C10orf62 (chromosome 10 open reading frame 62) - Rat Genome Database

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Gene: C10orf62 (chromosome 10 open reading frame 62) Homo sapiens
Analyze
Symbol: C10orf62
Name: chromosome 10 open reading frame 62
RGD ID: 1351899
HGNC Page HGNC:23294
Description: INTERACTS WITH antirheumatic drug; benzo[a]pyrene; sodium arsenite
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bA548K23.1; hypothetical protein LOC414157; uncharacterized protein C10orf62
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,589,721 - 97,590,934 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,589,721 - 97,590,934 (+)EnsemblGRCh38hg38GRCh38
GRCh371099,349,478 - 99,350,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361099,339,474 - 99,340,681 (+)NCBINCBI36Build 36hg18NCBI36
Build 341099,339,473 - 99,340,680NCBI
Celera1093,086,753 - 93,087,994 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1092,975,499 - 92,976,740 (+)NCBIHuRef
CHM1_11099,631,180 - 99,632,421 (+)NCBICHM1_1
T2T-CHM13v2.01098,469,900 - 98,471,113 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:11076863   PMID:12477932   PMID:15164054   PMID:15489334   PMID:15489336   PMID:16189514   PMID:16381901   PMID:19060904   PMID:19447967   PMID:25416956   PMID:32296183   PMID:33961781  
PMID:36758106  


Genomics

Comparative Map Data
C10orf62
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,589,721 - 97,590,934 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,589,721 - 97,590,934 (+)EnsemblGRCh38hg38GRCh38
GRCh371099,349,478 - 99,350,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361099,339,474 - 99,340,681 (+)NCBINCBI36Build 36hg18NCBI36
Build 341099,339,473 - 99,340,680NCBI
Celera1093,086,753 - 93,087,994 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1092,975,499 - 92,976,740 (+)NCBIHuRef
CHM1_11099,631,180 - 99,632,421 (+)NCBICHM1_1
T2T-CHM13v2.01098,469,900 - 98,471,113 (+)NCBIT2T-CHM13v2.0
4933411K16Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,040,667 - 42,042,067 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,040,687 - 42,042,066 (+)EnsemblGRCm39 Ensembl
GRCm381942,052,228 - 42,053,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,052,248 - 42,053,627 (+)EnsemblGRCm38mm10GRCm38
MGSCv371942,126,718 - 42,128,118 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,105,414 - 42,106,940 (+)NCBIMGSCv36mm8
Celera1942,856,099 - 42,857,499 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1935.68NCBI
MGC93861
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,812,707 - 250,814,066 (+)NCBIGRCr8
mRatBN7.21240,863,403 - 240,864,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,857,263 - 240,867,394 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,008,787 - 249,010,146 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,705,929 - 255,707,288 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01248,358,959 - 248,360,318 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01261,298,147 - 261,299,506 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01268,750,619 - 268,751,978 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41248,798,767 - 248,800,126 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1236,697,888 - 236,699,247 (+)NCBICelera
Cytogenetic Map1q54NCBI
CUNH10orf62
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555073,691,334 - 3,692,636 (+)NCBIChiLan1.0ChiLan1.0
C8H10orf62
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28109,497,020 - 109,506,786 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110109,502,339 - 109,508,342 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01094,208,946 - 94,211,468 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11097,701,693 - 97,703,608 (+)NCBIpanpan1.1PanPan1.1panPan2
C28H10orf62
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,852,218 - 10,853,971 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2810,852,839 - 10,853,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,037,189 - 11,038,948 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,177,097 - 11,178,792 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,177,723 - 11,178,445 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12810,838,656 - 10,839,929 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02810,898,887 - 10,900,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,038,845 - 11,040,540 (+)NCBIUU_Cfam_GSD_1.0
CUNH10orf62
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721336,080,796 - 36,082,316 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366362,119,515 - 2,121,432 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C14H10orf62
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14108,958,876 - 108,966,469 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114108,963,231 - 108,971,343 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214118,467,692 - 118,469,741 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH10orf62
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,750,849 - 90,752,884 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604851,647,827 - 51,650,321 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH10orf62
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247379,233,083 - 9,234,311 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C10orf62
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3
pathogenic
GRCh38/hg38 10q23.33-24.2(chr10:92626680-97755102)x1 copy number loss See cases [RCV000052564] Chr10:92626680..97755102 [GRCh38]
Chr10:94386437..99514859 [GRCh37]
Chr10:94376417..99504849 [NCBI36]
Chr10:10q23.33-24.2
pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NC_000010.10:g.(?_99344461)_(105992004_?)dup duplication not provided [RCV003107322] Chr10:99344461..105992004 [GRCh37]
Chr10:10q24.2-25.1
uncertain significance
GRCh37/hg19 10q24.1-24.2(chr10:99070594-99445724) copy number gain not specified [RCV002052884] Chr10:99070594..99445724 [GRCh37]
Chr10:10q24.1-24.2
uncertain significance
NM_001009997.3(C10orf62):c.539A>C (p.Lys180Thr) single nucleotide variant not specified [RCV004233488] Chr10:97590436 [GRCh38]
Chr10:99350193 [GRCh37]
Chr10:10q24.2
uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3
pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3
pathogenic
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2
pathogenic
NM_001009997.3(C10orf62):c.297G>T (p.Lys99Asn) single nucleotide variant not provided [RCV003740614] Chr10:97590194 [GRCh38]
Chr10:99349951 [GRCh37]
Chr10:10q24.2
uncertain significance
GRCh37/hg19 10q23.33-24.2(chr10:94283369-101820913)x1 copy number loss not specified [RCV003986912] Chr10:94283369..101820913 [GRCh37]
Chr10:10q23.33-24.2
pathogenic
GRCh37/hg19 10q23.31-24.2(chr10:90796994-100067505)x1 copy number loss not specified [RCV003986861] Chr10:90796994..100067505 [GRCh37]
Chr10:10q23.31-24.2
pathogenic
GRCh37/hg19 10q24.1-24.2(chr10:99109931-99405396)x3 copy number gain not specified [RCV003986892] Chr10:99109931..99405396 [GRCh37]
Chr10:10q24.1-24.2
uncertain significance
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3 copy number gain not specified [RCV003986893] Chr10:95078198..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1 copy number loss See cases [RCV000512315] Chr10:93908171..101809723 [GRCh37]
Chr10:10q23.32-24.2
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:223
Interacting mature miRNAs:239
Transcripts:ENST00000370640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2314551GLUCO52_HGlucose level QTL 52 (human)1.4Glucose level1077605006103605006Human

Markers in Region
RH92617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371099,350,446 - 99,350,580UniSTSGRCh37
Build 361099,340,436 - 99,340,570RGDNCBI36
Celera1093,087,749 - 93,087,883RGD
Cytogenetic Map10q24.2UniSTS
HuRef1092,976,495 - 92,976,629UniSTS
GeneMap99-GB4 RH Map10460.07UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
811 1318 2291 2101 3881 1483 1751 533 572 413 1436 5112 4355 14 3116 688 1388 1120 127

Sequence


Ensembl Acc Id: ENST00000370640   ⟹   ENSP00000359674
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1097,589,721 - 97,590,934 (+)Ensembl
RefSeq Acc Id: NM_001009997   ⟹   NP_001009997
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381097,589,721 - 97,590,934 (+)NCBI
GRCh371099,349,450 - 99,350,691 (+)RGD
Build 361099,339,474 - 99,340,681 (+)NCBI Archive
Celera1093,086,753 - 93,087,994 (+)RGD
HuRef1092,975,499 - 92,976,740 (+)ENTREZGENE
CHM1_11099,631,180 - 99,632,421 (+)NCBI
T2T-CHM13v2.01098,469,900 - 98,471,113 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001009997 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH37252 (Get FASTA)   NCBI Sequence Viewer  
  EAW49915 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000359674
  ENSP00000359674.3
GenBank Protein Q5T681 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009997   ⟸   NM_001009997
- UniProtKB: Q49A70 (UniProtKB/Swiss-Prot),   Q8N3Y6 (UniProtKB/Swiss-Prot),   Q5T681 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000359674   ⟸   ENST00000370640

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5T681-F1-model_v2 AlphaFold Q5T681 1-223 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23294 AgrOrtholog
COSMIC C10orf62 COSMIC
Ensembl Genes ENSG00000203942 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000370640 ENTREZGENE
  ENST00000370640.5 UniProtKB/Swiss-Prot
GTEx ENSG00000203942 GTEx
HGNC ID HGNC:23294 ENTREZGENE
Human Proteome Map C10orf62 Human Proteome Map
InterPro C10orf62 UniProtKB/Swiss-Prot
KEGG Report hsa:414157 UniProtKB/Swiss-Prot
NCBI Gene 414157 ENTREZGENE
PANTHER CHROMOSOME 28 C10ORF62 HOMOLOG UniProtKB/Swiss-Prot
  PTHR23008 UniProtKB/Swiss-Prot
Pfam DUF5569 UniProtKB/Swiss-Prot
PharmGKB PA134924151 PharmGKB
UniProt CJ062_HUMAN UniProtKB/Swiss-Prot
  Q49A70 ENTREZGENE
  Q5T681 ENTREZGENE
  Q8N3Y6 ENTREZGENE
UniProt Secondary Q49A70 UniProtKB/Swiss-Prot
  Q8N3Y6 UniProtKB/Swiss-Prot