Gene: PTPN12 (protein tyrosine phosphatase, non-receptor type 12) Homo sapiens
Symbol: PTPN12
Name: protein tyrosine phosphatase, non-receptor type 12
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: OTTHUMP00000161275; OTTHUMP00000208615; OTTHUMP00000208616; protein-tyrosine phosphatase G1; PTP-PEST; PTPG1; tyrosine-protein phosphatase non-receptor type 12
Mus musculus (house mouse) : Ptpn12 (protein tyrosine phosphatase, non-receptor type 12)  MGI  AGR
Rattus norvegicus (Norway rat) : Ptpn12 (protein tyrosine phosphatase, non-receptor type 12)  AGR
Chinchilla lanigera (long-tailed chinchilla) : Ptpn12 (protein tyrosine phosphatase, non-receptor type 12)
Pan paniscus (bonobo/pygmy chimpanzee) : PTPN12 (protein tyrosine phosphatase, non-receptor type 12)
Canis lupus familiaris (dog) : PTPN12 (protein tyrosine phosphatase, non-receptor type 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptpn12 (protein tyrosine phosphatase, non-receptor type 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38777,537,160 - 77,640,071 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37777,166,773 - 77,269,388 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36777,004,771 - 77,107,322 (+)NCBINCBI36hg18NCBI36
Build 34776,811,485 - 76,914,037NCBI
Celera771,867,421 - 71,970,039 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef771,768,818 - 71,871,494 (+)NCBIHuRef
CHM1_1777,097,083 - 77,199,758 (+)NCBICHM1_1
CRA_TCAGchr7v2776,499,836 - 76,602,451 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PTPN12
AGR Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346224
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2017-11-21
Status: ACTIVE