Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | SKP1 | Human | (1->4)-beta-D-glucan | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SKP1 mRNA | CTD | PMID:36331819 | SKP1 | Human | 17alpha-ethynylestradiol | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKP1 mRNA | CTD | PMID:17942748 | SKP1 | Human | 17alpha-ethynylestradiol | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of SKP1 mRNA | CTD | PMID:17942748 | SKP1 | Human | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | SKP1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Skp1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SKP1 mRNA | CTD | PMID:21570461 | SKP1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SKP1 mRNA | CTD | PMID:33387578 | SKP1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SKP1 mRNA | CTD | PMID:34747641 | SKP1 | Human | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SKP1 mRNA | CTD | PMID:17942748 | SKP1 | Human | 2,4,6-tribromophenol | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | SKP1 | Human | 3,3',5,5'-tetrabromobisphenol A | decreases expression | EXP | | 6480464 | tetrabromobisphenol A results in decreased expression of SKP1 protein | CTD | PMID:31675489 | SKP1 | Human | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKP1 mRNA | CTD | PMID:28628672 | SKP1 | Human | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of SKP1 gene | CTD | PMID:31601247 | SKP1 | Human | 5-aza-2'-deoxycytidine | decreases expression | ISO | Skp1 (Mus musculus) | 6480464 | Decitabine results in decreased expression of SKP1 mRNA | CTD | PMID:27915011 | SKP1 | Human | acrylamide | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Acrylamide results in increased expression of SKP1 mRNA | CTD | PMID:28959563 | SKP1 | Human | actinomycin D | multiple interactions | EXP | | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of SKP1 protein | CTD | PMID:38460933 | SKP1 | Human | arsane | increases expression | EXP | | 6480464 | Arsenic results in increased expression of SKP1 mRNA | CTD | PMID:19945496 | SKP1 | Human | arsenic atom | increases expression | EXP | | 6480464 | Arsenic results in increased expression of SKP1 mRNA | CTD | PMID:19945496 | SKP1 | Human | arsenite(3-) | multiple interactions | EXP | | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to SKP1 mRNA] | CTD | PMID:32406909 | SKP1 | Human | benzo[a]pyrene | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SKP1 mRNA | CTD | PMID:22228805 | SKP1 | Human | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SKP1 protein | CTD | PMID:31675489 | SKP1 | Human | Bisphenol B | increases expression | EXP | | 6480464 | bisphenol B results in increased expression of SKP1 protein | CTD | PMID:34186270 | SKP1 | Human | bisphenol F | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKP1 mRNA | CTD | PMID:28628672 | SKP1 | Human | Brodifacoum | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | bromfenacoum results in increased expression of SKP1 protein | CTD | PMID:28903499 | SKP1 | Human | calycosin | increases expression | EXP | | 6480464 | 7 and 3'-dihydroxy-4'-methoxyisoflavone results in increased expression of SKP1 mRNA | CTD | PMID:24455688 | SKP1 | Human | cannabidiol | multiple interactions | EXP | | 6480464 | [Cuprizone co-treated with Cannabidiol] results in decreased expression of SKP1 protein | CTD | PMID:34122009 | SKP1 | Human | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of SKP1 mRNA | CTD | PMID:25979313 | SKP1 | Human | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes and Carbon results in decreased expression of SKP1 protein | CTD | PMID:22157353 | SKP1 | Human | carbon nanotube | decreases expression | ISO | Skp1 (Mus musculus) | 6480464 | Nanotubes and Carbon results in decreased expression of SKP1 mRNA | CTD | PMID:25620056 | SKP1 | Human | CGP 52608 | multiple interactions | EXP | | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SKP1 gene] | CTD | PMID:28238834 | SKP1 | Human | clofibrate | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SKP1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SKP1 mRNA] | CTD | PMID:17585979 | SKP1 | Human | clofibrate | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | Clofibrate results in increased expression of SKP1 mRNA | CTD | PMID:17585979 | SKP1 | Human | clozapine | decreases expression | EXP | | 6480464 | Clozapine results in decreased expression of SKP1 protein | CTD | PMID:34122009 | SKP1 | Human | coumarin | decreases phosphorylation | EXP | | 6480464 | coumarin results in decreased phosphorylation of SKP1 protein | CTD | PMID:35688186 | SKP1 | Human | Cuprizon | multiple interactions | EXP | | 6480464 | [Cuprizone co-treated with Cannabidiol] results in decreased expression of SKP1 protein | CTD | PMID:34122009 | SKP1 | Human | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of SKP1 mRNA | CTD | PMID:25562108 | SKP1 | Human | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of SKP1 protein | CTD | PMID:31675489 | SKP1 | Human | deguelin | decreases expression | EXP | | 6480464 | deguelin results in decreased expression of SKP1 mRNA | CTD | PMID:33512557 | SKP1 | Human | dexamethasone | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKP1 mRNA | CTD | PMID:28628672 | SKP1 | Human | Dibutyl phosphate | affects expression | EXP | | 6480464 | di-n-butylphosphoric acid affects the expression of SKP1 mRNA | CTD | PMID:37042841 | SKP1 | Human | dicrotophos | decreases expression | EXP | | 6480464 | dicrotophos results in decreased expression of SKP1 mRNA | CTD | PMID:28302478 | SKP1 | Human | dimethylarsinous acid | increases expression | EXP | | 6480464 | dimethylarsinous acid results in increased expression of SKP1 mRNA | CTD | PMID:20886546 | SKP1 | Human | disodium selenite | increases expression | EXP | | 6480464 | Sodium Selenite results in increased expression of SKP1 mRNA | CTD | PMID:18175754 | SKP1 | Human | endosulfan | affects expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Endosulfan affects the expression of SKP1 mRNA and Endosulfan affects the expression of SKP1 protein | CTD | PMID:31464424 | SKP1 | Human | ethanol | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | Ethanol results in increased expression of SKP1 mRNA | CTD | PMID:30319688 | SKP1 | Human | ethanol | affects splicing | ISO | Skp1 (Mus musculus) | 6480464 | Ethanol affects the splicing of SKP1 mRNA | CTD | PMID:30319688 | SKP1 | Human | fipronil | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | fipronil results in increased expression of SKP1 mRNA | CTD | PMID:23962444 | SKP1 | Human | flutamide | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Flutamide results in increased expression of SKP1 mRNA | CTD | PMID:24136188 | SKP1 | Human | folpet | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | folpet results in increased expression of SKP1 mRNA | CTD | PMID:31558096 | SKP1 | Human | FR900359 | increases phosphorylation | EXP | | 6480464 | FR900359 results in increased phosphorylation of SKP1 protein | CTD | PMID:37730182 | SKP1 | Human | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol S co-treated with Fulvestrant] results in increased methylation of SKP1 gene | CTD | PMID:31601247 | SKP1 | Human | graphite | decreases expression | EXP | | 6480464 | Graphite results in decreased expression of SKP1 protein | CTD | PMID:22157353 | SKP1 | Human | indometacin | multiple interactions | EXP | | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of SKP1 mRNA | CTD | PMID:28628672 | SKP1 | Human | inulin | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SKP1 mRNA | CTD | PMID:36331819 | SKP1 | Human | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of SKP1 protein | CTD | PMID:32959892 | SKP1 | Human | methidathion | affects expression | ISO | Skp1 (Mus musculus) | 6480464 | methidathion affects the expression of SKP1 mRNA | CTD | PMID:34813904 | SKP1 | Human | methylisothiazolinone | increases expression | EXP | | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of SKP1 mRNA | CTD | PMID:31629900 | SKP1 | Human | methylmercury chloride | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | methylmercuric chloride results in increased expression of SKP1 mRNA | CTD | PMID:20061341 | SKP1 | Human | N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of SKP1 mRNA | CTD | PMID:20061341 | SKP1 | Human | nefazodone | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of SKP1 mRNA | CTD | PMID:24136188 | SKP1 | Human | nimesulide | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | nimesulide results in increased expression of SKP1 mRNA | CTD | PMID:24136188 | SKP1 | Human | Nutlin-3 | multiple interactions | EXP | | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased secretion of SKP1 protein | CTD | PMID:38460933 | SKP1 | Human | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SKP1 mRNA | CTD | PMID:21420995 | SKP1 | Human | paracetamol | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SKP1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of SKP1 mRNA] | CTD | PMID:17585979 | SKP1 | Human | pentachlorophenol | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of SKP1 mRNA | CTD | PMID:23892564 | SKP1 | Human | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Skp1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SKP1 mRNA more ... | CTD | PMID:36331819 | SKP1 | Human | pirinixic acid | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SKP1 mRNA | CTD | PMID:18301758 and PMID:23811191 | SKP1 | Human | piroxicam | decreases expression | EXP | | 6480464 | Piroxicam results in decreased expression of SKP1 mRNA | CTD | PMID:21858171 | SKP1 | Human | sertraline | decreases expression | EXP | | 6480464 | Sertraline results in decreased expression of SKP1 mRNA | CTD | PMID:24865413 | SKP1 | Human | sodium arsenite | increases expression | EXP | | 6480464 | sodium arsenite results in increased expression of SKP1 mRNA | CTD | PMID:28595984 and PMID:38568856 | SKP1 | Human | sodium arsenite | increases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | sodium arsenite results in increased expression of SKP1 mRNA | CTD | PMID:19072884 | SKP1 | Human | sodium arsenite | decreases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | sodium arsenite results in decreased expression of SKP1 protein | CTD | PMID:29459688 | SKP1 | Human | sodium fluoride | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | Sodium Fluoride results in increased expression of SKP1 protein | CTD | PMID:28918527 | SKP1 | Human | T-2 toxin | affects expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | T-2 Toxin affects the expression of SKP1 protein | CTD | PMID:26141394 | SKP1 | Human | thapsigargin | decreases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Thapsigargin results in decreased expression of SKP1 protein | CTD | PMID:35544339 | SKP1 | Human | thiram | increases expression | EXP | | 6480464 | Thiram results in increased expression of SKP1 mRNA | CTD | PMID:38568856 | SKP1 | Human | trichloroethene | decreases expression | ISO | Skp1 (Rattus norvegicus) | 6480464 | Trichloroethylene results in decreased expression of SKP1 mRNA | CTD | PMID:33387578 | SKP1 | Human | triphenyl phosphate | affects expression | EXP | | 6480464 | triphenyl phosphate affects the expression of SKP1 mRNA | CTD | PMID:37042841 | SKP1 | Human | triptonide | increases expression | ISO | Skp1 (Mus musculus) | 6480464 | triptonide results in increased expression of SKP1 mRNA | CTD | PMID:33045310 | SKP1 | Human | urethane | increases expression | EXP | | 6480464 | Urethane results in increased expression of SKP1 mRNA | CTD | PMID:28818685 | SKP1 | Human | valproic acid | increases methylation | EXP | | 6480464 | Valproic Acid results in increased methylation of SKP1 gene | CTD | PMID:29154799 | SKP1 | Human | valproic acid | increases expression | EXP | | 6480464 | Valproic Acid results in increased expression of SKP1 mRNA | CTD | PMID:23179753 | SKP1 | Human | vitamin E | increases expression | EXP | | 6480464 | Vitamin E results in increased expression of SKP1 mRNA | CTD | PMID:19244175 | SKP1 | Human | zoledronic acid | decreases expression | EXP | | 6480464 | zoledronic acid results in decreased expression of SKP1 protein | CTD | PMID:28871336 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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