FDX1 (ferredoxin 1) - Rat Genome Database

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Gene: FDX1 (ferredoxin 1) Homo sapiens
Analyze
Symbol: FDX1
Name: ferredoxin 1
RGD ID: 1347130
HGNC Page HGNC:3638
Description: Enables 2 iron, 2 sulfur cluster binding activity and electron transfer activity. Involved in cholesterol metabolic process and hormone biosynthetic process. Located in mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: adrenal ferredoxin; adrenodoxin, mitochondrial; ADX; FDX; ferredoxin-1; hepatoredoxin; LOH11CR1D; mitochondrial adrenodoxin
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: FDX1P1   FDX1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811110,429,331 - 110,464,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11110,429,948 - 110,464,884 (+)EnsemblGRCh38hg38GRCh38
GRCh3711110,300,672 - 110,335,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611109,805,804 - 109,840,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411109,805,803 - 109,840,814NCBI
Celera11107,454,082 - 107,489,091 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11106,225,358 - 106,260,247 (+)NCBIHuRef
CHM1_111110,183,752 - 110,218,730 (+)NCBICHM1_1
T2T-CHM13v2.011110,439,522 - 110,475,104 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
aconitine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
colforsin daropate hydrochloride  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
diuron  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
ferulic acid  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
FR900359  (EXP)
glafenine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ketoconazole  (ISO)
lead(0)  (EXP)
lipopolysaccharide  (EXP)
methimazole  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
myricetin  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sulfadimethoxine  (ISO)
tert-butyl ethyl ether  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
zearalenone  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator. Ji B, etal., Physiol Genomics. 2003 Jun 24;14(1):59-72.
3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
4. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1429635   PMID:1863359   PMID:1909889   PMID:1917982   PMID:2340092   PMID:2969697   PMID:3229285   PMID:3339111   PMID:3343244   PMID:3872685   PMID:6270113   PMID:9890963  
PMID:10899784   PMID:12477932   PMID:12699818   PMID:12782149   PMID:15146197   PMID:15489334   PMID:15927889   PMID:17188650   PMID:18029348   PMID:18519826   PMID:19616115   PMID:20379614  
PMID:20547883   PMID:20689807   PMID:20877624   PMID:21636783   PMID:21873635   PMID:22101253   PMID:23435367   PMID:24684796   PMID:26058080   PMID:26370181   PMID:26431901   PMID:26496610  
PMID:28001042   PMID:28355486   PMID:28380382   PMID:28991453   PMID:31536960   PMID:32877691   PMID:34015331   PMID:34079125   PMID:34130686   PMID:34373451   PMID:34800366   PMID:35559673  
PMID:36173462   PMID:36225932   PMID:36280795   PMID:36605188   PMID:36752638   PMID:36766692   PMID:37144519   PMID:37193786   PMID:37430022   PMID:37453661   PMID:37481209   PMID:37734220  
PMID:38114959   PMID:38126112   PMID:38802900  


Genomics

Comparative Map Data
FDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811110,429,331 - 110,464,884 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11110,429,948 - 110,464,884 (+)EnsemblGRCh38hg38GRCh38
GRCh3711110,300,672 - 110,335,608 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611109,805,804 - 109,840,815 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411109,805,803 - 109,840,814NCBI
Celera11107,454,082 - 107,489,091 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11106,225,358 - 106,260,247 (+)NCBIHuRef
CHM1_111110,183,752 - 110,218,730 (+)NCBICHM1_1
T2T-CHM13v2.011110,439,522 - 110,475,104 (+)NCBIT2T-CHM13v2.0
Fdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39951,854,323 - 51,874,902 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl951,854,606 - 51,874,856 (-)EnsemblGRCm39 Ensembl
GRCm38951,943,023 - 51,963,602 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl951,943,306 - 51,963,556 (-)EnsemblGRCm38mm10GRCm38
MGSCv37951,751,412 - 51,771,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36951,695,672 - 51,715,898 (-)NCBIMGSCv36mm8
Celera949,216,519 - 49,236,839 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map928.62NCBI
Fdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8861,164,839 - 61,183,645 (-)NCBIGRCr8
mRatBN7.2852,268,536 - 52,287,344 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl852,268,536 - 52,287,414 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx857,817,827 - 57,836,608 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0856,096,794 - 56,115,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0853,961,051 - 53,979,836 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0856,373,729 - 56,393,199 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl856,373,723 - 56,393,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0854,958,315 - 54,977,222 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4855,291,396 - 55,310,507 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1855,323,249 - 55,329,561 (-)NCBI
Celera851,793,129 - 51,811,786 (-)NCBICelera
Cytogenetic Map8q24NCBI
Fdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541212,286,408 - 12,316,707 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541212,280,900 - 12,312,930 (+)NCBIChiLan1.0ChiLan1.0
FDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29111,170,868 - 111,207,767 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111112,262,007 - 112,298,701 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011105,311,613 - 105,345,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111109,158,419 - 109,190,869 (+)NCBIpanpan1.1PanPan1.1panPan2
FDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1522,452,011 - 22,485,581 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl522,451,209 - 22,485,395 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha522,371,400 - 22,404,749 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0522,477,844 - 22,511,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl522,479,333 - 22,511,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1522,536,376 - 22,569,968 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0522,436,016 - 22,540,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0522,485,417 - 22,518,946 (-)NCBIUU_Cfam_GSD_1.0
Fdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494792,799,925 - 92,827,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366123,874,748 - 3,905,825 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366123,878,179 - 3,905,678 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl938,375,984 - 38,404,832 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1938,376,147 - 38,399,026 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11101,777,499 - 101,813,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1101,777,678 - 101,816,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604324,135,097 - 24,172,218 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247845,406,459 - 5,460,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FDX1
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2
pathogenic
NM_004109.5(FDX1):c.414C>T (p.Leu138=) single nucleotide variant not provided [RCV000880461] Chr11:110457021 [GRCh38]
Chr11:110327745 [GRCh37]
Chr11:11q22.3
benign
GRCh37/hg19 11q22.3-23.3(chr11:104101411-116680918)x1 copy number loss not provided [RCV000848741] Chr11:104101411..116680918 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
GRCh37/hg19 11q22.3-23.2(chr11:103320065-114349787)x1 copy number loss not provided [RCV001006439] Chr11:103320065..114349787 [GRCh37]
Chr11:11q22.3-23.2
pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:105699599-114524876)x1 copy number loss not provided [RCV001006445] Chr11:105699599..114524876 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1
pathogenic
NC_000011.9:g.104288964_134937416dup duplication Distal trisomy 11q [RCV001250234] Chr11:104288964..134937416 [GRCh37]
Chr11:11q22.3-25
pathogenic
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3
uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25
pathogenic
GRCh37/hg19 11q22.3-23.3(chr11:109328787-116414966)x1 copy number loss not provided [RCV002474547] Chr11:109328787..116414966 [GRCh37]
Chr11:11q22.3-23.3
pathogenic
NM_004109.5(FDX1):c.296A>G (p.Asp99Gly) single nucleotide variant not specified [RCV004151687] Chr11:110435944 [GRCh38]
Chr11:110306668 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.472A>G (p.Lys158Glu) single nucleotide variant not specified [RCV004121425] Chr11:110462385 [GRCh38]
Chr11:110333109 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.122G>C (p.Arg41Pro) single nucleotide variant not specified [RCV004186518] Chr11:110430242 [GRCh38]
Chr11:110300966 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.13G>A (p.Gly5Arg) single nucleotide variant not specified [RCV004183534] Chr11:110430133 [GRCh38]
Chr11:110300857 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.388A>G (p.Ile130Val) single nucleotide variant not specified [RCV004212687] Chr11:110456995 [GRCh38]
Chr11:110327719 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.62C>T (p.Ala21Val) single nucleotide variant not specified [RCV004152177] Chr11:110430182 [GRCh38]
Chr11:110300906 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.538G>A (p.Val180Met) single nucleotide variant not specified [RCV004252583] Chr11:110462451 [GRCh38]
Chr11:110333175 [GRCh37]
Chr11:11q22.3
likely benign
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25
pathogenic
NM_004109.5(FDX1):c.61G>C (p.Ala21Pro) single nucleotide variant not specified [RCV004391685] Chr11:110430181 [GRCh38]
Chr11:110300905 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.125G>A (p.Gly42Glu) single nucleotide variant not specified [RCV004391682] Chr11:110430245 [GRCh38]
Chr11:110300969 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.79C>G (p.His27Asp) single nucleotide variant not specified [RCV004391687] Chr11:110430199 [GRCh38]
Chr11:110300923 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.532A>G (p.Ile178Val) single nucleotide variant not specified [RCV004391684] Chr11:110462445 [GRCh38]
Chr11:110333169 [GRCh37]
Chr11:11q22.3
likely benign
NM_004109.5(FDX1):c.274G>A (p.Val92Ile) single nucleotide variant not specified [RCV004391683] Chr11:110435922 [GRCh38]
Chr11:110306646 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.10G>T (p.Ala4Ser) single nucleotide variant not specified [RCV004391681] Chr11:110430130 [GRCh38]
Chr11:110300854 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.62C>G (p.Ala21Gly) single nucleotide variant not specified [RCV004391686] Chr11:110430182 [GRCh38]
Chr11:110300906 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.367A>G (p.Ile123Val) single nucleotide variant not specified [RCV004618584] Chr11:110456974 [GRCh38]
Chr11:110327698 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.74T>C (p.Leu25Pro) single nucleotide variant not specified [RCV004618583] Chr11:110430194 [GRCh38]
Chr11:110300918 [GRCh37]
Chr11:11q22.3
uncertain significance
NM_004109.5(FDX1):c.67C>T (p.Arg23Trp) single nucleotide variant not specified [RCV004618585] Chr11:110430187 [GRCh38]
Chr11:110300911 [GRCh37]
Chr11:11q22.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1295
Count of miRNA genes:550
Interacting mature miRNAs:596
Transcripts:ENST00000260270
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559115SCL20_HSerum cholesterol level QTL 20 (human)3.220.001213Lipid levelLDL cholesterol11100442501126442501Human

Markers in Region
D11S1300  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,301,688 - 110,302,037UniSTSGRCh37
GRCh3711110,301,688 - 110,302,038UniSTSGRCh37
Build 3611109,806,898 - 109,807,247RGDNCBI36
Celera11107,455,176 - 107,455,526UniSTS
Celera11107,455,176 - 107,455,525RGD
Cytogenetic Map11q22UniSTS
HuRef11106,226,385 - 106,226,734UniSTS
HuRef11106,226,385 - 106,226,735UniSTS
Marshfield Genetic Map11100.62RGD
Marshfield Genetic Map11100.62UniSTS
deCODE Assembly Map11109.43UniSTS
RH69129  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,333,532 - 110,333,671UniSTSGRCh37
Build 3611109,838,742 - 109,838,881RGDNCBI36
Celera11107,487,018 - 107,487,157RGD
Cytogenetic Map11q22UniSTS
HuRef11106,258,171 - 106,258,310UniSTS
RH67935  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,333,087 - 110,333,199UniSTSGRCh37
GRCh372033,063,722 - 33,063,834UniSTSGRCh37
Build 3611109,838,297 - 109,838,409RGDNCBI36
Celera11107,486,573 - 107,486,685RGD
Celera2029,813,190 - 29,813,302UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map11q22UniSTS
HuRef11106,257,726 - 106,257,838UniSTS
HuRef2029,844,658 - 29,844,770UniSTS
GDB:197839  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,333,128 - 110,333,588UniSTSGRCh37
Build 3611109,838,338 - 109,838,798RGDNCBI36
Celera11107,486,614 - 107,487,074RGD
Cytogenetic Map11q22UniSTS
HuRef11106,257,767 - 106,258,227UniSTS
G64373  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,303,551 - 110,303,682UniSTSGRCh37
Build 3611109,808,761 - 109,808,892RGDNCBI36
Celera11107,457,039 - 107,457,170RGD
Cytogenetic Map11q22UniSTS
HuRef11106,228,248 - 106,228,379UniSTS
RH36031  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,334,683 - 110,334,870UniSTSGRCh37
Build 3611109,839,893 - 109,840,080RGDNCBI36
Celera11107,488,169 - 107,488,356RGD
Cytogenetic Map11q22UniSTS
HuRef11106,259,322 - 106,259,509UniSTS
GeneMap99-GB4 RH Map11369.14UniSTS
D4S3130  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,333,268 - 110,333,588UniSTSGRCh37
Build 3611109,838,478 - 109,838,798RGDNCBI36
Celera11107,486,754 - 107,487,074RGD
Cytogenetic Map11q22UniSTS
HuRef11106,257,907 - 106,258,227UniSTS
Stanford-G3 RH Map114872.0UniSTS
GeneMap99-GB4 RH Map11369.14UniSTS
Whitehead-RH Map11502.9UniSTS
NCBI RH Map111004.0UniSTS
GeneMap99-G3 RH Map114872.0UniSTS
A004I10  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711110,335,308 - 110,335,477UniSTSGRCh37
Build 3611109,840,518 - 109,840,687RGDNCBI36
Celera11107,488,794 - 107,488,963RGD
Cytogenetic Map11q22UniSTS
HuRef11106,259,947 - 106,260,116UniSTS
GeneMap99-GB4 RH Map11369.14UniSTS
RH28627  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q22UniSTS
D11S1300  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q22UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA505582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB096243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ650029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN333249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB459133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF444978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M34788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000260270   ⟹   ENSP00000260270
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11110,429,948 - 110,464,884 (+)Ensembl
RefSeq Acc Id: NM_004109   ⟹   NP_004100
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811110,429,948 - 110,464,884 (+)NCBI
GRCh3711110,300,661 - 110,335,608 (+)NCBI
Build 3611109,805,804 - 109,840,815 (+)NCBI Archive
HuRef11106,225,358 - 106,260,247 (+)NCBI
CHM1_111110,183,752 - 110,218,730 (+)NCBI
T2T-CHM13v2.011110,440,139 - 110,475,104 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047426566   ⟹   XP_047282522
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811110,429,331 - 110,464,884 (+)NCBI
RefSeq Acc Id: XM_054368047   ⟹   XP_054224022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011110,439,522 - 110,475,104 (+)NCBI
RefSeq Acc Id: NP_004100   ⟸   NM_004109
- Peptide Label: precursor
- UniProtKB: B0YJ14 (UniProtKB/Swiss-Prot),   Q53YD6 (UniProtKB/Swiss-Prot),   P10109 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000260270   ⟸   ENST00000260270
RefSeq Acc Id: XP_047282522   ⟸   XM_047426566
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054224022   ⟸   XM_054368047
- Peptide Label: isoform X1
Protein Domains
2Fe-2S ferredoxin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10109-F1-model_v2 AlphaFold P10109 1-184 view protein structure

Promoters
RGD ID:6788921
Promoter ID:HG_KWN:14139
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004109
Position:
Human AssemblyChrPosition (strand)Source
Build 3611109,805,696 - 109,806,196 (+)MPROMDB
RGD ID:7222047
Promoter ID:EPDNEW_H16769
Type:initiation region
Name:FDX1_1
Description:ferredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16765  EPDNEW_H16768  EPDNEW_H16770  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811110,429,960 - 110,430,020EPDNEW
RGD ID:7222049
Promoter ID:EPDNEW_H16770
Type:initiation region
Name:FDX1_3
Description:ferredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16765  EPDNEW_H16768  EPDNEW_H16769  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811110,430,103 - 110,430,163EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3638 AgrOrtholog
COSMIC FDX1 COSMIC
Ensembl Genes ENSG00000137714 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000260270 ENTREZGENE
  ENST00000260270.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.30 UniProtKB/Swiss-Prot
GTEx ENSG00000137714 GTEx
HGNC ID HGNC:3638 ENTREZGENE
Human Proteome Map FDX1 Human Proteome Map
InterPro 2Fe-2S_ferredoxin-like_sf UniProtKB/Swiss-Prot
  2Fe-2S_ferredoxin-type UniProtKB/Swiss-Prot
  Adrenodoxin UniProtKB/Swiss-Prot
  Adrenodoxin_Fe-S_BS UniProtKB/Swiss-Prot
  Beta-grasp_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:2230 UniProtKB/Swiss-Prot
NCBI Gene 2230 ENTREZGENE
OMIM 103260 OMIM
PANTHER ADRENODOXIN, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR23426 UniProtKB/Swiss-Prot
Pfam Fer2 UniProtKB/Swiss-Prot
PharmGKB PA28082 PharmGKB
PRINTS ADRENODOXIN UniProtKB/Swiss-Prot
PROSITE 2FE2S_FER_2 UniProtKB/Swiss-Prot
  ADX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54292 UniProtKB/Swiss-Prot
UniProt ADX_HUMAN UniProtKB/Swiss-Prot
  B0YJ14 ENTREZGENE
  P10109 ENTREZGENE
  Q53YD6 ENTREZGENE
UniProt Secondary B0YJ14 UniProtKB/Swiss-Prot
  Q53YD6 UniProtKB/Swiss-Prot