MECP2 (methyl-CpG binding protein 2) - Rat Genome Database

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Gene: MECP2 (methyl-CpG binding protein 2) Homo sapiens
Symbol: MECP2
Name: methyl-CpG binding protein 2
RGD ID: 1349232
HGNC Page HGNC:6990
Description: Enables several functions, including double-stranded methylated DNA binding activity; molecular condensate scaffold activity; and transcription corepressor activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; positive regulation of microtubule nucleation; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within regulation of gene expression by genomic imprinting. Located in centrosome; heterochromatin; and nucleoplasm. Implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AUTSX3; DKFZp686A24160; meCp-2 protein; mental retardation, X-linked 16; mental retardation, X-linked 79; methyl CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; mutant methyl CpG binding protein 2; mutant methyl CpG binding protein 2 transcript 1; mutant methyl CpG binding protein 2 variant 1; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X154,021,573 - 154,097,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,287,024 - 153,363,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
T2T-CHM13v2.0X152,295,254 - 152,371,375 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)