MAP1LC3B (microtubule associated protein 1 light chain 3 beta) - Rat Genome Database

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Gene: MAP1LC3B (microtubule associated protein 1 light chain 3 beta) Homo sapiens
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Symbol: MAP1LC3B
Name: microtubule associated protein 1 light chain 3 beta
RGD ID: 1350223
HGNC Page HGNC:13352
Description: Enables ceramide binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in cellular response to starvation and macroautophagy. Located in autophagosome membrane; cytoplasmic vesicle; and mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATG8F; autophagy-related protein LC3 B; autophagy-related ubiquitin-like modifier LC3 B; LC3B; MAP1 light chain 3-like protein 2; MAP1A/1BLC3; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; MAP1LC3B-a; microtubule-associated protein 1 light chain 3 beta; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3B
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: AC006199.1   GS1-279B7.1   LOC387869   MAP1LC3P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,392,336 - 87,404,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1687,383,953 - 87,404,779 (+)EnsemblGRCh38hg38GRCh38
GRCh371687,425,942 - 87,438,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,983,320 - 85,995,881 (+)NCBINCBI36Build 36hg18NCBI36
Build 341685,983,450 - 85,995,880NCBI
Celera1671,722,569 - 71,735,146 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1673,168,889 - 73,180,793 (+)NCBIHuRef
CHM1_11688,837,611 - 88,850,167 (+)NCBICHM1_1
T2T-CHM13v2.01693,463,228 - 93,475,656 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-monopalmitoylglycerol  (EXP)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (EXP)
2-deoxy-D-glucose  (EXP)
2-hydroxyethyl methacrylate  (EXP)
25-hydroxycholesterol  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-methyladenine  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-methoxy-TEMPO  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (ISO)
abamectin  (ISO)
ABT-737  (EXP)
acadesine  (EXP)
acetaldehyde  (ISO)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
Aescin  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alginic acid  (ISO)
all-trans-retinoic acid  (EXP)
allethrin  (EXP)
aloxistatin  (EXP,ISO)
alpha,alpha-trehalose  (ISO)
alpha-amanitin  (EXP,ISO)
Alpinetin  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP)
amitrole  (ISO)
ammonium chloride  (EXP,ISO)
amphotericin B  (ISO)
amsacrine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP)
apigenin  (EXP)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asperuloside  (ISO)
atazanavir sulfate  (EXP)
atorvastatin calcium  (ISO)
atrazine  (ISO)
auramine O  (EXP)
AZD4547  (EXP)
bafilomycin A1  (EXP,ISO)
Bafilomycin B1  (EXP,ISO)
BAPTA  (ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP,ISO)
beta-ionone  (EXP)
beta-lapachone  (EXP)
betulinic acid  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (ISO)
bortezomib  (EXP)
brefeldin A  (EXP)
buprofezin  (EXP)
buspirone  (ISO)
busulfan  (ISO)
butachlor  (ISO)
butanal  (EXP)
butein  (EXP)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcidiol  (EXP)
calcitriol  (ISO)
calix[6]arene  (EXP)
Calpeptin  (EXP)
capivasertib  (EXP)
carbamazepine  (ISO)
carbon disulfide  (ISO)
carbon nanotube  (EXP,ISO)
carglumic acid  (ISO)
carteolol  (EXP)
celecoxib  (EXP)
cerium trichloride  (EXP)
CGP 52608  (EXP)
CGS-21680  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chloropicrin  (EXP)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
colistin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
Cryptotanshinone  (EXP)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyanamide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
D-mannopyranose  (EXP)
dapagliflozin  (ISO)
DDE  (EXP,ISO)
deguelin  (EXP)
Dehydroeburicoic acid  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenzofuran  (EXP)
Dibromoacetonitrile  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dideuterium oxide  (EXP)
diethyl malate  (EXP)
diisononyl phthalate  (EXP,ISO)
diosgenin  (EXP,ISO)
dioxygen  (EXP,ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
EHT 1864  (EXP)
elemental selenium  (ISO)
entinostat  (EXP)
enzalutamide  (EXP)
erastin  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
everolimus  (EXP)
fangchinoline  (EXP)
fenofibrate  (ISO)
ferric ammonium citrate  (EXP)
ferric oxide  (ISO)
ferrostatin-1  (ISO)
finasteride  (ISO)
flavokawain B  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP,ISO)
fructose  (ISO)
fumonisin B1  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Garcinol  (EXP)
gefitinib  (EXP)
gingerol  (EXP)
Ginkgoic acid  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rg2  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycerol 2-phosphate  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhizinic acid  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (EXP)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
indoxyl sulfate  (ISO)
inositol  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoliquiritigenin  (ISO)
ivermectin  (EXP)
JTE-013  (ISO)
juglone  (EXP)
kainic acid  (ISO)
L-ascorbic acid 2-phosphate  (EXP)
L-leucine  (ISO)
L-serine  (ISO)
lactucin  (EXP)
lactulose  (ISO)
lanthanum trichloride  (EXP,ISO)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
LY294002  (EXP,ISO)
lycopene  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
melibiose  (ISO)
menadione  (EXP)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylphenidate  (ISO)
metyrapone  (EXP)
miconazole  (EXP)
mitoxantrone  (EXP)
MJN110  (ISO)
MK-2206  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
myriocin  (EXP)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acylsphinganine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
Naftopidil  (EXP)
nefazodone  (EXP,ISO)
nelfinavir  (EXP)
nickel dichloride  (ISO)
niclosamide  (EXP)
nicotinamide  (EXP)
nimesulide  (ISO)
Nivalenol  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
octreotide  (ISO)
olaparib  (EXP,ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP)
Ophiopogonin D  (EXP)
osthole  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraformaldehyde macromolecule  (ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PD 0325901  (EXP)
pectolinarigenin  (EXP)
Pentoxifylline  (ISO)
pepstatin A  (EXP,ISO)
perfluorobutyric acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylethanolamine  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
potassium chromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin B2  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
rac-1-monopalmitoylglycerol  (EXP)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
rimonabant  (ISO)
rotenone  (EXP,ISO)
roxadustat  (ISO)
ruthenium red  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 203580  (EXP,ISO)
SCH772984  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
sepantronium  (EXP)
serpentine asbestos  (EXP)
sertraline  (EXP)
sevoflurane  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sphingosine 1-phosphate  (ISO)
spironolactone  (ISO)
stattic  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (ISO)
swainsonine  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
Tartrolon D  (EXP,ISO)
taurine  (EXP,ISO)
taurocholic acid  (ISO)
tebufenpyrad  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (EXP)
thiamine(1+) chloride  (ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (EXP,ISO)
toosendanin  (EXP,ISO)
trametinib  (EXP)
tricalcium bis(phosphate)  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (EXP)
trifloxystrobin  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
trovafloxacin  (EXP)
tunicamycin  (EXP,ISO)
tyloxapol  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vismodegib  (EXP)
vorinostat  (EXP,ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
autophagy pathway  (IMP,TAS)

References

References - curated
# Reference Title Reference Citation
1. Network organization of the human autophagy system. Behrends C, etal., Nature. 2010 Jul 1;466(7302):68-76. Epub 2010 Jun 20.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
5. LC3 conjugation system in mammalian autophagy. Tanida I, etal., Int J Biochem Cell Biol. 2004 Dec;36(12):2503-18.
6. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
Additional References at PubMed
PMID:2212989   PMID:8997639   PMID:11060023   PMID:11076863   PMID:11256614   PMID:11825910   PMID:11890701   PMID:12477932   PMID:12740394   PMID:12932674   PMID:14702039   PMID:14713272  
PMID:15187094   PMID:15231747   PMID:15355958   PMID:15489334   PMID:15489336   PMID:16169070   PMID:16189514   PMID:16303767   PMID:16344560   PMID:16381901   PMID:17580304   PMID:18083104  
PMID:18184459   PMID:18296641   PMID:19250911   PMID:19279012   PMID:19322194   PMID:19492063   PMID:19623642   PMID:20010802   PMID:20038797   PMID:20100911   PMID:20153330   PMID:20200478  
PMID:20417604   PMID:20863706   PMID:20889906   PMID:20956295   PMID:21099673   PMID:21383079   PMID:21617041   PMID:21873635   PMID:21900206   PMID:21988832   PMID:22056771   PMID:22080440  
PMID:22095627   PMID:22170153   PMID:22174682   PMID:22267086   PMID:22354992   PMID:22434781   PMID:22470510   PMID:22472876   PMID:22482402   PMID:22496786   PMID:22922758   PMID:22948227  
PMID:22963397   PMID:23043107   PMID:23203033   PMID:23209295   PMID:23209807   PMID:23333919   PMID:23371253   PMID:23427159   PMID:23429496   PMID:23459205   PMID:23629966   PMID:23721406  
PMID:23736261   PMID:23787295   PMID:23805866   PMID:23878278   PMID:23935917   PMID:24023838   PMID:24067654   PMID:24089205   PMID:24113030   PMID:24141623   PMID:24220335   PMID:24288667  
PMID:24290141   PMID:24566975   PMID:24582747   PMID:24646892   PMID:24668264   PMID:24671035   PMID:24690104   PMID:24879152   PMID:24900981   PMID:24983366   PMID:25007327   PMID:25126726  
PMID:25126727   PMID:25127057   PMID:25144556   PMID:25215947   PMID:25244949   PMID:25256671   PMID:25339774   PMID:25416948   PMID:25416956   PMID:25419843   PMID:25439234   PMID:25483098  
PMID:25490467   PMID:25503069   PMID:25607473   PMID:25653352   PMID:25666616   PMID:25684205   PMID:25771791   PMID:25847297   PMID:26040720   PMID:26347139   PMID:26413874   PMID:26451915  
PMID:26468287   PMID:26486079   PMID:26502823   PMID:26506894   PMID:26524528   PMID:26638075   PMID:26654586   PMID:26719147   PMID:26794413   PMID:26880484   PMID:26965179   PMID:26979828  
PMID:27158844   PMID:27250034   PMID:27490928   PMID:27554286   PMID:27561680   PMID:27655288   PMID:27757847   PMID:27764541   PMID:27791183   PMID:27791457   PMID:27791468   PMID:27875067  
PMID:28017329   PMID:28085563   PMID:28223137   PMID:28253953   PMID:28287329   PMID:28325809   PMID:28358429   PMID:28393217   PMID:28404643   PMID:28423666   PMID:28442745   PMID:28470758  
PMID:28482233   PMID:28506764   PMID:28558758   PMID:28668392   PMID:28855742   PMID:29021346   PMID:29044928   PMID:29048433   PMID:29091866   PMID:29149599   PMID:29196475   PMID:29251248  
PMID:29328502   PMID:29385656   PMID:29416008   PMID:29426817   PMID:29545906   PMID:29592877   PMID:29599373   PMID:29723445   PMID:29761913   PMID:29859041   PMID:29867141   PMID:29897944  
PMID:29941173   PMID:29965781   PMID:29995557   PMID:30202024   PMID:30217973   PMID:30238850   PMID:30258106   PMID:30272335   PMID:30282803   PMID:30286180   PMID:30316511   PMID:30420355  
PMID:30442766   PMID:30504397   PMID:30572598   PMID:30633346   PMID:30679426   PMID:30721460   PMID:30778222   PMID:30806153   PMID:30849520   PMID:30853400   PMID:30902965   PMID:30907226  
PMID:30941888   PMID:31006538   PMID:31036602   PMID:31114135   PMID:31177901   PMID:31213539   PMID:31286822   PMID:31410188   PMID:31448673   PMID:31515488   PMID:31659150   PMID:31685529  
PMID:31692446   PMID:31857374   PMID:31880195   PMID:31960529   PMID:31971854   PMID:31987044   PMID:32272685   PMID:32296183   PMID:32296703   PMID:32315611   PMID:32453962   PMID:32541814  
PMID:32612200   PMID:32685993   PMID:32762616   PMID:32814053   PMID:33076962   PMID:33081014   PMID:33176581   PMID:33184773   PMID:33201170   PMID:33241194   PMID:33302793   PMID:33310865  
PMID:33368531   PMID:33391467   PMID:33436498   PMID:33499712   PMID:33526872   PMID:33535890   PMID:33545068   PMID:33577797   PMID:33664238   PMID:33783314   PMID:33988680   PMID:34037656  
PMID:34084775   PMID:34349018   PMID:34524948   PMID:34654847   PMID:34774801   PMID:34799561   PMID:34819832   PMID:34831341   PMID:34836490   PMID:34845370   PMID:34855092   PMID:34929165  
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PMID:36029500   PMID:36042481   PMID:36215168   PMID:36334211   PMID:36509521   PMID:36574265   PMID:36692217   PMID:36719634   PMID:36758105   PMID:36842152   PMID:36935496   PMID:37219487  
PMID:37225996   PMID:37315562   PMID:37405374   PMID:37827155   PMID:37943659   PMID:38285778   PMID:38388661   PMID:38412240   PMID:38527804   PMID:39009827   PMID:39098523  


Genomics

Comparative Map Data
MAP1LC3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381687,392,336 - 87,404,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1687,383,953 - 87,404,779 (+)EnsemblGRCh38hg38GRCh38
GRCh371687,425,942 - 87,438,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,983,320 - 85,995,881 (+)NCBINCBI36Build 36hg18NCBI36
Build 341685,983,450 - 85,995,880NCBI
Celera1671,722,569 - 71,735,146 (+)NCBICelera
Cytogenetic Map16q24.2NCBI
HuRef1673,168,889 - 73,180,793 (+)NCBIHuRef
CHM1_11688,837,611 - 88,850,167 (+)NCBICHM1_1
T2T-CHM13v2.01693,463,228 - 93,475,656 (+)NCBIT2T-CHM13v2.0
Map1lc3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,317,177 - 122,325,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8122,317,100 - 122,325,499 (+)EnsemblGRCm39 Ensembl
GRCm388121,590,438 - 121,598,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,590,361 - 121,598,760 (+)EnsemblGRCm38mm10GRCm38
MGSCv378124,114,368 - 124,121,947 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368124,476,528 - 124,484,107 (+)NCBIMGSCv36mm8
Celera8125,811,811 - 125,819,390 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.67NCBI
Map1lc3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81966,571,631 - 66,582,270 (+)NCBIGRCr8
mRatBN7.21949,665,795 - 49,673,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,994,128 - 70,994,606 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1949,665,791 - 49,677,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1956,456,727 - 56,464,411 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01957,140,942 - 57,148,612 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01959,355,262 - 59,362,946 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01953,635,449 - 53,643,970 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1953,629,779 - 53,646,058 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01964,373,068 - 64,381,400 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41951,847,187 - 51,854,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11951,852,067 - 51,859,738 (+)NCBI
Celera1948,912,797 - 48,920,467 (+)NCBICelera
Cytogenetic Map19q12NCBI
Map1lc3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555411,852,388 - 1,868,194 (+)NCBIChiLan1.0ChiLan1.0
MAP1LC3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21897,140,144 - 97,163,688 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116103,065,985 - 103,080,043 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01668,063,869 - 68,076,772 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11687,393,976 - 87,399,736 (+)NCBIpanpan1.1PanPan1.1panPan2
MAP1LC3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1565,669,553 - 65,683,445 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha565,681,248 - 65,695,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0565,891,103 - 65,905,466 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1565,915,961 - 65,929,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0565,747,849 - 65,761,805 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0566,161,995 - 66,175,961 (-)NCBIUU_Cfam_GSD_1.0
MAP1LC3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,915,387 - 1,941,069 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,919,879 - 1,941,069 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,007,809 - 2,029,003 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP1LC3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1572,762,428 - 72,774,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl572,763,050 - 72,772,770 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660472,921,927 - 2,933,888 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map1lc3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247463,084,392 - 3,094,250 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247463,084,418 - 3,094,250 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP1LC3B
12 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q23.1-24.3(chr16:78816291-90081985)x3 copy number gain See cases [RCV000050840] Chr16:78816291..90081985 [GRCh38]
Chr16:78850188..90148393 [GRCh37]
Chr16:77407689..88675894 [NCBI36]
Chr16:16q23.1-24.3
pathogenic
GRCh38/hg38 16q22.1-24.3(chr16:70514631-90081985)x3 copy number gain See cases [RCV000052422] Chr16:70514631..90081985 [GRCh38]
Chr16:70548534..90148393 [GRCh37]
Chr16:69106035..88675894 [NCBI36]
Chr16:16q22.1-24.3
pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:76873569-90081985)x3 copy number gain See cases [RCV000052423] Chr16:76873569..90081985 [GRCh38]
Chr16:76907466..90148393 [GRCh37]
Chr16:75464967..88675894 [NCBI36]
Chr16:16q23.1-24.3
pathogenic
GRCh38/hg38 16q23.3-24.3(chr16:82173150-90081985)x3 copy number gain See cases [RCV000052424] Chr16:82173150..90081985 [GRCh38]
Chr16:82206755..90148393 [GRCh37]
Chr16:80764256..88675894 [NCBI36]
Chr16:16q23.3-24.3
pathogenic
GRCh38/hg38 16q24.1-24.3(chr16:84707538-90081985)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052425]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052425]|See cases [RCV000052425] Chr16:84707538..90081985 [GRCh38]
Chr16:84741144..90148393 [GRCh37]
Chr16:83298645..88675894 [NCBI36]
Chr16:16q24.1-24.3
pathogenic
GRCh38/hg38 16q23.1-24.2(chr16:78704275-87819342)x1 copy number loss See cases [RCV000053359] Chr16:78704275..87819342 [GRCh38]
Chr16:78738172..87852948 [GRCh37]
Chr16:77295673..86410449 [NCBI36]
Chr16:16q23.1-24.2
pathogenic
GRCh38/hg38 16q24.2-24.3(chr16:87306529-89269079)x1 copy number loss See cases [RCV000053362] Chr16:87306529..89269079 [GRCh38]
Chr16:87340135..89335487 [GRCh37]
Chr16:85897636..87862988 [NCBI36]
Chr16:16q24.2-24.3
pathogenic
GRCh38/hg38 16q24.1-24.2(chr16:86672163-87766879)x1 copy number loss See cases [RCV000134960] Chr16:86672163..87766879 [GRCh38]
Chr16:86705769..87800485 [GRCh37]
Chr16:85263270..86357986 [NCBI36]
Chr16:16q24.1-24.2
likely pathogenic
GRCh38/hg38 16q23.3-24.3(chr16:83988570-90081985)x3 copy number gain See cases [RCV000135659] Chr16:83988570..90081985 [GRCh38]
Chr16:84022175..90148393 [GRCh37]
Chr16:82579676..88675894 [NCBI36]
Chr16:16q23.3-24.3
likely pathogenic
GRCh38/hg38 16q24.2(chr16:87223779-87853460)x1 copy number loss See cases [RCV000135624] Chr16:87223779..87853460 [GRCh38]
Chr16:87257385..87887066 [GRCh37]
Chr16:85814886..86444567 [NCBI36]
Chr16:16q24.2
uncertain significance
GRCh38/hg38 16q24.2(chr16:87150123-87812135)x1 copy number loss See cases [RCV000135595] Chr16:87150123..87812135 [GRCh38]
Chr16:87183729..87845741 [GRCh37]
Chr16:85741230..86403242 [NCBI36]
Chr16:16q24.2
likely pathogenic|uncertain significance
GRCh38/hg38 16q24.2(chr16:87223779-87440975)x1 copy number loss See cases [RCV000136537] Chr16:87223779..87440975 [GRCh38]
Chr16:87257385..87474581 [GRCh37]
Chr16:85814886..86032082 [NCBI36]
Chr16:16q24.2
uncertain significance
GRCh38/hg38 16q23.2-24.3(chr16:80946659-90081985)x3 copy number gain See cases [RCV000136898] Chr16:80946659..90081985 [GRCh38]
Chr16:80980556..90148393 [GRCh37]
Chr16:79538057..88675894 [NCBI36]
Chr16:16q23.2-24.3
pathogenic|likely pathogenic
GRCh38/hg38 16q22.1-24.3(chr16:70749398-90096995)x3 copy number gain See cases [RCV000137495] Chr16:70749398..90096995 [GRCh38]
Chr16:70783301..90163403 [GRCh37]
Chr16:69340802..88690904 [NCBI36]
Chr16:16q22.1-24.3
pathogenic
GRCh38/hg38 16q23.3-24.3(chr16:83478453-89932910)x3 copy number gain See cases [RCV000137980] Chr16:83478453..89932910 [GRCh38]
Chr16:83512058..89999318 [GRCh37]
Chr16:82069559..88526819 [NCBI36]
Chr16:16q23.3-24.3
likely pathogenic
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:75377981-90081992)x3 copy number gain See cases [RCV000139302] Chr16:75377981..90081992 [GRCh38]
Chr16:75411879..90148400 [GRCh37]
Chr16:73969380..88675901 [NCBI36]
Chr16:16q23.1-24.3
pathogenic
GRCh38/hg38 16q24.1-24.3(chr16:85552976-90096995)x3 copy number gain See cases [RCV000139658] Chr16:85552976..90096995 [GRCh38]
Chr16:85586582..90163403 [GRCh37]
Chr16:84144083..88690904 [NCBI36]
Chr16:16q24.1-24.3
pathogenic
GRCh38/hg38 16q24.2(chr16:87038922-87766879)x1 copy number loss See cases [RCV000139802] Chr16:87038922..87766879 [GRCh38]
Chr16:87072528..87800485 [GRCh37]
Chr16:85630029..86357986 [NCBI36]
Chr16:16q24.2
uncertain significance
GRCh38/hg38 16q23.2-24.3(chr16:80717291-90096662)x3 copy number gain See cases [RCV000141128] Chr16:80717291..90096662 [GRCh38]
Chr16:80751188..90163070 [GRCh37]
Chr16:79308689..88690571 [NCBI36]
Chr16:16q23.2-24.3
pathogenic
GRCh38/hg38 16q23.1-24.3(chr16:76336203-90088654)x3 copy number gain See cases [RCV000141700] Chr16:76336203..90088654 [GRCh38]
Chr16:76370100..90155062 [GRCh37]
Chr16:74927601..88682563 [NCBI36]
Chr16:16q23.1-24.3
pathogenic
GRCh38/hg38 16q23.2-24.3(chr16:80067315-90057871)x3 copy number gain See cases [RCV000142698] Chr16:80067315..90057871 [GRCh38]
Chr16:80101212..90124279 [GRCh37]
Chr16:78658713..88651780 [NCBI36]
Chr16:16q23.2-24.3
pathogenic
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic|likely pathogenic
GRCh38/hg38 16q24.2(chr16:87382052-87766879)x1 copy number loss See cases [RCV000142722] Chr16:87382052..87766879 [GRCh38]
Chr16:87415658..87800485 [GRCh37]
Chr16:85973159..86357986 [NCBI36]
Chr16:16q24.2
likely pathogenic|uncertain significance
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q24.1-24.3(chr16:86950106-89335814)x1 copy number loss See cases [RCV000143624] Chr16:86950106..89335814 [GRCh38]
Chr16:86983712..89402222 [GRCh37]
Chr16:85541213..87929723 [NCBI36]
Chr16:16q24.1-24.3
pathogenic
GRCh38/hg38 16q24.2(chr16:87267492-87780225)x1 copy number loss See cases [RCV000143657] Chr16:87267492..87780225 [GRCh38]
Chr16:87301098..87813831 [GRCh37]
Chr16:85858599..86371332 [NCBI36]
Chr16:16q24.2
likely pathogenic|uncertain significance
GRCh37/hg19 16q23.1-24.3(chr16:74872514-90274440)x3 copy number gain See cases [RCV000240108] Chr16:74872514..90274440 [GRCh37]
Chr16:16q23.1-24.3
pathogenic
t(5;16)(p15.31;q23.1) translocation not provided [RCV000203391] Chr5:1..8180513 [GRCh37]
Chr16:76935310..90354753 [GRCh37]
Chr5:5p15.33-15.31
Chr16:16q23.1-24.3
likely pathogenic
Single allele deletion 16q24.3 microdeletion syndrome [RCV000258230] Chr16:87183661..89520803 [GRCh37]
Chr16:16q24.2-24.3
pathogenic
Single allele deletion 16q24.3 microdeletion syndrome [RCV000258380] Chr16:87340135..89335428 [GRCh37]
Chr16:16q24.2-24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q22.2-24.3(chr16:72107834-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207182] Chr16:72107834..90142285 [GRCh37]
Chr16:16q22.2-24.3
uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16q24.2(chr16:87409427-87446304)x1 copy number loss See cases [RCV000446674] Chr16:87409427..87446304 [GRCh37]
Chr16:16q24.2
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q24.1-24.2(chr16:85491404-87883528)x1 copy number loss See cases [RCV000510624] Chr16:85491404..87883528 [GRCh37]
Chr16:16q24.1-24.2
pathogenic
GRCh37/hg19 16q24.2-24.3(chr16:87219866-89561087)x1 copy number loss not provided [RCV000509325] Chr16:87219866..89561087 [GRCh37]
Chr16:16q24.2-24.3
not provided
GRCh37/hg19 16q24.2(chr16:87428533-87486111)x1 copy number loss See cases [RCV000511653] Chr16:87428533..87486111 [GRCh37]
Chr16:16q24.2
uncertain significance
GRCh37/hg19 16q24.2(chr16:87333237-87457042)x1 copy number loss See cases [RCV000511682] Chr16:87333237..87457042 [GRCh37]
Chr16:16q24.2
likely pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16q24.1-24.3(chr16:84937273-89836905)x4 copy number gain See cases [RCV000511606] Chr16:84937273..89836905 [GRCh37]
Chr16:16q24.1-24.3
likely pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3
pathogenic
GRCh37/hg19 16q24.1-24.3(chr16:85838574-90155062)x3 copy number gain See cases [RCV000512440] Chr16:85838574..90155062 [GRCh37]
Chr16:16q24.1-24.3
pathogenic
GRCh37/hg19 16q23.3-24.3(chr16:83001540-90155062)x3 copy number gain See cases [RCV000512468] Chr16:83001540..90155062 [GRCh37]
Chr16:16q23.3-24.3
likely pathogenic
Single allele deletion not provided [RCV000677910] Chr16:86890893..89398630 [GRCh37]
Chr16:16q24.1-24.3
pathogenic
GRCh37/hg19 16q24.2(chr16:87307128-87551687)x1 copy number loss not provided [RCV000683855] Chr16:87307128..87551687 [GRCh37]
Chr16:16q24.2
uncertain significance
GRCh37/hg19 16q24.2(chr16:87149360-87848903)x1 copy number loss not provided [RCV000683854] Chr16:87149360..87848903 [GRCh37]
Chr16:16q24.2
uncertain significance
GRCh37/hg19 16q23.2-24.3(chr16:79400436-90155062)x3 copy number gain not provided [RCV000683845] Chr16:79400436..90155062 [GRCh37]
Chr16:16q23.2-24.3
pathogenic
GRCh37/hg19 16q22.2-24.3(chr16:72515938-90155062)x3 copy number gain not provided [RCV000683831] Chr16:72515938..90155062 [GRCh37]
Chr16:16q22.2-24.3
pathogenic
GRCh37/hg19 16q24.1-24.2(chr16:84872102-87678641) copy number loss Alveolar capillary dysplasia with pulmonary venous misalignment [RCV001004081] Chr16:84872102..87678641 [GRCh37]
Chr16:16q24.1-24.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q24.2(chr16:87153890-87518829)x1 copy number loss not provided [RCV000751802] Chr16:87153890..87518829 [GRCh37]
Chr16:16q24.2
benign
GRCh37/hg19 16q24.2(chr16:87409427-87603006)x1 copy number loss not provided [RCV001006837] Chr16:87409427..87603006 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.72A>T (p.Arg24=) single nucleotide variant not provided [RCV000930843] Chr16:87398846 [GRCh38]
Chr16:87432452 [GRCh37]
Chr16:16q24.2
likely benign
GRCh37/hg19 16q23.3-24.3(chr16:82761333-90055381) copy number gain not provided [RCV000767619] Chr16:82761333..90055381 [GRCh37]
Chr16:16q23.3-24.3
pathogenic
NM_022818.5(MAP1LC3B):c.73G>C (p.Glu25Gln) single nucleotide variant not provided [RCV000962565] Chr16:87398847 [GRCh38]
Chr16:87432453 [GRCh37]
Chr16:16q24.2
benign
NM_022818.5(MAP1LC3B):c.345C>T (p.Ser115=) single nucleotide variant not provided [RCV000926609] Chr16:87403064 [GRCh38]
Chr16:87436670 [GRCh37]
Chr16:16q24.2
likely benign
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3
not provided
GRCh37/hg19 16q23.2-24.3(chr16:80386595-90163348)x3 copy number gain not provided [RCV001795551] Chr16:80386595..90163348 [GRCh37]
Chr16:16q23.2-24.3
pathogenic
NC_000016.9:g.86243180_87703229del deletion Alveolar capillary dysplasia with pulmonary venous misalignment [RCV001199829] Chr16:86243180..87703229 [GRCh37]
Chr16:16q24.1-24.2
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16q22.2-24.3(chr16:71641395-90161959)x3 copy number gain Syndromic anorectal malformation [RCV002286607] Chr16:71641395..90161959 [GRCh37]
Chr16:16q22.2-24.3
likely pathogenic
NM_022818.5(MAP1LC3B):c.256C>G (p.His86Asp) single nucleotide variant not specified [RCV004322637] Chr16:87402975 [GRCh38]
Chr16:87436581 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.167A>G (p.Asp56Gly) single nucleotide variant not specified [RCV004140045] Chr16:87402245 [GRCh38]
Chr16:87435851 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.32G>T (p.Arg11Leu) single nucleotide variant not specified [RCV004091019] Chr16:87392459 [GRCh38]
Chr16:87426065 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.5C>G (p.Pro2Arg) single nucleotide variant not specified [RCV004195951] Chr16:87392432 [GRCh38]
Chr16:87426038 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.130C>T (p.Leu44Phe) single nucleotide variant not specified [RCV004149714] Chr16:87402208 [GRCh38]
Chr16:87435814 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.131T>C (p.Leu44Pro) single nucleotide variant not specified [RCV004149715] Chr16:87402209 [GRCh38]
Chr16:87435815 [GRCh37]
Chr16:16q24.2
uncertain significance
NM_022818.5(MAP1LC3B):c.271G>A (p.Val91Ile) single nucleotide variant not specified [RCV004241926] Chr16:87402990 [GRCh38]
Chr16:87436596 [GRCh37]
Chr16:16q24.2
uncertain significance
GRCh37/hg19 16q24.1-24.2(chr16:86544176-88110267)x1 copy number loss not provided [RCV003222894] Chr16:86544176..88110267 [GRCh37]
Chr16:16q24.1-24.2
pathogenic
NM_022818.5(MAP1LC3B):c.86C>T (p.Thr29Ile) single nucleotide variant not specified [RCV004284793] Chr16:87398860 [GRCh38]
Chr16:87432466 [GRCh37]
Chr16:16q24.2
uncertain significance