NUTF2 (nuclear transport factor 2) - Rat Genome Database

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Gene: NUTF2 (nuclear transport factor 2) Homo sapiens
Analyze
Symbol: NUTF2
Name: nuclear transport factor 2
RGD ID: 1345837
HGNC Page HGNC:13722
Description: Enables identical protein binding activity and small GTPase binding activity. A structural constituent of nuclear pore. Involved in protein export from nucleus and protein import into nucleus. Located in cytosol and nucleoplasm. Biomarker of diabetic retinopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: NTF-2; NTF2; placental protein 15; PP15
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: NUTF2P2   NUTF2P3   NUTF2P5   NUTF2P6   NUTF2P7   NUTF2P8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,846,933 - 67,872,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,846,882 - 67,872,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,880,836 - 67,906,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,438,320 - 66,462,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 341666,438,319 - 66,462,719NCBI
Celera1652,389,231 - 52,413,631 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,772,086 - 53,778,310 (+)NCBIHuRef
CHM1_11669,289,001 - 69,313,401 (+)NCBICHM1_1
T2T-CHM13v2.01673,642,707 - 73,668,340 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. Li B, etal., Mol Vis. 2009;15:861-9. Epub 2009 Apr 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3380696   PMID:7458421   PMID:7744965   PMID:8707840   PMID:8757804   PMID:9102465   PMID:9368653   PMID:9533885   PMID:9562972   PMID:9822603   PMID:10228171   PMID:10679025  
PMID:11129791   PMID:11310559   PMID:12477932   PMID:15342556   PMID:15489334   PMID:15522285   PMID:16169070   PMID:16449645   PMID:16730000   PMID:18029348   PMID:18266911   PMID:19060906  
PMID:19060911   PMID:19098896   PMID:19322201   PMID:19369352   PMID:20458337   PMID:20805321   PMID:21195711   PMID:21873635   PMID:22658674   PMID:22880006   PMID:22939629   PMID:23376485  
PMID:23533145   PMID:24855949   PMID:25056061   PMID:25416956   PMID:26344197   PMID:26823604   PMID:27107014   PMID:28514442   PMID:29017749   PMID:29117863   PMID:30033366   PMID:30575818  
PMID:30884312   PMID:31515488   PMID:32296183   PMID:32344865   PMID:32353859   PMID:32416067   PMID:33060197   PMID:33961781   PMID:34189442   PMID:34324340   PMID:34373451   PMID:34428256  
PMID:34880267   PMID:35271311   PMID:35446349   PMID:35831314   PMID:36215168   PMID:37827155   PMID:38113892  


Genomics

Comparative Map Data
NUTF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,846,933 - 67,872,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,846,882 - 67,872,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371667,880,836 - 67,906,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,438,320 - 66,462,720 (+)NCBINCBI36Build 36hg18NCBI36
Build 341666,438,319 - 66,462,719NCBI
Celera1652,389,231 - 52,413,631 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,772,086 - 53,778,310 (+)NCBIHuRef
CHM1_11669,289,001 - 69,313,401 (+)NCBICHM1_1
T2T-CHM13v2.01673,642,707 - 73,668,340 (+)NCBIT2T-CHM13v2.0
Nutf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,587,165 - 106,607,034 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,587,212 - 106,605,962 (+)EnsemblGRCm39 Ensembl
GRCm388105,860,533 - 105,880,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1953,588,168 - 53,589,068 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,860,580 - 105,879,330 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,384,534 - 108,404,302 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368108,749,763 - 108,769,531 (+)NCBIMGSCv36mm8
Celera8110,088,387 - 110,108,163 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.05NCBI
Nutf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,662,168 - 50,683,457 (+)NCBIGRCr8
mRatBN7.21933,752,319 - 33,773,595 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,752,291 - 33,773,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1940,567,859 - 40,589,139 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01941,221,179 - 41,242,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,519,512 - 43,540,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,830,917 - 37,852,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,830,917 - 37,852,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,697,685 - 48,718,960 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,697,564 - 35,718,839 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11935,702,444 - 35,723,720 (+)NCBI
Celera1933,179,879 - 33,201,155 (+)NCBICelera
Cytogenetic Map19q12NCBI
Nutf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,832,871 - 8,854,135 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,832,871 - 8,854,151 (-)NCBIChiLan1.0ChiLan1.0
NUTF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,373,841 - 77,398,249 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11683,285,274 - 83,309,681 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01648,188,533 - 48,214,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,575,435 - 67,601,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,575,842 - 67,601,053 (+)Ensemblpanpan1.1panPan2
NUTF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,614,916 - 81,632,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,604,848 - 81,622,631 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,050,257 - 82,068,040 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,050,394 - 82,096,914 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1581,876,451 - 81,894,465 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,558,516 - 81,576,296 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,200,756 - 82,218,537 (-)NCBIUU_Cfam_GSD_1.0
Nutf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,356,708 - 41,374,581 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647518,214,267 - 18,232,442 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647518,214,593 - 18,232,406 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUTF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,469,505 - 28,489,005 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,469,274 - 28,489,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,643,308 - 25,663,373 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUTF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,567,429 - 59,592,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,566,171 - 59,592,843 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604722,291,136 - 22,318,807 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nutf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,504,303 - 18,524,957 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474618,505,935 - 18,525,335 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NUTF2
2 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2		 pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1		 pathogenic
GRCh38/hg38 16q21-22.1(chr16:64311275-68062011)x1 copy number loss See cases [RCV000053335] Chr16:64311275..68062011 [GRCh38]
Chr16:64345179..68095914 [GRCh37]
Chr16:62902680..66653415 [NCBI36]
Chr16:16q21-22.1		 pathogenic
GRCh38/hg38 16q22.1(chr16:66694180-67865445)x1 copy number loss See cases [RCV000053336] Chr16:66694180..67865445 [GRCh38]
Chr16:66728083..67899348 [GRCh37]
Chr16:65285584..66456849 [NCBI36]
Chr16:16q22.1		 pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1		 pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Breast ductal adenocarcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2		 likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q22.1(chr16:67654566-68404073)x1 copy number loss See cases [RCV000449234] Chr16:67654566..68404073 [GRCh37]
Chr16:16q22.1		 likely pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q22.1(chr16:67132790-68166320) copy number loss not provided [RCV000767617] Chr16:67132790..68166320 [GRCh37]
Chr16:16q22.1		 pathogenic
GRCh37/hg19 16q21-22.1(chr16:65669673-70180183)x1 copy number loss not provided [RCV001006797] Chr16:65669673..70180183 [GRCh37]
Chr16:16q21-22.1		 pathogenic
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3		 not provided
GRCh37/hg19 16q22.1(chr16:67765964-68246270)x1 copy number loss not provided [RCV001259860] Chr16:67765964..68246270 [GRCh37]
Chr16:16q22.1		 uncertain significance
NC_000016.9:g.(?_66545871)_(72146396_?)dup duplication Dyskeratosis congenita, autosomal dominant 6 [RCV001900384]|Immunodeficiency [RCV001900385]|not provided [RCV001900386] Chr16:66545871..72146396 [GRCh37]
Chr16:16q21-22.2		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
NC_000016.9:g.(?_65821800)_(72146396_?)del deletion Dyskeratosis congenita, autosomal dominant 6 [RCV003122496] Chr16:65821800..72146396 [GRCh37]
Chr16:16q21-22.2		 uncertain significance
GRCh37/hg19 16q22.1(chr16:67498380-68754276)x3 copy number gain not provided [RCV003485117] Chr16:67498380..68754276 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q22.1(chr16:67583728-69977397)x3 copy number gain not specified [RCV003987175] Chr16:67583728..69977397 [GRCh37]
Chr16:16q22.1		 uncertain significance
NC_000016.9:g.(?_48799549)_(70756330_?)dup duplication Chromosome 16q12 duplication syndrome [RCV004595820] Chr16:48799549..70756330 [GRCh37]
Chr16:16q12.1-22.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1930
Count of miRNA genes:854
Interacting mature miRNAs:1022
Transcripts:ENST00000219169, ENST00000567105, ENST00000568233, ENST00000568390, ENST00000568396, ENST00000569436, ENST00000570026
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407345285GWAS994261_Hhigh density lipoprotein cholesterol measurement QTL GWAS994261 (human)5e-13high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166784808667848087Human
407129350GWAS778326_Htriglycerides in small HDL measurement QTL GWAS778326 (human)2e-16triglycerides in small HDL measurementblood high density lipoprotein triglyceride level (CMO:0002686)166786816767868168Human
407236470GWAS885446_Hapolipoprotein A 1 measurement QTL GWAS885446 (human)7e-12apolipoprotein A 1 measurementblood apolipoprotein AI level (CMO:0000520)166784808667848087Human
406982097GWAS631073_Hhigh density lipoprotein cholesterol measurement QTL GWAS631073 (human)7e-09high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166786816767868168Human
407028118GWAS677094_Hhigh density lipoprotein cholesterol measurement QTL GWAS677094 (human)9e-13high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166786816767868168Human
406889435GWAS538411_Hhigh density lipoprotein cholesterol measurement QTL GWAS538411 (human)3e-39high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166786358467863585Human
406889436GWAS538412_Hhigh density lipoprotein cholesterol measurement QTL GWAS538412 (human)0.000001high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166786358467863585Human
407021406GWAS670382_Hhigh density lipoprotein cholesterol measurement QTL GWAS670382 (human)8e-16high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166786816767868168Human
406889437GWAS538413_Hhigh density lipoprotein cholesterol measurement QTL GWAS538413 (human)3e-47high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)166786358467863585Human

Markers in Region
SHGC-153756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371667,898,605 - 67,898,917UniSTSGRCh37
Build 361666,456,106 - 66,456,418RGDNCBI36
Celera1652,407,017 - 52,407,329RGD
Cytogenetic Map16q22.1UniSTS
HuRef1653,771,686 - 53,771,998UniSTS
TNG Radiation Hybrid Map1629199.0UniSTS
NUTF2_9060  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371667,904,730 - 67,905,218UniSTSGRCh37
GRCh37X70,235,997 - 70,236,458UniSTSGRCh37
Build 36X70,152,722 - 70,153,183RGDNCBI36
CeleraX70,589,865 - 70,590,326RGD
Celera1652,413,142 - 52,413,630UniSTS
Celera1760,568,559 - 60,569,037UniSTS
HuRef1653,777,821 - 53,778,309UniSTS
HuRefX64,055,753 - 64,056,214UniSTS
HuRef1759,388,517 - 59,388,995UniSTS
SHGC-31645  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X70,236,173 - 70,236,376UniSTSGRCh37
GRCh371667,904,818 - 67,905,024UniSTSGRCh37
Build 36X70,152,898 - 70,153,101RGDNCBI36
Celera1652,413,230 - 52,413,436UniSTS
CeleraX70,590,041 - 70,590,244RGD
Cytogenetic Map16q22.1UniSTS
Cytogenetic MapXq13.1UniSTS
HuRef1653,777,909 - 53,778,115UniSTS
HuRefX64,055,929 - 64,056,132UniSTS
Stanford-G3 RH MapX2832.0UniSTS
GeneMap99-GB4 RH Map16405.16UniSTS
Whitehead-RH Map16304.7UniSTS
NCBI RH MapX446.9UniSTS
NCBI RH Map16508.6UniSTS
GeneMap99-G3 RH MapX2180.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2435 2788 2247 4949 1724 2349 5 622 1948 464 2268 7293 6463 52 3715 851 1740 1615 172

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001322038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001322041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC040162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC033653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP216441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX394845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY123109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000219169   ⟹   ENSP00000219169
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,933 - 67,872,567 (+)Ensembl
Ensembl Acc Id: ENST00000567105   ⟹   ENSP00000456428
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,935 - 67,870,852 (+)Ensembl
Ensembl Acc Id: ENST00000568233
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,903 - 67,871,063 (+)Ensembl
Ensembl Acc Id: ENST00000568390
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,923 - 67,868,741 (+)Ensembl
Ensembl Acc Id: ENST00000568396   ⟹   ENSP00000457022
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,847,211 - 67,871,323 (+)Ensembl
Ensembl Acc Id: ENST00000569436   ⟹   ENSP00000457989
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,847,114 - 67,872,549 (+)Ensembl
Ensembl Acc Id: ENST00000570026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,847,216 - 67,871,056 (+)Ensembl
Ensembl Acc Id: ENST00000587481
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,869,960 - 67,872,567 (+)Ensembl
Ensembl Acc Id: ENST00000700610   ⟹   ENSP00000515098
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,882 - 67,871,134 (+)Ensembl
Ensembl Acc Id: ENST00000700611   ⟹   ENSP00000515101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,933 - 67,871,146 (+)Ensembl
Ensembl Acc Id: ENST00000700612   ⟹   ENSP00000515102
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,933 - 67,871,309 (+)Ensembl
Ensembl Acc Id: ENST00000700613   ⟹   ENSP00000515103
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,846,935 - 67,872,549 (+)Ensembl
Ensembl Acc Id: ENST00000700614   ⟹   ENSP00000515104
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,847,159 - 67,872,549 (+)Ensembl
Ensembl Acc Id: ENST00000700615   ⟹   ENSP00000515105
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1667,847,195 - 67,871,146 (+)Ensembl
RefSeq Acc Id: NM_001322038   ⟹   NP_001308967
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,846,933 - 67,872,567 (+)NCBI
CHM1_11669,288,817 - 69,314,652 (+)NCBI
T2T-CHM13v2.01673,642,707 - 73,668,340 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001322039   ⟹   NP_001308968
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,846,933 - 67,872,567 (+)NCBI
CHM1_11669,288,817 - 69,314,652 (+)NCBI
T2T-CHM13v2.01673,642,707 - 73,668,340 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001322040   ⟹   NP_001308969
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,847,192 - 67,872,567 (+)NCBI
CHM1_11669,289,199 - 69,314,652 (+)NCBI
T2T-CHM13v2.01673,642,966 - 73,668,340 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001322041   ⟹   NP_001308970
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,847,192 - 67,872,567 (+)NCBI
CHM1_11669,289,199 - 69,314,652 (+)NCBI
T2T-CHM13v2.01673,642,966 - 73,668,340 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005796   ⟹   NP_005787
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,846,933 - 67,872,567 (+)NCBI
GRCh371667,880,819 - 67,906,470 (+)NCBI
Build 361666,438,320 - 66,462,720 (+)NCBI Archive
HuRef1653,772,086 - 53,778,310 (+)ENTREZGENE
CHM1_11669,288,817 - 69,314,652 (+)NCBI
T2T-CHM13v2.01673,642,707 - 73,668,340 (+)NCBI
Sequence:
RefSeq Acc Id: NP_005787   ⟸   NM_005796
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   B2R4G7 (UniProtKB/Swiss-Prot),   Q6IB67 (UniProtKB/Swiss-Prot),   P61970 (UniProtKB/Swiss-Prot),   H3BRV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308968   ⟸   NM_001322039
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   B2R4G7 (UniProtKB/Swiss-Prot),   Q6IB67 (UniProtKB/Swiss-Prot),   P61970 (UniProtKB/Swiss-Prot),   H3BRV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308967   ⟸   NM_001322038
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   B2R4G7 (UniProtKB/Swiss-Prot),   Q6IB67 (UniProtKB/Swiss-Prot),   P61970 (UniProtKB/Swiss-Prot),   H3BRV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308970   ⟸   NM_001322041
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   B2R4G7 (UniProtKB/Swiss-Prot),   Q6IB67 (UniProtKB/Swiss-Prot),   P61970 (UniProtKB/Swiss-Prot),   H3BRV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001308969   ⟸   NM_001322040
- UniProtKB: P13662 (UniProtKB/Swiss-Prot),   B2R4G7 (UniProtKB/Swiss-Prot),   Q6IB67 (UniProtKB/Swiss-Prot),   P61970 (UniProtKB/Swiss-Prot),   H3BRV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000457989   ⟸   ENST00000569436
Ensembl Acc Id: ENSP00000219169   ⟸   ENST00000219169
Ensembl Acc Id: ENSP00000456428   ⟸   ENST00000567105
Ensembl Acc Id: ENSP00000457022   ⟸   ENST00000568396
Ensembl Acc Id: ENSP00000515102   ⟸   ENST00000700612
Ensembl Acc Id: ENSP00000515101   ⟸   ENST00000700611
Ensembl Acc Id: ENSP00000515104   ⟸   ENST00000700614
Ensembl Acc Id: ENSP00000515105   ⟸   ENST00000700615
Ensembl Acc Id: ENSP00000515098   ⟸   ENST00000700610
Ensembl Acc Id: ENSP00000515103   ⟸   ENST00000700613
Protein Domains
NTF2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61970-F1-model_v2 AlphaFold P61970 1-127 view protein structure

Promoters
RGD ID:6793348
Promoter ID:HG_KWN:24056
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000268871
Position:
Human AssemblyChrPosition (strand)Source
Build 361666,437,356 - 66,438,457 (+)MPROMDB
RGD ID:6852342
Promoter ID:EP73978
Type:initiation region
Name:HS_NUTF2
Description:Nuclear transport factor 2.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361666,438,339 - 66,438,399EPD
RGD ID:7232587
Promoter ID:EPDNEW_H22039
Type:initiation region
Name:NUTF2_1
Description:nuclear transport factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,846,935 - 67,846,995EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13722 AgrOrtholog
COSMIC NUTF2 COSMIC
Ensembl Genes ENSG00000102898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000219169 ENTREZGENE
  ENST00000219169.9 UniProtKB/Swiss-Prot
  ENST00000567105 ENTREZGENE
  ENST00000567105.5 UniProtKB/TrEMBL
  ENST00000568233.6 UniProtKB/TrEMBL
  ENST00000568390.5 UniProtKB/TrEMBL
  ENST00000568396 ENTREZGENE
  ENST00000568396.2 UniProtKB/Swiss-Prot
  ENST00000569436 ENTREZGENE
  ENST00000569436.7 UniProtKB/Swiss-Prot
  ENST00000570026.2 UniProtKB/TrEMBL
  ENST00000700610.1 UniProtKB/TrEMBL
  ENST00000700611.1 UniProtKB/TrEMBL
  ENST00000700612.1 UniProtKB/TrEMBL
  ENST00000700613 ENTREZGENE
  ENST00000700613.1 UniProtKB/Swiss-Prot
  ENST00000700614.1 UniProtKB/Swiss-Prot
  ENST00000700615.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000102898 GTEx
HGNC ID HGNC:13722 ENTREZGENE
Human Proteome Map NUTF2 Human Proteome Map
InterPro NTF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF2-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTF2/Mtr2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_transport_factor_2_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10204 UniProtKB/Swiss-Prot
NCBI Gene 10204 ENTREZGENE
OMIM 605813 OMIM
PANTHER NUCLEAR TRANSPORT FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12612 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NTF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA38365 PharmGKB
PROSITE NTF2_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54427 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8V8TPY3_HUMAN UniProtKB/TrEMBL
  A0A8V8TR25_HUMAN UniProtKB/TrEMBL
  A0A8V8TR28_HUMAN UniProtKB/TrEMBL
  A0A8V8TRD3_HUMAN UniProtKB/TrEMBL
  B2R4G7 ENTREZGENE
  B4DEQ2_HUMAN UniProtKB/TrEMBL
  H3BRV9 ENTREZGENE, UniProtKB/TrEMBL
  NTF2_HUMAN UniProtKB/Swiss-Prot
  P13662 ENTREZGENE
  P61970 ENTREZGENE
  Q6IB67 ENTREZGENE
UniProt Secondary B2R4G7 UniProtKB/Swiss-Prot
  P13662 UniProtKB/Swiss-Prot
  Q6IB67 UniProtKB/Swiss-Prot