TrEMBL, UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf2  KLF transcription factor 2  Klf2  Kruppel-like factor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Klf2  Kruppel-like factor 2  Klf2  Kruppel-like factor 2 (lung)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Klf2  Kruppel-like factor 2 (lung)   Klf2_predicted  Kruppel-like factor 2 (lung) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Klf2_predicted  Kruppel-like factor 2 (lung) (predicted)  Klf2  Kruppel-like factor  Name updated 1299863 APPROVED
2005-12-06 Klf2  Kruppel-like factor      Symbol and Name updated 1559027 APPROVED
2005-07-29 Klf2  Kruppel-like factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease is not mutated in the autoimmune IDDM-prone BB rat 1359759
gene_homology inactivation of the mouse homolog causes development of autoimmune insulin dependent diabetes mellitus 1359759