IL6 (interleukin 6) - Rat Genome Database

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Gene: IL6 (interleukin 6) Homo sapiens
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Symbol: IL6
Name: interleukin 6
RGD ID: 1352582
HGNC Page HGNC:6018
Description: Enables cytokine activity; growth factor activity; and identical protein binding activity. Contributes to interleukin-6 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule biosynthetic process; and regulation of peptide hormone secretion. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; positive regulation of leukocyte adhesion to vascular endothelial cell; and positive regulation of macromolecule metabolic process. Part of interleukin-6 receptor complex. Is active in extracellular space. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B cell stimulatory factor-2; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; BSF2; CDF; CTL differentiation factor; HGF; HSF; hybridoma growth factor; IFN-beta-2; IFNB2; IL-6; interferon beta-2; interferon, beta 2; interleukin BSF-2; interleukin-6
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW322_H BMD2_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,727,200 - 22,731,998 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,725,884 - 22,732,002 (+)EnsemblGRCh38hg38GRCh38
GRCh37722,766,819 - 22,771,617 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,733,343 - 22,738,145 (+)NCBINCBI36Build 36hg18NCBI36
Build 34722,540,059 - 22,544,856NCBI
Celera722,752,396 - 22,757,251 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,649,846 - 22,654,701 (+)NCBIHuRef
CHM1_1722,767,669 - 22,772,524 (+)NCBICHM1_1
T2T-CHM13v2.0722,861,319 - 22,867,916 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,817,875 - 22,822,730 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model