C10orf95 (chromosome 10 open reading frame 95) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: C10orf95 (chromosome 10 open reading frame 95) Homo sapiens
Analyze
Symbol: C10orf95
Name: chromosome 10 open reading frame 95
RGD ID: 1349493
HGNC Page HGNC:25880
Description: ASSOCIATED WITH desmoplastic/nodular medulloblastoma; INTERACTS WITH aflatoxin B1; benzo[a]pyrene; cisplatin
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ14280; hypothetical protein LOC79946; uncharacterized protein C10orf95
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,449,837 - 102,451,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,449,837 - 102,451,543 (-)EnsemblGRCh38hg38GRCh38
GRCh3710104,209,594 - 104,211,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,199,584 - 104,201,290 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410104,199,583 - 104,201,290NCBI
Celera1097,950,507 - 97,952,213 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,843,302 - 97,845,271 (-)NCBIHuRef
CHM1_110104,493,060 - 104,494,766 (-)NCBICHM1_1
T2T-CHM13v2.010103,334,824 - 103,336,530 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:15164054   PMID:15489334   PMID:21572394   PMID:23535732   PMID:32393512  


Genomics

Comparative Map Data
C10orf95
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,449,837 - 102,451,543 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,449,837 - 102,451,543 (-)EnsemblGRCh38hg38GRCh38
GRCh3710104,209,594 - 104,211,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,199,584 - 104,201,290 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410104,199,583 - 104,201,290NCBI
Celera1097,950,507 - 97,952,213 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,843,302 - 97,845,271 (-)NCBIHuRef
CHM1_110104,493,060 - 104,494,766 (-)NCBICHM1_1
T2T-CHM13v2.010103,334,824 - 103,336,530 (-)NCBIT2T-CHM13v2.0
2310034G01Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,336,640 - 46,337,427 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,336,640 - 46,338,741 (-)EnsemblGRCm39 Ensembl
GRCm381946,348,201 - 46,348,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,348,201 - 46,350,302 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,422,691 - 46,432,834 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,422,691 - 46,423,914 (-)NCBIMGSCv36mm8
Celera1947,111,549 - 47,121,732 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.82NCBI
C1h10orf95
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,143,264 - 255,157,901 (-)NCBIGRCr8
mRatBN7.21245,210,228 - 245,212,080 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,210,973 - 245,211,602 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,331,660 - 253,333,512 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,026,277 - 260,028,129 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,678,080 - 252,679,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Cytogenetic Map1q54NCBI
C8H10orf95
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,337,781 - 114,338,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,343,103 - 114,344,289 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01099,053,081 - 99,054,982 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C28H10orf95
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,947,869 - 14,949,414 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,948,373 - 14,949,032 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,120,691 - 15,121,783 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,422,368 - 15,423,460 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,422,396 - 15,423,055 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,967,401 - 14,968,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,006,506 - 15,007,598 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,139,122 - 15,140,214 (-)NCBIUU_Cfam_GSD_1.0
CUNH10orf95
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,825,661 - 31,828,488 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366003,428,561 - 3,429,778 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUNH10orf95
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,479,426 - 95,481,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604856,585,418 - 56,587,021 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in C10orf95
3 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.33-25.3(chr10:95112607-116776637)x3 copy number gain See cases [RCV000050747] Chr10:95112607..116776637 [GRCh38]
Chr10:96872364..118383651 [GRCh37]
Chr10:96862354..118526138 [NCBI36]
Chr10:10q23.33-25.3		 pathogenic
GRCh38/hg38 10q24.32-24.33(chr10:102243341-103929730)x1 copy number loss See cases [RCV000052568] Chr10:102243341..103929730 [GRCh38]
Chr10:104003098..105689488 [GRCh37]
Chr10:103993088..105679478 [NCBI36]
Chr10:10q24.32-24.33		 pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100194215-132432797)x3 copy number gain See cases [RCV000053564] Chr10:100194215..132432797 [GRCh38]
Chr10:101953972..134246301 [GRCh37]
Chr10:101943962..134096291 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh38/hg38 10q24.31-26.3(chr10:100600492-133622588)x3 copy number gain See cases [RCV000137747] Chr10:100600492..133622588 [GRCh38]
Chr10:102360249..135436092 [GRCh37]
Chr10:102350239..135286082 [NCBI36]
Chr10:10q24.31-26.3		 pathogenic
GRCh37/hg19 10q24.32-26.3(chr10:103288313-135512075)x3 copy number gain See cases [RCV000240457] Chr10:103288313..135512075 [GRCh37]
Chr10:10q24.32-26.3		 pathogenic
GRCh37/hg19 10q24.2-26.3(chr10:100780957-135427143)x3 copy number gain See cases [RCV000446733] Chr10:100780957..135427143 [GRCh37]
Chr10:10q24.2-26.3		 pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1		 pathogenic|drug response
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q24.32-25.3(chr10:104030479-115410590)x1 copy number loss See cases [RCV000448581] Chr10:104030479..115410590 [GRCh37]
Chr10:10q24.32-25.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh37/hg19 10q24.32-24.33(chr10:103891057-105339973)x1 copy number loss not provided [RCV000683260] Chr10:103891057..105339973 [GRCh37]
Chr10:10q24.32-24.33		 likely pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q24.32(chr10:104031306-104366150)x3 copy number gain not provided [RCV002473842] Chr10:104031306..104366150 [GRCh37]
Chr10:10q24.32		 uncertain significance
NC_000010.10:g.(?_99344461)_(105992004_?)dup duplication not provided [RCV003107322] Chr10:99344461..105992004 [GRCh37]
Chr10:10q24.2-25.1		 uncertain significance
GRCh37/hg19 10q24.32-25.3(chr10:104030479-115410590) copy number loss not specified [RCV002052885] Chr10:104030479..115410590 [GRCh37]
Chr10:10q24.32-25.3		 pathogenic
NM_001363580.1(C10orf95):c.507G>A (p.Gln169=) single nucleotide variant not specified [RCV004215629] Chr10:102450587 [GRCh38]
Chr10:104210344 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_001363580.1(C10orf95):c.440G>A (p.Arg147His) single nucleotide variant not specified [RCV004071568] Chr10:102450654 [GRCh38]
Chr10:104210411 [GRCh37]
Chr10:10q24.32		 uncertain significance
NM_001363580.1(C10orf95):c.410T>C (p.Leu137Pro) single nucleotide variant not specified [RCV004241380] Chr10:102450684 [GRCh38]
Chr10:104210441 [GRCh37]
Chr10:10q24.32		 uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:95078198-135427143)x3 copy number gain not specified [RCV003986893] Chr10:95078198..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
NC_000010.11:g.(102444036_?)_(?_104726221)del deletion Desmoplastic/nodular medulloblastoma [RCV000003754] Chr10:102444036..104726221 [GRCh38]
Chr10:10q24.32-25.1		 pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:521
Count of miRNA genes:326
Interacting mature miRNAs:347
Transcripts:ENST00000239125
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2314551GLUCO52_HGlucose level QTL 52 (human)1.4Glucose level1077605006103605006Human

Markers in Region
RH48442  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710104,209,711 - 104,209,845UniSTSGRCh37
Build 3610104,199,701 - 104,199,835RGDNCBI36
Celera1097,950,624 - 97,950,758RGD
Cytogenetic Map10q24.32UniSTS
HuRef1097,843,419 - 97,843,553UniSTS
GeneMap99-GB4 RH Map10482.26UniSTS
NCBI RH Map101105.5UniSTS
UniSTS:485839  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3710104,210,144 - 104,211,245UniSTSGRCh37
Celera1097,951,057 - 97,952,158UniSTS
HuRef1097,843,852 - 97,845,216UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 8 1 16 2 1 1 48 90 1 1
Low 927 175 1125 236 927 80 1788 116 1638 250 983 1451 168 1 93 927 4
Below cutoff 1247 1986 482 296 804 294 1911 1475 1934 162 399 63 4 893 1331

Sequence


Ensembl Acc Id: ENST00000625129   ⟹   ENSP00000489684
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl10102,449,837 - 102,451,543 (-)Ensembl
RefSeq Acc Id: NM_001363580   ⟹   NP_001350509
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810102,449,837 - 102,451,543 (-)NCBI
T2T-CHM13v2.010103,334,824 - 103,336,530 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001350509 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI26460 (Get FASTA)   NCBI Sequence Viewer  
  BAB14892 (Get FASTA)   NCBI Sequence Viewer  
  EAW49692 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000489684
  ENSP00000489684.1
RefSeq Acc Id: NP_001350509   ⟸   NM_001363580
- UniProtKB: A0A1B0GTG0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSP00000489684   ⟸   ENST00000625129

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H7T3-F1-model_v2 AlphaFold Q9H7T3 1-257 view protein structure

Promoters
RGD ID:7218529
Promoter ID:EPDNEW_H15010
Type:initiation region
Name:C10orf95_1
Description:chromosome 10 open reading frame 95
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3810102,451,507 - 102,451,567EPDNEW
RGD ID:6788096
Promoter ID:HG_KWN:10984
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_024886,   OTTHUMT00000050064,   OTTHUMT00000050066
Position:
Human AssemblyChrPosition (strand)Source
Build 3610104,201,036 - 104,201,536 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
COSMIC C10orf95 COSMIC
Ensembl Genes ENSG00000120055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000625129 ENTREZGENE
  ENST00000625129.1 UniProtKB/TrEMBL
GTEx ENSG00000120055 GTEx
HGNC ID HGNC:25880 ENTREZGENE
Human Proteome Map C10orf95 Human Proteome Map
NCBI Gene 79946 ENTREZGENE
PharmGKB PA134908188 PharmGKB
UniProt A0A1B0GTG0 ENTREZGENE, UniProtKB/TrEMBL
  CJ095_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A0AVQ7 UniProtKB/Swiss-Prot