CBL (Cbl proto-oncogene) - Rat Genome Database

Name: CBL
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: CBL (Cbl proto-oncogene) Homo sapiens

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Symbol:

CBL

Name:

Cbl proto-oncogene

RGD ID:

1345184

HGNC Page

HGNC:1541

Description:

Enables SH3 domain binding activity and ephrin receptor binding activity. Involved in several processes, including positive regulation of receptor-mediated endocytosis; regulation of signal transduction; and ubiquitin-dependent protein catabolic process. Located in several cellular components, including Golgi apparatus; cilium; and cytosol. Implicated in acute myeloid leukemia; congestive heart failure; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Biomarker of colorectal cancer; congestive heart failure; hepatocellular carcinoma; multiple myeloma; and osteosarcoma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

C-CBL; Cas-Br-M (murine) ecotropic retroviral transforming sequence; casitas B-lineage lymphoma proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; signal transduction protein CBL

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Cbl (Casitas B-lineage lymphoma)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Cbl (Cbl proto-oncogene)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Cbl (Cbl proto-oncogene)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	CBL (Cbl proto-oncogene)	NCBI	Ortholog
Canis lupus familiaris (dog):	CBL (Cbl proto-oncogene)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cbl (Cbl proto-oncogene)	NCBI	Ortholog
Sus scrofa (pig):	CBL (Cbl proto-oncogene)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	CBL (Cbl proto-oncogene)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Cbl (Cbl proto-oncogene)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Cblb (Casitas B-lineage lymphoma b)	HGNC	OrthoMCL
Alliance orthologs ³
Mus musculus (house mouse):	Cbl (Casitas B-lineage lymphoma)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Cbl (Cbl proto-oncogene)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cbl (Cbl proto-oncogene, E3 ubiquitin protein ligase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Cbl	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	sli-1	Alliance	DIOPT (Hieranoid\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	119,206,339 - 119,308,149 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	119,206,298 - 119,313,926 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	119,077,049 - 119,178,859 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	118,582,200 - 118,684,069 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	118,582,199 - 118,684,068	NCBI
Celera	11	116,236,024 - 116,339,059 (+)	NCBI		Celera
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	115,017,373 - 115,119,562 (+)	NCBI		HuRef
CHM1_1	11	118,963,252 - 119,065,411 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	119,226,712 - 119,328,785 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Imported Human Phenotype Annotations - HPO

Imported Human Phenotype Annotations - ClinVar

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