MRGPRG (MAS related GPR family member G) - Rat Genome Database

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Gene: MRGPRG (MAS related GPR family member G) Homo sapiens
Analyze
Symbol: MRGPRG
Name: MAS related GPR family member G
RGD ID: 1351155
HGNC Page HGNC:24829
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein-coupled receptor 169; G protein-coupled receptor MRGG; G-protein coupled receptor 169; GPR169; mas-related G-protein coupled receptor member G; MAS-related GPR, member G; MRGG
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,217,944 - 3,218,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,217,944 - 3,218,813 (-)EnsemblGRCh38hg38GRCh38
GRCh37113,239,174 - 3,240,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,195,750 - 3,198,081 (-)NCBINCBI36Build 36hg18NCBI36
Celera113,274,767 - 3,275,638 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,029,004 - 3,029,873 (-)NCBIHuRef
CHM1_1113,238,850 - 3,239,719 (-)NCBICHM1_1
T2T-CHM13v2.0113,308,916 - 3,309,785 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12679517   PMID:15164054   PMID:21873635   PMID:37704626  


Genomics

Comparative Map Data
MRGPRG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,217,944 - 3,218,813 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,217,944 - 3,218,813 (-)EnsemblGRCh38hg38GRCh38
GRCh37113,239,174 - 3,240,043 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,195,750 - 3,198,081 (-)NCBINCBI36Build 36hg18NCBI36
Celera113,274,767 - 3,275,638 (-)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,029,004 - 3,029,873 (-)NCBIHuRef
CHM1_1113,238,850 - 3,239,719 (-)NCBICHM1_1
T2T-CHM13v2.0113,308,916 - 3,309,785 (-)NCBIT2T-CHM13v2.0
Mrgprg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,317,447 - 143,320,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,317,447 - 143,320,730 (-)EnsemblGRCm39 Ensembl
GRCm387143,763,710 - 143,766,993 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,763,710 - 143,766,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,949,615 - 150,952,898 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367143,573,100 - 143,576,383 (-)NCBIMGSCv36mm8
Celera7143,520,089 - 143,523,372 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.31NCBI
Mrgprg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,377,008 - 208,380,916 (-)NCBIGRCr8
mRatBN7.21198,947,648 - 198,951,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1198,947,229 - 198,951,517 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1207,328,592 - 207,329,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,410,565 - 214,411,434 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,084,737 - 207,085,606 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,952,942 - 216,955,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,953,130 - 216,953,999 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,809,194 - 223,809,867 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,153,951 - 204,154,820 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11204,307,403 - 204,308,273 (-)NCBI
Celera1196,512,203 - 196,513,072 (-)NCBICelera
Cytogenetic Map1q42NCBI
Mrgprg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542214,962,676 - 14,967,828 (-)NCBIChiLan1.0ChiLan1.0
MRGPRG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v295,618,069 - 5,619,833 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1114,829,371 - 4,831,135 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,231,969 - 3,233,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1113,253,104 - 3,253,973 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,253,104 - 3,253,973 (-)Ensemblpanpan1.1panPan2
MRGPRG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,134,505 - 47,138,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1847,134,505 - 47,138,223 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,742,771 - 45,746,490 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,815,077 - 47,818,793 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,815,077 - 47,818,793 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11847,258,253 - 47,261,966 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,842,141 - 46,845,858 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01847,588,707 - 47,592,424 (-)NCBIUU_Cfam_GSD_1.0
Mrgprg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049473,362,728 - 3,364,387 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367941,303,746 - 1,307,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRGPRG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.122,296,515 - 2,315,412 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MRGPRG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113,035,191 - 3,038,635 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl13,035,455 - 3,036,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038100,229,634 - 100,231,252 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrgprg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476715,971,077 - 15,973,007 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MRGPRG
30 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-15.4(chr11:196966-3377077)x3 copy number gain See cases [RCV000050947] Chr11:196966..3377077 [GRCh38]
Chr11:196966..3398307 [GRCh37]
Chr11:186966..3354883 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-4435344)x3 copy number gain See cases [RCV000050927] Chr11:196966..4435344 [GRCh38]
Chr11:196966..4456574 [GRCh37]
Chr11:186966..4413150 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:218365-3377077)x3 copy number gain See cases [RCV000053614] Chr11:218365..3377077 [GRCh38]
Chr11:218365..3398307 [GRCh37]
Chr11:208365..3354883 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-3624139)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|See cases [RCV000053592] Chr11:196966..3624139 [GRCh38]
Chr11:196966..3645369 [GRCh37]
Chr11:186966..3601945 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:1537379-3360769)x3 copy number gain See cases [RCV000136847] Chr11:1537379..3360769 [GRCh38]
Chr11:1558609..3381999 [GRCh37]
Chr11:1515185..3338575 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:1975511-3624139)x1 copy number loss See cases [RCV000137066] Chr11:1975511..3624139 [GRCh38]
Chr11:1996741..3645369 [GRCh37]
Chr11:1953317..3601945 [NCBI36]
Chr11:11p15.5-15.4
uncertain significance
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196855-5321874)x3 copy number gain See cases [RCV000142890] Chr11:196855..5321874 [GRCh38]
Chr11:196855..5343104 [GRCh37]
Chr11:186855..5299680 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:193187-5291338)x3 copy number gain See cases [RCV000446036] Chr11:193187..5291338 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Silver-Russell syndrome 1 [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-6644927)x3 copy number gain See cases [RCV000449417] Chr11:230615..6644927 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_001164377.1(MRGPRG):c.350G>A (p.Arg117Gln) single nucleotide variant not specified [RCV004304695] Chr11:3218464 [GRCh38]
Chr11:3239694 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-9704511)x3 copy number gain not provided [RCV000683369] Chr11:230615..9704511 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.4(chr11:3237787-3247346)x1 copy number loss not provided [RCV000749909] Chr11:3237787..3247346 [GRCh37]
Chr11:11p15.4
benign
GRCh37/hg19 11p15.4(chr11:3239184-3243346)x1 copy number loss not provided [RCV000749910] Chr11:3239184..3243346 [GRCh37]
Chr11:11p15.4
benign
GRCh37/hg19 11p15.4(chr11:3239184-3247346)x1 copy number loss not provided [RCV000749911] Chr11:3239184..3247346 [GRCh37]
Chr11:11p15.4
benign
GRCh37/hg19 11p15.4(chr11:3239559-3247346)x1 copy number loss not provided [RCV000749912] Chr11:3239559..3247346 [GRCh37]
Chr11:11p15.4
benign
NM_001164377.1(MRGPRG):c.858G>T (p.Met286Ile) single nucleotide variant not specified [RCV004319015] Chr11:3217956 [GRCh38]
Chr11:3239186 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:210300-8664358)x3 copy number gain Silver-Russell syndrome 1 [RCV001263222] Chr11:210300..8664358 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-4851537)x3 copy number gain See cases [RCV001263059] Chr11:230615..4851537 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
NC_000011.9:g.(?_298501)_(4113028_?)dup duplication Early infantile epileptic encephalopathy with suppression bursts [RCV001316682] Chr11:298501..4113028 [GRCh37]
Chr11:11p15.5-15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:10701-5080415)x2 copy number gain See cases [RCV001310286] Chr11:10701..5080415 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-5525355)x3 copy number gain not provided [RCV001825269] Chr11:230615..5525355 [GRCh37]
Chr11:11p15.5-15.4
not provided
NC_000011.9:g.(?_721044)_(3988932_?)dup duplication not provided [RCV003113442] Chr11:721044..3988932 [GRCh37]
Chr11:11p15.5-15.4
uncertain significance
GRCh37/hg19 11p15.5-14.2(chr11:230615-26881146)x3 copy number gain See cases [RCV002286351] Chr11:230615..26881146 [GRCh37]
Chr11:11p15.5-14.2
pathogenic
NC_000011.10:g.(499700_4999400)_(5279346_5279697)del deletion Thalassemia, gamma-delta-beta [RCV000015529] Chr11:4999400..5279346 [GRCh38]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230616-8250724)x3 copy number gain not provided [RCV002472435] Chr11:230616..8250724 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
NM_001164377.1(MRGPRG):c.118C>T (p.Arg40Cys) single nucleotide variant not specified [RCV004194844] Chr11:3218696 [GRCh38]
Chr11:3239926 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.817G>A (p.Glu273Lys) single nucleotide variant not specified [RCV004102472] Chr11:3217997 [GRCh38]
Chr11:3239227 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.196G>T (p.Gly66Cys) single nucleotide variant not specified [RCV004149018] Chr11:3218618 [GRCh38]
Chr11:3239848 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.119G>A (p.Arg40His) single nucleotide variant not specified [RCV004220866] Chr11:3218695 [GRCh38]
Chr11:3239925 [GRCh37]
Chr11:11p15.4
likely benign
NM_001164377.1(MRGPRG):c.785C>T (p.Pro262Leu) single nucleotide variant not specified [RCV004200816] Chr11:3218029 [GRCh38]
Chr11:3239259 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.80C>G (p.Pro27Arg) single nucleotide variant not specified [RCV004152487] Chr11:3218734 [GRCh38]
Chr11:3239964 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.748T>C (p.Tyr250His) single nucleotide variant not specified [RCV004236554] Chr11:3218066 [GRCh38]
Chr11:3239296 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.571C>T (p.Arg191Cys) single nucleotide variant not specified [RCV004228355] Chr11:3218243 [GRCh38]
Chr11:3239473 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.604G>A (p.Gly202Ser) single nucleotide variant not specified [RCV004128205] Chr11:3218210 [GRCh38]
Chr11:3239440 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.416T>G (p.Leu139Arg) single nucleotide variant not specified [RCV004102670] Chr11:3218398 [GRCh38]
Chr11:3239628 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.329C>G (p.Pro110Arg) single nucleotide variant not specified [RCV004210105] Chr11:3218485 [GRCh38]
Chr11:3239715 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.807G>C (p.Arg269Ser) single nucleotide variant not specified [RCV004196663] Chr11:3218007 [GRCh38]
Chr11:3239237 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.646T>A (p.Phe216Ile) single nucleotide variant not specified [RCV004075700] Chr11:3218168 [GRCh38]
Chr11:3239398 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.191G>T (p.Arg64Leu) single nucleotide variant not specified [RCV004163600] Chr11:3218623 [GRCh38]
Chr11:3239853 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.509T>A (p.Leu170Gln) single nucleotide variant not specified [RCV004166854] Chr11:3218305 [GRCh38]
Chr11:3239535 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.374T>C (p.Leu125Pro) single nucleotide variant not specified [RCV004087261] Chr11:3218440 [GRCh38]
Chr11:3239670 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.193G>A (p.Val65Met) single nucleotide variant not specified [RCV004283265] Chr11:3218621 [GRCh38]
Chr11:3239851 [GRCh37]
Chr11:11p15.4
likely benign
NM_001164377.1(MRGPRG):c.77G>A (p.Gly26Glu) single nucleotide variant not specified [RCV004365600] Chr11:3218737 [GRCh38]
Chr11:3239967 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.90C>A (p.Asn30Lys) single nucleotide variant not specified [RCV004360232] Chr11:3218724 [GRCh38]
Chr11:3239954 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.598G>T (p.Val200Phe) single nucleotide variant not specified [RCV004359258] Chr11:3218216 [GRCh38]
Chr11:3239446 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:192764-3362853)x3 copy number gain not provided [RCV003484828] Chr11:192764..3362853 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-8821443)x3 copy number gain Russell-Silver syndrome [RCV003444025] Chr11:230615..8821443 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
NM_001164377.1(MRGPRG):c.685C>T (p.Pro229Ser) single nucleotide variant not specified [RCV004499374] Chr11:3218129 [GRCh38]
Chr11:3239359 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.169G>T (p.Asp57Tyr) single nucleotide variant not specified [RCV004499327] Chr11:3218645 [GRCh38]
Chr11:3239875 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.97G>T (p.Val33Leu) single nucleotide variant not specified [RCV004499406] Chr11:3218717 [GRCh38]
Chr11:3239947 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.113G>A (p.Gly38Asp) single nucleotide variant not specified [RCV004499321] Chr11:3218701 [GRCh38]
Chr11:3239931 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.197G>T (p.Gly66Val) single nucleotide variant not specified [RCV004499345] Chr11:3218617 [GRCh38]
Chr11:3239847 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.370G>A (p.Val124Ile) single nucleotide variant not specified [RCV004499355] Chr11:3218444 [GRCh38]
Chr11:3239674 [GRCh37]
Chr11:11p15.4
likely benign
NM_001164377.1(MRGPRG):c.686C>A (p.Pro229His) single nucleotide variant not specified [RCV004499382] Chr11:3218128 [GRCh38]
Chr11:3239358 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.194T>C (p.Val65Ala) single nucleotide variant not specified [RCV004499338] Chr11:3218620 [GRCh38]
Chr11:3239850 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001164377.1(MRGPRG):c.251T>C (p.Leu84Pro) single nucleotide variant not specified [RCV004643557] Chr11:3218563 [GRCh38]
Chr11:3239793 [GRCh37]
Chr11:11p15.4
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:280
Interacting mature miRNAs:292
Transcripts:ENST00000332314
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558691SCL8_HSerum cholesterol level QTL 8 (human)1.2Lipid levelHDL cholesterol1115227071Human
1559107SCL32_HSerum cholesterol level QTL 32 (human)3.27Lipid levelLDL cholesterol11289243028892430Human
1559113SCL31_HSerum cholesterol level QTL 31 (human)3.72Lipid levelLDL cholesterol11289243028892430Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
93 173 246 136 511 373 300 95 134 14 243 487 465 1 393 77 694 245 81

Sequence


Ensembl Acc Id: ENST00000332314   ⟹   ENSP00000330612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl113,217,944 - 3,218,813 (-)Ensembl
RefSeq Acc Id: NM_001164377   ⟹   NP_001157849
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38113,217,944 - 3,218,813 (-)NCBI
GRCh37113,239,174 - 3,240,043 (-)RGD
Celera113,274,767 - 3,275,638 (-)RGD
HuRef113,029,004 - 3,029,873 (-)ENTREZGENE
CHM1_1113,238,850 - 3,239,719 (-)NCBI
T2T-CHM13v2.0113,308,916 - 3,309,785 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001157849 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO85095 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000330612
  ENSP00000330612.3
GenBank Protein Q86SM5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001157849   ⟸   NM_001164377
- UniProtKB: Q86SM5 (UniProtKB/Swiss-Prot),   W8W3J0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000330612   ⟸   ENST00000332314
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q86SM5-F1-model_v2 AlphaFold Q86SM5 1-289 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:24829 AgrOrtholog
COSMIC MRGPRG COSMIC
Ensembl Genes ENSG00000182170 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000332314 ENTREZGENE
  ENST00000332314.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000182170 GTEx
HGNC ID HGNC:24829 ENTREZGENE
Human Proteome Map MRGPRG Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:386746 UniProtKB/Swiss-Prot
NCBI Gene 386746 ENTREZGENE
OMIM 607234 OMIM
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER G UniProtKB/TrEMBL
  PTHR11334 UniProtKB/Swiss-Prot
  PTHR11334:SF32 UniProtKB/Swiss-Prot
PharmGKB PA134953683 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt MRGRG_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  W8W3J0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 MRGPRG  MAS related GPR family member G    MAS-related GPR, member G  Symbol and/or name change 5135510 APPROVED