HMGA1 (high mobility group AT-hook 1) - Rat Genome Database

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Gene: HMGA1 (high mobility group AT-hook 1) Homo sapiens
Analyze
Symbol: HMGA1
Name: high mobility group AT-hook 1
RGD ID: 1345409
HGNC Page HGNC:5010
Description: Enables several functions, including DNA binding activity; catalytic activity, acting on DNA; and nuclear retinoid X receptor binding activity. Involved in several processes, including base-excision repair; oncogene-induced cell senescence; and regulation of DNA-templated transcription. Located in cytosol; nucleus; and senescence-associated heterochromatin focus. Implicated in type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: high mobility group AT-hook protein 1; high mobility group protein A1; high mobility group protein HMG-I/HMG-Y; high mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; HMG-I(Y); HMG-R; HMGA1A; HMGIY; MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: HMGA1P1   HMGA1P2   HMGA1P3   HMGA1P4   HMGA1P5   HMGA1P6   HMGA1P7   HMGA1P8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,236,873 - 34,246,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,236,873 - 34,246,231 (+)EnsemblGRCh38hg38GRCh38
GRCh37634,204,650 - 34,214,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,312,628 - 34,321,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 34634,314,545 - 34,321,986NCBI
Celera635,758,945 - 35,768,381 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,927,318 - 33,936,673 (+)NCBIHuRef
CHM1_1634,207,231 - 34,216,597 (+)NCBICHM1_1
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4,6-tribromophenol  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dimethoxyphenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (EXP)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
acetamide  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
alpha-Zearalanol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antimony(0)  (EXP)
aristolochic acid A  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP)
Brodifacoum  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chromium atom  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
coumarin  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diethylstilbestrol  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
Ethylenethiourea  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
FR900359  (EXP)
furfural  (EXP)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
ivermectin  (EXP)
lipopolysaccharide  (EXP)
methamphetamine  (EXP,ISO)
methidathion  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
mitomycin C  (EXP)
N-nitrosodimethylamine  (EXP)
nicotine  (EXP)
nitrates  (ISO)
O-methyleugenol  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pepstatin A  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
pterostilbene  (EXP,ISO)
quercetin  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
sodium chloride  (EXP)
Soman  (ISO)
sunitinib  (EXP)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetrahydropalmatine  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (EXP)
vancomycin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
Additional References at PubMed
PMID:1692833   PMID:1939057   PMID:2505228   PMID:2701943   PMID:2806554   PMID:2920035   PMID:3619901   PMID:7791781   PMID:7862168   PMID:8376587   PMID:8414980   PMID:8548797  
PMID:8550844   PMID:8895530   PMID:9038339   PMID:9188609   PMID:9253416   PMID:9341202   PMID:9388234   PMID:9545312   PMID:9751634   PMID:9809067   PMID:9823775   PMID:10074149  
PMID:10357819   PMID:10400641   PMID:10428834   PMID:10713105   PMID:10871404   PMID:10889043   PMID:10891489   PMID:11034995   PMID:11069991   PMID:11076660   PMID:11106736   PMID:11156965  
PMID:11406267   PMID:11498590   PMID:11593421   PMID:11978964   PMID:12002338   PMID:12097287   PMID:12477932   PMID:12653562   PMID:12665574   PMID:12700639   PMID:12761578   PMID:13680222  
PMID:14702039   PMID:14729942   PMID:14960313   PMID:15213251   PMID:15231747   PMID:15247513   PMID:15302935   PMID:15350136   PMID:15378028   PMID:15489334   PMID:15569996   PMID:15591590  
PMID:15609325   PMID:15631895   PMID:15835918   PMID:15875659   PMID:15893306   PMID:15901130   PMID:15924147   PMID:16033759   PMID:16075307   PMID:16157300   PMID:16159886   PMID:16166307  
PMID:16189514   PMID:16204234   PMID:16256199   PMID:16293633   PMID:16344560   PMID:16403635   PMID:16791210   PMID:16901784   PMID:17005673   PMID:17045586   PMID:17081983   PMID:17178855  
PMID:17434141   PMID:17550233   PMID:17616660   PMID:17654722   PMID:17723105   PMID:17877762   PMID:17903177   PMID:17935122   PMID:17960875   PMID:18202751   PMID:18234858   PMID:18279675  
PMID:18310298   PMID:18316571   PMID:18391951   PMID:18473350   PMID:18670638   PMID:18783938   PMID:18817785   PMID:18850631   PMID:19060921   PMID:19074878   PMID:19250063   PMID:19266077  
PMID:19274049   PMID:19343178   PMID:19389484   PMID:19396169   PMID:19454010   PMID:19465398   PMID:19609535   PMID:19687300   PMID:19729480   PMID:19738201   PMID:19739099   PMID:19750561  
PMID:19759913   PMID:19820691   PMID:19848064   PMID:19893584   PMID:19903768   PMID:19913121   PMID:19956671   PMID:20004941   PMID:20189936   PMID:20194618   PMID:20201926   PMID:20301750  
PMID:20335021   PMID:20347905   PMID:20360068   PMID:20379614   PMID:20397748   PMID:20546612   PMID:20628086   PMID:20881960   PMID:20935630   PMID:20975707   PMID:21087998   PMID:21089648  
PMID:21138859   PMID:21156240   PMID:21244100   PMID:21282977   PMID:21300033   PMID:21319273   PMID:21329653   PMID:21364139   PMID:21423176   PMID:21573994   PMID:21656127   PMID:21873635  
PMID:21957495   PMID:21984063   PMID:21998595   PMID:22106824   PMID:22113938   PMID:22139073   PMID:22156211   PMID:22199144   PMID:22207709   PMID:22210315   PMID:22214847   PMID:22221703  
PMID:22249617   PMID:22332738   PMID:22355763   PMID:22379092   PMID:22392906   PMID:22411136   PMID:22503056   PMID:22564666   PMID:22615915   PMID:22745191   PMID:22898640   PMID:22939624  
PMID:22939629   PMID:22961697   PMID:23036517   PMID:23149213   PMID:23166588   PMID:23201162   PMID:23275563   PMID:23302499   PMID:23311322   PMID:23392246   PMID:23394223   PMID:23398456  
PMID:23508853   PMID:23512162   PMID:23530587   PMID:23545254   PMID:23563607   PMID:23658826   PMID:23796420   PMID:23798998   PMID:23835740   PMID:23935884   PMID:24122990   PMID:24148075  
PMID:24367622   PMID:24452592   PMID:24684280   PMID:24696416   PMID:24711643   PMID:24740910   PMID:24803022   PMID:24833610   PMID:24976238   PMID:24981860   PMID:25344216   PMID:25429064  
PMID:25455159   PMID:25557289   PMID:25586095   PMID:25595895   PMID:25609649   PMID:25755724   PMID:25772486   PMID:26009886   PMID:26167880   PMID:26251519   PMID:26265440   PMID:26296198  
PMID:26381412   PMID:26496610   PMID:26527623   PMID:26657872   PMID:26687479   PMID:26708416   PMID:26717491   PMID:26777405   PMID:26895108   PMID:26898758   PMID:26980699   PMID:27001612  
PMID:27008379   PMID:27045138   PMID:27445976   PMID:27470368   PMID:27486901   PMID:27537384   PMID:27561949   PMID:27576135   PMID:27602961   PMID:27634302   PMID:27725726   PMID:27839822  
PMID:27855356   PMID:27880917   PMID:27882471   PMID:27976729   PMID:27991577   PMID:28065597   PMID:28190768   PMID:28192407   PMID:28255268   PMID:28290473   PMID:28319085   PMID:28345487  
PMID:28389416   PMID:28393241   PMID:28515276   PMID:28753127   PMID:28777374   PMID:28831670   PMID:28924209   PMID:28927264   PMID:29052178   PMID:29152644   PMID:29298432   PMID:29316384  
PMID:29374701   PMID:29467282   PMID:29478914   PMID:29568061   PMID:29676528   PMID:29697014   PMID:29789601   PMID:29867121   PMID:29872149   PMID:29945308   PMID:30021884   PMID:30196744  
PMID:30308301   PMID:30320910   PMID:30349055   PMID:30462309   PMID:30572598   PMID:30575818   PMID:30614613   PMID:30686591   PMID:30766549   PMID:30776481   PMID:30804502   PMID:30816441  
PMID:30884312   PMID:30997501   PMID:30999005   PMID:31076808   PMID:31096664   PMID:31116627   PMID:31167352   PMID:31180492   PMID:31229266   PMID:31239290   PMID:31300541   PMID:31311575  
PMID:31340016   PMID:31340839   PMID:31343991   PMID:31394192   PMID:31410930   PMID:31531802   PMID:31586073   PMID:31686521   PMID:31779212   PMID:31822558   PMID:31980649   PMID:32041737  
PMID:32051553   PMID:32052688   PMID:32127525   PMID:32329839   PMID:32416067   PMID:32572906   PMID:32707033   PMID:32877691   PMID:32908313   PMID:32989212   PMID:33022573   PMID:33139812  
PMID:33150374   PMID:33169939   PMID:33194618   PMID:33332531   PMID:33526059   PMID:33536335   PMID:33545068   PMID:33545070   PMID:33644029   PMID:33684176   PMID:33755320   PMID:33835503  
PMID:33845483   PMID:33858292   PMID:33916271   PMID:33961781   PMID:34072941   PMID:34079125   PMID:34133714   PMID:34167089   PMID:34185411   PMID:34189442   PMID:34349018   PMID:34373451  
PMID:34431162   PMID:34483139   PMID:34537242   PMID:34560189   PMID:34780483   PMID:34887392   PMID:34954155   PMID:34970695   PMID:34973275   PMID:35013218   PMID:35031058   PMID:35040749  
PMID:35114891   PMID:35122331   PMID:35130798   PMID:35163710   PMID:35253629   PMID:35271311   PMID:35282770   PMID:35356984   PMID:35459188   PMID:35575683   PMID:35583604   PMID:35785026  
PMID:35805937   PMID:35831314   PMID:35833506   PMID:35864955   PMID:35944360   PMID:35948739   PMID:36057605   PMID:36087034   PMID:36123327   PMID:36215168   PMID:36217030   PMID:36232890  
PMID:36244648   PMID:36273042   PMID:36352838   PMID:36373674   PMID:36470235   PMID:36506071   PMID:36537216   PMID:36574265   PMID:36614035   PMID:36635290   PMID:36705364   PMID:36776216  
PMID:36919699   PMID:36966392   PMID:37071682   PMID:37146833   PMID:37423548   PMID:37506885   PMID:37586214   PMID:37640791   PMID:37688756   PMID:37689310   PMID:37815624   PMID:38270169  
PMID:38334954   PMID:38341427   PMID:38697112   PMID:38725843   PMID:38758230   PMID:38922788   PMID:39134516   PMID:39147351   PMID:39238192   PMID:39358380  


Genomics

Comparative Map Data
HMGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38634,236,873 - 34,246,231 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl634,236,873 - 34,246,231 (+)EnsemblGRCh38hg38GRCh38
GRCh37634,204,650 - 34,214,008 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36634,312,628 - 34,321,986 (+)NCBINCBI36Build 36hg18NCBI36
Build 34634,314,545 - 34,321,986NCBI
Celera635,758,945 - 35,768,381 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,927,318 - 33,936,673 (+)NCBIHuRef
CHM1_1634,207,231 - 34,216,597 (+)NCBICHM1_1
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBIT2T-CHM13v2.0
Hmga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,774,798 - 27,782,649 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,775,471 - 27,782,648 (+)EnsemblGRCm39 Ensembl
GRCm381727,556,574 - 27,563,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,556,497 - 27,563,674 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,762,794 - 120,764,419 (+)EnsemblGRCm38mm10GRCm38
MGSCv371727,693,519 - 27,700,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361727,284,171 - 27,291,260 (+)NCBIMGSCv36mm8
Celera1728,108,639 - 28,115,776 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.5NCBI
Hmga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8205,612,902 - 5,620,596 (+)NCBIGRCr8
mRatBN7.2205,611,088 - 5,618,755 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,611,694 - 5,618,752 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx206,327,117 - 6,330,067 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,688,869 - 5,691,819 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,169,005 - 6,171,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,132,501 - 7,140,155 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,136,007 - 7,138,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,334,866 - 9,342,510 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,769,052 - 5,772,269 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,769,278 - 5,772,496 (+)NCBI
Celera207,177,471 - 7,180,533 (+)NCBICelera
Cytogenetic Map20p12NCBI
Hmga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,478,414 - 2,486,809 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,478,414 - 2,486,809 (+)NCBIChiLan1.0ChiLan1.0
HMGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2548,712,783 - 48,722,294 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1644,580,061 - 44,589,567 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0633,807,171 - 33,816,603 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,914,923 - 34,920,482 (+)NCBIpanpan1.1PanPan1.1panPan2
HMGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,528,818 - 3,538,533 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,533,102 - 3,538,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,544,725 - 3,554,094 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,865,251 - 3,874,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,865,303 - 3,888,352 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,527,697 - 3,537,024 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,609,068 - 3,618,412 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,707,513 - 3,716,880 (+)NCBIUU_Cfam_GSD_1.0
Hmga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494639,156,880 - 39,164,376 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647624,795,877 - 24,801,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647624,795,854 - 24,803,138 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl730,320,410 - 30,329,408 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1730,320,090 - 30,329,413 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,981,570 - 34,990,089 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q11NCBI
HMGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11737,848,110 - 37,857,835 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1737,849,412 - 37,853,880 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604434,150,889 - 34,160,977 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475422,892,226 - 22,898,807 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475422,888,052 - 22,900,685 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HMGA1
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
HMGA1, 1-BP INS, IVS5, -13 insertion Diabetes mellitus type 2, susceptibility to [RCV000023030] Chr6:6p21 risk factor
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p21.31(chr6:34202573-34206718)x0 copy number loss not provided [RCV000745623] Chr6:34202573..34206718 [GRCh37]
Chr6:6p21.31
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_145899.3(HMGA1):c.57C>T (p.Asp19=) single nucleotide variant not provided [RCV000965345] Chr6:34240837 [GRCh38]
Chr6:34208614 [GRCh37]
Chr6:6p21.31
benign
NM_145899.3(HMGA1):c.136-14dup duplication Diabetes mellitus type 2, susceptibility to [RCV002284223]|not provided [RCV001690423] Chr6:34242693..34242694 [GRCh38]
Chr6:34210470..34210471 [GRCh37]
Chr6:6p21.31
risk factor|benign
NC_000006.11:g.(?_30695893)_(36953949_?)dup duplication Proteasome-associated autoinflammatory syndrome 1 [RCV003113679] Chr6:30695893..36953949 [GRCh37]
Chr6:6p21.33-21.2
uncertain significance
NM_145899.3(HMGA1):c.29A>G (p.Gln10Arg) single nucleotide variant not specified [RCV004115269] Chr6:34240809 [GRCh38]
Chr6:34208586 [GRCh37]
Chr6:6p21.31
uncertain significance
NM_145899.3(HMGA1):c.11C>T (p.Ser4Leu) single nucleotide variant not specified [RCV004212326] Chr6:34240791 [GRCh38]
Chr6:34208568 [GRCh37]
Chr6:6p21.31
uncertain significance
NC_000006.11:g.(?_32148920)_(36953949_?)dup duplication not provided [RCV003154914] Chr6:32148920..36953949 [GRCh37]
Chr6:6p21.32-21.2
uncertain significance
NM_145899.3(HMGA1):c.102G>A (p.Pro34=) single nucleotide variant not specified [RCV004399650] Chr6:34240882 [GRCh38]
Chr6:34208659 [GRCh37]
Chr6:6p21.31
likely benign
NM_145899.3(HMGA1):c.296C>T (p.Ser99Leu) single nucleotide variant not specified [RCV004933444] Chr6:34244856 [GRCh38]
Chr6:34212633 [GRCh37]
Chr6:6p21.31
uncertain significance
NM_145899.3(HMGA1):c.95A>G (p.Gln32Arg) single nucleotide variant not specified [RCV004933445] Chr6:34240875 [GRCh38]
Chr6:34208652 [GRCh37]
Chr6:6p21.31
uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR26A1hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22245693
MIR26A1hsa-miR-26a-5pOncomiRDBexternal_infoNANA22245693
MIR124-2hsa-miR-124-3pMirtarbaseexternal_infoFlow//Immunohistochemistry//Immunoprecipitaion//LuFunctional MTI22249617
MIR26A2hsa-miR-26a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22245693
MIR16-1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19250063
MIR26A2hsa-miR-26a-5pOncomiRDBexternal_infoNANA22245693
MIRLET7A2hsa-let-7a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19179606
MIRLET7A1hsa-let-7a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI19179606
MIR296hsa-miR-296-5pOncomiRDBexternal_infoNANA21138859
MIR16-2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19250063

Predicted Target Of
Summary Value
Count of predictions:5251
Count of miRNA genes:682
Interacting mature miRNAs:770
Transcripts:ENST00000311487, ENST00000347617, ENST00000374116, ENST00000395004, ENST00000401473, ENST00000447654, ENST00000478214
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597189144GWAS1285218_Hforced expiratory volume QTL GWAS1285218 (human)1e-25forced expiratory volumeforced expiratory volume (CMO:0000254)63424021334240214Human
597479257GWAS1575331_Hplatelet crit QTL GWAS1575331 (human)4e-11platelet quantity (VT:0003179)plateletcrit (CMO:0001349)63423707734237078Human
597294044GWAS1390118_Htype 2 diabetes mellitus QTL GWAS1390118 (human)1e-12type 2 diabetes mellitus63423749534237496Human
597292190GWAS1388264_Hsize QTL GWAS1388264 (human)7e-85size63423768834237689Human
597316498GWAS1412572_HBMI-adjusted waist circumference QTL GWAS1412572 (human)6e-68body size trait (VT:0100005)63423768834237689Human
597333650GWAS1429724_Hgluteofemoral adipose tissue measurement QTL GWAS1429724 (human)4e-08gluteofemoral adipose tissue measurement63424356434243565Human
597134109GWAS1230183_Hbody weight QTL GWAS1230183 (human)6e-23body mass (VT:0001259)body weight (CMO:0000012)63423804534238046Human
596978266GWAS1097785_Hbody height QTL GWAS1097785 (human)6e-12body height63423687334236874Human
596968454GWAS1087973_Hbody height QTL GWAS1087973 (human)3e-36body height63423790234237903Human
596953292GWAS1072811_Hsize QTL GWAS1072811 (human)7e-85size63423768834237689Human
597218500GWAS1314574_Hbody weight QTL GWAS1314574 (human)2e-14body mass (VT:0001259)body weight (CMO:0000012)63423768834237689Human
597228740GWAS1324814_Happendicular lean mass QTL GWAS1324814 (human)9e-77appendicular lean mass63423768834237689Human
1358857MULTSCL19_HMultiple sclerosis susceptibility QTL 19 (human)Multiple sclerosis susceptibility61958431145584311Human
597177285GWAS1273359_Hbody mass index QTL GWAS1273359 (human)5e-12body mass indexbody mass index (BMI) (CMO:0000105)63424099634240997Human
407056737GWAS705713_Hheel bone mineral density QTL GWAS705713 (human)1e-08heel bone mineral densitybone mineral density (CMO:0001226)63423804634238047Human
1358839MULTSCL5_HMultiple sclerosis susceptibility QTL 5 (human)Multiple sclerosis susceptibility61958431145584311Human
597033715GWAS1129789_Hsystolic blood pressure QTL GWAS1129789 (human)1e-08systolic blood pressuresystolic blood pressure (CMO:0000004)63424041334240414Human
597068414GWAS1164488_HBMI-adjusted waist circumference QTL GWAS1164488 (human)3e-12body size trait (VT:0100005)63423969834239701Human
596963645GWAS1083164_Htype 2 diabetes mellitus QTL GWAS1083164 (human)1e-12type 2 diabetes mellitus63423749534237496Human
596979196GWAS1098715_Hbody height QTL GWAS1098715 (human)6e-52body height63423760734237608Human
597170993GWAS1267067_HBMI-adjusted hip circumference QTL GWAS1267067 (human)6e-16BMI-adjusted hip circumferencehip circumference (CMO:0000014)63423768834237689Human
596976638GWAS1096157_Hbody height QTL GWAS1096157 (human)2e-60body height63423804634238047Human
1298431RA11_HRheumatoid arthritis QTL 11 (human)0.0000024Joint/bone inflammationrheumatoid arthritis61991188340191709Human
597185205GWAS1281279_Hvital capacity QTL GWAS1281279 (human)4e-25vital capacity63424021334240214Human
597254454GWAS1350528_HBMI-adjusted waist circumference QTL GWAS1350528 (human)5e-25body size trait (VT:0100005)63423768834237689Human
596978916GWAS1098435_Hbody height QTL GWAS1098435 (human)1e-17body height63423707734237078Human
597581295GWAS1638155_Htype 2 diabetes mellitus QTL GWAS1638155 (human)5e-39type 2 diabetes mellitus63424150434241505Human
596977440GWAS1096959_Hbody height QTL GWAS1096959 (human)2e-18body height63423701234237013Human
597337135GWAS1433209_Hsexual dimorphism measurement QTL GWAS1433209 (human)3e-28sexual dimorphism measurement63423768834237689Human
597329314GWAS1425388_Hsexual dimorphism measurement QTL GWAS1425388 (human)4e-48sexual dimorphism measurement63423768834237689Human
597221664GWAS1317738_Hplatelet count QTL GWAS1317738 (human)1e-10platelet quantity (VT:0003179)platelet count (CMO:0000029)63423804534238046Human
597045678GWAS1141752_Hhemoglobin measurement QTL GWAS1141752 (human)3e-10hemoglobin measurementhemoglobin measurement (CMO:0000508)63424346134243462Human
597268960GWAS1365034_HBMI-adjusted hip circumference QTL GWAS1365034 (human)1e-12BMI-adjusted hip circumferencehip circumference (CMO:0000014)63423768834237689Human
597380193GWAS1476267_Hlymphocyte count QTL GWAS1476267 (human)2e-10lymphocyte countblood lymphocyte count (CMO:0000031)63423707734237078Human
407012344GWAS661320_Hbody mass index QTL GWAS661320 (human)7e-10body mass indexbody mass index (BMI) (CMO:0000105)63424346134243462Human
597055789GWAS1151863_HBMI-adjusted waist circumference QTL GWAS1151863 (human)2e-08body size trait (VT:0100005)63423804634238047Human

Markers in Region
MARC_1047-1048:991929773:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37634,213,666 - 34,213,972UniSTSGRCh37
Build 36634,321,644 - 34,321,950RGDNCBI36
Celera635,768,039 - 35,768,345RGD
HuRef633,936,331 - 33,936,637UniSTS
RH46847  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p23.3UniSTS
G11813  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p23.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001319082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF176039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK096863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL354740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071864 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE269847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX785762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA049639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA467015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA574958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA936387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB029421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC338100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC374225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI519558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF731633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L17131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z36875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000311487   ⟹   ENSP00000308227
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,236,873 - 34,246,231 (+)Ensembl
Ensembl Acc Id: ENST00000347617   ⟹   ENSP00000288245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,236,873 - 34,246,231 (+)Ensembl
Ensembl Acc Id: ENST00000374116   ⟹   ENSP00000363230
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,238,791 - 34,246,230 (+)Ensembl
Ensembl Acc Id: ENST00000401473   ⟹   ENSP00000385693
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,236,873 - 34,246,231 (+)Ensembl
Ensembl Acc Id: ENST00000447654   ⟹   ENSP00000399888
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,236,873 - 34,246,230 (+)Ensembl
Ensembl Acc Id: ENST00000478214
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,237,204 - 34,245,151 (+)Ensembl
Ensembl Acc Id: ENST00000674029   ⟹   ENSP00000501006
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,236,873 - 34,240,870 (+)Ensembl
Ensembl Acc Id: ENST00000703808   ⟹   ENSP00000515486
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,236,920 - 34,244,979 (+)Ensembl
Ensembl Acc Id: ENST00000703809   ⟹   ENSP00000515487
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl634,240,737 - 34,246,230 (+)Ensembl
RefSeq Acc Id: NM_001319077   ⟹   NP_001306006
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319078   ⟹   NP_001306007
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319079   ⟹   NP_001306008
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319080   ⟹   NP_001306009
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319081   ⟹   NP_001306010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001319082   ⟹   NP_001306011
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002131   ⟹   NP_002122
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
GRCh37634,204,577 - 34,214,008 (+)ENTREZGENE
Build 36634,312,628 - 34,321,986 (+)NCBI Archive
HuRef633,927,318 - 33,936,673 (+)ENTREZGENE
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145899   ⟹   NP_665906
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
GRCh37634,204,577 - 34,214,008 (+)ENTREZGENE
Build 36634,312,628 - 34,321,986 (+)NCBI Archive
HuRef633,927,318 - 33,936,673 (+)ENTREZGENE
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145901   ⟹   NP_665908
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
GRCh37634,204,577 - 34,214,008 (+)ENTREZGENE
Build 36634,312,907 - 34,321,986 (+)NCBI Archive
HuRef633,927,318 - 33,936,673 (+)ENTREZGENE
CHM1_1634,207,304 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145902   ⟹   NP_665909
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
GRCh37634,204,577 - 34,214,008 (+)ENTREZGENE
Build 36634,312,907 - 34,321,986 (+)NCBI Archive
HuRef633,927,318 - 33,936,673 (+)ENTREZGENE
CHM1_1634,207,304 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145903   ⟹   NP_665910
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,873 - 34,246,231 (+)NCBI
GRCh37634,204,577 - 34,214,008 (+)ENTREZGENE
Build 36634,312,628 - 34,321,986 (+)NCBI Archive
HuRef633,927,318 - 33,936,673 (+)ENTREZGENE
CHM1_1634,207,231 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,060,576 - 34,069,936 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145905   ⟹   NP_665912
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,238,791 - 34,246,231 (+)NCBI
GRCh37634,204,577 - 34,214,008 (+)ENTREZGENE
Build 36634,314,546 - 34,321,986 (+)NCBI Archive
HuRef633,927,318 - 33,936,673 (+)ENTREZGENE
CHM1_1634,209,156 - 34,216,597 (+)NCBI
T2T-CHM13v2.0634,062,496 - 34,069,936 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001306006 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306007 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306008 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306009 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306010 (Get FASTA)   NCBI Sequence Viewer  
  NP_001306011 (Get FASTA)   NCBI Sequence Viewer  
  NP_002122 (Get FASTA)   NCBI Sequence Viewer  
  NP_665906 (Get FASTA)   NCBI Sequence Viewer  
  NP_665908 (Get FASTA)   NCBI Sequence Viewer  
  NP_665909 (Get FASTA)   NCBI Sequence Viewer  
  NP_665910 (Get FASTA)   NCBI Sequence Viewer  
  NP_665912 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA35998 (Get FASTA)   NCBI Sequence Viewer  
  AAA88072 (Get FASTA)   NCBI Sequence Viewer  
  AAA88073 (Get FASTA)   NCBI Sequence Viewer  
  AAA88074 (Get FASTA)   NCBI Sequence Viewer  
  AAA88075 (Get FASTA)   NCBI Sequence Viewer  
  AAA88076 (Get FASTA)   NCBI Sequence Viewer  
  AAB00145 (Get FASTA)   NCBI Sequence Viewer  
  AAD53889 (Get FASTA)   NCBI Sequence Viewer  
  AAH04924 (Get FASTA)   NCBI Sequence Viewer  
  AAH08832 (Get FASTA)   NCBI Sequence Viewer  
  AAH15789 (Get FASTA)   NCBI Sequence Viewer  
  AAH63434 (Get FASTA)   NCBI Sequence Viewer  
  AAH67083 (Get FASTA)   NCBI Sequence Viewer  
  AAH71863 (Get FASTA)   NCBI Sequence Viewer  
  AAH71864 (Get FASTA)   NCBI Sequence Viewer  
  AAP35420 (Get FASTA)   NCBI Sequence Viewer  
  BAG62962 (Get FASTA)   NCBI Sequence Viewer  
  CAA33080 (Get FASTA)   NCBI Sequence Viewer  
  CAA33081 (Get FASTA)   NCBI Sequence Viewer  
  CBX54360 (Get FASTA)   NCBI Sequence Viewer  
  EAX03762 (Get FASTA)   NCBI Sequence Viewer  
  EAX03763 (Get FASTA)   NCBI Sequence Viewer  
  EAX03764 (Get FASTA)   NCBI Sequence Viewer  
  EAX03765 (Get FASTA)   NCBI Sequence Viewer  
  EAX03766 (Get FASTA)   NCBI Sequence Viewer  
  EAX03767 (Get FASTA)   NCBI Sequence Viewer  
  EAX03768 (Get FASTA)   NCBI Sequence Viewer  
  EAX03769 (Get FASTA)   NCBI Sequence Viewer  
  EAX03770 (Get FASTA)   NCBI Sequence Viewer  
  EAX03771 (Get FASTA)   NCBI Sequence Viewer  
  EAX03772 (Get FASTA)   NCBI Sequence Viewer  
  EAX03773 (Get FASTA)   NCBI Sequence Viewer  
  EAX03774 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000288245
  ENSP00000288245.9
  ENSP00000308227
  ENSP00000308227.4
  ENSP00000363230
  ENSP00000363230.3
  ENSP00000385693
  ENSP00000385693.2
  ENSP00000399888
  ENSP00000399888.1
  ENSP00000501006.1
  ENSP00000515486
  ENSP00000515486.1
  ENSP00000515487.1
GenBank Protein P17096 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_665906   ⟸   NM_145899
- Peptide Label: isoform a
- UniProtKB: Q5T6U9 (UniProtKB/Swiss-Prot),   P10910 (UniProtKB/Swiss-Prot),   Q9UKB0 (UniProtKB/Swiss-Prot),   P17096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_002122   ⟸   NM_002131
- Peptide Label: isoform b
- UniProtKB: Q5T6U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_665910   ⟸   NM_145903
- Peptide Label: isoform b
- UniProtKB: Q5T6U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_665908   ⟸   NM_145901
- Peptide Label: isoform a
- UniProtKB: Q5T6U9 (UniProtKB/Swiss-Prot),   P10910 (UniProtKB/Swiss-Prot),   Q9UKB0 (UniProtKB/Swiss-Prot),   P17096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_665909   ⟸   NM_145902
- Peptide Label: isoform b
- UniProtKB: Q5T6U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_665912   ⟸   NM_145905
- Peptide Label: isoform b
- UniProtKB: Q5T6U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306011   ⟸   NM_001319082
- Peptide Label: isoform a
- UniProtKB: Q5T6U9 (UniProtKB/Swiss-Prot),   P10910 (UniProtKB/Swiss-Prot),   Q9UKB0 (UniProtKB/Swiss-Prot),   P17096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306009   ⟸   NM_001319080
- Peptide Label: isoform c
- UniProtKB: A0A994J434 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306007   ⟸   NM_001319078
- Peptide Label: isoform a
- UniProtKB: Q5T6U9 (UniProtKB/Swiss-Prot),   P10910 (UniProtKB/Swiss-Prot),   Q9UKB0 (UniProtKB/Swiss-Prot),   P17096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306008   ⟸   NM_001319079
- Peptide Label: isoform a
- UniProtKB: Q5T6U9 (UniProtKB/Swiss-Prot),   P10910 (UniProtKB/Swiss-Prot),   Q9UKB0 (UniProtKB/Swiss-Prot),   P17096 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001306006   ⟸   NM_001319077
- Peptide Label: isoform b
- UniProtKB: Q5T6U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001306010   ⟸   NM_001319081
- Peptide Label: isoform a
- UniProtKB: Q5T6U9 (UniProtKB/Swiss-Prot),   P10910 (UniProtKB/Swiss-Prot),   Q9UKB0 (UniProtKB/Swiss-Prot),   P17096 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000501006   ⟸   ENST00000674029
Ensembl Acc Id: ENSP00000288245   ⟸   ENST00000347617
Ensembl Acc Id: ENSP00000363230   ⟸   ENST00000374116
Ensembl Acc Id: ENSP00000385693   ⟸   ENST00000401473
Ensembl Acc Id: ENSP00000308227   ⟸   ENST00000311487
Ensembl Acc Id: ENSP00000399888   ⟸   ENST00000447654
Ensembl Acc Id: ENSP00000515486   ⟸   ENST00000703808
Ensembl Acc Id: ENSP00000515487   ⟸   ENST00000703809

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17096-F1-model_v2 AlphaFold P17096 1-107 view protein structure

Promoters
RGD ID:6872912
Promoter ID:EPDNEW_H9621
Type:initiation region
Name:HMGA1_1
Description:high mobility group AT-hook 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9622  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,236,905 - 34,236,965EPDNEW
RGD ID:6872914
Promoter ID:EPDNEW_H9622
Type:initiation region
Name:HMGA1_2
Description:high mobility group AT-hook 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9621  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,237,156 - 34,237,216EPDNEW
RGD ID:6813038
Promoter ID:HG_ACW:68061
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:HMGA1.VDAPR07,   LOC729916.AAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36634,311,366 - 34,311,866 (-)MPROMDB
RGD ID:6804063
Promoter ID:HG_KWN:53276
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000327014,   ENST00000347617,   ENST00000357318,   ENST00000374117,   ENST00000395004,   UC003OIT.1,   UC003OIU.1,   UC003OIV.1,   UC003OIX.1,   UC003OIY.1,   UC003OIZ.1,   UC003OJA.1,   UC010JVL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36634,311,631 - 34,312,547 (+)MPROMDB
RGD ID:6804351
Promoter ID:HG_KWN:53277
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000374116
Position:
Human AssemblyChrPosition (strand)Source
Build 36634,313,546 - 34,314,632 (+)MPROMDB
RGD ID:6804064
Promoter ID:HG_KWN:53278
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000360434,   UC003OJD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36634,315,531 - 34,316,932 (+)MPROMDB
RGD ID:6815562
Promoter ID:HG_MRA:13660
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AK130027
Position:
Human AssemblyChrPosition (strand)Source
Build 36634,317,341 - 34,317,841 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5010 AgrOrtholog
COSMIC HMGA1 COSMIC
Ensembl Genes ENSG00000137309 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000311487 ENTREZGENE
  ENST00000311487.9 UniProtKB/Swiss-Prot
  ENST00000347617 ENTREZGENE
  ENST00000347617.10 UniProtKB/Swiss-Prot
  ENST00000374116 ENTREZGENE
  ENST00000374116.3 UniProtKB/Swiss-Prot
  ENST00000401473 ENTREZGENE
  ENST00000401473.7 UniProtKB/Swiss-Prot
  ENST00000447654 ENTREZGENE
  ENST00000447654.5 UniProtKB/Swiss-Prot
  ENST00000674029.1 UniProtKB/TrEMBL
  ENST00000703808 ENTREZGENE
  ENST00000703808.1 UniProtKB/TrEMBL
  ENST00000703809.1 UniProtKB/TrEMBL
GTEx ENSG00000137309 GTEx
HGNC ID HGNC:5010 ENTREZGENE
Human Proteome Map HMGA1 Human Proteome Map
InterPro AT_hook_DNA-bd_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGI/Y_DNA-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3159 UniProtKB/Swiss-Prot
NCBI Gene 3159 ENTREZGENE
OMIM 600701 OMIM
PANTHER HIGH MOBILITY GROUP PROTEIN HMG-I/HMG-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIGH MOBILITY GROUP PROTEINS HMG-A AND C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AT_hook UniProtKB/TrEMBL
PharmGKB PA35094 PharmGKB
PRINTS ATHOOK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIGHMOBLTYIY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HMGI_Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AT_hook UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A669KAX1_HUMAN UniProtKB/TrEMBL
  A0A994J434 ENTREZGENE, UniProtKB/TrEMBL
  A0A994J705_HUMAN UniProtKB/TrEMBL
  HMGA1_HUMAN UniProtKB/Swiss-Prot
  P10910 ENTREZGENE
  P17096 ENTREZGENE
  Q5T6U8 ENTREZGENE, UniProtKB/TrEMBL
  Q5T6U9 ENTREZGENE
  Q6IPL9_HUMAN UniProtKB/TrEMBL
  Q9UKB0 ENTREZGENE
UniProt Secondary P10910 UniProtKB/Swiss-Prot
  Q5T6U9 UniProtKB/Swiss-Prot
  Q9UKB0 UniProtKB/Swiss-Prot