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Gene: HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1) Homo sapiens

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Symbol:

HLA-DQB1

Name:

major histocompatibility complex, class II, DQ beta 1

RGD ID:

1353906

HGNC Page

HGNC:4944

Description:

Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Involved in T cell receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; and humoral immune response. Located in membrane. Implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); hematologic cancer (multiple); and liver disease (multiple).

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

CELIAC1; HLA class II antigen; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA-DQB; HLA-DRB1; IDDM1; lymphocyte antigen; major histocompatibility complex class II beta; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MHC class2 antigen; MHC DQ beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	H2-Ab1 (histocompatibility 2, class II antigen A, beta 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	RT1-Bb (RT1 class II, locus Bb)	HGNC	Ensembl, HomoloGene, OMA, OrthoDB, Panther, Treefam
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100972994 (HLA class II histocompatibility antigen, DQ beta 1 chain)	NCBI	Ortholog
Canis lupus familiaris (dog):	DLA-DQB1 (major histocompatibility complex, class II, DQ beta 1)	HGNC	HomoloGene, NCBI
Heterocephalus glaber (naked mole-rat):	LOC101703821 (HLA class II histocompatibility antigen, DQ beta 1 chain)	NCBI	Ortholog
Other homologs ²
Sus scrofa (pig):	SLA-DQB1 (SLA-DQ beta1 domain)	HGNC	Ensembl, OMA, OrthoDB, Panther, Treefam
Canis lupus familiaris (dog):	LOC100856137 (HLA class II histocompatibility antigen, DQ beta 2 chain)	HGNC	HomoloGene
Rattus norvegicus (Norway rat):	RT1-B (RT1 class II, locus B)	HGNC	Panther
Alliance orthologs ³
Rattus norvegicus (Norway rat):	RT1-B (RT1 class II, locus B)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	RT1-Bb (RT1 class II, locus Bb)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	H2-Ab1 (histocompatibility 2, class II antigen A, beta 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:busm1-228j01.6	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-33b17.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mhc2dbb (major histocompatibility complex class II DBB gene)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:zfos-2070c2.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:busm1-104n07.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mhc2dab (major histocompatibility complex class II DAB gene)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-158p21.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mhc2dhb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mhc2dgb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mhc2-dcb	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	32,659,467 - 32,666,657 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	32,659,467 - 32,668,383 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	32,627,244 - 32,634,434 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,735,635 - 32,742,444 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	34,177,338 - 34,182,264 (-)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	32,368,943 - 32,376,157 (-)	NCBI		HuRef
CHM1_1	6	32,629,719 - 32,636,944 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	32,482,491 - 32,489,842 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

achalasia (EXP,IAGP)

acute disseminated encephalomyelitis (IAGP)

acute lymphoblastic leukemia (IAGP)

acute myeloid leukemia (IAGP)

Addison's disease (IAGP)

agranulocytosis (IAGP)

allergic bronchopulmonary aspergillosis (IAGP)

allergic disease (EXP,IAGP)

alopecia areata (IAGP)

alveolar echinococcosis (IAGP)

Amebic Liver Abscess (IAGP)

angioedema (EXP)

ankylosing spondylitis (IAGP)

antiphospholipid syndrome (IAGP)

aplastic anemia (IAGP)

arthritis (IAGP)

aspirin-induced respiratory disease (IAGP)

asthma (EXP,IAGP)

atrophic gastritis (IAGP)

autoimmune disease (IAGP)

autoimmune hepatitis (IAGP)

autoimmune pancreatitis (IAGP)

autoimmune polyendocrine syndrome (IAGP)

autoimmune polyendocrine syndrome type 2 (IAGP)

autoimmune thrombocytopenic purpura (IAGP)

autoimmune thyroiditis (IAGP)

bacterial infectious disease (IAGP)

Behcet's disease (IAGP)

beta thalassemia (IAGP)

Cataplexy (IAGP)

celiac disease (EXP,IAGP,IMP)

cervical cancer (IAGP)

cervical dystonia (IAGP)

Chemical and Drug Induced Liver Injury (EXP,IAGP)

chikungunya (IAGP)

choreatic disease (IAGP)

Chronic Hepatitis B (IAGP)

Chronic Hepatitis C (IAGP)

chronic myeloid leukemia (IAGP)

cicatricial pemphigoid (IAGP)

colorectal cancer (IAGP)

common variable immunodeficiency (IAGP)

common wart (IAGP)

COVID-19 (HEP)

Creutzfeldt-Jakob disease (EXP,IAGP)

Crohn's disease (IAGP)

cystic echinococcosis (IAGP)

degenerative myopia (IAGP)

Delayed Hypersensitivity (ISO)

dental caries (IAGP)

diabetic retinopathy (IAGP)

dilated cardiomyopathy (IAGP)

dilated cardiomyopathy 1H (IAGP)

Drug Eruptions (EXP)

Drug-induced Neutropenia (IAGP)

End Stage Liver Disease (IAGP)

erythema multiforme (IAGP)

Experimental Autoimmune Encephalomyelitis (IMP,ISO)

glaucoma (IAGP)

Graves' disease (IAGP)

Hashimoto Disease (IAGP)

Helicobacter Infections (IAGP)

hepatitis B (IAGP)

hepatitis C (IAGP)

hepatocellular carcinoma (IAGP)

human immunodeficiency virus infectious disease (IAGP)

hyperthyroidism (IAGP)

hypothyroidism (IAGP)

Idiopathic Hypersomnolence (IAGP)

IgA glomerulonephritis (EXP,IAGP)

immunoglobulin alpha deficiency (IAGP)

iridocyclitis (IAGP)

juvenile rheumatoid arthritis (IAGP)

latex allergy (IAGP)

liver cirrhosis (IAGP)

marginal zone lymphoma (IAGP)

multidrug-resistant tuberculosis (IAGP)

multiple sclerosis (EXP,IAGP)

myasthenia gravis (IAGP)

mycosis fungoides (IAGP)

myocarditis (IAGP)

myositis (IAGP)

narcolepsy (EXP,IAGP)

Nasal Polyps (IAGP)

neuromyelitis optica (IAGP)

optic neuritis (IAGP)

Oropharyngeal Neoplasms (EXP)

osteomyelitis (IAGP)

paroxysmal nocturnal hemoglobinuria (IAGP)

pemphigus (IAGP)

pemphigus vulgaris (IAGP)

Plasmodium falciparum malaria (IAGP)

pneumoconiosis (IAGP)

pneumocystosis (ISO)

pre-eclampsia (IAGP)

primary progressive multiple sclerosis (IAGP)

primary sclerosing cholangitis (IAGP)

proteasome-associated autoinflammatory syndrome 1 (IAGP)

psoriasis (IAGP)

pulmonary tuberculosis (IAGP)

pure red-cell aplasia (IAGP)

Recurrent Respiratory Papillomatosis (IAGP)

rheumatic fever (IAGP)

rheumatic heart disease (IAGP)

rheumatoid arthritis (IAGP)

rhinitis (IAGP)

rhinoscleroma (IAGP)

Rhinosinusitis, Allergic Fungal (IAGP)

sarcoidosis (IAGP)

Seasonal Allergic Rhinitis (IAGP)

sickle cell anemia (IAGP)

silicosis (IAGP)

Sjogren's syndrome (IAGP)

Sleep Initiation and Maintenance Disorders (IAGP)

Small Fiber Neuropathy (IAGP)

Stevens-Johnson syndrome (IAGP)

stomach disease (IAGP)

Stroke (IAGP)

systemic lupus erythematosus (IAGP)

systemic scleroderma (EXP)

thrombotic thrombocytopenic purpura (IAGP)

Transplant Rejection (ISO)

tropical spastic paraparesis (IAGP)

tuberculosis (IAGP)

Tubulointerstitial Nephritis and Uveitis (IAGP)

type 1 diabetes mellitus (EXP,IAGP)

typhoid fever (IAGP)

ulcerative colitis (IAGP)

urticaria (EXP)

Uterine Cervical Dysplasia (IAGP)

uveitis (ISO)

Veno-Occlusive Disease (IAGP)

vitiligo (IAGP)

Vogt-Koyanagi-Harada disease (IAGP)

vulva cancer (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (EXP)

1,2-dimethylhydrazine (ISO)

1,4-dioxane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2,4,6-trinitrotoluene (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-butoxyethanol (ISO)

2-nitrofluorene (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (EXP)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (EXP,ISO)

amoxicillin (EXP)

antirheumatic drug (EXP)

arsane (EXP)

arsenic atom (EXP)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

Benzo[ghi]perylene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

C60 fullerene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

capsaicin (ISO)

carbamazepine (EXP)

carbon nanotube (ISO)

cefuroxime (EXP)

chlorohydrocarbon (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

choline (ISO)

clothianidin (EXP)

copper atom (ISO)

copper(0) (ISO)

corn oil (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

daidzein (ISO)

DDT (ISO)

decabromodiphenyl ether (ISO)

dexamethasone (EXP,ISO)

dextran sulfate (ISO)

Dibutyl phosphate (EXP)

diclofenac (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

diquat (ISO)

doramapimod (ISO)

dorsomorphin (EXP)

doxorubicin (EXP,ISO)

elemental selenium (EXP)

endosulfan (ISO)

entinostat (EXP)

fenoprofen (EXP)

fenthion (ISO)

ferroheme b (ISO)

folic acid (ISO)

fructose (ISO)

fulvestrant (EXP)

furan (ISO)

genistein (ISO)

gentamycin (ISO)

glucose (ISO)

glycidol (ISO)

glyphosate (ISO)

heme b (ISO)

hexachlorobenzene (ISO)

iron atom (ISO)

iron(0) (ISO)

isoprenaline (ISO)

isotretinoin (EXP)

ketoconazole (ISO)

ketoprofen (EXP)

L-methionine (ISO)

lead diacetate (ISO)

levonorgestrel (EXP)

lipopolysaccharide (ISO)

lumiracoxib (EXP)

menadione (ISO)

mercury atom (EXP,ISO)

mercury(0) (EXP,ISO)

methyl methanesulfonate (EXP)

methylisothiazolinone (EXP)

methylmercury chloride (EXP,ISO)

metronidazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-(6-acetamidohexyl)acetamide (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (ISO)

nickel atom (EXP)

nickel dichloride (EXP)

nicotine (EXP)

nifedipine (EXP)

oxaprozin (EXP)

ozone (ISO)

palladium (EXP)

panobinostat (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

pentamidine (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenacetin (ISO)

phenobarbital (ISO)

phenylhydrazine (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

quercetin (ISO)

raloxifene (ISO)

rifampicin (EXP)

SB 431542 (EXP)

selenium atom (EXP)

silicon dioxide (EXP,ISO)

simvastatin (EXP)

sodium arsenite (ISO)

sodium dichromate (ISO)

sulfasalazine (ISO)

tamibarotene (EXP)

tamoxifen (ISO)

testosterone (ISO)

testosterone enanthate (EXP)

testosterone undecanoate (EXP)

tetrachloromethane (ISO)

titanium dioxide (ISO)

tolmetin (EXP)

toluene (ISO)

toluene 2,4-diisocyanate (EXP)

Tributyltin oxide (ISO)

trichloroethene (ISO)

trichostatin A (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

tungsten (ISO)

valproic acid (EXP,ISO)

vancomycin (ISO)

vinclozolin (ISO)

vitamin E (EXP)

vorinostat (ISO)

zebularine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive immune response (IEA)

antigen processing and presentation (IEA,ISO)

antigen processing and presentation of exogenous peptide antigen via MHC class II (IBA,IDA,ISO)

antigen processing and presentation of peptide antigen (ISO)

antigen processing and presentation of peptide antigen via MHC class I (IEA)

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (IEA)

cellular response to dexamethasone stimulus (ISO)

cellular response to glucocorticoid stimulus (ISO)

cellular response to morphine (ISO)

defense response to fungus (ISO)

humoral immune response (IMP)

immune response (IEA,ISO,NAS)

negative regulation of T cell proliferation (ISO)

peptide antigen assembly with MHC class II protein complex (IBA)

positive regulation of immune response (IBA)

positive regulation of T cell activation (IBA)

T cell receptor signaling pathway (IDA)

Cellular Component

cell surface (IEA,ISO)

clathrin-coated endocytic vesicle membrane (TAS)

early endosome (ISO)

early endosome membrane (IEA)

endocytic vesicle membrane (TAS)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

endosome (IEA)

endosome membrane (IEA)

ER to Golgi transport vesicle membrane (IEA,TAS)

external side of plasma membrane (ISO)

Golgi apparatus (IEA)

Golgi membrane (TAS)

late endosome membrane (IBA)

lumenal side of endoplasmic reticulum membrane (IEA,TAS)

lysosomal membrane (IBA,IEA,TAS)

lysosome (IEA)

membrane (HDA,IEA,NAS)

MHC class I protein complex (IEA)

MHC class II protein complex (IBA,IEA,ISS)

multivesicular body (ISO)

phagocytic vesicle membrane (IEA)

plasma membrane (IEA,TAS)

recycling endosome membrane (IEA)

trans-Golgi network membrane (TAS)

transport vesicle membrane (TAS)

Molecular Function

metal ion binding (IEA)

MHC class II protein complex binding (IBA)

MHC class II receptor activity (NAS)

peptide antigen binding (IBA,ISS)

protein binding (IPI)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

allograft rejection pathway (IEA)

antigen processing and presentation pathway (IEA)

asthma pathway (IEA)

autoimmune thyroiditis pathway (IEA)

graft-versus-host disease pathway (IEA)

Leishmaniasis pathway (IEA)

myocarditis pathway (IEA)

rheumatoid arthritis pathway (IEA)

Staphylococcus aureus infection pathway (IEA)

systemic lupus erythematosus pathway (IEA)

toxoplasmosis pathway (IEA)

tuberculosis pathway (IEA)

type 1 diabetes mellitus pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Abdominal distention (IAGP)

Abdominal pain (IAGP)

Abnormal blistering of the skin (IAGP)

Abnormal cerebellum morphology (IAGP)

Abnormal cerebrospinal fluid morphology (IAGP)

Abnormal conjunctiva morphology (IAGP)

Abnormal nervous system physiology (IAGP)

Abnormal platelet count (IAGP)

Abnormal pupillary function (IAGP)

Abnormal rapid eye movement sleep (IAGP)

Abnormal stomach morphology (IAGP)

Abnormality of the abdominal wall (IAGP)

Abnormality of the coagulation cascade (IAGP)

Abnormality of the thyroid gland (IAGP)

Adult onset (IAGP)

Alopecia (IAGP)

Anemia (IAGP)

Anterior uveitis (IAGP)

Anti-BP180 antibody positivity (IAGP)

Anti-BP230 antibody positivity (IAGP)

Antinuclear antibody positivity (IAGP)

Anxiety (IAGP)

Apathy (IAGP)

Aphasia (IAGP)

Arthralgia (IAGP)

Arthritis (IAGP)

Asthma (IAGP)

Ataxia (IAGP)

Attention deficit hyperactivity disorder (IAGP)

Atypical behavior (IAGP)

Autoimmune antibody positivity (IAGP)

Autoimmunity (IAGP)

Autosomal dominant inheritance (IAGP)

Autosomal recessive inheritance (IAGP)

Back pain (IAGP)

Bronchitis (IAGP)

Cataplexy (IAGP)

Celiac disease (IAGP)

Cerebral calcification (IAGP)

Chest pain (IAGP)

Chorea (IAGP)

Chronic sinusitis (IAGP)

CNS demyelination (IAGP)

Confusion (IAGP)

Constipation (IAGP)

Cough (IAGP)

Decreased circulating IgA concentration (IAGP)

Decreased circulating prealbumin concentration (IAGP)

Decreased circulating vitamin B12 concentration (IAGP)

Decreased circulating vitamin D concentration (IAGP)

Decreased circulating vitamin K concentration (IAGP)

Decreased thyroid-stimulating hormone level (IAGP)

Delayed puberty (IAGP)

Delusion (IAGP)

Dementia (IAGP)

Depression (IAGP)

Diabetes mellitus (IAGP)

Diarrhea (IAGP)

Diplopia (IAGP)

Drooling (IAGP)

Dysphagia (IAGP)

Eczematoid dermatitis (IAGP)

EEG abnormality (IAGP)

Elevated circulating D-dimer concentration (IAGP)

Elevated circulating hepatic transaminase concentration (IAGP)

Elevated circulating thyroid-stimulating hormone concentration (IAGP)

EMG abnormality (IAGP)

Emotional lability (IAGP)

Enamel hypoplasia (IAGP)

Erythema (IAGP)

Excessive daytime somnolence (IAGP)

Extrapyramidal muscular rigidity (IAGP)

Failure to thrive (IAGP)

Fatigable weakness (IAGP)

Female sexual dysfunction (IAGP)

Fever (IAGP)

Gait ataxia (IAGP)

Gastroesophageal reflux (IAGP)

Genital ulcers (IAGP)

Goiter (IAGP)

Hallucinations (IAGP)

Hemiparesis (IAGP)

Hemiplegia (IAGP)

Hemolytic anemia (IAGP)

Hyperhidrosis (IAGP)

Hypertension (IAGP)

Hypnagogic hallucination (IAGP)

Hypnopompic hallucination (IAGP)

Hypocalcemia (IAGP)

Impaired temperature sensation (IAGP)

Incoordination (IAGP)

Increased circulating antibody concentration (IAGP)

Increased circulating free T3 (IAGP)

Increased circulating IgE concentration (IAGP)

Increased circulating T4 concentration (IAGP)

Increased CSF protein concentration (IAGP)

Infertility (IAGP)

Inflammatory abnormality of the skin (IAGP)

Insomnia (IAGP)

Invasive parasitic infection (IAGP)

Iron deficiency anemia (IAGP)

Irritability (IAGP)

Ischemic stroke (IAGP)

Keratoconjunctivitis sicca (IAGP)

Linear IgG deposits along the epidermal basement membrane zone (IAGP)

Loss of facial expression (IAGP)

Lymphoma (IAGP)

Macrocytic anemia (IAGP)

Macule (IAGP)

Male sexual dysfunction (IAGP)

Malnutrition (IAGP)

Memory impairment (IAGP)

Middle age onset (IAGP)

Migraine (IAGP)

Morphological central nervous system abnormality (IAGP)

Muscle weakness (IAGP)

Myocarditis (IAGP)

Myoclonus (IAGP)

Myositis (IAGP)

Narcolepsy (IAGP)

Nasal congestion (IAGP)

Nasal polyposis (IAGP)

Nocturia (IAGP)

Non-Mendelian inheritance (IAGP)

NREM parasomnia (IAGP)

Obesity (IAGP)

Optic neuritis (IAGP)

Oral mucosal blisters (IAGP)

Oral ulcer (IAGP)

Osteomyelitis (IAGP)

Osteoporosis (IAGP)

Pancreatitis (IAGP)

Paresthesia (IAGP)

Personality changes (IAGP)

Polyneuropathy (IAGP)

Postnatal growth retardation (IAGP)

Precocious puberty (IAGP)

Primary adrenal insufficiency (IAGP)

Prolonged partial thromboplastin time (IAGP)

Prolonged prothrombin time (IAGP)

Pruritus (IAGP)

Psoriasiform dermatitis (IAGP)

Psychosis (IAGP)

Rapidly progressive (IAGP)

Recurrent aphthous stomatitis (IAGP)

Recurrent aspiration pneumonia (IAGP)

Recurrent infections (IAGP)

Reduced blood folate concentration (IAGP)

Restless legs (IAGP)

Restlessness (IAGP)

Reticulocytopenia (IAGP)

Reticulocytosis (IAGP)

Retinal hemorrhage (IAGP)

Retinal vascular malformation (IAGP)

Rhinorrhea (IAGP)

Rickets (IAGP)

Sacroiliac arthritis (IAGP)

Seizure (IAGP)

Short stature (IAGP)

Sleep abnormality (IAGP)

Sleep apnea (IAGP)

Sleep paralysis (IAGP)

Slurred speech (IAGP)

Spasticity (IAGP)

Steatorrhea (IAGP)

Stomatitis (IAGP)

Subcutaneous nodule (IAGP)

Supranuclear gaze palsy (IAGP)

Syncope (IAGP)

Thrombocytosis (IAGP)

Thyroid hyperplasia (IAGP)

Thyroiditis (IAGP)

Transient global amnesia (IAGP)

Type I diabetes mellitus (IAGP)

Urinary hesitancy (IAGP)

Urinary incontinence (IAGP)

Urticaria (IAGP)

Uveitis (IAGP)

Visual impairment (IAGP)

Vomiting (IAGP)

Weight loss (IAGP)

Wheezing (IAGP)

Xerostomia (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Treatment of autoimmune anterior uveitis with recombinant TCR ligands.	Adamus G, etal., Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2555-61.
2.	HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM.	Agardh D, etal., Diabetologia. 1996 Nov;39(11):1313-7.
3.	Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia.	Al-Ola K, etal., Tissue Antigens. 2008 May;71(5):453-7. doi: 10.1111/j.1399-0039.2008.01012.x. Epub 2008 Feb 28.
4.	Acute disseminated encephalomyelitis: clinical features, HLA DRB11501, HLA DRB11503, HLA DQA10102, HLA DQB10602, and HLA DPA1*0301 allelic association study.	Alves-Leon SV, etal., Arq Neuropsiquiatr. 2009 Sep;67(3A):643-51.
5.	[Immunogenetic aspects of the course and treatment of pulmonary tuberculosis].	Archakova LI, etal., Probl Tuberk Bolezn Legk. 2008;(12):34-7.
6.	HLA, PTPN22 and PD-1 associations as markers of autoimmunity in neuromyelitis optica.	Asgari N, etal., Mult Scler. 2012 Jan;18(1):23-30. doi: 10.1177/1352458511417480. Epub 2011 Sep 9.
7.	Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.	Athanasiou MC, etal., J Clin Psychiatry. 2011 Apr;72(4):458-63. doi: 10.4088/JCP.09m05527yel. Epub 2010 Sep 21.
8.	Risk of recurrence of primary sclerosing cholangitis after liver transplantation is associated with de novo inflammatory bowel disease.	Bajer L, etal., World J Gastroenterol. 2018 Nov 21;24(43):4939-4949. doi: 10.3748/wjg.v24.i43.4939.
9.	[Association of the relationship between HLA-DQB1 alleles and major beta-thalassemia in 42 guangdong Chinese].	Bao R, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002 Feb;10(1):87-8.
10.	Opposing effects of the HLA-DRB10301-DQB10201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel.	Benedek G, etal., Genes Immun. 2010 Jul;11(5):423-31. Epub 2010 May 13.
11.	HLA class II distribution in Congolese with hyperthyroidism: preliminary results.	Bidingija M, etal., Ann Endocrinol (Paris). 2006 Dec;67(6):596-603.
12.	Genetic basis of the latex-fruit syndrome: association with HLA class II alleles in a Spanish population.	Blanco C, etal., J Allergy Clin Immunol. 2004 Nov;114(5):1070-6.
13.	Identification of HLA-DR and -DQ alleles conferring susceptibility to pollen allergy and pollen associated food allergy.	Boehncke WH, etal., Clin Exp Allergy. 1998 Apr;28(4):434-41.
14.	HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis.	Bonagura VR, etal., Hum Immunol. 2004 Aug;65(8):773-82.
15.	Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.	Bonagura VR, etal., Hum Immunol. 2010 Feb;71(2):212-9. doi: 10.1016/j.humimm.2009.10.009. Epub 2009 Oct 25.
16.	Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study.	Book L, etal., Am J Med Genet. 2001 Jan 1;98(1):70-4.
17.	HLA-DQ: Celiac disease vs inflammatory bowel disease.	Bosca-Watts MM, etal., World J Gastroenterol. 2018 Jan 7;24(1):96-103. doi: 10.3748/wjg.v24.i1.96.
18.	Increased occurrence of anti-AQP4 seropositivity and unique HLA Class II associations with neuromyelitis optica (NMO), among Muslim Arabs in Israel.	Brill L, etal., J Neuroimmunol. 2016 Apr 15;293:65-70. doi: 10.1016/j.jneuroim.2016.02.006. Epub 2016 Feb 15.
19.	Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo.	Buc M, etal., Eur J Dermatol. 1998 Jan-Feb;8(1):13-5.
20.	Two-domain MHC class II molecules form stable complexes with myelin basic protein 69-89 peptide that detect and inhibit rat encephalitogenic T cells and treat experimental autoimmune encephalomyelitis.	Burrows GG, etal., J Immunol. 1998 Dec 1;161(11):5987-96.
21.	HLA class II gene polymorphisms in antiphospholipid syndrome: haplotype analysis in 83 Caucasoid patients.	Caliz R, etal., Rheumatology (Oxford). 2001 Jan;40(1):31-6.
22.	HLA class II alleles and chronic hepatitis C virus infection.	Cangussu LOF, etal., Scand J Immunol. 2011 Sep;74(3):282-287. doi: 10.1111/j.1365-3083.2011.02568.x.
23.	Tumour necrosis factor microsatellites and HLA-DRB1, HLA-DQA1, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis.	Castro F, etal., Ann Rheum Dis. 2001 Aug;60(8):791-5.
24.	HLA class II allele polymorphism in an outbreak of chikungunya fever in Middle Andaman, India.	Chaaithanya IK, etal., Immunology. 2013 Oct;140(2):202-10. doi: 10.1111/imm.12128.
25.	Significantly increased occurrence of HLA-DQB1*0301 allele in patients with ocular cicatricial pemphigoid.	Chan LS, etal., J Invest Dermatol. 1997 Feb;108(2):129-32.
26.	The association between HLA-DQB1 polymorphism and antituberculosis drug-induced liver injury: a Case-Control Study.	Chen R, etal., J Clin Pharm Ther. 2015 Feb;40(1):110-5. doi: 10.1111/jcpt.12211. Epub 2014 Sep 24.
27.	Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages.	Cheng BH, etal., BMC Microbiol. 2010 Apr 8;10:103.
28.	Tumour necrosis factor-alpha single nucleotide polymorphisms are not independent of HLA class I in UK Caucasians with adult onset idiopathic inflammatory myopathies.	Chinoy H, etal., Rheumatology (Oxford). 2007 Sep;46(9):1411-6. Epub 2007 Jun 22.
29.	[Analysis of HLA-DQB1 polymorphism for patients with allergic rhinitis of Uygur and Han people in Xinjiang].	Cui Z, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 Jul;25(14):645-8.
30.	Allorecognition of isolated, denatured chains of class I and class II major histocompatibility complex molecules. Evidence for an important role for indirect allorecognition in transplantation.	Dalchau R, etal., Eur J Immunol. 1992 Mar;22(3):669-77.
31.	Association between human leukocyte antigen polymorphism and human papillomavirus 16-positive vulval intraepithelial neoplasia in British women.	Davidson EJ, etal., Cancer Res. 2003 Jan 15;63(2):400-3.
32.	Resistance to celiac disease in humanized HLA-DR3-DQ2-transgenic mice expressing specific anti-gliadin CD4+ T cells.	de Kauwe AL, etal., J Immunol. 2009 Jun 15;182(12):7440-50.
33.	HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID).	De La Concha EG, etal., Clin Exp Immunol. 1999 Jun;116(3):516-20.
34.	Association of HLA Class II alleles and haplotypes with cervical dystonia: HLA DR13-DQ6 (DQB1*0604) homozygotes are at greatly increased risk of cervical dystonia in Caucasian Americans.	Deitiker PR, etal., Autoimmunity. 2011 May;44(3):167-76. Epub 2010 Sep 15.
35.	HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis.	Djilali-Saiah I, etal., J Hepatol. 2006 Dec;45(6):844-50. Epub 2006 Sep 28.
36.	HLA-DRB1 and HLA-DQB1 genes in susceptibility and resistance to cicatricial pemphigoid in French Caucasians.	Drouet M, etal., Eur J Dermatol. 1998 Jul-Aug;8(5):330-3.
37.	Genes of the class II and class III major histocompatibility complex are associated with typhoid fever in Vietnam.	Dunstan SJ, etal., J Infect Dis. 2001 Jan 15;183(2):261-268. doi: 10.1086/317940. Epub 2000 Dec 21.
38.	Persistent HPV16/18 infection in Indian women with the A-allele (rs6457617) of HLA-DQB1 and T-allele (rs16944) of IL-1β -511 is associated with development of cervical carcinoma.	Dutta S, etal., Cancer Immunol Immunother. 2015 Jul;64(7):843-51. doi: 10.1007/s00262-015-1693-5. Epub 2015 Apr 17.
39.	No association between bronchial asthma and HLA-DRB1, -DQB1 alleles in the Slovak population.	Dzurilla M, etal., Bratisl Lek Listy. 2013;114(2):93-5.
40.	HLA and alveolar echinococcosis.	Eiermann TH, etal., Tissue Antigens. 1998 Aug;52(2):124-9. doi: 10.1111/j.1399-0039.1998.tb02275.x.
41.	Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study.	El-Bendary M, etal., J Viral Hepat. 2016 Dec;23(12):961-970. doi: 10.1111/jvh.12573. Epub 2016 Sep 7.
42.	Differential effects of DRB10301 and DQA10501-DQB1*0201 on the activation and progression of islet cell autoimmunity.	Eller E, etal., Genes Immun. 2007 Dec;8(8):628-33. Epub 2007 Aug 30.
43.	HLA-DRB and HLA-DQ genetic variability in patients with aspirin-exacerbated respiratory disease.	Esmaeilzadeh H, etal., Am J Rhinol Allergy. 2015 May-Jun;29(3):e63-9. doi: 10.2500/ajra.2015.29.4154.
44.	HLA class II haplotype DRB104-DQB10301 contributes to risk of familial generalized vitiligo and early disease onset.	Fain PR, etal., Pigment Cell Res. 2006 Feb;19(1):51-7.
45.	DQA1 and DQB1 association and nasal polyposis.	Fajardo-Dolci G, etal., Otolaryngol Head Neck Surg. 2006 Aug;135(2):243-7.
46.	[Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1, DQB1 genes].	Fan XY, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Aug;23(4):278-81.
47.	Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias.	Fernandes TA, etal., Blood Cells Mol Dis. 2010 Mar-Apr;44(2):69-73. doi: 10.1016/j.bcmd.2009.10.006. Epub 2010 Jan 3.
48.	High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.	Ferreira RC, etal., PLoS Genet. 2012 Jan;8(1):e1002476. doi: 10.1371/journal.pgen.1002476. Epub 2012 Jan 26.
49.	HLA profile in patients with AIDS and tuberculosis.	Figueiredo JF, etal., Braz J Infect Dis. 2008 Aug;12(4):278-80. doi: 10.1590/s1413-86702008000400004.
50.	HLA typing in acute optic neuritis. Relation to multiple sclerosis and magnetic resonance imaging findings.	Frederiksen JL, etal., Arch Neurol. 1997 Jan;54(1):76-80.
51.	Identification of a highly promiscuous and an HLA allele-specific T-cell epitope in the birch major allergen Bet v 1: HLA restriction, epitope mapping and TCR sequence comparisons.	Friedl-Hajek R, etal., Clin Exp Allergy. 1999 Apr;29(4):478-87.
52.	An original Eurasian haplotype, HLA-DRB114:54-DQB105:03, influences the susceptibility to idiopathic achalasia.	Furuzawa-Carballeda J, etal., PLoS One. 2018 Aug 9;13(8):e0201676. doi: 10.1371/journal.pone.0201676. eCollection 2018.
53.	Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects.	Gao J, etal., Chin Med J (Engl). 2003 Jul;116(7):1078-82.
54.	Study of the association between human leukocyte antigens (HLA) and pemphigus vulgaris in Brazilian patients.	Gil JM, etal., Int J Dermatol. 2017 May;56(5):557-562. doi: 10.1111/ijd.13577. Epub 2017 Feb 15.
55.	HLA-DRB and HLA-DQB loci in the genetic susceptibility to develop glaucoma in Mexicans.	Gil-Carrasco F, etal., Am J Ophthalmol. 1999 Sep;128(3):297-300.
56.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
57.	Renal vascular sclerosis is associated with inherited thrombophilias.	Goforth RL, etal., Kidney Int. 2006 Aug;70(4):743-50. Epub 2006 Jun 7.
58.	Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease.	Gundogdu F, etal., J Heart Valve Dis. 2007 May;16(3):293-9.
59.	[Association between asthma and the polymorphism of HLA-DQ genes].	Guo X, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2001 Mar;24(3):139-41.
60.	Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients.	Han YN, etal., World J Gastroenterol. 2005 Sep 28;11(36):5721-4. doi: 10.3748/wjg.v11.i36.5721.
61.	Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection.	Hardie RA, etal., AIDS. 2008 Apr 23;22(7):807-16.
62.	Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population.	Hashimoto K, etal., Horm Res. 2005;64(5):253-60. Epub 2005 Oct 27.
63.	Prevalent HLA Class II Alleles in Mexico City Appear to Confer Resistance to the Development of Amebic Liver Abscess.	Hernández EG, etal., PLoS One. 2015 May 4;10(5):e0126195. doi: 10.1371/journal.pone.0126195. eCollection 2015.
64.	Familial mycosis fungoides: report of 6 kindreds and a study of the HLA system.	Hodak E, etal., J Am Acad Dermatol. 2005 Mar;52(3 Pt 1):393-402.
65.	HLA-DQB1 and HLA-DPB1 genotypes in severe preeclampsia.	Honda K, etal., Obstet Gynecol. 2000 Sep;96(3):385-9. doi: 10.1016/s0029-7844(00)00918-2.
66.	[Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children].	Huang YK, etal., Zhonghua Er Ke Za Zhi. 2005 Feb;43(2):137-40.
67.	Identification of multiple independent susceptibility loci in the HLA region in Behcet's disease.	Hughes T, etal., Nat Genet. 2013 Mar;45(3):319-24. doi: 10.1038/ng.2551. Epub 2013 Feb 10.
68.	Does HLA Class II haplotype play a role in adult acute disseminated encephalomyelitis? Preliminary findings from a Southern Italy hospital-based study.	Imbesi D, etal., Arch Ital Biol. 2012 Mar;150(1):1-4. doi: 10.4449/aib.v150i1.1384.
69.	Profiles of autoimmune hepatitis in Brunei Darussalam.	Jalihal A, etal., Hepatobiliary Pancreat Dis Int. 2009 Dec;8(6):602-7.
70.	HLA-DQB1 allele and hypocretin in Korean narcoleptics with cataplexy.	Jeong JH, etal., J Korean Med Sci. 2007 Feb;22(1):127-31.
71.	Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjogren's syndrome.	Kang HI, etal., J Immunol. 1993 Apr 15;150(8 Pt 1):3615-23.
72.	Genetic aspect of venom allergy: association with HLA class I and class II antigens.	Karakis GP, etal., Ann Agric Environ Med. 2010 Jun;17(1):119-23.
73.	Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population.	Katahira M, etal., Hum Immunol. 2010 Aug;71(8):789-94. Epub 2010 May 25.
74.	HLA-DQA10103-DQB10601 haplotype and Helicobacter pylori-positive gastric mucosa-associated lymphoid tissue lymphoma.	Kawahara Y, etal., Clin Gastroenterol Hepatol. 2005 Sep;3(9):865-8.
75.	HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice.	Khare M, etal., J Neuroimmunol. 2005 Dec;169(1-2):1-12. Epub 2005 Sep 27.
76.	HLA-DQB1 subtypes predict diabetic retinopathy in patients with type I diabetes mellitus.	Khazaee MH, etal., Eur J Ophthalmol. 2009 Jul-Aug;19(4):638-45.
77.	HLA class II allele and haplotype frequencies in Iranian patients with leukemia.	Khosravi F, etal., Iran J Allergy Asthma Immunol. 2007 Sep;6(3):137-42.
78.	Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma.	Knutsen AP, etal., Clin Mol Allergy. 2010 Mar 18;8:5.
79.	Major histocompatibility complex class II (DRB1, DQA1, and DQB1) and DRB104 subtypes' associations of Hashimoto's thyroiditis in a Greek population.	Kokaraki G, etal., Tissue Antigens. 2009 Mar;73(3):199-205.
80.	HLA associations with multiple sclerosis in Greece.	Kouri I, etal., J Neurol Sci. 2011 Jul 7.
81.	The 8.1 ancestral MHC haplotype is associated with delayed onset of colonization in cystic fibrosis.	Laki J, etal., Int Immunol. 2006 Nov;18(11):1585-90. Epub 2006 Sep 20.
82.	Celiac disease in children with autoimmune thyroid disease.	Larizza D, etal., J Pediatr. 2001 Nov;139(5):738-40.
83.	HLA class II DRB1 and DQB1 allelic polymorphism and sclerosing lymphocytic lobulitis of the breast.	Lee AH, etal., J Clin Pathol. 1999 Jun;52(6):445-9.
84.	Effects of smoking on the association of human leukocyte antigen with ulcerative colitis.	Lee HS, etal., J Gastroenterol Hepatol. 2019 Apr 30. doi: 10.1111/jgh.14695.
85.	Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome-wide association study.	Lee MH, etal., Hepatology. 2018 Feb;67(2):651-661. doi: 10.1002/hep.29531. Epub 2018 Jan 1.
86.	Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia.	Legge SE, etal., Mol Psychiatry. 2017 Oct;22(10):1502-1508. doi: 10.1038/mp.2016.97. Epub 2016 Jul 12.
87.	Association between HLA-DQB1 and cervical dysplasia in Vietnamese women.	Lema C, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1269-77. doi: 10.1111/j.1525-1438.2006.00459.x.
88.	Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome.	Levinson RD, etal., Invest Ophthalmol Vis Sci. 2003 Feb;44(2):653-7.
89.	[Study on the association of pathologic myopia with HLA-DQB1 gene].	Li S, etal., Zhonghua Yan Ke Za Zhi. 2001 Jul;37(4):263-6.
90.	Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.	Li X, etal., J Allergy Clin Immunol. 2010 Feb;125(2):328-335.e11. doi: 10.1016/j.jaci.2009.11.018.
91.	[HLA-DQ molecules associated with myasthenia gravis in Chinese patients].	Li X, etal., Yi Chuan Xue Bao. 1999;26(4):295-300.
92.	[Studies of the association of pathological myopia in Chinese patients with HLA alleles].	Li X, etal., Yi Chuan Xue Bao. 2000;27(3):189-94.
93.	HLA-DQA1, -DQB1 polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy in Hans of northern China.	Liu W, etal., Ann Hum Genet. 2005 Jul;69(Pt 4):382-8.
94.	Polymorphisms of HLA-DQB1 predict survival of hepatitis B virus-related hepatocellular carcinoma patients receiving hepatic resection.	Liu X, etal., Clin Res Hepatol Gastroenterol. 2016 Dec;40(6):739-747. doi: 10.1016/j.clinre.2016.04.005. Epub 2016 Jun 7.
95.	Human leukocyte antigen class II associations in patients with idiopathic dilated cardiomyopathy. Myocarditis Treatment Trial Investigators.	Lozano MD, etal., J Card Fail. 1997 Jun;3(2):97-103.
96.	[Distribution of HLA specificity frequencies in patients with cystic echinococcosis].	Lukmanova GI, etal., Med Parazitol (Mosk). 2011 Oct-Dec;(4):14-6.
97.	The same HLA-DQ alleles determine either susceptibility or resistance to different coxsackievirus-mediated autoimmune diseases.	Luppi P, etal., J Biol Regul Homeost Agents. 1999 Jan-Mar;13(1):14-26.
98.	HLA-A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 frequencies in German immunoglobulin A-deficient individuals.	MacHulla HK, etal., Scand J Immunol. 2000 Aug;52(2):207-11.
99.	Association of the HLA-DRB10301 and HLA-DQA10501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds.	Maciel LM, etal., Thyroid. 2001 Jan;11(1):31-5.
100.	HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.	Mahdi N, etal., Clin Vaccine Immunol. 2008 Apr;15(4):729-31. doi: 10.1128/CVI.00425-07. Epub 2008 Feb 13.
101.	HLA DRB1130101-DQB1060101 haplotype is associated with acute chest syndrome in sickle cell anemia patients.	Mahdi N, etal., Tissue Antigens. 2009 Mar;73(3):245-9. doi: 10.1111/j.1399-0039.2008.01189.x.
102.	Recurrent herpes simplex virus-induced erythema multiforme: different HLA-DQB1 alleles associate with severe mucous membrane versus skin attacks.	Malo A, etal., Scand J Immunol. 1998 May;47(5):408-11.
103.	Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes.	Manan H, etal., Hum Immunol. 2010 Dec;71(12):1238-42. Epub 2010 Sep 19.
104.	IL28B CC-genotype association with HLA-DQB1*0301 allele increases the prediction of spontaneous HCV RNA clearance in thalassaemic HCV-infected patients.	Mangia A, etal., Antivir Ther. 2011;16(8):1309-16. doi: 10.3851/IMP1913.
105.	HLA class II antigens associated with lupus nephritis in Italian SLE patients.	Marchini M, etal., Hum Immunol. 2003 Apr;64(4):462-8. doi: 10.1016/s0198-8859(03)00017-x.
106.	Human leukocyte antigen type and progression from onset of symptoms to development of asthma.	Martyn MB, etal., Allergy Asthma Proc. 2010 Mar;31(2):120-5. Epub 2010 Mar 8.
107.	A rapid and sensitive assay to identify HLA-DQ2/8 risk alleles for celiac disease using real-time PCR method.	Mashayekhi K, etal., Gastroenterol Hepatol Bed Bench. 2018 Summer;11(3):250-258.
108.	Association between HLA class II alleles and hepatitis B virus infection in Transylvania, Romania.	Matei HV, etal., Immunol Invest. 2018 Oct;47(7):735-744. doi: 10.1080/08820139.2018.1489832. Epub 2018 Jul 6.
109.	HLA-DQB1*0501-restricted Th1 type immune responses to Plasmodium falciparum liver stage antigen 1 protect against malaria anemia and reinfections.	May J, etal., J Infect Dis. 2001 Jan 1;183(1):168-72. Epub 2000 Nov 10.
110.	HLA class II antigens positively and negatively associated with hepatosplenic schistosomiasis in a Chinese population.	McManus DP, etal., Int J Parasitol. 2001 May 15;31(7):674-80. doi: 10.1016/s0020-7519(01)00132-1.
111.	Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis.	Melin-Aldana H, etal., J Pediatr. 1992 Jul;121(1):56-60.
112.	Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.	Mignot E, etal., Am J Hum Genet. 2001 Mar;68(3):686-99. Epub 2001 Feb 13.
113.	[Polymorphism of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome].	Min HY, etal., Zhonghua Yan Ke Za Zhi. 2007 Apr;43(4):355-60.
114.	[Single nucleotide polymorphisms of promoter of human leukocyte antigen-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome].	Min HY, etal., Zhonghua Yan Ke Za Zhi. 2008 Oct;44(10):870-5.
115.	Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB11501-DQB10602 haplotype.	Miyagawa T, etal., J Hum Genet. 2010 Jan;55(1):63-5. Epub 2009 Nov 20.
116.	HLA-A*11 and novel associations in Malays and Chinese with systemic lupus erythematosus.	Mohd-Yusuf Y, etal., Immunol Lett. 2011 Sep 30;139(1-2):68-72. Epub 2011 May 30.
117.	HLA-DRB1, -DQA1, and -DQB1 genotypes in patients with nasal polyposis.	Molnar-Gabor E, etal., Laryngoscope. 2000 Mar;110(3 Pt 1):422-5.
118.	Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.	Monsuur AJ, etal., PLoS One. 2008 May 28;3(5):e2270.
119.	Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.	Moriguchi M, etal., Metabolism. 2011 Jun;60(6):761-6. Epub 2010 Sep 9.
120.	Association of HLA class II alleles with childhood asthma and Total IgE levels.	Movahedi M, etal., Iran J Allergy Asthma Immunol. 2008 Dec;7(4):215-20.
121.	HLA-DQ2 and -DQ8 genotype frequency in Syrian celiac disease children: HLA-DQ relative risks evaluation.	Murad H, etal., BMC Gastroenterol. 2018 May 24;18(1):70. doi: 10.1186/s12876-018-0802-2.
122.	HLA-DRB1 and HLA-DQB1 genes on susceptibility to and protection from allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.	Muro M, etal., Microbiol Immunol. 2013 Mar;57(3):193-7. doi: 10.1111/1348-0421.12020.
123.	HLA DQ gene dosage and risk and severity of celiac disease.	Murray JA, etal., Clin Gastroenterol Hepatol. 2007 Dec;5(12):1406-12. Epub 2007 Oct 24.
124.	Identification of a specific HLA class II haplotype strongly associated with susceptibility to cyclosporine-dependent aplastic anemia.	Nakao S, etal., Blood. 1994 Dec 15;84(12):4257-61.
125.	HLA-DRB116: 01-DQB105: 02 is a novel genetic risk factor for flupirtine-induced liver injury.	Nicoletti P, etal., Pharmacogenet Genomics. 2016 May;26(5):218-24. doi: 10.1097/FPC.0000000000000209.
126.	[Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children].	Nizhevich AA, etal., Eksp Klin Gastroenterol. 2010;(1):58-63.
127.	Genetic analysis of HLA- and HPA-typing in idiopathic (autoimmune) thrombocytopenic purpura patients treated with cepharanthin.	Nomura S, etal., Autoimmunity. 1999;30(2):99-105.
128.	Molecular analysis of HLA class II-associated susceptibility to neuroinflammatory diseases in Korean children.	Oh HH, etal., J Korean Med Sci. 2004 Jun;19(3):426-30. doi: 10.3346/jkms.2004.19.3.426.
129.	Immunogenetic characteristics of patients with autoimmune gastritis.	Oksanen AM, etal., World J Gastroenterol. 2010 Jan 21;16(3):354-8.
130.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
131.	Association between HLA-DQB1 gene and patients with acute lymphoblastic leukemia (ALL).	Orouji E, etal., Int J Hematol. 2012 May;95(5):551-5. doi: 10.1007/s12185-012-1051-8. Epub 2012 Mar 21.
132.	Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease.	Pani MA, etal., Clin Endocrinol (Oxf). 2002 Jun;56(6):773-7.
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PMID:15853903	PMID:15853909	PMID:15854524	PMID:15858601	PMID:15871822	PMID:15885635	PMID:15902698	PMID:15906352	PMID:15908298	PMID:15935893	PMID:15941540	PMID:15958261
PMID:15969672	PMID:15982255	PMID:15985473	PMID:15991024	PMID:15993714	PMID:15993720	PMID:16005098	PMID:16005527	PMID:16019679	PMID:16025255	PMID:16029431	PMID:16042135
PMID:16042197	PMID:16043129	PMID:16049290	PMID:16078082	PMID:16091223	PMID:16096810	PMID:16096857	PMID:16101833	PMID:16107511	PMID:16107953	PMID:16109069	PMID:16112030
PMID:16122986	PMID:16125818	PMID:16133177	PMID:16142706	PMID:16148166	PMID:16157380	PMID:16158194	PMID:16180280	PMID:16201295	PMID:16208405	PMID:16225776	PMID:16242130
PMID:16245224	PMID:16261886	PMID:16267776	PMID:16276008	PMID:16277691	PMID:16297186	PMID:16303674	PMID:16320082	PMID:16337001	PMID:16343061	PMID:16352685	PMID:16354571
PMID:16358956	PMID:16365741	PMID:16386646	PMID:16386650	PMID:16390391	PMID:16393997	PMID:16405603	PMID:16409268	PMID:16426242	PMID:16430717	PMID:16433795	PMID:16437632
PMID:16441488	PMID:16441489	PMID:16451208	PMID:16453260	PMID:16454711	PMID:16464953	PMID:16473309	PMID:16484124	PMID:16507114	PMID:16509868	PMID:16540751	PMID:16567828
PMID:16573562	PMID:16579847	PMID:16604509	PMID:16614815	PMID:16629714	PMID:16640876	PMID:16691379	PMID:16698430	PMID:16709874	PMID:16712649	PMID:16720210	PMID:16720217
PMID:16731854	PMID:16769963	PMID:16781300	PMID:16783473	PMID:16792673	PMID:16796128	PMID:16799707	PMID:16802776	PMID:16803690	PMID:16829307	PMID:16829309	PMID:16836882
PMID:16849401	PMID:16857416	PMID:16865785	PMID:16866883	PMID:16866885	PMID:16875346	PMID:16878175	PMID:16879301	PMID:16879749	PMID:16883535	PMID:16883536	PMID:16883543
PMID:16890179	PMID:16891216	PMID:16905561	PMID:16911023	PMID:16916661	PMID:16916662	PMID:16922942	PMID:16939368	PMID:16941709	PMID:16948649	PMID:16964961	PMID:16966600
PMID:16988007	PMID:17002902	PMID:17002906	PMID:17016821	PMID:17026464	PMID:17047287	PMID:17062033	PMID:17106278	PMID:17119950	PMID:17124999	PMID:17126830	PMID:17129633
PMID:17130528	PMID:17130566	PMID:17130569	PMID:17143607	PMID:17144392	PMID:17153701	PMID:17162989	PMID:17180363	PMID:17190762	PMID:17203517	PMID:17203524	PMID:17207713
PMID:17212706	PMID:17212715	PMID:17234427	PMID:17256150	PMID:17257313	PMID:17257319	PMID:17287608	PMID:17301827	PMID:17305280	PMID:17306585	PMID:17310371	PMID:17311339
PMID:17318773	PMID:17325942	PMID:17329717	PMID:17334650	PMID:17344279	PMID:17349874	PMID:17350686	PMID:17364902	PMID:17370149	PMID:17378697	PMID:17379283	PMID:17387388
PMID:17388766	PMID:17389012	PMID:17389015	PMID:17389030	PMID:17392350	PMID:17406641	PMID:17406854	PMID:17406941	PMID:17407088	PMID:17433060	PMID:17437273	PMID:17438108
PMID:17445172	PMID:17445173	PMID:17460569	PMID:17461431	PMID:17484621	PMID:17484883	PMID:17489940	PMID:17498269	PMID:17513705	PMID:17531857	PMID:17538887	PMID:17541908
PMID:17554059	PMID:17554300	PMID:17559577	PMID:17573956	PMID:17576097	PMID:17578052	PMID:17584581	PMID:17584585	PMID:17592398	PMID:17610416	PMID:17629023	PMID:17629515
PMID:17631742	PMID:17641683	PMID:17652306	PMID:17652848	PMID:17653284	PMID:17661909	PMID:17662002	PMID:17673320	PMID:17678725	PMID:17681393	PMID:17686102	PMID:17688234
PMID:17714036	PMID:17714903	PMID:17722421	PMID:17726164	PMID:17767549	PMID:17767551	PMID:17785583	PMID:17785916	PMID:17845309	PMID:17869653	PMID:17875181	PMID:17900288
PMID:17906106	PMID:17911430	PMID:17919266	PMID:17927716	PMID:17936227	PMID:17956579	PMID:17959659	PMID:17964196	PMID:17967566	PMID:17971177	PMID:17989838	PMID:17997607
PMID:17999653	PMID:18001300	PMID:18003662	PMID:18007983	PMID:18022727	PMID:18028350	PMID:18036100	PMID:18036312	PMID:18036860	PMID:18038917	PMID:18039812	PMID:18053473
PMID:18057383	PMID:18065200	PMID:18065518	PMID:18070207	PMID:18073310	PMID:18084828	PMID:18085741	PMID:18086267	PMID:18177450	PMID:18198357	PMID:18200971	PMID:18211635
PMID:18236804	PMID:18241227	PMID:18241860	PMID:18248305	PMID:18252895	PMID:18257894	PMID:18259107	PMID:18273032	PMID:18273034	PMID:18279373	PMID:18279642	PMID:18282752
PMID:18289678	PMID:18292987	PMID:18295738	PMID:18301962	PMID:18312478	PMID:18316396	PMID:18331414	PMID:18332098	PMID:18339073	PMID:18345414	PMID:18351579	PMID:18352820
PMID:18356404	PMID:18356750	PMID:18372357	PMID:18385790	PMID:18390988	PMID:18396213	PMID:18401547	PMID:18408266	PMID:18433881	PMID:18447907	PMID:18449200	PMID:18450852
PMID:18451182	PMID:18481581	PMID:18495081	PMID:18496418	PMID:18504544	PMID:18523354	PMID:18535809	PMID:18537178	PMID:18544086	PMID:18554163	PMID:18556337	PMID:18561316
PMID:18562179	PMID:18565729	PMID:18569076	PMID:18573919	PMID:18593440	PMID:18599937	PMID:18636124	PMID:18650831	PMID:18652916	PMID:18706091	PMID:18721466	PMID:18722491
PMID:18726686	PMID:18728522	PMID:18728523	PMID:18756979	PMID:18769865	PMID:18774995	PMID:18778327	PMID:18801688	PMID:18820539	PMID:18821214	PMID:18824733	PMID:18839133
PMID:18852273	PMID:18854880	PMID:18930994	PMID:18932050	PMID:18945465	PMID:18955791	PMID:18955792	PMID:18958335	PMID:18976432	PMID:18976440	PMID:18987644	PMID:18987854
PMID:19000139	PMID:19005023	PMID:19013100	PMID:19023492	PMID:19027045	PMID:19027490	PMID:19039244	PMID:19041429	PMID:19055605	PMID:19104471	PMID:19116923	PMID:19117368
PMID:19120272	PMID:19120276	PMID:19120278	PMID:19122664	PMID:19124916	PMID:19143810	PMID:19143811	PMID:19143812	PMID:19143813	PMID:19143814	PMID:19143818	PMID:19143820
PMID:19143821	PMID:19149577	PMID:19154326	PMID:19184295	PMID:19188433	PMID:19200828	PMID:19200845	PMID:19204159	PMID:19207936	PMID:19208355	PMID:19223392	PMID:19227412
PMID:19246116	PMID:19251712	PMID:19254257	PMID:19255754	PMID:19272325	PMID:19286445	PMID:19290000	PMID:19295542	PMID:19295543	PMID:19299434	PMID:19317743	PMID:19332095
PMID:19342211	PMID:19347328	PMID:19349081	PMID:19350523	PMID:19364514	PMID:19380721	PMID:19390203	PMID:19401421	PMID:19404393	PMID:19409091	PMID:19410617	PMID:19429597
PMID:19439981	PMID:19449444	PMID:19458352	PMID:19474744	PMID:19478349	PMID:19479859	PMID:19480851	PMID:19486004	PMID:19487887	PMID:19490211	PMID:19490212	PMID:19493426
PMID:19500688	PMID:19506770	PMID:19523767	PMID:19539001	PMID:19539218	PMID:19543113	PMID:19544559	PMID:19553558	PMID:19571811	PMID:19585166	PMID:19587357	PMID:19589487
PMID:19592628	PMID:19593686	PMID:19596691	PMID:19597844	PMID:19620308	PMID:19625333	PMID:19653987	PMID:19654407	PMID:19654877	PMID:19655145	PMID:19663932	PMID:19664674
PMID:19668019	PMID:19683555	PMID:19690132	PMID:19698125	PMID:19703234	PMID:19714482	PMID:19750928	PMID:19758197	PMID:19761839	PMID:19769302	PMID:19770068	PMID:19812988
PMID:19817985	PMID:19819281	PMID:19819768	PMID:19820007	PMID:19820376	PMID:19833889	PMID:19834793	PMID:19837788	PMID:19845915	PMID:19851445	PMID:19858318	PMID:19884273
PMID:19890026	PMID:19895409	PMID:19896518	PMID:19896562	PMID:19906105	PMID:19915493	PMID:19924143	PMID:19927780	PMID:19931565	PMID:19937591	PMID:19946888	PMID:19956635
PMID:19961590	PMID:20002609	PMID:20003135	PMID:20012522	PMID:20016199	PMID:20031464	PMID:20035815	PMID:20062572	PMID:20073143	PMID:20073992	PMID:20090103	PMID:20101097
PMID:20110394	PMID:20120618	PMID:20138312	PMID:20141578	PMID:20169624	PMID:20170930	PMID:20190752	PMID:20191588	PMID:20193456	PMID:20225292	PMID:20230523	PMID:20230525
PMID:20237496	PMID:20300660	PMID:20301407	PMID:20301720	PMID:20305777	PMID:20307907	PMID:20335219	PMID:20337975	PMID:20345871	PMID:20352225	PMID:20356827	PMID:20380523
PMID:20383147	PMID:20392899	PMID:20395221	PMID:20403137	PMID:20443243	PMID:20445565	PMID:20453840	PMID:20462405	PMID:20462916	PMID:20466734	PMID:20486920	PMID:20492596
PMID:20492597	PMID:20492599	PMID:20507388	PMID:20522202	PMID:20536993	PMID:20547426	PMID:20549830	PMID:20550778	PMID:20559009	PMID:20561992	PMID:20569042	PMID:20586801
PMID:20595243	PMID:20595679	PMID:20603341	PMID:20606439	PMID:20608062	PMID:20614846	PMID:20631027	PMID:20639878	PMID:20639880	PMID:20639881	PMID:20666704	PMID:20668555
PMID:20670354	PMID:20685690	PMID:20691532	PMID:20711174	PMID:20719952	PMID:20725783	PMID:20739684	PMID:20798335	PMID:20805278	PMID:20823837	PMID:20836749	PMID:20849903
PMID:20851016	PMID:20861181	PMID:20923326	PMID:20923327	PMID:20937338	PMID:20966625	PMID:20970669	PMID:20975052	PMID:20977916	PMID:21029659	PMID:21029690	PMID:21031025
PMID:21049023	PMID:21059899	PMID:21067613	PMID:21075156	PMID:21091360	PMID:21108609	PMID:21118624	PMID:21133715	PMID:21251479	PMID:21318258	PMID:21325036	PMID:21388362
PMID:21395562	PMID:21399633	PMID:21417892	PMID:21418452	PMID:21422625	PMID:21533074	PMID:21570397	PMID:21606539	PMID:21633537	PMID:21652028	PMID:21670772	PMID:21692766
PMID:21694611	PMID:21712058	PMID:21720852	PMID:21732917	PMID:21750111	PMID:21762399	PMID:21778700	PMID:21779181	PMID:21796887	PMID:21804548	PMID:21873635	PMID:21896673
PMID:21917268	PMID:21922073	PMID:21943816	PMID:21946350	PMID:21955839	PMID:22013116	PMID:22036600	PMID:22086417	PMID:22103833	PMID:22103834	PMID:22106694	PMID:22175768
PMID:22184118	PMID:22218223	PMID:22234791	PMID:22272574	PMID:22281000	PMID:22284614	PMID:22285112	PMID:22289814	PMID:22326585	PMID:22362761	PMID:22404765	PMID:22493691
PMID:22494469	PMID:22509268	PMID:22511809	PMID:22521184	PMID:22588649	PMID:22594481	PMID:22662777	PMID:22799313	PMID:22860026	PMID:22862152	PMID:22876559	PMID:22898764
PMID:22913598	PMID:22938381	PMID:23028341	PMID:23065995	PMID:23085892	PMID:23128233	PMID:23136848	PMID:23146381	PMID:23177929	PMID:23184486	PMID:23218978	PMID:23243276
PMID:23257407	PMID:23266558	PMID:23273495	PMID:23278608	PMID:23284291	PMID:23317308	PMID:23318129	PMID:23326239	PMID:23333304	PMID:23349640	PMID:23376458	PMID:23380142
PMID:23402837	PMID:23420232	PMID:23421483	PMID:23428460	PMID:23443026	PMID:23472185	PMID:23535732	PMID:23593151	PMID:23628390	PMID:23628399	PMID:23745951	PMID:23793423
PMID:23806156	PMID:23809616	PMID:23817569	PMID:23817571	PMID:23918589	PMID:23968403	PMID:23993985	PMID:24050898	PMID:24056069	PMID:24067471	PMID:24204280	PMID:24204295
PMID:24268496	PMID:24304973	PMID:24321473	PMID:24338389	PMID:24376798	PMID:24377640	PMID:24381092	PMID:24388013	PMID:24490781	PMID:24571861	PMID:24572971	PMID:24602055
PMID:24660172	PMID:24738569	PMID:24758334	PMID:24763718	PMID:24768947	PMID:24782177	PMID:24806356	PMID:24853027	PMID:24904546	PMID:24917237	PMID:25009391	PMID:25064009
PMID:25070808	PMID:25156535	PMID:25157096	PMID:25172978	PMID:25187353	PMID:25197808	PMID:25200477	PMID:25209151	PMID:25256355	PMID:25329634	PMID:25337265	PMID:25383971
PMID:25413104	PMID:25501240	PMID:25523979	PMID:25531278	PMID:25651370	PMID:25673541	PMID:25732907	PMID:25773770	PMID:25845749	PMID:25851465	PMID:25965561	PMID:25971824
PMID:26007157	PMID:26085212	PMID:26088570	PMID:26088816	PMID:26095634	PMID:26168013	PMID:26180102	PMID:26204120	PMID:26362370	PMID:26398634	PMID:26443252	PMID:26476208
PMID:26566811	PMID:26671138	PMID:26681219	PMID:26684212	PMID:26733285	PMID:26733291	PMID:26744784	PMID:26769539	PMID:26817698	PMID:26818121	PMID:26822082	PMID:26829741
PMID:26856406	PMID:26882171	PMID:26883458	PMID:26884287	PMID:26951409	PMID:27000234	PMID:27013183	PMID:27048628	PMID:27056075	PMID:27072514	PMID:27105925	PMID:27116456
PMID:27181991	PMID:27214100	PMID:27236152	PMID:27241705	PMID:27301744	PMID:27355582	PMID:27383202	PMID:27485170	PMID:27496342	PMID:27500575	PMID:27505846	PMID:27580864
PMID:27611588	PMID:27623983	PMID:27762046	PMID:27896619	PMID:27921409	PMID:28026029	PMID:28032448	PMID:28045995	PMID:28083611	PMID:28101965	PMID:28110239	PMID:28218480
PMID:28239644	PMID:28359736	PMID:28385185	PMID:28455285	PMID:28624488	PMID:28658402	PMID:28743287	PMID:28771107	PMID:28865411	PMID:28875928	PMID:28881103	PMID:28919585
PMID:29088299	PMID:29106857	PMID:29129831	PMID:29138492	PMID:29149785	PMID:29182409	PMID:29203362	PMID:29307887	PMID:29307888	PMID:29321349	PMID:29361871	PMID:29443768
PMID:29483614	PMID:29496482	PMID:29513033	PMID:29582787	PMID:29619906	PMID:29663655	PMID:29667729	PMID:29800590	PMID:29858267	PMID:29958949	PMID:29997244	PMID:30125434
PMID:30136608	PMID:30187366	PMID:30352277	PMID:30488586	PMID:30590628	PMID:30906300	PMID:31025255	PMID:31121940	PMID:31187155	PMID:31211758	PMID:31299142	PMID:31301374
PMID:31331105	PMID:31333001	PMID:31339184	PMID:31361165	PMID:31408207	PMID:31469245	PMID:31540313	PMID:31742498	PMID:32102547	PMID:32142224	PMID:32183599	PMID:32276294
PMID:32276964	PMID:32341563	PMID:32350356	PMID:32393512	PMID:32506829	PMID:32693929	PMID:32767547	PMID:32890573	PMID:32965138	PMID:32998048	PMID:33045884	PMID:33057914
PMID:33175217	PMID:33241914	PMID:33350597	PMID:33547763	PMID:33550712	PMID:33591409	PMID:33657520	PMID:33713561	PMID:33723390	PMID:33730444	PMID:33846855	PMID:33929277
PMID:33961781	PMID:33993163	PMID:34113337	PMID:34145318	PMID:34186245	PMID:34293232	PMID:34378354	PMID:34382732	PMID:34418318	PMID:34484213	PMID:34628871	PMID:34637605
PMID:34655711	PMID:34686989	PMID:34709727	PMID:35088569	PMID:35090584	PMID:35111164	PMID:35186163	PMID:35363186	PMID:35523683	PMID:35916345	PMID:36076647	PMID:36271816
PMID:36468571	PMID:36592642	PMID:36852518	PMID:37120605	PMID:37314216	PMID:37317656	PMID:37406822	PMID:37652095	PMID:37688529	PMID:37697931	PMID:37719057	PMID:37884160
PMID:38579189	PMID:38799118	PMID:39041300

Genomics

Comparative Map Data

HLA-DQB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	32,659,467 - 32,666,657 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	32,659,467 - 32,668,383 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	32,627,244 - 32,634,434 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,735,635 - 32,742,444 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	34,177,338 - 34,182,264 (-)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	32,368,943 - 32,376,157 (-)	NCBI		HuRef
CHM1_1	6	32,629,719 - 32,636,944 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	32,482,491 - 32,489,842 (-)	NCBI		T2T-CHM13v2.0

H2-Ab1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,482,201 - 34,488,392 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,476,663 - 34,488,393 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,263,227 - 34,269,418 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,257,689 - 34,269,419 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,400,172 - 34,406,363 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	33,871,432 - 33,877,605 (+)	NCBI		MGSCv36	mm8
Celera	17	37,017,337 - 37,030,239 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

RT1-Bb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	4,598,475 - 4,604,118 (-)	NCBI		GRCr8
mRatBN7.2	20	4,596,558 - 4,602,201 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,596,559 - 4,607,597 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_WKY_Bbb_1.0	20	5,193,861 - 5,199,480 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,043,726 - 4,049,367 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,039,413 - 4,049,711 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,123,272 - 6,128,913 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,730,559 - 4,736,201 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,730,786 - 4,736,413 (-)	NCBI
Celera	20	6,197,565 - 6,203,195 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

LOC100972994
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	47,142,796 - 47,149,644 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	43,014,552 - 43,021,397 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	32,237,395 - 32,244,201 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	33,353,599 - 33,360,284 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	33,353,599 - 33,360,272 (-)	Ensembl	panpan1.1		panPan2

DLA-DQB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,305,307 - 2,307,711 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
ROS_Cfam_1.0	12	2,520,814 - 2,526,447 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	12	2,243,878 - 2,249,524 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,325,185 - 2,330,844 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,399,342 - 2,404,990 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101703821
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,895,607 - 23,906,713 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,895,509 - 23,902,487 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in HLA-DQB1
49 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6p21.32(chr6:32482945-32669311)x3	copy number gain	See cases [RCV000136379]	Chr6:32482945..32669311 [GRCh38] Chr6:32450722..32637088 [GRCh37] Chr6:32558700..32745066 [NCBI36] Chr6:6p21.32	benign
GRCh38/hg38 6p21.32(chr6:32529565-32721089)x3	copy number gain	See cases [RCV000138472]	Chr6:32529565..32721089 [GRCh38] Chr6:32497342..32688866 [GRCh37] Chr6:32605320..32796844 [NCBI36] Chr6:6p21.32	likely benign
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3	copy number gain	See cases [RCV000143497]	Chr6:156974..46789291 [GRCh38] Chr6:156974..46757028 [GRCh37] Chr6:101974..46864987 [NCBI36] Chr6:6p25.3-12.3	pathogenic
Single allele	complex	Breast ductal adenocarcinoma [RCV000207075]	Chr6:32188383..32629802 [GRCh37] Chr6:6p21.32	uncertain significance
chr6:32609097-32629809 complex variant	complex	Breast ductal adenocarcinoma [RCV000207301]	Chr6:32609097..32629809 [GRCh37] Chr6:6p21.32	uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367)	copy number gain	not provided [RCV000767714]	Chr6:29455465..81447367 [GRCh37] Chr6:6p22.1-q14.1	pathogenic
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3	copy number gain	not provided [RCV001005791]	Chr6:31036397..34088832 [GRCh37] Chr6:6p21.33-21.31	likely pathogenic
NC_000006.11:g.(?_30695893)_(36953949_?)dup	duplication	Proteasome-associated autoinflammatory syndrome 1 [RCV003113679]	Chr6:30695893..36953949 [GRCh37] Chr6:6p21.33-21.2	uncertain significance
NC_000006.11:g.(?_32148920)_(36953949_?)dup	duplication	not provided [RCV003154914]	Chr6:32148920..36953949 [GRCh37] Chr6:6p21.32-21.2	uncertain significance
NM_002123.5(HLA-DQB1):c.81C>T (p.Ser27=)	single nucleotide variant	not provided [RCV003431802]	Chr6:32666527 [GRCh38] Chr6:32634304 [GRCh37] Chr6:6p21.32	likely benign
NM_002123.5(HLA-DQB1):c.84A>C (p.Leu28=)	single nucleotide variant	not provided [RCV003431801]	Chr6:32666524 [GRCh38] Chr6:32634301 [GRCh37] Chr6:6p21.32	likely benign
NM_002123.5(HLA-DQB1):c.319T>C (p.Leu107=)	single nucleotide variant	not provided [RCV003428823]	Chr6:32664858 [GRCh38] Chr6:32632635 [GRCh37] Chr6:6p21.32	likely benign
NM_002123.5(HLA-DQB1):c.80_81insTT (p.Leu28fs)	insertion	not provided [RCV003428824]	Chr6:32666527..32666528 [GRCh38] Chr6:32634304..32634305 [GRCh37] Chr6:6p21.32	benign
NM_002123.5(HLA-DQB1):c.370_379+2del	deletion	Susceptibility to severe COVID-19 [RCV004598565]	Chr6:32664796..32664807 [GRCh38] Chr6:32632573..32632584 [GRCh37] Chr6:6p21.32	likely pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2461
Count of miRNA genes:	551
Interacting mature miRNAs:	592
Transcripts:	ENST00000374943, ENST00000399079, ENST00000399082, ENST00000399084, ENST00000434651, ENST00000460185, ENST00000484729, ENST00000487676
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
407015459	GWAS664435_H	drug-induced liver injury QTL GWAS664435 (human)		5e-14	drug-induced liver injury		6	32665055	32665056	Human
1358839	MULTSCL5_H	Multiple sclerosis susceptibility QTL 5 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
1643377	BW325_H	Body weight QTL 325 (human)	2.32	0.0005	Body fat amount		6	6911960	32911960	Human
1643569	GLUCO21_H	Glucose level QTL 21 (human)		0.021	Glucose level	non-insulin-dependent	6	6911960	32911960	Human
407043690	GWAS692666_H	eosinophil percentage of leukocytes QTL GWAS692666 (human)		9e-16	eosinophil percentage of leukocytes	blood eosinophil count to total leukocyte count ratio (CMO:0000369)	6	32665470	32665471	Human
1298458	BW9_H	Body weight QTL 9 (human)	2.7	0.0002	Body fat amount		6	6911960	32911960	Human
1298431	RA11_H	Rheumatoid arthritis QTL 11 (human)		0.0000024	Joint/bone inflammation	rheumatoid arthritis	6	19911883	40191709	Human
1358854	MULTSCL4_H	Multiple sclerosis susceptibility QTL 4 (human)			Multiple sclerosis susceptibility		6	6911960	32911960	Human
407135479	GWAS784455_H	L lactate dehydrogenase measurement QTL GWAS784455 (human)		2e-22	L lactate dehydrogenase measurement		6	32664821	32664822	Human
407081109	GWAS730085_H	ulcerative colitis QTL GWAS730085 (human)		0.000002	ulcerative colitis		6	32659937	32659938	Human
407043989	GWAS692965_H	ocular sarcoidosis QTL GWAS692965 (human)		0.000001	eye integrity trait (VT:0011107)		6	32666449	32666450	Human
406967037	GWAS616013_H	narcolepsy-cataplexy syndrome, age at onset QTL GWAS616013 (human)		2e-08	narcolepsy-cataplexy syndrome, age at onset		6	32665936	32665937	Human
1358857	MULTSCL19_H	Multiple sclerosis suscepti

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Manual Human Phenotype Annotations - RGD

Imported Human Phenotype Annotations - HPO