Frem2<sup>fpl</sup> (Fras1 related extracellular matrix protein 2;fpl mutant) - Rat Genome Database

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Gene: Frem2fpl (Fras1 related extracellular matrix protein 2;fpl mutant) Rattus norvegicus
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Symbol: Frem2fpl
Name: Fras1 related extracellular matrix protein 2;fpl mutant
RGD ID: 13464330
Description: A spontaneous, nonsense mutation that introduced a stop codon at serine 2005 in the rat Frem2. The original fused pulmonary lobes was identified in a colony of Jcl:Wistar.
ASSOCIATED WITH abnormal eyelid fusion; fused right lung lobes; syndactyly; ASSOCIATED WITH Fraser syndrome 2
Type: allele  of Frem2  
Previously known as: Frem2^[fpl]; Frem2fpl
Is Marker For: Strains:   FPL/Iet  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Fused pulmonary lobes is a rat model of human Fraser syndrome. Kiyozumi D, etal., Biochem Biophys Res Commun. 2011 Jul 29;411(2):440-4. doi: 10.1016/j.bbrc.2011.06.174. Epub 2011 Jul 2.
2. Calprotectin and neutrophil gelatinase-associated lipocalin in the differentiation of pre-renal and intrinsic acute kidney injury. Seibert FS, etal., Acta Physiol (Oxf). 2013 Apr;207(4):700-8. doi: 10.1111/apha.12064. Epub 2013 Feb 14.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Frem2fpl-var1 chr2 137637371 137637371 G T point_mutation mRatBN7.2
Frem2fpl-var1 chr2 142782178 142782178 G T point_mutation Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Frem2fpl
FPL/Iet    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information