CBL (Cbl proto-oncogene) - Rat Genome Database

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Gene: CBL (Cbl proto-oncogene) Homo sapiens
Symbol: CBL
Name: Cbl proto-oncogene
RGD ID: 1345184
HGNC Page HGNC:1541
Description: Enables SH3 domain binding activity and ephrin receptor binding activity. Involved in several processes, including positive regulation of receptor-mediated endocytosis; regulation of signal transduction; and ubiquitin-dependent protein catabolic process. Located in several cellular components, including Golgi apparatus; cilium; and cytosol. Implicated in acute myeloid leukemia; congestive heart failure; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Biomarker of colorectal cancer; congestive heart failure; hepatocellular carcinoma; multiple myeloma; and osteosarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C-CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; signal transduction protein CBL
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3811119,206,339 - 119,308,149 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11119,206,298 - 119,313,926 (+)EnsemblGRCh38hg38GRCh38
GRCh3711119,077,049 - 119,178,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611118,582,200 - 118,684,069 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411118,582,199 - 118,684,068NCBI
Celera11116,236,024 - 116,339,059 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11115,017,373 - 115,119,562 (+)NCBIHuRef
CHM1_111118,963,252 - 119,065,411 (+)NCBICHM1_1
T2T-CHM13v2.011119,226,712 - 119,328,785 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)