IL20 (interleukin 20) - Rat Genome Database

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Gene: IL20 (interleukin 20) Homo sapiens
Analyze
Symbol: IL20
Name: interleukin 20
RGD ID: 1353403
HGNC Page HGNC:6002
Description: Predicted to enable interleukin-20 receptor binding activity. Predicted to be involved in positive regulation of keratinocyte differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of inflammatory response. Predicted to act upstream of or within positive regulation of osteoclast differentiation. Predicted to be located in extracellular region. Implicated in psoriasis. Biomarker of end stage renal disease and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cytokine Zcyto10; four alpha helix cytokine; IL-20; IL10D; interleukin-20; MGC96907; ZCYTO10
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,863,565 - 206,869,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,865,623 - 206,869,223 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,036,910 - 207,042,568 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,105,777 - 205,109,191 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,427,548 - 203,430,962NCBI
Celera1180,290,690 - 180,294,104 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,737,423 - 177,740,838 (+)NCBIHuRef
CHM1_11208,311,726 - 208,315,140 (+)NCBICHM1_1
T2T-CHM13v2.01206,127,873 - 206,133,530 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The association between the IL-20-1723C-->G allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. Chen XY, etal., Dermatology. 2011 Feb;222(1):24-30. Epub 2010 Nov 27.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Interleukin-20 antibody is a potential therapeutic agent for experimental arthritis. Hsu YH and Chang MS, Arthritis Rheum. 2010 Nov;62(11):3311-21. doi: 10.1002/art.27689.
4. Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis. Hsu YH, etal., Arthritis Rheum. 2006 Sep;54(9):2722-33.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Interleukin-20 targets renal cells and is associated with chronic kidney disease. Wei CC, etal., Biochem Biophys Res Commun. 2008 Sep 26;374(3):448-53. Epub 2008 Jul 17.
Additional References at PubMed
PMID:11163236   PMID:11470428   PMID:12023331   PMID:12351624   PMID:12477932   PMID:12667095   PMID:12855566   PMID:12975309   PMID:14580208   PMID:14675174   PMID:15340161   PMID:15489334  
PMID:15815689   PMID:15857508   PMID:15950941   PMID:16511554   PMID:16645593   PMID:16709143   PMID:16778121   PMID:16908179   PMID:17083366   PMID:17255956   PMID:17263806   PMID:17465720  
PMID:17703412   PMID:18061474   PMID:18281438   PMID:18479293   PMID:18758357   PMID:18771958   PMID:19087313   PMID:19258923   PMID:19342680   PMID:19430480   PMID:19481430   PMID:19802007  
PMID:19830738   PMID:20061404   PMID:20237496   PMID:20503287   PMID:20976276   PMID:21565488   PMID:22232181   PMID:22802649   PMID:22930279   PMID:22948742   PMID:22962576   PMID:23000500  
PMID:23128233   PMID:23183096   PMID:23207823   PMID:23271730   PMID:23812620   PMID:23892591   PMID:24470401   PMID:24628979   PMID:25028099   PMID:25178435   PMID:25543042   PMID:25631632  
PMID:26297177   PMID:26354610   PMID:26404542   PMID:27573644   PMID:27806114   PMID:28150860   PMID:28369789   PMID:28424238   PMID:28514748   PMID:28662439   PMID:29334679   PMID:30048054  
PMID:31947776   PMID:32622964   PMID:32730761   PMID:33961781   PMID:34403503   PMID:34704818   PMID:35384009   PMID:35486004   PMID:35613844   PMID:35681232   PMID:36175183   PMID:36233301  
PMID:37759746   PMID:37884352   PMID:38356138  


Genomics

Comparative Map Data
IL20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,863,565 - 206,869,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,865,623 - 206,869,223 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,036,910 - 207,042,568 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,105,777 - 205,109,191 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,427,548 - 203,430,962NCBI
Celera1180,290,690 - 180,294,104 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,737,423 - 177,740,838 (+)NCBIHuRef
CHM1_11208,311,726 - 208,315,140 (+)NCBICHM1_1
T2T-CHM13v2.01206,127,873 - 206,133,530 (+)NCBIT2T-CHM13v2.0
Il20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,834,722 - 130,839,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,834,722 - 130,839,188 (-)EnsemblGRCm39 Ensembl
GRCm381130,906,985 - 130,911,296 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,906,985 - 130,911,451 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,803,769 - 132,807,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,734,738 - 132,738,842 (-)NCBIMGSCv36mm8
Celera1133,530,468 - 133,533,922 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Il20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,933,249 - 44,936,893 (-)NCBIGRCr8
mRatBN7.21342,380,981 - 42,384,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,380,981 - 42,384,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,987,452 - 44,991,125 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,275,581 - 46,279,254 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,530,681 - 43,534,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,644,071 - 47,651,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,644,071 - 47,647,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,734,137 - 52,741,281 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,860,611 - 43,863,964 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1342,730,161 - 42,733,821 (-)NCBICelera
Cytogenetic Map13q13NCBI
Il20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,398,782 - 42,401,490 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,398,510 - 42,401,561 (+)NCBIChiLan1.0ChiLan1.0
IL20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,505,180 - 42,508,807 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,471,143 - 42,477,085 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,468,571 - 182,472,440 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,747,086 - 186,750,952 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,747,086 - 186,750,952 (+)Ensemblpanpan1.1panPan2
IL20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,019,879 - 6,022,707 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,019,442 - 6,023,219 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,584,102 - 5,586,865 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,709,300 - 5,711,995 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,708,817 - 5,712,450 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,643,808 - 5,646,571 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,744,856 - 5,747,553 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,784,484 - 5,787,180 (+)NCBIUU_Cfam_GSD_1.0
Il20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,508,558 - 68,511,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,749,419 - 5,751,776 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,749,419 - 5,751,776 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,498,813 - 67,502,096 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,498,788 - 67,502,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,840,712 - 73,859,139 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,486,860 - 22,494,210 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,488,338 - 22,491,129 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,159,198 - 23,164,908 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,617,738 - 4,620,843 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,618,378 - 4,620,844 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL20
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
GRCh38/hg38 1q32.1-32.2(chr1:204990129-210220258)x3 copy number gain See cases [RCV000051859] Chr1:204990129..210220258 [GRCh38]
Chr1:204959257..210572305 [GRCh37]
Chr1:203225880..208638928 [NCBI36]
Chr1:1q32.1-32.2		 pathogenic
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12		 pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13		 pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q32.1-32.2(chr1:206961307-207252090)x1 copy number loss See cases [RCV000510174] Chr1:206961307..207252090 [GRCh37]
Chr1:1q32.1-32.2		 likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:204682513-212815646) copy number loss Global developmental delay [RCV000626524] Chr1:204682513..212815646 [GRCh37]
Chr1:1q32.1-32.3		 pathogenic
NM_018724.4(IL20):c.287A>T (p.Lys96Ile) single nucleotide variant not specified [RCV004333217] Chr1:206866545 [GRCh38]
Chr1:207039890 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NC_000001.11:g.(?_204033173)_(208209798_?)del deletion Autism [RCV000754138] Chr1:204033173..208209798 [GRCh38]
Chr1:1q32.1-32.2		 likely pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2		 not provided
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
GRCh37/hg19 1q32.1-32.3(chr1:206329070-213263817)x3 copy number gain not provided [RCV000848713] Chr1:206329070..213263817 [GRCh37]
Chr1:1q32.1-32.3		 uncertain significance
GRCh37/hg19 1q32.1-44(chr1:204045948-249218992)x3 copy number gain See cases [RCV001007407] Chr1:204045948..249218992 [GRCh37]
Chr1:1q32.1-44		 pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NC_000001.10:g.(?_206941981)_(208391267_?)dup duplication Immunodeficiency, common variable, 7 [RCV001939950]|Inflammatory bowel disease [RCV001916125] Chr1:206941981..208391267 [GRCh37]
Chr1:1q32.1-32.2		 uncertain significance
NM_018724.4(IL20):c.490G>A (p.Glu164Lys) single nucleotide variant not provided [RCV002224657] Chr1:206868523 [GRCh38]
Chr1:207041868 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_200522516)_(208391267_?)dup duplication Hypokalemic periodic paralysis, type 1 [RCV003119239]|not provided [RCV003119240] Chr1:200522516..208391267 [GRCh37]
Chr1:1q32.1-32.2		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_018724.4(IL20):c.439A>C (p.Ser147Arg) single nucleotide variant not specified [RCV004223412] Chr1:206867444 [GRCh38]
Chr1:207040789 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_018724.4(IL20):c.251G>A (p.Arg84His) single nucleotide variant not specified [RCV004194190] Chr1:206866509 [GRCh38]
Chr1:207039854 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_018724.4(IL20):c.86A>G (p.Asn29Ser) single nucleotide variant not specified [RCV004253211] Chr1:206865938 [GRCh38]
Chr1:207039283 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_018724.4(IL20):c.195A>C (p.Leu65Phe) single nucleotide variant not specified [RCV004258245] Chr1:206866334 [GRCh38]
Chr1:207039679 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_018724.4(IL20):c.106G>A (p.Ala36Thr) single nucleotide variant not specified [RCV004405152] Chr1:206865958 [GRCh38]
Chr1:207039303 [GRCh37]
Chr1:1q32.1		 likely benign
NM_018724.4(IL20):c.301C>A (p.Pro101Thr) single nucleotide variant not specified [RCV004405153] Chr1:206866559 [GRCh38]
Chr1:207039904 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_018724.4(IL20):c.490G>C (p.Glu164Gln) single nucleotide variant not specified [RCV004405154] Chr1:206868523 [GRCh38]
Chr1:207041868 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_190829412)_(216061974_?)del deletion not provided [RCV004579260] Chr1:190829412..216061974 [GRCh37]
Chr1:1q31.2-41		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:476
Count of miRNA genes:269
Interacting mature miRNAs:285
Transcripts:ENST00000367096, ENST00000367098, ENST00000391930
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406987028GWAS636004_HOral ulcer QTL GWAS636004 (human)3e-45Oral ulcer1206867269206867270Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
664 802 1253 463 1852 795 1096 1 285 630 143 1437 2228 2255 14 772 414 1231 795 148

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001385165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001385167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF224266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF402002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY876922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC117390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000367096   ⟹   ENSP00000356063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1206,865,809 - 206,868,914 (+)Ensembl
Ensembl Acc Id: ENST00000367098   ⟹   ENSP00000356065
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1206,865,623 - 206,869,223 (+)Ensembl
Ensembl Acc Id: ENST00000391930   ⟹   ENSP00000375796
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1206,865,809 - 206,869,217 (+)Ensembl
RefSeq Acc Id: NM_001385165   ⟹   NP_001372094
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,865,623 - 206,869,223 (+)NCBI
T2T-CHM13v2.01206,129,931 - 206,133,530 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001385166   ⟹   NP_001372095
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,863,565 - 206,869,223 (+)NCBI
T2T-CHM13v2.01206,127,873 - 206,133,530 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001385167   ⟹   NP_001372096
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,863,565 - 206,869,223 (+)NCBI
T2T-CHM13v2.01206,127,873 - 206,133,530 (+)NCBI
Sequence:
RefSeq Acc Id: NM_018724   ⟹   NP_061194
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,865,623 - 206,869,223 (+)NCBI
GRCh371207,038,699 - 207,042,568 (+)NCBI
Build 361205,105,777 - 205,109,191 (+)NCBI Archive
HuRef1177,737,423 - 177,740,838 (+)ENTREZGENE
CHM1_11208,311,726 - 208,315,140 (+)NCBI
T2T-CHM13v2.01206,129,931 - 206,133,530 (+)NCBI
Sequence:
RefSeq Acc Id: NP_061194   ⟸   NM_018724
- Peptide Label: isoform 1 precursor
- UniProtKB: Q2THG6 (UniProtKB/Swiss-Prot),   Q17RB3 (UniProtKB/Swiss-Prot),   Q96QZ6 (UniProtKB/Swiss-Prot),   Q9NYY1 (UniProtKB/Swiss-Prot),   A0A7R8C4W0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000375796   ⟸   ENST00000391930
Ensembl Acc Id: ENSP00000356065   ⟸   ENST00000367098
Ensembl Acc Id: ENSP00000356063   ⟸   ENST00000367096
RefSeq Acc Id: NP_001372096   ⟸   NM_001385167
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9NYY1 (UniProtKB/Swiss-Prot),   Q2THG6 (UniProtKB/Swiss-Prot),   Q17RB3 (UniProtKB/Swiss-Prot),   Q96QZ6 (UniProtKB/Swiss-Prot),   A0A7R8C4W0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001372095   ⟸   NM_001385166
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9NYY1 (UniProtKB/Swiss-Prot),   Q2THG6 (UniProtKB/Swiss-Prot),   Q17RB3 (UniProtKB/Swiss-Prot),   Q96QZ6 (UniProtKB/Swiss-Prot),   A0A7R8C4W0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001372094   ⟸   NM_001385165
- Peptide Label: isoform 2 precursor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9NYY1-F1-model_v2 AlphaFold Q9NYY1 1-176 view protein structure

Promoters
RGD ID:6785782
Promoter ID:HG_KWN:7091
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:ENST00000367098,   NM_018724,   UC009XBY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361205,104,911 - 205,105,411 (+)MPROMDB
RGD ID:6858806
Promoter ID:EPDNEW_H2568
Type:multiple initiation site
Name:IL20_1
Description:interleukin 20
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2569  EPDNEW_H2570  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,863,565 - 206,863,625EPDNEW
RGD ID:6858808
Promoter ID:EPDNEW_H2569
Type:initiation region
Name:IL20_2
Description:interleukin 20
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2568  EPDNEW_H2570  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,865,395 - 206,865,455EPDNEW
RGD ID:6858810
Promoter ID:EPDNEW_H2570
Type:initiation region
Name:IL20_3
Description:interleukin 20
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H2568  EPDNEW_H2569  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,865,623 - 206,865,683EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6002 AgrOrtholog
COSMIC IL20 COSMIC
Ensembl Genes ENSG00000162891 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000367096.7 UniProtKB/Swiss-Prot
  ENST00000367098 ENTREZGENE
  ENST00000367098.6 UniProtKB/Swiss-Prot
  ENST00000391930 ENTREZGENE
  ENST00000391930.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000162891 GTEx
HGNC ID HGNC:6002 ENTREZGENE
Human Proteome Map IL20 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10/19/20/22/24/26_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10_family_cytokines UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:50604 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 50604 ENTREZGENE
OMIM 605619 OMIM
PANTHER INTERLEUKIN-19-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29817 PharmGKB
PRINTS INTRLEUKIN20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7R8C4W0 ENTREZGENE, UniProtKB/TrEMBL
  IL20_HUMAN UniProtKB/Swiss-Prot
  Q17RB3 ENTREZGENE
  Q2THG6 ENTREZGENE
  Q96QZ6 ENTREZGENE
  Q9NYY1 ENTREZGENE
UniProt Secondary Q17RB3 UniProtKB/Swiss-Prot
  Q2THG6 UniProtKB/Swiss-Prot
  Q96QZ6 UniProtKB/Swiss-Prot