GPX2 (glutathione peroxidase 2) - Rat Genome Database

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Gene: GPX2 (glutathione peroxidase 2) Homo sapiens
Analyze
Symbol: GPX2
Name: glutathione peroxidase 2
RGD ID: 1345750
HGNC Page HGNC:4554
Description: Enables glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to act upstream of or within several processes, including negative regulation of inflammatory response to antigenic stimulus; response to symbiotic bacterium; and temperature homeostasis. Located in cytosol; intercellular bridge; and mitotic spindle. Biomarker of colorectal adenoma; colorectal cancer; colorectal carcinoma; and ulcerative colitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: gastrointestinal glutathione peroxidase; gastrointestinal glutathione peroxidase 2; GI-GPx; glutathione peroxidase 2 (gastrointestinal); glutathione peroxidase-gastrointestinal; glutathione peroxidase-related protein 2; GPRP; GPRP-2; GPx-2; GPx-GI; GSHPx-2; GSHPX-GI; phospholipid hydroperoxide glutathione peroxidase GPX2; selenoprotein GPX2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,939,158 - 64,942,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,939,152 - 64,942,746 (-)EnsemblGRCh38hg38GRCh38
GRCh371465,405,876 - 65,409,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,475,625 - 64,479,284 (-)NCBINCBI36Build 36hg18NCBI36
Build 341464,475,624 - 64,479,284NCBI
Celera1445,460,457 - 45,464,116 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,575,494 - 45,579,247 (-)NCBIHuRef
CHM1_11465,344,036 - 65,347,793 (-)NCBICHM1_1
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (ISO)
(S)-naringenin  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-nitroquinoline N-oxide  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
antimonite  (EXP)
aristolochic acid A  (ISO)
arotinoid acid  (EXP)
arsane  (EXP)
arsenic acid  (ISO)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
atazanavir sulfate  (EXP)
atrazine  (ISO)
Augmentin  (EXP)
azathioprine  (EXP)
Bardoxolone methyl  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (EXP)
calcitriol  (EXP)
cannabidiol  (EXP)
carbamazepine  (EXP,ISO)
cefaloridine  (ISO)
ceric oxide  (ISO)
cerium trichloride  (EXP)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
CHIR 99021  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clavulanic acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cobicistat  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (EXP)
CU-O LINKAGE  (EXP)
cumene hydroperoxide  (EXP)
cyclosporin A  (EXP)
cyfluthrin  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
deoxycholic acid  (EXP)
diazinon  (ISO)
Dibutyl phosphate  (EXP)
diclofenac  (EXP)
dicyclanil  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (ISO)
genistein  (ISO)
glucobrassicin  (EXP)
glucoraphanin  (EXP,ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxytyrosol  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (EXP)
L-ascorbic acid  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
L-methionine  (ISO)
lead(II) chloride  (EXP,ISO)
linoleic acid hydroperoxide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lutein  (ISO)
lycopene  (ISO)
melatonin  (ISO)
menadione  (EXP)
mercaptopurine  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
Mitotane  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (EXP)
nickel atom  (EXP,ISO)
nitric oxide  (ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
omeprazole  (ISO)
orphenadrine  (ISO)
oxfendazole  (ISO)
ozone  (ISO)
p-toluidine  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phosgene  (ISO)
phoxim  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (ISO)
SB 431542  (EXP)
selenium atom  (ISO)
selenium ion  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium cholate  (ISO)
sodium dichromate  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (EXP)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
Tributyltin oxide  (EXP,ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP,ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
XAV939  (EXP)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,TAS)
cytosol  (IDA,IEA,TAS)
intercellular bridge  (IDA)
mitotic spindle  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Banning A, etal., Antioxid Redox Signal. 2008 Sep;10(9):1491-500. doi: 10.1089/ars.2008.2047.
2. Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. Blum NM, etal., Biol Trace Elem Res. 2013 Mar;151(3):384-99. doi: 10.1007/s12011-012-9567-6. Epub 2012 Dec 29.
3. Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon. Drew JE, etal., Biochem Pharmacol. 2005 Sep 15;70(6):888-93. doi: 10.1016/j.bcp.2005.06.011.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
6. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. Saxena A, etal., Cancer Biol Ther. 2017 Apr 3;18(4):257-267. doi: 10.1080/15384047.2016.1276130. Epub 2017 Jan 3.
Additional References at PubMed
PMID:2388849   PMID:8125298   PMID:8287691   PMID:8428933   PMID:8833155   PMID:8889549   PMID:9501919   PMID:10652368   PMID:10737800   PMID:10806356   PMID:11368344   PMID:11373322  
PMID:11811519   PMID:12477932   PMID:12674495   PMID:12751789   PMID:15489334   PMID:15910762   PMID:15923610   PMID:16446369   PMID:16794261   PMID:17277236   PMID:17937616   PMID:18029348  
PMID:18056462   PMID:18483336   PMID:18676680   PMID:19047153   PMID:19161995   PMID:19170196   PMID:19573080   PMID:19625176   PMID:19692168   PMID:19773279   PMID:19884766   PMID:19913121  
PMID:20200426   PMID:20628086   PMID:20813000   PMID:21873635   PMID:21988832   PMID:22683372   PMID:22758632   PMID:23376485   PMID:23934683   PMID:24562575   PMID:25261240   PMID:25813210  
PMID:26698667   PMID:27388201   PMID:28453466   PMID:28631563   PMID:28635398   PMID:28916653   PMID:30652380   PMID:31765890   PMID:31774184   PMID:32215178   PMID:33622868   PMID:34954079  
PMID:35193955   PMID:36608588   PMID:36796200   PMID:37138031   PMID:37743483   PMID:37810778  


Genomics

Comparative Map Data
GPX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,939,158 - 64,942,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,939,152 - 64,942,746 (-)EnsemblGRCh38hg38GRCh38
GRCh371465,405,876 - 65,409,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,475,625 - 64,479,284 (-)NCBINCBI36Build 36hg18NCBI36
Build 341464,475,624 - 64,479,284NCBI
Celera1445,460,457 - 45,464,116 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,575,494 - 45,579,247 (-)NCBIHuRef
CHM1_11465,344,036 - 65,347,793 (-)NCBICHM1_1
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBIT2T-CHM13v2.0
Gpx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,839,109 - 76,842,328 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,839,107 - 76,842,273 (-)EnsemblGRCm39 Ensembl
GRCm381276,792,335 - 76,795,554 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,792,333 - 76,795,554 (-)EnsemblGRCm38mm10GRCm38
MGSCv371277,893,322 - 77,896,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361277,711,177 - 77,714,346 (-)NCBIMGSCv36mm8
Celera1277,874,684 - 77,877,908 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Gpx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,226,745 - 101,230,033 (-)NCBIGRCr8
mRatBN7.2695,493,589 - 95,496,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx695,882,234 - 95,885,509 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,180,771 - 96,184,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,609,574 - 95,612,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,839,960 - 99,843,245 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06109,236,420 - 109,239,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4699,372,418 - 99,376,230 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1699,375,879 - 99,379,686 (-)NCBI
Celera693,912,759 - 93,916,226 (-)NCBICelera
Cytogenetic Map6q24NCBI
Gpx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554664,984,631 - 4,987,457 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554664,983,532 - 4,987,780 (+)NCBIChiLan1.0ChiLan1.0
GPX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21566,048,329 - 66,056,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,264,842 - 65,273,236 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,522,558 - 45,526,678 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,401,921 - 64,405,720 (-)NCBIpanpan1.1PanPan1.1panPan2
GPX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,322,040 - 39,325,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,322,034 - 39,325,817 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha839,014,111 - 39,017,902 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0839,544,781 - 39,548,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,544,775 - 39,548,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1839,166,063 - 39,169,883 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,238,883 - 39,242,643 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,597,955 - 39,601,701 (-)NCBIUU_Cfam_GSD_1.0
Gpx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,598,245 - 65,601,474 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,590,556 - 8,593,367 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,590,225 - 8,593,511 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl789,007,375 - 89,011,620 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1789,007,636 - 89,011,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,388,550 - 95,392,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12442,151,205 - 42,155,335 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605330,321,541 - 30,325,285 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,086,902 - 36,089,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473436,086,831 - 36,090,180 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPX2
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q23.1-23.3(chr14:59917051-66750803)x1 copy number loss See cases [RCV000050892] Chr14:59917051..66750803 [GRCh38]
Chr14:60383769..67217521 [GRCh37]
Chr14:59453522..66287274 [NCBI36]
Chr14:14q23.1-23.3
pathogenic
GRCh38/hg38 14q22.3-23.3(chr14:57041036-67208231)x1 copy number loss See cases [RCV000051521] Chr14:57041036..67208231 [GRCh38]
Chr14:57507754..67674948 [GRCh37]
Chr14:56577507..66744701 [NCBI36]
Chr14:14q22.3-23.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q23.2-23.3(chr14:62252700-65753416)x1 copy number loss See cases [RCV000138250] Chr14:62252700..65753416 [GRCh38]
Chr14:62719418..66220134 [GRCh37]
Chr14:61789171..65289887 [NCBI36]
Chr14:14q23.2-23.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-23.3(chr14:64016496-65834490)x3 copy number gain See cases [RCV002285053] Chr14:64016496..65834490 [GRCh37]
Chr14:14q23.2-23.3
uncertain significance
GRCh37/hg19 14q23.1-23.3(chr14:61409856-65742610)x3 copy number gain not provided [RCV001259780] Chr14:61409856..65742610 [GRCh37]
Chr14:14q23.1-23.3
likely pathogenic
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3
likely pathogenic
NC_000014.8:g.(?_64746679)_(66975329_?)del deletion Sulfite oxidase deficiency due to molybdenum cofactor deficiency type C [RCV002007295] Chr14:64746679..66975329 [GRCh37]
Chr14:14q23.2-23.3
pathogenic
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33
pathogenic
NM_002083.4(GPX2):c.167G>A (p.Arg56His) single nucleotide variant not specified [RCV004193536] Chr14:64942560 [GRCh38]
Chr14:65409278 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.551G>T (p.Arg184Leu) single nucleotide variant not specified [RCV004162755] Chr14:64939510 [GRCh38]
Chr14:65406228 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.413A>G (p.Lys138Arg) single nucleotide variant not specified [RCV004241505] Chr14:64939648 [GRCh38]
Chr14:65406366 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.31C>T (p.Leu11Phe) single nucleotide variant not specified [RCV004269942] Chr14:64942696 [GRCh38]
Chr14:65409414 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.11T>C (p.Ile4Thr) single nucleotide variant not specified [RCV004341254] Chr14:64942716 [GRCh38]
Chr14:65409434 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.439C>T (p.Arg147Cys) single nucleotide variant not specified [RCV004338699] Chr14:64939622 [GRCh38]
Chr14:65406340 [GRCh37]
Chr14:14q23.3
uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33
pathogenic
GRCh37/hg19 14q22.3-24.1(chr14:57588965-68334517)x3 copy number gain not provided [RCV003485034] Chr14:57588965..68334517 [GRCh37]
Chr14:14q22.3-24.1
likely pathogenic
NM_002083.4(GPX2):c.334G>A (p.Glu112Lys) single nucleotide variant not specified [RCV004393510] Chr14:64939727 [GRCh38]
Chr14:65406445 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.335A>T (p.Glu112Val) single nucleotide variant not specified [RCV004393511] Chr14:64939726 [GRCh38]
Chr14:65406444 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.134G>A (p.Arg45Gln) single nucleotide variant not specified [RCV004393509] Chr14:64942593 [GRCh38]
Chr14:65409311 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.74C>A (p.Thr25Lys) single nucleotide variant not specified [RCV004393513] Chr14:64942653 [GRCh38]
Chr14:65409371 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.74C>T (p.Thr25Met) single nucleotide variant not specified [RCV004393514] Chr14:64942653 [GRCh38]
Chr14:65409371 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.512G>A (p.Arg171His) single nucleotide variant not specified [RCV004393512] Chr14:64939549 [GRCh38]
Chr14:65406267 [GRCh37]
Chr14:14q23.3
uncertain significance
NM_002083.4(GPX2):c.91G>A (p.Val31Met) single nucleotide variant not specified [RCV004393515] Chr14:64942636 [GRCh38]
Chr14:65409354 [GRCh37]
Chr14:14q23.3
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1291
Count of miRNA genes:590
Interacting mature miRNAs:648
Transcripts:ENST00000389614, ENST00000553522, ENST00000557049, ENST00000557323
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407152041GWAS801017_Hlung carcinoma QTL GWAS801017 (human)0.000005lung carcinoma146493956164939562Human

Markers in Region
WI-7016  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371465,405,875 - 65,406,199UniSTSGRCh37
Build 361464,475,628 - 64,475,952RGDNCBI36
Celera1445,460,460 - 45,460,784RGD
Cytogenetic Map14q24.1UniSTS
HuRef1445,575,499 - 45,575,823UniSTS
Whitehead-YAC Contig Map14 UniSTS
GPX2_2113  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371465,405,676 - 65,406,532UniSTSGRCh37
Build 361464,475,429 - 64,476,285RGDNCBI36
Celera1445,460,261 - 45,461,117RGD
HuRef1445,575,300 - 45,576,156UniSTS
RH48489  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371465,408,644 - 65,408,766UniSTSGRCh37
Build 361464,478,397 - 64,478,519RGDNCBI36
Celera1445,463,229 - 45,463,351RGD
Cytogenetic Map14q24.1UniSTS
HuRef1445,578,268 - 45,578,390UniSTS
GeneMap99-GB4 RH Map14153.14UniSTS
NCBI RH Map14647.8UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1184 2418 2756 2192 4864 1716 2327 3 624 1802 465 2240 7053 6229 34 3634 1 838 1725 1592 173 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_046320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_046321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_138078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA135289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF199441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY785560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF207526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF759921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG429974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI015236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X53463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000389614   ⟹   ENSP00000374265
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,939,158 - 64,942,745 (-)Ensembl
Ensembl Acc Id: ENST00000553522   ⟹   ENSP00000450991
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,939,152 - 64,942,745 (-)Ensembl
Ensembl Acc Id: ENST00000557049   ⟹   ENSP00000451721
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,939,417 - 64,942,720 (-)Ensembl
Ensembl Acc Id: ENST00000557323   ⟹   ENSP00000451844
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,939,508 - 64,942,746 (-)Ensembl
Ensembl Acc Id: ENST00000612794   ⟹   ENSP00000478082
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1464,939,153 - 64,942,905 (-)Ensembl
RefSeq Acc Id: NM_002083   ⟹   NP_002074
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,939,158 - 64,942,745 (-)NCBI
GRCh371465,405,870 - 65,409,623 (-)NCBI
Build 361464,475,625 - 64,479,284 (-)NCBI Archive
HuRef1445,575,494 - 45,579,247 (-)NCBI
CHM1_11465,344,036 - 65,347,793 (-)NCBI
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBI
Sequence:
RefSeq Acc Id: NR_046320
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,939,158 - 64,942,745 (-)NCBI
GRCh371465,405,870 - 65,409,623 (-)NCBI
HuRef1445,575,494 - 45,579,247 (-)NCBI
CHM1_11465,344,036 - 65,347,793 (-)NCBI
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBI
Sequence:
RefSeq Acc Id: NR_046321
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,939,158 - 64,942,745 (-)NCBI
GRCh371465,405,870 - 65,409,623 (-)NCBI
HuRef1445,575,494 - 45,579,247 (-)NCBI
CHM1_11465,344,036 - 65,347,793 (-)NCBI
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBI
Sequence:
RefSeq Acc Id: NR_138078
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,939,158 - 64,942,745 (-)NCBI
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002074   ⟸   NM_002083
- UniProtKB: Q8WWI7 (UniProtKB/Swiss-Prot),   Q6PJ52 (UniProtKB/Swiss-Prot),   Q9NRP9 (UniProtKB/Swiss-Prot),   P18283 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000451844   ⟸   ENST00000557323
Ensembl Acc Id: ENSP00000451721   ⟸   ENST00000557049
Ensembl Acc Id: ENSP00000374265   ⟸   ENST00000389614
Ensembl Acc Id: ENSP00000478082   ⟸   ENST00000612794
Ensembl Acc Id: ENSP00000450991   ⟸   ENST00000553522

Promoters
RGD ID:6791617
Promoter ID:HG_KWN:19592
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:NM_002083,   UC001XHY.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361464,479,054 - 64,479,554 (-)MPROMDB
RGD ID:6852764
Promoter ID:EP74197
Type:initiation region
Name:HS_GPX2
Description:Glutathione peroxidase 2 (gastrointestinal).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361464,479,216 - 64,479,276EPD
RGD ID:7227895
Promoter ID:EPDNEW_H19693
Type:initiation region
Name:GPX2_1
Description:glutathione peroxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19694  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,942,741 - 64,942,801EPDNEW
RGD ID:7227897
Promoter ID:EPDNEW_H19694
Type:initiation region
Name:GPX2_2
Description:glutathione peroxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19693  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381464,942,864 - 64,942,924EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4554 AgrOrtholog
COSMIC GPX2 COSMIC
Ensembl Genes ENSG00000176153 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000389614 ENTREZGENE
  ENST00000389614.6 UniProtKB/Swiss-Prot
  ENST00000553522 ENTREZGENE
  ENST00000553522.1 UniProtKB/TrEMBL
  ENST00000557049.1 UniProtKB/TrEMBL
  ENST00000557323.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000176153 GTEx
HGNC ID HGNC:4554 ENTREZGENE
Human Proteome Map GPX2 Human Proteome Map
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2877 UniProtKB/Swiss-Prot
NCBI Gene 2877 ENTREZGENE
OMIM 138319 OMIM
PANTHER GLUTATHIONE PEROXIDASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28950 PharmGKB
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V323_HUMAN UniProtKB/TrEMBL
  G3V4J6_HUMAN UniProtKB/TrEMBL
  GPX2_HUMAN UniProtKB/Swiss-Prot
  H0YJK8_HUMAN UniProtKB/TrEMBL
  P18283 ENTREZGENE
  Q6PJ52 ENTREZGENE
  Q8WWI7 ENTREZGENE
  Q9NRP9 ENTREZGENE
UniProt Secondary Q6PJ52 UniProtKB/Swiss-Prot
  Q8WWI7 UniProtKB/Swiss-Prot
  Q9NRP9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 GPX2  glutathione peroxidase 2  GPX2  glutathione peroxidase 2 (gastrointestinal)  Symbol and/or name change 5135510 APPROVED