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Gene: GLIS3 (GLIS family zinc finger 3) Homo sapiens
Symbol: GLIS3
Name: GLIS family zinc finger 3
RGD ID: 1348907
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Predicted to localize to nucleus. Implicated in neonatal diabetes mellitus with congenital hypothyroidism.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ38999; FLJ90578; GLI-similar 3; MGC33662; NDH; OK/KNS-cl.4; zinc finger protein 515; zinc finger protein GLIS3; ZNF515
Mus musculus (house mouse) : Glis3 (GLIS family zinc finger 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Glis3 (GLIS family zinc finger 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glis3 (GLIS family zinc finger 3)
Pan paniscus (bonobo/pygmy chimpanzee) : GLIS3 (GLIS family zinc finger 3)
Canis lupus familiaris (dog) : GLIS3 (GLIS family zinc finger 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glis3 (GLIS family zinc finger 3)
Sus scrofa (pig) : GLIS3 (GLIS family zinc finger 3)
Chlorocebus sabaeus (African green monkey) : GLIS3 (GLIS family zinc finger 3)
Heterocephalus glaber (naked mole-rat) : Glis3 (GLIS family zinc finger 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl93,824,127 - 4,348,392 (-)EnsemblGRCh38hg38GRCh38
GRCh3893,824,127 - 4,310,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3793,824,128 - 4,300,036 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3693,814,128 - 4,290,035 (-)NCBINCBI36hg18NCBI36
Build 3493,817,676 - 4,142,183NCBI
Celera93,742,092 - 4,217,855 (-)NCBI
Cytogenetic Map9p24.2NCBI
HuRef93,779,368 - 4,255,081 (-)NCBIHuRef
CHM1_193,824,581 - 4,300,359 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GLIS3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348907
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.