TAS2R41 (taste 2 receptor member 41) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: TAS2R41 (taste 2 receptor member 41) Homo sapiens
Analyze
Symbol: TAS2R41
Name: taste 2 receptor member 41
RGD ID: 1353850
HGNC Page HGNC:18883
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and sensory perception of taste. Located in membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC119928; MGC119929; T2R41; T2R59; taste receptor type 2 member 41; taste receptor type 2 member 59; taste receptor, type 2, member 41
RGD Orthologs
Mouse
Rat
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,477,873 - 143,478,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,477,873 - 143,478,796 (+)EnsemblGRCh38hg38GRCh38
GRCh377143,174,966 - 143,175,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,885,088 - 142,886,011 (+)NCBINCBI36Build 36hg18NCBI36
Build 347142,691,802 - 142,692,724NCBI
Celera7138,012,198 - 138,013,121 (+)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7137,512,170 - 137,513,093 (+)NCBIHuRef
CHM1_17143,111,911 - 143,112,834 (+)NCBICHM1_1
T2T-CHM13v2.07144,833,246 - 144,834,169 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,577,066 - 142,577,989 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IBA,IDA,IEA)
plasma membrane  (IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11696554   PMID:12139982   PMID:12379855   PMID:12477932   PMID:12581520   PMID:12584440   PMID:15496549   PMID:15744053   PMID:20022913   PMID:21873635   PMID:23632330   PMID:26186194  
PMID:28514442   PMID:32296183   PMID:33961781  


Genomics

Comparative Map Data
TAS2R41
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,477,873 - 143,478,796 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,477,873 - 143,478,796 (+)EnsemblGRCh38hg38GRCh38
GRCh377143,174,966 - 143,175,889 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,885,088 - 142,886,011 (+)NCBINCBI36Build 36hg18NCBI36
Build 347142,691,802 - 142,692,724NCBI
Celera7138,012,198 - 138,013,121 (+)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7137,512,170 - 137,513,093 (+)NCBIHuRef
CHM1_17143,111,911 - 143,112,834 (+)NCBICHM1_1
T2T-CHM13v2.07144,833,246 - 144,834,169 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,577,066 - 142,577,989 (+)NCBI
Tas2r126
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39642,411,469 - 42,412,395 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl642,411,469 - 42,412,398 (+)EnsemblGRCm39 Ensembl
GRCm38642,434,535 - 42,435,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl642,434,535 - 42,435,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv37642,384,534 - 42,385,460 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36642,364,142 - 42,365,068 (+)NCBIMGSCv36mm8
Celera642,379,045 - 42,379,971 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.72NCBI
Tas2r126
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8472,300,448 - 72,301,374 (+)NCBIGRCr8
mRatBN7.2471,333,821 - 71,334,747 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl471,333,821 - 71,334,747 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx476,260,333 - 76,261,259 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0472,173,580 - 72,174,506 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,593,136 - 70,594,062 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,836,677 - 71,837,603 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,836,677 - 71,837,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,637,499 - 136,638,425 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4470,215,672 - 70,216,598 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1470,491,801 - 70,492,728 (+)NCBI
Celera466,263,693 - 66,264,619 (+)NCBICelera
Cytogenetic Map4q24NCBI
TAS2R41
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,230,851 - 6,231,777 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,230,851 - 6,231,777 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,219,842 - 7,220,768 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,084,491 - 6,085,417 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl166,084,491 - 6,085,417 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1166,032,471 - 6,033,397 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0165,884,022 - 5,884,948 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0165,959,197 - 5,960,123 (-)NCBIUU_Cfam_GSD_1.0
TAS2R41
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,780,808 - 6,781,731 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,780,212 - 6,781,731 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,018,210 - 7,019,869 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAS2R41
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,373,893 - 112,376,564 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,374,760 - 112,375,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660729,122,230 - 9,123,459 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TAS2R41
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q34-35(chr7:142578948-144254897)x1 copy number loss See cases [RCV000050639] Chr7:142578948..144254897 [GRCh38]
Chr7:142528609..143951990 [GRCh37]
Chr7:141967554..143582923 [NCBI36]
Chr7:7q34-35
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 copy number gain See cases [RCV000053576] Chr7:136309982..159307523 [GRCh38]
Chr7:135994730..159100212 [GRCh37]
Chr7:135645270..158792973 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:142021716-159325876)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053577]|See cases [RCV000053577] Chr7:142021716..159325876 [GRCh38]
Chr7:142528609..159118566 [GRCh37]
Chr7:141367985..158811327 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:142358524-159282531)x1 copy number loss See cases [RCV000054177] Chr7:142358524..159282531 [GRCh38]
Chr7:142528609..159075220 [GRCh37]
Chr7:141726947..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1
pathogenic
GRCh38/hg38 7q33-35(chr7:135414108-144140219)x1 copy number loss See cases [RCV000054173] Chr7:135414108..144140219 [GRCh38]
Chr7:135098857..143837312 [GRCh37]
Chr7:134749397..143468245 [NCBI36]
Chr7:7q33-35
pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:140754198-159307523)x1 copy number loss See cases [RCV000054176] Chr7:140754198..159307523 [GRCh38]
Chr7:140453998..159100212 [GRCh37]
Chr7:140100467..158792973 [NCBI36]
Chr7:7q34-36.3
pathogenic
NM_176883.2(TAS2R41):c.471A>T (p.Gln157His) single nucleotide variant Malignant melanoma [RCV000067723] Chr7:143478343 [GRCh38]
Chr7:143175436 [GRCh37]
Chr7:142885558 [NCBI36]
Chr7:7q35
not provided
NM_176883.2(TAS2R41):c.574C>T (p.Pro192Ser) single nucleotide variant Malignant melanoma [RCV000067724] Chr7:143478446 [GRCh38]
Chr7:143175539 [GRCh37]
Chr7:142885661 [NCBI36]
Chr7:7q35
not provided
NM_176883.2(TAS2R41):c.388G>A (p.Val130Met) single nucleotide variant Malignant melanoma [RCV000061583] Chr7:143478260 [GRCh38]
Chr7:143175353 [GRCh37]
Chr7:142885475 [NCBI36]
Chr7:7q35
not provided
NM_176883.2(TAS2R41):c.720C>T (p.Leu240=) single nucleotide variant Lung cancer [RCV000105700] Chr7:143478592 [GRCh38]
Chr7:143175685 [GRCh37]
Chr7:7q35
uncertain significance
GRCh38/hg38 7q34-35(chr7:141126407-145652221)x3 copy number gain See cases [RCV000133645] Chr7:141126407..145652221 [GRCh38]
Chr7:140826207..145349314 [GRCh37]
Chr7:140472676..144980247 [NCBI36]
Chr7:7q34-35
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 copy number gain See cases [RCV000136592] Chr7:137751200..154815582 [GRCh38]
Chr7:137435946..154607292 [GRCh37]
Chr7:137086486..154238225 [NCBI36]
Chr7:7q33-36.2
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:141960861-159335866)x1 copy number loss See cases [RCV000137256] Chr7:141960861..159335866 [GRCh38]
Chr7:142528609..159128556 [GRCh37]
Chr7:141307130..158821317 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 copy number loss See cases [RCV000138120] Chr7:134666829..158591882 [GRCh38]
Chr7:134351581..158384574 [GRCh37]
Chr7:134002121..158077335 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 copy number loss See cases [RCV000138903] Chr7:135017687..148807400 [GRCh38]
Chr7:134702438..148504492 [GRCh37]
Chr7:134352978..148135425 [NCBI36]
Chr7:7q33-36.1
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q34-35(chr7:140061285-144622893)x3 copy number gain See cases [RCV000143724] Chr7:140061285..144622893 [GRCh38]
Chr7:139761085..144319986 [GRCh37]
Chr7:139407554..143950919 [NCBI36]
Chr7:7q34-35
uncertain significance
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137589621-159119707)x3 copy number gain See cases [RCV000449264] Chr7:137589621..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 copy number loss See cases [RCV000448836] Chr7:133799185..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140636858-159119707)x1 copy number loss See cases [RCV000510250] Chr7:140636858..159119707 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:136758593-159119707)x3 copy number gain See cases [RCV000510490] Chr7:136758593..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137917376-159119707)x1 copy number loss See cases [RCV000511889] Chr7:137917376..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:138620939-159233475)x3 copy number gain Neurodevelopmental disorder [RCV003327610] Chr7:138620939..159233475 [GRCh38]
Chr7:7q34-36.3
likely pathogenic
GRCh37/hg19 7q34-36.3(chr7:140133025-158982771)x1 copy number loss not provided [RCV000682910] Chr7:140133025..158982771 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-35(chr7:139623170-143710268)x3 copy number gain not provided [RCV000747069] Chr7:139623170..143710268 [GRCh37]
Chr7:7q34-35
benign
GRCh37/hg19 7q34-36.3(chr7:139623170-158329903)x3 copy number gain not provided [RCV000747070] Chr7:139623170..158329903 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:141938235-159126310)x1 copy number loss not provided [RCV000747083] Chr7:141938235..159126310 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 copy number gain not provided [RCV000849569] Chr7:130592554..159119707 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q34-35(chr7:141751875-147105208)x3 copy number gain not provided [RCV000848670] Chr7:141751875..147105208 [GRCh37]
Chr7:7q34-35
uncertain significance
GRCh37/hg19 7q32.3-36.3(chr7:131414604-159126310)x1 copy number loss See cases [RCV001007432] Chr7:131414604..159126310 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:137463392-159345973)x3 copy number gain Neurodevelopmental disorder [RCV003327609] Chr7:137463392..159345973 [GRCh38]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q35-36.3(chr7:143107740-156886246)x3 copy number gain not provided [RCV001249383] Chr7:143107740..156886246 [GRCh37]
Chr7:7q35-36.3
not provided
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q33-35(chr7:133848099-145814115)x1 copy number loss Hypertelorism [RCV001801200] Chr7:133848099..145814115 [GRCh37]
Chr7:7q33-35
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133851002-159119707)x3 copy number gain not provided [RCV001834520] Chr7:133851002..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q34-35(chr7:142691458-143193361) copy number gain not specified [RCV002053738] Chr7:142691458..143193361 [GRCh37]
Chr7:7q34-35
uncertain significance
NC_000007.13:g.(?_130781014)_(150301047_?)del deletion not provided [RCV003116360] Chr7:130781014..150301047 [GRCh37]
Chr7:7q32.3-36.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3
uncertain significance
NM_176883.2(TAS2R41):c.413T>A (p.Val138Asp) single nucleotide variant not specified [RCV004286615] Chr7:143478285 [GRCh38]
Chr7:143175378 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.217A>G (p.Lys73Glu) single nucleotide variant not specified [RCV004142038] Chr7:143478089 [GRCh38]
Chr7:143175182 [GRCh37]
Chr7:7q35
uncertain significance
GRCh37/hg19 7q32.3-36.1(chr7:131779213-149042734)x1 copy number loss not provided [RCV002472560] Chr7:131779213..149042734 [GRCh37]
Chr7:7q32.3-36.1
pathogenic
NM_176883.2(TAS2R41):c.55C>G (p.Leu19Val) single nucleotide variant not specified [RCV004202997] Chr7:143477927 [GRCh38]
Chr7:143175020 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.811G>A (p.Ala271Thr) single nucleotide variant not specified [RCV004232205] Chr7:143478683 [GRCh38]
Chr7:143175776 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.56T>C (p.Leu19Pro) single nucleotide variant not specified [RCV004190654] Chr7:143477928 [GRCh38]
Chr7:143175021 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.713C>A (p.Ser238Tyr) single nucleotide variant not specified [RCV004178564] Chr7:143478585 [GRCh38]
Chr7:143175678 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.245G>A (p.Arg82Gln) single nucleotide variant not specified [RCV004209264] Chr7:143478117 [GRCh38]
Chr7:143175210 [GRCh37]
Chr7:7q35
likely benign
NM_176883.2(TAS2R41):c.751A>C (p.Ile251Leu) single nucleotide variant not specified [RCV004115805] Chr7:143478623 [GRCh38]
Chr7:143175716 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.787G>A (p.Asp263Asn) single nucleotide variant not specified [RCV004152498] Chr7:143478659 [GRCh38]
Chr7:143175752 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.806A>G (p.Gln269Arg) single nucleotide variant not specified [RCV004155570] Chr7:143478678 [GRCh38]
Chr7:143175771 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.65C>T (p.Ala22Val) single nucleotide variant not specified [RCV004087276] Chr7:143477937 [GRCh38]
Chr7:143175030 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.683C>A (p.Ala228Asp) single nucleotide variant not specified [RCV004260158] Chr7:143478555 [GRCh38]
Chr7:143175648 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.853T>A (p.Phe285Ile) single nucleotide variant not specified [RCV004271922] Chr7:143478725 [GRCh38]
Chr7:143175818 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.575C>A (p.Pro192His) single nucleotide variant not specified [RCV004323384] Chr7:143478447 [GRCh38]
Chr7:143175540 [GRCh37]
Chr7:7q35
uncertain significance
GRCh37/hg19 7q34-36.1(chr7:140154317-152551638)x1 copy number loss not provided [RCV003334300] Chr7:140154317..152551638 [GRCh37]
Chr7:7q34-36.1
pathogenic
GRCh37/hg19 7q33-36.3(chr7:135639005-159119707)x1 copy number loss not provided [RCV003482988] Chr7:135639005..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q34-35(chr7:142833114-143218955)x3 copy number gain not provided [RCV003484702] Chr7:142833114..143218955 [GRCh37]
Chr7:7q34-35
uncertain significance
GRCh37/hg19 7q34-36.3(chr7:142099013-159119707)x1 copy number loss not provided [RCV003482989] Chr7:142099013..159119707 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137456457-159119707)x3 copy number gain not specified [RCV003986713] Chr7:137456457..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:141690279-159119707)x3 copy number gain See cases [RCV004442845] Chr7:141690279..159119707 [GRCh37]
Chr7:7q34-36.3
pathogenic
NM_176883.2(TAS2R41):c.120G>C (p.Arg40Ser) single nucleotide variant not specified [RCV004471466] Chr7:143477992 [GRCh38]
Chr7:143175085 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.164G>A (p.Arg55His) single nucleotide variant not specified [RCV004471467] Chr7:143478036 [GRCh38]
Chr7:143175129 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.412G>A (p.Val138Ile) single nucleotide variant not specified [RCV004471468] Chr7:143478284 [GRCh38]
Chr7:143175377 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.877G>A (p.Val293Met) single nucleotide variant not specified [RCV004471469] Chr7:143478749 [GRCh38]
Chr7:143175842 [GRCh37]
Chr7:7q35
uncertain significance
NM_176883.2(TAS2R41):c.433A>C (p.Thr145Pro) single nucleotide variant not specified [RCV004673272] Chr7:143478305 [GRCh38]
Chr7:143175398 [GRCh37]
Chr7:7q35
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:292
Count of miRNA genes:241
Interacting mature miRNAs:254
Transcripts:ENST00000408916
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559221SCL67_HSerum cholesterol level QTL 67 (human)2.980.002Lipid leveltriglyceride7141776251159345973Human
1559237SCL70_HSerum cholesterol level QTL 70 (human)3.520.002Lipid leveltriglyceride7141776251159345973Human
1578618SCL127_HSerum cholesterol level QTL 127 (human)3.7Lipid leveltriglyceride7141776251159345973Human
1559218SCL69_HSerum cholesterol level QTL 69 (human)3.410.002Lipid leveltriglyceride7141776251159345973Human
1559232SCL66_HSerum cholesterol level QTL 66 (human)2.980.002Lipid leveltriglyceride7141776251159345973Human
1559264SCL68_HSerum cholesterol level QTL 68 (human)3.10.002Lipid leveltriglyceride7141776251159345973Human
1559263SCL72_HSerum cholesterol level QTL 72 (human)3.25Lipid leveltriglyceride7141776251159345973Human
1559213SCL71_HSerum cholesterol level QTL 71 (human)3.46Lipid leveltriglyceride7141776251159345973Human
1578610SCL128_HSerum cholesterol level QTL 128 (human)2.2Lipid levelLDL cholesterol7141776251159345973Human

Markers in Region
UniSTS:484183  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377143,174,966 - 143,175,889UniSTSGRCh37
Celera7138,012,198 - 138,013,121UniSTS
HuRef7137,512,170 - 137,513,093UniSTS
CRA_TCAGchr7v27142,577,066 - 142,577,989UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
177 439 526 387 533 156 277 1 65 291 28 440 967 987 5 287 73 238 225 38

Sequence


Ensembl Acc Id: ENST00000408916   ⟹   ENSP00000386201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7143,477,873 - 143,478,796 (+)Ensembl
RefSeq Acc Id: NM_176883   ⟹   NP_795364
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387143,477,873 - 143,478,796 (+)NCBI
GRCh377143,174,966 - 143,175,889 (+)RGD
Build 367142,885,088 - 142,886,011 (+)NCBI Archive
Celera7138,012,198 - 138,013,121 (+)RGD
HuRef7137,512,170 - 137,513,093 (+)RGD
CHM1_17143,111,911 - 143,112,834 (+)NCBI
T2T-CHM13v2.07144,833,246 - 144,834,169 (+)NCBI
CRA_TCAGchr7v27142,577,066 - 142,577,989 (+)ENTREZGENE
Sequence:
RefSeq Acc Id: NP_795364   ⟸   NM_176883
- UniProtKB: P59536 (UniProtKB/Swiss-Prot),   Q50KJ7 (UniProtKB/Swiss-Prot),   Q50KJ6 (UniProtKB/Swiss-Prot),   Q50KJ5 (UniProtKB/Swiss-Prot),   Q495I2 (UniProtKB/Swiss-Prot),   P59550 (UniProtKB/Swiss-Prot),   Q645W7 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000386201   ⟸   ENST00000408916

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59536-F1-model_v2 AlphaFold P59536 1-307 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18883 AgrOrtholog
COSMIC TAS2R41 COSMIC
Ensembl Genes ENSG00000221855 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000284982 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000408916 ENTREZGENE
  ENST00000408916.1 UniProtKB/Swiss-Prot
  ENST00000646750.1 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
GTEx ENSG00000221855 GTEx
  ENSG00000284982 GTEx
HGNC ID HGNC:18883 ENTREZGENE
Human Proteome Map TAS2R41 Human Proteome Map
InterPro T2R UniProtKB/Swiss-Prot
KEGG Report hsa:259287 UniProtKB/Swiss-Prot
NCBI Gene 259287 ENTREZGENE
OMIM 613965 OMIM
PANTHER TASTE RECEPTOR TYPE 2 UniProtKB/Swiss-Prot
  TASTE RECEPTOR TYPE 2 MEMBER 41 UniProtKB/Swiss-Prot
Pfam TAS2R UniProtKB/Swiss-Prot
PharmGKB PA38737 PharmGKB
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt P59536 ENTREZGENE
  P59550 ENTREZGENE
  Q495I2 ENTREZGENE
  Q50KJ5 ENTREZGENE
  Q50KJ6 ENTREZGENE
  Q50KJ7 ENTREZGENE
  Q645W7 ENTREZGENE
  T2R41_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary P59550 UniProtKB/Swiss-Prot
  Q495I2 UniProtKB/Swiss-Prot
  Q50KJ5 UniProtKB/Swiss-Prot
  Q50KJ6 UniProtKB/Swiss-Prot
  Q50KJ7 UniProtKB/Swiss-Prot
  Q645W7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 TAS2R41  taste 2 receptor member 41    taste receptor, type 2, member 41  Symbol and/or name change 5135510 APPROVED