GPX5 (glutathione peroxidase 5) - Rat Genome Database

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Gene: GPX5 (glutathione peroxidase 5) Homo sapiens
Analyze
Symbol: GPX5
Name: glutathione peroxidase 5
RGD ID: 1352844
HGNC Page HGNC:4557
Description: Predicted to enable glutathione peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to act upstream of or within cellular response to oxidative stress. Predicted to be located in extracellular space and sperm plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EGLP; epididymal androgen-related protein; epididymal secretory glutathione peroxidase; epididymis secretory sperm binding protein Li 75p; epididymis-specific glutathione peroxidase-like protein; GPx-5; GSHPx-5; HEL-S-75p
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38628,525,881 - 28,534,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl628,525,881 - 28,534,955 (+)EnsemblGRCh38hg38GRCh38
GRCh37628,493,658 - 28,502,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36628,601,768 - 28,609,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 34628,601,767 - 28,609,923NCBI
Celera630,100,218 - 30,109,121 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef628,300,120 - 28,309,014 (+)NCBIHuRef
CHM1_1628,496,188 - 28,505,099 (+)NCBICHM1_1
T2T-CHM13v2.0628,397,310 - 28,406,348 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Megacolon  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1386734   PMID:9110319   PMID:9501919   PMID:9639555   PMID:9783843   PMID:10652368   PMID:11076863   PMID:11368344   PMID:12211066   PMID:12477932   PMID:14574404   PMID:14702039  
PMID:15910762   PMID:16344560   PMID:19913121   PMID:20200426   PMID:20628086   PMID:21873635   PMID:23728617  


Genomics

Comparative Map Data
GPX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38628,525,881 - 28,534,955 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl628,525,881 - 28,534,955 (+)EnsemblGRCh38hg38GRCh38
GRCh37628,493,658 - 28,502,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36628,601,768 - 28,609,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 34628,601,767 - 28,609,923NCBI
Celera630,100,218 - 30,109,121 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef628,300,120 - 28,309,014 (+)NCBIHuRef
CHM1_1628,496,188 - 28,505,099 (+)NCBICHM1_1
T2T-CHM13v2.0628,397,310 - 28,406,348 (+)NCBIT2T-CHM13v2.0
Gpx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391321,470,599 - 21,476,897 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1321,470,599 - 21,476,901 (-)EnsemblGRCm39 Ensembl
GRCm381321,286,429 - 21,292,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1321,286,429 - 21,292,731 (-)EnsemblGRCm38mm10GRCm38
MGSCv371321,378,298 - 21,384,555 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361321,293,898 - 21,300,151 (-)NCBIMGSCv36mm8
Celera1321,553,579 - 21,559,835 (-)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map137.73NCBI
Gpx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81748,131,853 - 48,138,801 (+)NCBIGRCr8
mRatBN7.21743,436,126 - 43,443,074 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1743,416,340 - 43,443,074 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1745,493,484 - 45,500,432 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01750,252,586 - 50,259,534 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01744,743,174 - 44,750,131 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01745,508,657 - 45,518,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1745,467,015 - 45,518,686 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01757,952,807 - 57,962,120 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11751,091,844 - 51,098,176 (+)NCBI
Celera1753,035,706 - 53,042,631 (-)NCBICelera
Cytogenetic Map17q11NCBI
GPX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2543,153,860 - 43,162,096 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1639,154,800 - 39,163,014 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0628,340,291 - 28,348,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1629,010,528 - 29,018,737 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl629,010,528 - 29,018,737 (+)Ensemblpanpan1.1panPan2
GPX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13525,653,627 - 25,662,490 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3525,653,615 - 25,662,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3525,512,937 - 25,521,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03525,952,095 - 25,960,969 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3525,952,083 - 25,960,969 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13525,615,767 - 25,624,631 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03525,671,318 - 25,679,525 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03527,140,044 - 27,148,915 (+)NCBIUU_Cfam_GSD_1.0
Gpx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494628,952,020 - 28,961,691 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936914487,163 - 496,465 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl722,291,986 - 22,300,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1722,289,432 - 22,300,727 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2724,233,520 - 24,244,829 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11744,027,538 - 44,037,304 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1744,028,543 - 44,036,686 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604428,225,741 - 28,234,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in GPX5
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33		 pathogenic
NM_001509.2(GPX5):c.259G>A (p.Glu87Lys) single nucleotide variant Malignant melanoma [RCV000061374] Chr6:28531795 [GRCh38]
Chr6:28499572 [GRCh37]
Chr6:28607551 [NCBI36]
Chr6:6p22.1		 not provided
NM_001509.3(GPX5):c.28C>T (p.Leu10=) single nucleotide variant not provided [RCV000122494] Chr6:28526041 [GRCh38]
Chr6:28493818 [GRCh37]
Chr6:6p22.1		 uncertain significance
GRCh38/hg38 6p22.2-22.1(chr6:26280579-28727313)x3 copy number gain See cases [RCV000133692] Chr6:26280579..28727313 [GRCh38]
Chr6:26280807..28695090 [GRCh37]
Chr6:26388786..28803069 [NCBI36]
Chr6:6p22.2-22.1		 uncertain significance
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33		 pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32		 uncertain significance
GRCh37/hg19 6p22.1(chr6:28483150-28522695)x1 copy number loss not provided [RCV000745594] Chr6:28483150..28522695 [GRCh37]
Chr6:6p22.1		 benign
GRCh37/hg19 6p22.1(chr6:28486822-28497769)x1 copy number loss not provided [RCV000745595] Chr6:28486822..28497769 [GRCh37]
Chr6:6p22.1		 benign
NC_000006.11:g.28005012_31683185del deletion Megacolon [RCV001290055] Chr6:28005012..31683185 [GRCh37]
Chr6:6p22.1-21.33		 likely pathogenic
NM_001509.3(GPX5):c.367C>T (p.Arg123Cys) single nucleotide variant not specified [RCV004141571] Chr6:28532328 [GRCh38]
Chr6:28500105 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.344T>A (p.Ile115Asn) single nucleotide variant not specified [RCV004089464] Chr6:28531880 [GRCh38]
Chr6:28499657 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.275A>G (p.Tyr92Cys) single nucleotide variant not specified [RCV004077291] Chr6:28531811 [GRCh38]
Chr6:28499588 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.94T>G (p.Cys32Gly) single nucleotide variant not specified [RCV004150700] Chr6:28529457 [GRCh38]
Chr6:28497234 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.217T>C (p.Cys73Arg) single nucleotide variant not specified [RCV004279515] Chr6:28529580 [GRCh38]
Chr6:28497357 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.481G>A (p.Glu161Lys) single nucleotide variant not specified [RCV004278142] Chr6:28533982 [GRCh38]
Chr6:28501759 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.208G>A (p.Ala70Thr) single nucleotide variant not specified [RCV004250413] Chr6:28529571 [GRCh38]
Chr6:28497348 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.236A>C (p.Tyr79Ser) single nucleotide variant not specified [RCV004366085] Chr6:28529599 [GRCh38]
Chr6:28497376 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.274T>G (p.Tyr92Asp) single nucleotide variant not specified [RCV004393524] Chr6:28531810 [GRCh38]
Chr6:28499587 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.445T>C (p.Phe149Leu) single nucleotide variant not specified [RCV004393525] Chr6:28532406 [GRCh38]
Chr6:28500183 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.601C>T (p.Arg201Trp) single nucleotide variant not specified [RCV004393527] Chr6:28534102 [GRCh38]
Chr6:28501879 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.638C>A (p.Ala213Glu) single nucleotide variant not specified [RCV004393528] Chr6:28534139 [GRCh38]
Chr6:28501916 [GRCh37]
Chr6:6p22.1		 likely benign
NM_001509.3(GPX5):c.220G>T (p.Gly74Cys) single nucleotide variant not specified [RCV004393523] Chr6:28529583 [GRCh38]
Chr6:28497360 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.18G>C (p.Arg6Ser) single nucleotide variant not specified [RCV004393522] Chr6:28526031 [GRCh38]
Chr6:28493808 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.466T>C (p.Cys156Arg) single nucleotide variant not specified [RCV004393526] Chr6:28533967 [GRCh38]
Chr6:28501744 [GRCh37]
Chr6:6p22.1		 uncertain significance
NM_001509.3(GPX5):c.301T>G (p.Cys101Gly) single nucleotide variant not specified [RCV004624017] Chr6:28531837 [GRCh38]
Chr6:28499614 [GRCh37]
Chr6:6p22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:966
Count of miRNA genes:640
Interacting mature miRNAs:695
Transcripts:ENST00000412168, ENST00000442674, ENST00000469384, ENST00000483784
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358854MULTSCL4_HMultiple sclerosis susceptibility QTL 4 (human)Multiple sclerosis susceptibility6691196032911960Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
1643377BW325_HBody weight QTL 325 (human)2.320.0005Body fat amount6691196032911960Human
1643569GLUCO21_HGlucose level QTL 21 (human)0.021Glucose levelnon-insulin-dependent6691196032911960Human
1298458BW9_HBody weight QTL 9 (human)2.70.0002Body fat amount6691196032911960Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
1643399BMD5_HBone mineral density QTL 5 (human)2.320.0005Bone mineral density6691196032911960Human

Markers in Region
G66704  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37628,499,480 - 28,499,734UniSTSGRCh37
Build 36628,607,459 - 28,607,713RGDNCBI36
Celera630,105,873 - 30,106,127RGD
Cytogenetic Map6p22.1UniSTS
HuRef628,305,766 - 28,306,020UniSTS
G66705  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37628,500,065 - 28,500,285UniSTSGRCh37
Build 36628,608,044 - 28,608,264RGDNCBI36
Celera630,106,458 - 30,106,678RGD
Cytogenetic Map6p22.1UniSTS
HuRef628,306,351 - 28,306,571UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
54 142 161 103 903 186 306 1 61 77 55 186 527 445 2 768 166 661 124 6

Sequence


Ensembl Acc Id: ENST00000412168   ⟹   ENSP00000392398
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl628,525,881 - 28,534,955 (+)Ensembl
Ensembl Acc Id: ENST00000442674
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl628,528,326 - 28,534,952 (+)Ensembl
Ensembl Acc Id: ENST00000469384   ⟹   ENSP00000419935
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl628,526,012 - 28,534,045 (+)Ensembl
Ensembl Acc Id: ENST00000483784
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl628,528,331 - 28,533,979 (+)Ensembl
RefSeq Acc Id: NM_001509   ⟹   NP_001500
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38628,525,881 - 28,534,955 (+)NCBI
GRCh37628,493,789 - 28,502,728 (+)ENTREZGENE
Build 36628,601,768 - 28,609,923 (+)NCBI Archive
HuRef628,300,120 - 28,309,014 (+)ENTREZGENE
CHM1_1628,496,188 - 28,505,099 (+)NCBI
T2T-CHM13v2.0628,397,310 - 28,406,348 (+)NCBI
Sequence:
RefSeq Acc Id: NM_003996   ⟹   NP_003987
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38628,526,012 - 28,534,951 (+)NCBI
GRCh37628,493,789 - 28,502,728 (+)ENTREZGENE
Build 36628,601,768 - 28,609,923 (+)NCBI Archive
HuRef628,300,120 - 28,309,014 (+)ENTREZGENE
CHM1_1628,496,188 - 28,505,099 (+)NCBI
T2T-CHM13v2.0628,397,441 - 28,406,344 (+)NCBI
Sequence:
RefSeq Acc Id: NR_144470
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38628,528,326 - 28,534,955 (+)NCBI
T2T-CHM13v2.0628,399,755 - 28,406,348 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001500   ⟸   NM_001509
- Peptide Label: isoform 1 precursor
- UniProtKB: A1A4Y0 (UniProtKB/Swiss-Prot),   O75715 (UniProtKB/Swiss-Prot),   V9HWN8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_003987   ⟸   NM_003996
- Peptide Label: isoform 2 precursor
- UniProtKB: O75715 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000392398   ⟸   ENST00000412168
Ensembl Acc Id: ENSP00000419935   ⟸   ENST00000469384

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O75715-F1-model_v2 AlphaFold O75715 1-221 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4557 AgrOrtholog
COSMIC GPX5 COSMIC
Ensembl Genes ENSG00000224586 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000257770 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000412168 ENTREZGENE
  ENST00000412168.7 UniProtKB/Swiss-Prot
  ENST00000469384 ENTREZGENE
  ENST00000469384.1 UniProtKB/Swiss-Prot
  ENST00000550775.5 UniProtKB/Swiss-Prot
  ENST00000551639.1 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000224586 GTEx
  ENSG00000257770 GTEx
HGNC ID HGNC:4557 ENTREZGENE
Human Proteome Map GPX5 Human Proteome Map
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2880 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2880 ENTREZGENE
OMIM 603435 OMIM
PANTHER EPIDIDYMAL SECRETORY GLUTATHIONE PEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28953 PharmGKB
PIRSF Glutathion_perox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1A4Y0 ENTREZGENE
  GPX5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  V9HWN8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A1A4Y0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-10-01 GPX5  glutathione peroxidase 5  GPX5  glutathione peroxidase 5 (epididymal androgen-related protein)  Symbol and/or name change 5135510 APPROVED