OR4D10 (olfactory receptor family 4 subfamily D member 10)

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Gene: OR4D10 (olfactory receptor family 4 subfamily D member 10) Homo sapiens

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Symbol:

OR4D10

Name:

olfactory receptor family 4 subfamily D member 10

RGD ID:

1348576

HGNC Page

HGNC:15173

Description:

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane; INTERACTS WITH CGP 52608; tebuconazole; 1,2-dichloroethane (ortholog).

Type:

pseudo (Ensembl: protein-coding)

Previously known as:

olfactory receptor 4D10; olfactory receptor OR11-251; olfactory receptor, family 4, subfamily D, member 10 pseudogene; OR11-251; OR4D10P; OST711; seven transmembrane helix receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	59,473,315 - 59,479,361 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	59,473,315 - 59,479,361 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	59,240,788 - 59,246,834 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	59,001,479 - 59,002,414 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	59,001,478 - 59,002,414	NCBI
Celera	11	56,606,185 - 56,607,120 (+)	NCBI		Celera
Cytogenetic Map	11	q12.1	NCBI
HuRef	11	55,592,733 - 55,593,668 (+)	NCBI		HuRef
CHM1_1	11	59,110,678 - 59,111,613 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	59,424,187 - 59,430,238 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (IAGP)

leukocyte adhesion deficiency 3 (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

CGP 52608 (EXP)

glyphosate (ISO)

lead diacetate (ISO)

tebuconazole (EXP)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of smell (IEA)

G protein-coupled receptor signaling pathway (IEA)

sensory perception of smell (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

olfactory receptor activity (IBA,IEA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Intellectual disability (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

OR4D10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	59,473,315 - 59,479,361 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	59,473,315 - 59,479,361 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	59,240,788 - 59,246,834 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	59,001,479 - 59,002,414 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	59,001,478 - 59,002,414	NCBI
Celera	11	56,606,185 - 56,607,120 (+)	NCBI		Celera
Cytogenetic Map	11	q12.1	NCBI
HuRef	11	55,592,733 - 55,593,668 (+)	NCBI		HuRef
CHM1_1	11	59,110,678 - 59,111,613 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	59,424,187 - 59,430,238 (+)	NCBI		T2T-CHM13v2.0

Or4d10b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	12,036,173 - 12,037,114 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	12,035,988 - 12,040,046 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	12,058,809 - 12,059,750 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	12,058,624 - 12,062,682 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	12,133,299 - 12,134,240 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	12,125,854 - 12,126,795 (-)	NCBI		MGSCv36	mm8
Celera	19	12,756,191 - 12,757,132 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	8.58	NCBI

Or4d10c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	218,441,392 - 218,442,327 (-)	NCBI		GRCr8
mRatBN7.2	1	209,016,663 - 209,017,598 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	209,015,124 - 209,020,125 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	217,391,321 - 217,392,256 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	224,367,473 - 224,368,408 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	217,145,756 - 217,146,691 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	228,523,504 - 228,524,439 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	228,523,504 - 228,524,439 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	235,587,344 - 235,588,279 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	214,940,573 - 214,941,508 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	215,099,002 - 215,099,938 (-)	NCBI
Celera	1	206,482,817 - 206,483,752 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

LOC100974724
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	60,611,350 - 60,612,288 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	61,654,471 - 61,655,406 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	54,705,497 - 54,706,508 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	58,157,201 - 58,158,212 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	58,157,252 - 58,158,187 (+)	Ensembl	panpan1.1		panPan2

OR4D9C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	37,249,661 - 37,250,596 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	37,249,661 - 37,250,596 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	36,899,044 - 36,899,979 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	37,890,200 - 37,891,135 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	37,890,200 - 37,891,135 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	37,479,712 - 37,480,647 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	37,055,850 - 37,056,785 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	37,685,536 - 37,686,471 (-)	NCBI		UU_Cfam_GSD_1.0

LOC110259087
(Sus scrofa - pig)

No map positions available.

LOC103234902
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	14,114,798 - 14,117,607 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	14,116,041 - 14,116,958 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	111,437,966 - 111,438,971 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in OR4D10
19 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_001004705.1(OR4D10):c.122G>A (p.Gly41Glu)	single nucleotide variant	Malignant melanoma [RCV000062297]	Chr11:59477551 [GRCh38] Chr11:59245024 [GRCh37] Chr11:59001600 [NCBI36] Chr11:11q12.1	not provided
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)	copy number gain	See cases [RCV000511729]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3	copy number gain	See cases [RCV000510881]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
NM_001004705.2(OR4D10):c.155A>C (p.Glu52Ala)	single nucleotide variant	not specified [RCV004323542]	Chr11:59477584 [GRCh38] Chr11:59245057 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.311T>A (p.Phe104Tyr)	single nucleotide variant	not specified [RCV004323602]	Chr11:59477740 [GRCh38] Chr11:59245213 [GRCh37] Chr11:11q12.1	uncertain significance
GRCh37/hg19 11q12.1-12.3(chr11:58935215-62177656)x3	copy number gain	not provided [RCV000683362]	Chr11:58935215..62177656 [GRCh37] Chr11:11q12.1-12.3	likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3	copy number gain	not provided [RCV000737348]	Chr11:198510..134934063 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3	copy number gain	not provided [RCV000749874]	Chr11:70864..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
NM_001004708.1(OR4D6):c.-19514_20175del	deletion	Preeclampsia [RCV000161631]	Chr11:59437447..59477135 [GRCh38] Chr11:59204920..59244608 [GRCh37] Chr11:11q12.1	not provided
Single allele	deletion	Intellectual disability [RCV001293382]	Chr11:118359328..118372573 [GRCh37] Chr11:11p15.3-q23.3	pathogenic
NC_000011.9:g.(?_58916346)_(64972349_?)dup	duplication	Leukocyte adhesion deficiency 3 [RCV003113394]\|not provided [RCV003113393]	Chr11:58916346..64972349 [GRCh37] Chr11:11q12.1-13.1	uncertain significance\|no classifications from unflagged records
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3	copy number gain	MISSED ABORTION [RCV002282973]	Chr11:32799481..134938470 [GRCh37] Chr11:11p13-q25	pathogenic
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3	copy number gain	See cases [RCV002286338]	Chr11:51581311..54891247 [GRCh37] Chr11:11p11.2-q12.2	pathogenic
NM_001004705.2(OR4D10):c.683A>C (p.Gln228Pro)	single nucleotide variant	not specified [RCV004332163]	Chr11:59478112 [GRCh38] Chr11:59245585 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.560T>C (p.Leu187Pro)	single nucleotide variant	not specified [RCV004113697]	Chr11:59477989 [GRCh38] Chr11:59245462 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.597G>T (p.Met199Ile)	single nucleotide variant	not specified [RCV004219307]	Chr11:59478026 [GRCh38] Chr11:59245499 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.125A>G (p.Asn42Ser)	single nucleotide variant	not specified [RCV004133118]	Chr11:59477554 [GRCh38] Chr11:59245027 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.500C>G (p.Pro167Arg)	single nucleotide variant	not specified [RCV004098828]	Chr11:59477929 [GRCh38] Chr11:59245402 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.61C>T (p.Arg21Trp)	single nucleotide variant	not specified [RCV004209399]	Chr11:59477490 [GRCh38] Chr11:59244963 [GRCh37] Chr11:11q12.1	likely benign
NM_001004705.2(OR4D10):c.512C>A (p.Pro171His)	single nucleotide variant	not specified [RCV004078661]	Chr11:59477941 [GRCh38] Chr11:59245414 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.62G>A (p.Arg21Gln)	single nucleotide variant	not specified [RCV004143873]	Chr11:59477491 [GRCh38] Chr11:59244964 [GRCh37] Chr11:11q12.1	likely benign
NM_001004705.2(OR4D10):c.190C>T (p.His64Tyr)	single nucleotide variant	not specified [RCV004178092]	Chr11:59477619 [GRCh38] Chr11:59245092 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.43C>T (p.Leu15Phe)	single nucleotide variant	not specified [RCV004080078]	Chr11:59477472 [GRCh38] Chr11:59244945 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.191A>G (p.His64Arg)	single nucleotide variant	not specified [RCV004180860]	Chr11:59477620 [GRCh38] Chr11:59245093 [GRCh37] Chr11:11q12.1	likely benign
NM_001004705.2(OR4D10):c.170C>T (p.Thr57Met)	single nucleotide variant	not specified [RCV004075275]	Chr11:59477599 [GRCh38] Chr11:59245072 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.301A>G (p.Met101Val)	single nucleotide variant	not specified [RCV004360734]	Chr11:59477730 [GRCh38] Chr11:59245203 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.568A>G (p.Thr190Ala)	single nucleotide variant	not specified [RCV004351402]	Chr11:59477997 [GRCh38] Chr11:59245470 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.620C>A (p.Thr207Asn)	single nucleotide variant	not specified [RCV004336993]	Chr11:59478049 [GRCh38] Chr11:59245522 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.42C>T (p.Phe14=)	single nucleotide variant	not provided [RCV003395814]	Chr11:59477471 [GRCh38] Chr11:59244944 [GRCh37] Chr11:11q12.1	likely benign
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3	copy number gain	not specified [RCV003986944]	Chr11:56895955..69295402 [GRCh37] Chr11:11q12.1-13.3	likely pathogenic
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3	copy number gain	not specified [RCV003986918]	Chr11:50398499..63924462 [GRCh37] Chr11:11p11.12-q13.1	likely pathogenic
NM_001004705.2(OR4D10):c.316C>T (p.Leu106Phe)	single nucleotide variant	not specified [RCV004504371]	Chr11:59477745 [GRCh38] Chr11:59245218 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.319A>C (p.Ile107Leu)	single nucleotide variant	not specified [RCV004504372]	Chr11:59477748 [GRCh38] Chr11:59245221 [GRCh37] Chr11:11q12.1	likely benign
NM_001004705.2(OR4D10):c.31G>A (p.Glu11Lys)	single nucleotide variant	not specified [RCV004504373]	Chr11:59477460 [GRCh38] Chr11:59244933 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.583C>T (p.Leu195Phe)	single nucleotide variant	not specified [RCV004504376]	Chr11:59478012 [GRCh38] Chr11:59245485 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.716C>T (p.Thr239Ile)	single nucleotide variant	not specified [RCV004504377]	Chr11:59478145 [GRCh38] Chr11:59245618 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.767A>G (p.Tyr256Cys)	single nucleotide variant	not specified [RCV004504378]	Chr11:59478196 [GRCh38] Chr11:59245669 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.354G>A (p.Met118Ile)	single nucleotide variant	not specified [RCV004504374]	Chr11:59477783 [GRCh38] Chr11:59245256 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.490C>T (p.Leu164Phe)	single nucleotide variant	not specified [RCV004504375]	Chr11:59477919 [GRCh38] Chr11:59245392 [GRCh37] Chr11:11q12.1	uncertain significance
NM_001004705.2(OR4D10):c.800T>C (p.Met267Thr)	single nucleotide variant	not specified [RCV004504379]	Chr11:59478229 [GRCh38] Chr11:59245702 [GRCh37] Chr11:11q12.1	likely benign
NM_001004705.2(OR4D10):c.853T>A (p.Leu285Met)	single nucleotide variant	not specified [RCV004504380]	Chr11:59478282 [GRCh38] Chr11:59245755 [GRCh37] Chr11:11q12.1	likely benign

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	40
Count of miRNA genes:	39
Interacting mature miRNAs:	39
Transcripts:	ENST00000530162
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	adipose tissue	appendage
High
Medium
Low	2		16	1	2	1		2	2		3	17
Below cutoff	78	55	63	29	86	24	149	63	80	19	279	50	5	31	75

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC019093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000530162 ⟹ ENSP00000436424

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	59,473,315 - 59,479,361 (+)	Ensembl

RefSeq Acc Id:

NM_001004705 ⟹ NP_001004705

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	59,473,315 - 59,479,361 (+)	NCBI
GRCh37	11	59,244,903 - 59,245,838 (+)	RGD
Build 36	11	59,001,479 - 59,002,414 (+)	NCBI Archive
Celera	11	56,606,185 - 56,607,120 (+)	RGD
HuRef	11	55,592,733 - 55,593,668 (+)	RGD
CHM1_1	11	59,110,678 - 59,111,613 (+)	NCBI
T2T-CHM13v2.0	11	59,424,187 - 59,430,238 (+)	NCBI

Sequence:

show sequence

CCCATTGAAACTCCCTTACCAACAGCAAAATCAGCCACTTGACTTCTCTGTTGTCCAATAACAT
TCTCTTTCCAATTCATAAATTAAGCATGAGCCTCAGAGGTTTGAACATAAGTCAAGGACACAAT
GGAAAAACTTTAAAAGATATGATTCTTTGAATCTGACTTTTCTCTCCAAAAGCAGAGCAAAGAC
ACTGCGATATTTAGCATAGCAAAGGGCTTAACTTTTAAACAAGATTTTCAAGAATTAATGCCAG
TAGTCTTCTGTTATGCACTATATCTAATAGCATCAAATTTGTAGTTGGAGTTTTGGGATCAAAG
GAACTAGGTATATCAAATGCTTCAGAGTTAAAATAATCATCTCAATGACAGAAACAACAAAGAC
TAACTGAAATCTGAAAAACGTGAACAATGCAACAAACTGCAAAAACTACAACCGCATGGGAAGT
TTCTGCACTGCATTCTAGGTGTTTAGGAAGACAACAAAATAAATATCCCAGTGCTTTCACATGA
CATGGTTTAAAACCAAAGAGAATAAAGAGGATGATTGAATGGAGATGGAAAACTGCACCAGGGT
AAAAGAATTTATTTTCCTTGGCCTGACCCAGAATCGGGAAGTGAGCTTAGTCTTATTTCTTTTC
CTACTCTTGGTGTATGTGACAACTTTGCTGGGAAACCTCCTCATCATGGTCACTGTTACCTGTG
AATCTCGCCTTCACACGCCCATGTATTTTTTGCTCCATAATTTATCTATTGCCGATATCTGCTT
CTCTTCCATCACAGTGCCCAAGGTTCTGGTGGACCTTCTGTCTGAAAGAAAGACCATCTCCTTC
AATCATTGCTTCACTCAGATGTTTCTATTCCACCTTATTGGAGGGGTGGATGTATTTTCTCTTT
CGGTGATGGCATTGGATCGATATGTGGCCATCTCCAAGCCCCTGCACTATGCGACTATCATGAG
TAGAGACCATTGCATTGGGCTCACAGTGGCTGCCTGGTTGGGGGGCTTTGTCCACTCCATCGTG
CAGATTTCCCTGTTGCTCCCACTCCCTTTCTGCGGACCCAATGTTCTTGACACTTTCTACTGTG
ATGTCCACCGGGTCCTCAAACTGGCCCATACAGACATTTTCATACTTGAACTACTAATGATTTC
CAACAATGGACTGCTCACCACACTGTGGTTTTTCCTGCTCCTGGTGTCCTACATAGTCATATTA
TCATTACCCAAGTCTCAGGCAGGAGAGGGCAGGAGGAAAGCCATCTCCACCTGCACCTCCCACA
TCACTGTGGTGACCCTGCATTTCGTGCCCTGCATCTATGTCTATGCCCGGCCCTTCACTGCCCT
CCCCATGGATAAGGCCATCTCTGTCACCTTCACTGTCATCTCCCCTCTGCTCAACCCCTTGATC
TACACTCTGAGGAACCATGAGATGAAGTCAGCCATGAGGAGACTGAAGAGAAGACTTGTGCCTT
CTGATAGAAAATAGAAAAAAAAATCCTCAGCTCTTCATCACCAAAGATATCTTATATTTATTAT
TTTTCCCATGAAGTCATATTCATATATTCAAATATATTGTCAAACCAACTACACTTAGTAATAA
TTAATTTTTCTATTTATGTTAGTAAGTAACTGATAAGCTTCTGGTCAGGGAGAGATTCACACCT
TCTAATTGAAAATAAACCAGAGCTCCCTCCTCTTTACCACCAAGATTTTGTTTCATGATTTTTC
TTCCATGGACTCCAAGTTCTGAAAGTGTTGCCTGCTGAATTGAATATATTTATTTAGTGATTGC
TAAGTATTTGTTTTATTTTCATAAGTAATACATAAAATTATATATATACCTAGCAAATGCATAT
TATATATAGTAAATCTTCTTATCTGCATTTAGTTGACATAAATATTAATAATTTAAACAGAGCC
TTTGTGATTCAGAAAAGAGAGGGAAAATTGTTAGCAAATGTGTATATGATTTTGCAGTCCAATT
TTAAAGAAAAATTAAGCCAAATGCACGCAGACATTATCATTACCTTTCTGCTCCTATTACAGTA
AATGAAGGTGTGGGGTGTATCTGAAACACAATGGAGTTTGGGGATTGACTTTCTGTATAATTTT
CATAAGGTAAACGTATCCTACATGATCCTTATGATGGGCAAGGTCATTACCTTGCCCTTTCTTG
AACCCCAAGCTCACTGGCCACCCTACCGCATTTCCTTGGCACTCTGTGCTTAGGGTTAGCATTG
CACTCAGGACTCTATTTTGAAATTTCCTATTTTCTTGTCTCTTTCTCTTACTGGGCAGTGACTT
CCCCAGGAGCAGGGATTATGTTTTATTTACTGTCACAGCAGCTAAAACATACTAAGACTTCAAC
AATATGTTGCTGAATAAATAGCTCAATGATTGAATGTTTTCACTTACTTGATATACTCTGTGGC
CTGTGAGTTTCTACAAATGACAAAAACACATTAAGCTACTTTAAGCTATG

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Protein Sequences


Ensembl Protein	ENSP00000436424.1

RefSeq Acc Id:

NP_001004705 ⟸ NM_001004705

- Sequence:

show sequence

MEMENCTRVKEFIFLGLTQNREVSLVLFLFLLLVYVTTLLGNLLIMVTVTCESRLHTPMYFLLH
NLSIADICFSSITVPKVLVDLLSERKTISFNHCFTQMFLFHLIGGVDVFSLSVMALDRYVAISK
PLHYATIMSRDHCIGLTVAAWLGGFVHSIVQISLLLPLPFCGPNVLDTFYCDVHRVLKLAHTDI
FILELLMISNNGLLTTLWFFLLLVSYIVILSLPKSQAGEGRRKAISTCTSHITVVTLHFVPCIY
VYARPFTALPMDKAISVTFTVISPLLNPLIYTLRNHEMKSAMRRLKRRLVPSDRK

hide sequence

Ensembl Acc Id:

ENSP00000436424 ⟸ ENST00000530162

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8NGI6-F1-model_v2	AlphaFold	Q8NGI6	1-311	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:15173	AgrOrtholog
COSMIC	OR4D10	COSMIC
Ensembl Genes	ENSG00000254466	Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000530162.2	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000254466	GTEx
HGNC ID	HGNC:15173	ENTREZGENE
Human Proteome Map	OR4D10	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Olfact_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Olfactory_Receptors	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:390197	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	OR4D10	ENTREZGENE
PANTHER	OLFACTORY RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OLFACTORY RECEPTOR 4D10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA32268	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OLFACTORYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A126GVJ1_HUMAN	UniProtKB/TrEMBL
	OR4DA_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	B2RNH6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-15	OR4D10	olfactory receptor family 4 subfamily D member 10	OR4D10	olfactory receptor, family 4, subfamily D, member 10	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Human Phenotype Annotations - ClinVar

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Imported Disease Annotations - ClinVar

Imported Human Phenotype Annotations - ClinVar