Dusp5<sup>em1Mcwi</sup> (dual specificity phosphatase 5; ZFN induced mutant1, Mcwi) - Rat Genome Database

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Gene: Dusp5em1Mcwi (dual specificity phosphatase 5; ZFN induced mutant1, Mcwi) Rattus norvegicus
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Symbol: Dusp5em1Mcwi
Name: dual specificity phosphatase 5; ZFN induced mutant1, Mcwi
RGD ID: 13451539
Description: This mutation was induced by injecting ZFNs targeting the following sequence CAGGGCAGCCGC- CACtggcaGAAGCTGCGGGAGGA in exon 1 of the rat Dusp5 gene into FHH-Chr 1BN/Mcwi embryos. The resulting mutation is a 14 bp deletion and a 3 bp insertion between nucleotides 449¿464 in Dusp5 mRNA that creates a frame shift mutation which is predicted to introduce a premature stop codon at amino acid (AA) 121.
ASSOCIATED WITH decreased vasoconstriction
Type: allele  of Dusp5  
Previously known as: Dusp5^[em1Mcwi]; Dusp5em1Mcwi
Is Marker For: Strains:   FHH-Chr 1BN-Dusp5em1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. Fan F, etal., PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.

Genomics


Related Rat Strains
The following Strains have been annotated to Dusp5em1Mcwi
FHH-Chr 1BN-Dusp5em1Mcwi    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information