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Gene: NELFE (negative elongation factor complex member E) Homo sapiens

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Symbol:

NELFE

Name:

negative elongation factor complex member E

RGD ID:

1344973

HGNC Page

HGNC:13974

Description:

Enables chromatin binding activity and mRNA binding activity. Involved in negative regulation of transcription elongation by RNA polymerase II. Located in nuclear body and plasma membrane. Part of NELF complex. Is active in chromatin and nucleus.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

D6S45; major histocompatibility complex gene RD; negative elongation factor E; negative elongation factor polypeptide E; NELF-E; nuclear protein; RD; RD RNA binding protein; RD RNA-binding protein; RDBP; RDP; RNA-binding protein RD

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,952,087 - 31,959,038 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,919,864 - 31,926,748 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,027,843 - 32,034,843 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,027,843 - 32,034,747	NCBI
Celera	6	33,519,627 - 33,526,530 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,706,833 - 31,713,834 (-)	NCBI		HuRef
CHM1_1	6	31,921,945 - 31,928,945 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteasome-associated autoinflammatory syndrome 1 (IAGP)

trichohepatoenteric syndrome (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (EXP)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (ISO)

acrolein (EXP)

aflatoxin B1 (ISO)

alpha-pinene (EXP)

aristolochic acid A (EXP)

arsane (EXP)

arsenic atom (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

caffeine (EXP)

CGP 52608 (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

coumarin (EXP)

cyclosporin A (EXP)

dibutyl phthalate (ISO)

dioxygen (ISO)

doxorubicin (EXP)

endosulfan (ISO)

enzyme inhibitor (EXP)

folic acid (ISO)

FR900359 (EXP)

genistein (EXP)

hexadecanoic acid (EXP)

hypochlorous acid (ISO)

isobutanol (EXP)

ivermectin (EXP)

lead(0) (EXP)

methyl methanesulfonate (EXP)

ozone (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

quercetin (EXP)

SB 431542 (EXP)

T-2 toxin (EXP)

tamoxifen (ISO)

temozolomide (EXP)

tetrahydropalmatine (EXP)

trichloroethene (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (EXP)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (IEA,ISO)

negative regulation of transcription elongation by RNA polymerase II (IBA,IDA,IEA,ISO)

positive regulation of ERK1 and ERK2 cascade (IEA,ISO)

positive regulation of protein modification process (ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

Cellular Component

chromatin (IDA,IEA)

chromosome (IEA)

NELF complex (IBA,IDA,IEA,IPI)

nuclear body (IDA)

nucleoplasm (IDA,TAS)

nucleus (IDA,IEA,NAS)

plasma membrane (IDA)

Molecular Function

chromatin binding (IDA,IEA,ISO)

mRNA binding (IDA)

protein binding (IPI)

RNA binding (HDA,IDA,IEA,NAS)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription elongation pathway (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Control of transcriptional elongation.	Kwak H and Lis JT, Annu Rev Genet. 2013;47:483-508. doi: 10.1146/annurev-genet-110711-155440. Epub 2013 Sep 11.
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2119325	PMID:2612324	PMID:3353717	PMID:8373374	PMID:9264031	PMID:9776767	PMID:9799600	PMID:10072631	PMID:10199401	PMID:11112772	PMID:11940650	PMID:12477932
PMID:12612062	PMID:12676794	PMID:14574404	PMID:14656967	PMID:14667819	PMID:14701750	PMID:15302935	PMID:15342491	PMID:15489334	PMID:15561718	PMID:16169070	PMID:16838299
PMID:16880520	PMID:16898873	PMID:16964243	PMID:17081983	PMID:17353931	PMID:17442680	PMID:17499042	PMID:17643375	PMID:18029348	PMID:18303858	PMID:18562274	PMID:19115949
PMID:19143814	PMID:19245807	PMID:19556007	PMID:19575011	PMID:19615732	PMID:19851445	PMID:20097260	PMID:20211142	PMID:20305087	PMID:20471948	PMID:21873635	PMID:22412018
PMID:22614758	PMID:22658674	PMID:22740393	PMID:23577725	PMID:23602568	PMID:24158816	PMID:24453987	PMID:24636995	PMID:24981860	PMID:25416956	PMID:25452129	PMID:25921289
PMID:26186194	PMID:26344197	PMID:26354767	PMID:26496610	PMID:26504077	PMID:27256882	PMID:27282391	PMID:28514442	PMID:28515276	PMID:29101316	PMID:29604130	PMID:29802200
PMID:30135580	PMID:30196744	PMID:30554943	PMID:30585729	PMID:30833661	PMID:30884312	PMID:30890647	PMID:31048545	PMID:31091453	PMID:31353912	PMID:31638184	PMID:32296183
PMID:32416067	PMID:32538781	PMID:32694731	PMID:32971831	PMID:33001583	PMID:33248388	PMID:33526068	PMID:33545068	PMID:33640491	PMID:33742100	PMID:33916271	PMID:33961781
PMID:34079125	PMID:34108663	PMID:34189442	PMID:34428256	PMID:34551306	PMID:34597346	PMID:34795231	PMID:35041643	PMID:35256949	PMID:35271311	PMID:35439318	PMID:35545047
PMID:35831314	PMID:35944360	PMID:36215168	PMID:36232890	PMID:36244648	PMID:36273042	PMID:36373674	PMID:36424410	PMID:36931259	PMID:37117180	PMID:37827155	PMID:38280479

Genomics

Comparative Map Data

NELFE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,952,087 - 31,959,038 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,919,864 - 31,926,748 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,027,843 - 32,034,843 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,027,843 - 32,034,747	NCBI
Celera	6	33,519,627 - 33,526,530 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,706,833 - 31,713,834 (-)	NCBI		HuRef
CHM1_1	6	31,921,945 - 31,928,945 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI		T2T-CHM13v2.0

Nelfe
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,069,367 - 35,075,348 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,069,367 - 35,075,348 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,850,391 - 34,856,372 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,850,391 - 34,856,372 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,987,336 - 34,993,317 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,458,975 - 34,464,214 (+)	NCBI		MGSCv36	mm8
Celera	17	37,945,699 - 37,951,680 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.4	NCBI

Nelfe
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,981,259 - 3,987,016 (-)	NCBI		GRCr8
mRatBN7.2	20	3,976,512 - 3,982,389 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,976,518 - 3,982,355 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,676,633 - 4,682,383 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,038,381 - 4,044,131 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,575,547 - 4,581,290 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,530,328 - 4,536,085 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,530,342 - 4,536,209 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,610,127 - 6,615,884 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,077,925 - 4,081,561 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,078,021 - 4,081,787 (-)	NCBI
Celera	20	4,048,306 - 4,054,061 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

Nelfe
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	466,690 - 473,084 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	467,018 - 473,084 (-)	NCBI	ChiLan1.0	ChiLan1.0

NELFE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,428,781 - 46,435,590 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,390,268 - 42,397,077 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,612,924 - 31,619,732 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,499,538 - 32,506,382 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,499,540 - 32,506,382 (-)	Ensembl	panpan1.1		panPan2

NELFE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,406,411 - 1,412,387 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,406,271 - 1,412,324 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,541,468 - 1,547,598 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,548,568 - 1,554,700 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,548,568 - 1,554,605 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,405,843 - 1,411,974 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,474,213 - 1,480,345 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,539,542 - 1,546,943 (-)	NCBI		UU_Cfam_GSD_1.0

Nelfe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,965,333 - 35,971,346 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,589,942 - 1,598,182 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,589,942 - 1,596,009 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NELFE
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	24,040,525 - 24,047,025 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	24,040,525 - 24,046,932 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	27,765,281 - 27,771,676 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NELFE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,063,298 - 40,069,714 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,063,755 - 40,198,451 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,868,805 - 31,875,524 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nelfe
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,300,602 - 24,310,671 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,300,012 - 24,310,777 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in NELFE
52 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_002904.5(NELFE):c.1002C>G (p.Pro334=)	single nucleotide variant	Malignant melanoma [RCV000067298]	Chr6:31953772 [GRCh38] Chr6:31921549 [GRCh37] Chr6:32029528 [NCBI36] Chr6:6p21.33	not provided
NM_002904.5(NELFE):c.756C>T (p.Phe252=)	single nucleotide variant	Malignant melanoma [RCV000067299]	Chr6:31954429 [GRCh38] Chr6:31922206 [GRCh37] Chr6:32030185 [NCBI36] Chr6:6p21.33	not provided
NM_002904.5(NELFE):c.624G>A (p.Arg208=)	single nucleotide variant	Malignant melanoma [RCV000067300]	Chr6:31954673 [GRCh38] Chr6:31922450 [GRCh37] Chr6:32030429 [NCBI36] Chr6:6p21.33	not provided
NM_002904.5(NELFE):c.331C>T (p.Gln111Ter)	single nucleotide variant	Malignant melanoma [RCV000067301]	Chr6:31955254 [GRCh38] Chr6:31923031 [GRCh37] Chr6:32031010 [NCBI36] Chr6:6p21.33	not provided
NM_001710.5(CFB):c.1518G>A (p.Lys506=)	single nucleotide variant	Malignant melanoma [RCV000061395]	Chr6:31950297 [GRCh38] Chr6:31918074 [GRCh37] Chr6:32026053 [NCBI36] Chr6:6p21.33	not provided
NM_001710.5(CFB):c.804C>T (p.Ser268=)	single nucleotide variant	Malignant melanoma [RCV000067296]	Chr6:31947988 [GRCh38] Chr6:31915765 [GRCh37] Chr6:32023744 [NCBI36] Chr6:6p21.33	not provided
NM_001710.5(CFB):c.1625-81G>T	single nucleotide variant	Malignant melanoma [RCV000067297]	Chr6:31950538 [GRCh38] Chr6:31918315 [GRCh37] Chr6:32026294 [NCBI36] Chr6:6p21.33	not provided
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3	copy number gain	See cases [RCV000143497]	Chr6:156974..46789291 [GRCh38] Chr6:156974..46757028 [GRCh37] Chr6:101974..46864987 [NCBI36] Chr6:6p25.3-12.3	pathogenic
NM_006929.4(SKIC2):c.-280G>T	single nucleotide variant	Trichohepatoenteric syndrome [RCV000340053]\|not provided [RCV004695925]	Chr6:31958913 [GRCh38] Chr6:31926690 [GRCh37] Chr6:6p21.33	uncertain significance
NM_006929.4(SKIC2):c.-370C>T	single nucleotide variant	Trichohepatoenteric syndrome [RCV000310756]\|not provided [RCV004705404]	Chr6:31958823 [GRCh38] Chr6:31926600 [GRCh37] Chr6:6p21.33	likely benign
NM_006929.4(SKIC2):c.-249C>G	single nucleotide variant	Trichohepatoenteric syndrome [RCV000361885]	Chr6:31958944 [GRCh38] Chr6:31926721 [GRCh37] Chr6:6p21.33	uncertain significance
NM_006929.4(SKIC2):c.-224G>A	single nucleotide variant	Trichohepatoenteric syndrome [RCV000260268]	Chr6:31958969 [GRCh38] Chr6:31926746 [GRCh37] Chr6:6p21.33	uncertain significance
NM_006929.4(SKIC2):c.-269T>C	single nucleotide variant	Trichohepatoenteric syndrome [RCV000304806]	Chr6:31958924 [GRCh38] Chr6:31926701 [GRCh37] Chr6:6p21.33	uncertain significance
NM_006929.4(SKIC2):c.-273G>A	single nucleotide variant	Trichohepatoenteric syndrome [RCV000393240]	Chr6:31958920 [GRCh38] Chr6:31926697 [GRCh37] Chr6:6p21.33	uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
NM_002904.6(NELFE):c.495C>A (p.Ser165Arg)	single nucleotide variant	not specified [RCV004317395]	Chr6:31954802 [GRCh38] Chr6:31922579 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.806A>G (p.Glu269Gly)	single nucleotide variant	not specified [RCV004307521]	Chr6:31954379 [GRCh38] Chr6:31922156 [GRCh37] Chr6:6p21.33	uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3	copy number gain	not provided [RCV000745592]	Chr6:28130359..32108367 [GRCh37] Chr6:6p22.1-21.32	uncertain significance
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367)	copy number gain	not provided [RCV000767714]	Chr6:29455465..81447367 [GRCh37] Chr6:6p22.1-q14.1	pathogenic
NC_000006.11:g.(?_30695893)_(31937492_?)dup	duplication	not provided [RCV003107453]	Chr6:30695893..31937492 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.76-6T>A	single nucleotide variant	not provided [RCV000883047]	Chr6:31957016 [GRCh38] Chr6:31924793 [GRCh37] Chr6:6p21.33	likely benign
NM_002904.6(NELFE):c.610CGGGATCGAGAC[1] (p.205DR[3])	microsatellite	not provided [RCV000949923]	Chr6:31954664..31954675 [GRCh38] Chr6:31922441..31922452 [GRCh37] Chr6:6p21.33	benign
NM_002904.6(NELFE):c.717CCGAGA[1] (p.237DR[2])	microsatellite	not provided [RCV000966193]	Chr6:31954569..31954574 [GRCh38] Chr6:31922346..31922351 [GRCh37] Chr6:6p21.33	benign
NM_002904.6(NELFE):c.660G>A (p.Arg220=)	single nucleotide variant	not provided [RCV000889577]	Chr6:31954637 [GRCh38] Chr6:31922414 [GRCh37] Chr6:6p21.33	likely benign
NM_002904.6(NELFE):c.791T>C (p.Leu264Pro)	single nucleotide variant	not specified [RCV004199413]	Chr6:31954394 [GRCh38] Chr6:31922171 [GRCh37] Chr6:6p21.33	uncertain significance
GRCh37/hg19 6p21.33-21.32(chr6:31916915-32278000)x3	copy number gain	not provided [RCV001005792]	Chr6:31916915..32278000 [GRCh37] Chr6:6p21.33-21.32	uncertain significance
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3	copy number gain	not provided [RCV001005791]	Chr6:31036397..34088832 [GRCh37] Chr6:6p21.33-21.31	likely pathogenic
NC_000006.12:g.31952140T>C	single nucleotide variant	not provided [RCV001609187]	Chr6:31952140 [GRCh38] Chr6:31919917 [GRCh37] Chr6:6p21.33	benign
NC_000006.12:g.31952179T>C	single nucleotide variant	not provided [RCV001673843]	Chr6:31952179 [GRCh38] Chr6:31919956 [GRCh37] Chr6:6p21.33	benign
NC_000006.11:g.(?_30695893)_(36953949_?)dup	duplication	Proteasome-associated autoinflammatory syndrome 1 [RCV003113679]	Chr6:30695893..36953949 [GRCh37] Chr6:6p21.33-21.2	uncertain significance
NM_002904.6(NELFE):c.1075C>T (p.Arg359Trp)	single nucleotide variant	not specified [RCV004090077]	Chr6:31952369 [GRCh38] Chr6:31920146 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.629G>A (p.Arg210Gln)	single nucleotide variant	not specified [RCV004234649]	Chr6:31954668 [GRCh38] Chr6:31922445 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.740G>A (p.Arg247His)	single nucleotide variant	not specified [RCV004130175]	Chr6:31954557 [GRCh38] Chr6:31922334 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.143G>A (p.Arg48His)	single nucleotide variant	not specified [RCV004143131]	Chr6:31956943 [GRCh38] Chr6:31924720 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.646C>T (p.Arg216Trp)	single nucleotide variant	not specified [RCV004114831]	Chr6:31954651 [GRCh38] Chr6:31922428 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.377G>T (p.Arg126Leu)	single nucleotide variant	not specified [RCV004187500]	Chr6:31955086 [GRCh38] Chr6:31922863 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.524G>A (p.Gly175Asp)	single nucleotide variant	not specified [RCV004236180]	Chr6:31954773 [GRCh38] Chr6:31922550 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.563G>A (p.Arg188Gln)	single nucleotide variant	not specified [RCV004242733]	Chr6:31954734 [GRCh38] Chr6:31922511 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.739C>T (p.Arg247Cys)	single nucleotide variant	not specified [RCV004247106]	Chr6:31954558 [GRCh38] Chr6:31922335 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.667G>A (p.Asp223Asn)	single nucleotide variant	not specified [RCV004085841]	Chr6:31954630 [GRCh38] Chr6:31922407 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.893C>T (p.Ala298Val)	single nucleotide variant	not specified [RCV004096752]	Chr6:31954129 [GRCh38] Chr6:31921906 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.517C>T (p.Arg173Cys)	single nucleotide variant	not specified [RCV004221969]	Chr6:31954780 [GRCh38] Chr6:31922557 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.664C>G (p.Arg222Gly)	single nucleotide variant	not specified [RCV004357913]	Chr6:31954633 [GRCh38] Chr6:31922410 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.701G>A (p.Arg234Gln)	single nucleotide variant	not specified [RCV004345212]	Chr6:31954596 [GRCh38] Chr6:31922373 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.805G>A (p.Glu269Lys)	single nucleotide variant	not specified [RCV004361968]	Chr6:31954380 [GRCh38] Chr6:31922157 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.568C>T (p.Arg190Cys)	single nucleotide variant	not specified [RCV004335107]	Chr6:31954729 [GRCh38] Chr6:31922506 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.1123A>G (p.Asn375Asp)	single nucleotide variant	not specified [RCV004362149]	Chr6:31952321 [GRCh38] Chr6:31920098 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.335G>T (p.Arg112Met)	single nucleotide variant	not specified [RCV004483803]	Chr6:31955250 [GRCh38] Chr6:31923027 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.376C>T (p.Arg126Cys)	single nucleotide variant	not specified [RCV004483805]	Chr6:31955087 [GRCh38] Chr6:31922864 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.425G>A (p.Arg142Gln)	single nucleotide variant	not specified [RCV004483810]	Chr6:31954872 [GRCh38] Chr6:31922649 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.491G>A (p.Arg164Gln)	single nucleotide variant	not specified [RCV004483812]	Chr6:31954806 [GRCh38] Chr6:31922583 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.518G>A (p.Arg173His)	single nucleotide variant	not specified [RCV004483822]	Chr6:31954779 [GRCh38] Chr6:31922556 [GRCh37] Chr6:6p21.33	likely benign
NM_002904.6(NELFE):c.605G>A (p.Arg202Gln)	single nucleotide variant	not specified [RCV004483836]	Chr6:31954692 [GRCh38] Chr6:31922469 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.985A>G (p.Ile329Val)	single nucleotide variant	not specified [RCV004483870]	Chr6:31953789 [GRCh38] Chr6:31921566 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.547C>G (p.Pro183Ala)	single nucleotide variant	not specified [RCV004483828]	Chr6:31954750 [GRCh38] Chr6:31922527 [GRCh37] Chr6:6p21.33	uncertain significance
NC_000006.11:g.(?_31620520)_(31937492_?)del	deletion	not provided [RCV004578883]	Chr6:31620520..31937492 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.1007T>A (p.Leu336Gln)	single nucleotide variant	not specified [RCV004654764]	Chr6:31953767 [GRCh38] Chr6:31921544 [GRCh37] Chr6:6p21.33	uncertain significance
NM_002904.6(NELFE):c.1102A>G (p.Ser368Gly)	single nucleotide variant	not specified [RCV004654765]	Chr6:31952342 [GRCh38] Chr6:31920119 [GRCh37] Chr6:6p21.33	uncertain significance

miRNA Target Status

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR628	hsa-miR-628-5p	Mirtarbase	external_info	CLASH	Functional MTI (Weak)	23622248

Predicted Target Of

	Summary Value
Count of predictions:	3338
Count of miRNA genes:	891
Interacting mature miRNAs:	1066
Transcripts:	ENST00000375425, ENST00000375429, ENST00000426722, ENST00000436289, ENST00000441998, ENST00000444811, ENST00000454913, ENST00000481121, ENST00000488426, ENST00000491139, ENST00000492185, ENST00000492539, ENST00000494956
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358854	MULTSCL4_H	Multiple sclerosis susceptibility QTL 4 (human)			Multiple sclerosis susceptibility		6	6911960	32911960	Human
1358839	MULTSCL5_H	Multiple sclerosis susceptibility QTL 5 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
1643377	BW325_H	Body weight QTL 325 (human)	2.32	0.0005	Body fat amount		6	6911960	32911960	Human
1643569	GLUCO21_H	Glucose level QTL 21 (human)		0.021	Glucose level	non-insulin-dependent	6	6911960	32911960	Human
406985482	GWAS634458_H	von Willebrand factor measurement QTL GWAS634458 (human)		3e-08	von Willebrand factor measurement		6	31958071	31958072	Human
1298458	BW9_H	Body weight QTL 9 (human)	2.7	0.0002	Body fat amount		6	6911960	32911960	Human
407009992	GWAS658968_H	age-related macular degeneration QTL GWAS658968 (human)		0.0000003	age-related macular degeneration		6	31952140	31952141	Human
1298431	RA11_H	Rheumatoid arthritis QTL 11 (human)		0.0000024	Joint/bone inflammation	rheumatoid arthritis	6	19911883	40191709	Human
1358857	MULTSCL19_H	Multiple sclerosis susceptibility QTL 19 (human)			Multiple sclerosis susceptibility		6	19584311	45584311	Human
1643399	BMD5_H	Bone mineral density QTL 5 (human)	2.32	0.0005	Bone mineral density		6	6911960	32911960	Human
407009981	GWAS658957_H	age-related macular degeneration QTL GWAS658957 (human)		2e-10	age-related macular degeneration		6	31952140	31952141	Human

Markers in Region

D6S45

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,922,312 - 31,922,596	UniSTS	GRCh37
Build 36	6	32,030,291 - 32,030,575	RGD	NCBI36
Celera	6	33,522,074 - 33,522,358	RGD
Cytogenetic Map	6	p21.3	UniSTS
HuRef	6	31,709,281 - 31,709,565	UniSTS

RH46865

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,920,035 - 31,920,164	UniSTS	GRCh37
Build 36	6	32,028,014 - 32,028,143	RGD	NCBI36
Celera	6	33,519,797 - 33,519,926	RGD
Cytogenetic Map	6	p21.3	UniSTS
HuRef	6	31,707,004 - 31,707,133	UniSTS
GeneMap99-GB4 RH Map	6	120.03	UniSTS

RDBP_8772

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,919,667 - 31,920,183	UniSTS	GRCh37
Build 36	6	32,027,646 - 32,028,162	RGD	NCBI36
Celera	6	33,519,429 - 33,519,945	RGD
HuRef	6	31,706,636 - 31,707,152	UniSTS

RH70616

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,926,834 - 31,926,975	UniSTS	GRCh37
Build 36	6	32,034,813 - 32,034,954	RGD	NCBI36
Celera	6	33,526,596 - 33,526,737	RGD
Cytogenetic Map	6	p21	UniSTS
Cytogenetic Map	6	p21.3	UniSTS
HuRef	6	31,713,804 - 31,713,945	UniSTS
GeneMap99-GB4 RH Map	6	119.71	UniSTS

SHGC-12705

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,919,865 - 31,920,068	UniSTS	GRCh37
Build 36	6	32,027,844 - 32,028,047	RGD	NCBI36
Celera	6	33,519,627 - 33,519,830	RGD
Cytogenetic Map	6	p21.3	UniSTS
HuRef	6	31,706,834 - 31,707,037	UniSTS
Stanford-G3 RH Map	6	1652.0	UniSTS
GeneMap99-G3 RH Map	6	1784.0	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2253	4974	1726	2351	6	624	1951	465	2270	7306	6472	53	3734	1	852	1744	1617	175	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_002904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006715205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011514913	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017011299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047419354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047419355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047419356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329905	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054329907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330398	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330399	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054330891	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331414	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054356409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054356410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054356411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF019413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH001508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH003444	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK302652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK303152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL049547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL645922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL662849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL844853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025235	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC050617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU935034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX005143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD579634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR388219	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR753845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR759782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JQ313904	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KY500480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L03411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X16105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X99296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000375425 ⟹ ENSP00000364574

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,952,229 - 31,958,852 (-)	Ensembl

Ensembl Acc Id:

ENST00000375429 ⟹ ENSP00000364578

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,952,087 - 31,958,971 (-)	Ensembl

Ensembl Acc Id:

ENST00000426722 ⟹ ENSP00000394340

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,954,820 - 31,958,859 (-)	Ensembl

Ensembl Acc Id:

ENST00000436289 ⟹ ENSP00000414029

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,954,389 - 31,958,571 (-)	Ensembl

Ensembl Acc Id:

ENST00000441998 ⟹ ENSP00000397914

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,953,758 - 31,958,957 (-)	Ensembl

Ensembl Acc Id:

ENST00000444811 ⟹ ENSP00000388400

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,952,229 - 31,958,960 (-)	Ensembl

Ensembl Acc Id:

ENST00000454913 ⟹ ENSP00000409389

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,954,304 - 31,958,479 (-)	Ensembl

Ensembl Acc Id:

ENST00000481121

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,952,228 - 31,958,962 (-)	Ensembl

Ensembl Acc Id:

ENST00000488426

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,952,228 - 31,958,919 (-)	Ensembl

Ensembl Acc Id:

ENST00000491139

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,955,065 - 31,958,965 (-)	Ensembl

Ensembl Acc Id:

ENST00000492185

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,952,227 - 31,959,038 (-)	Ensembl

Ensembl Acc Id:

ENST00000492539 ⟹ ENSP00000419183

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,954,773 - 31,958,968 (-)	Ensembl

Ensembl Acc Id:

ENST00000494956 ⟹ ENSP00000420205

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,955,084 - 31,958,954 (-)	Ensembl

Ensembl Acc Id:

ENST00000625905 ⟹ ENSP00000486884

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	31,957,400 - 31,958,446 (-)	Ensembl

RefSeq Acc Id:

NM_002904 ⟹ NP_002895

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI
GRCh37	6	31,919,864 - 31,926,864 (-)	ENTREZGENE
Build 36	6	32,027,843 - 32,034,843 (-)	NCBI Archive
HuRef	6	31,706,833 - 31,713,834 (-)	ENTREZGENE
CHM1_1	6	31,921,945 - 31,928,945 (-)	NCBI
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI

Sequence:

show sequence

GTCATCGTTGTGAGCCCGCTATCAGCGGCCAGCGCGGGCGCGGCCGGAGACCGTGGGGCCCCCG
GTTGCCGCCCCCTCGGGAGCCACCATGTTGGTGATACCCCCCGGACTGAGCGAGGAAGAGGAGG
CTCTGCAGAAGAAATTCAACAAGCTCAAGAAAAAGAAAAAGGCATTGCTGGCTCTGAAGAAGCA
AAGTAGCAGCAGCACAACCAGCCAAGGTGGTGTCAAACGCTCACTATCAGAGCAGCCTGTCATG
GACACAGCCACAGCAACAGAGCAGGCAAAGCAGCTGGTGAAGTCAGGAGCCATCAGTGCCATCA
AGGCTGAGACCAAGAACTCAGGCTTCAAGCGTTCTCGAACCCTTGAGGGGAAGTTAAAGGACCC
CGAGAAGGGACCAGTCCCCACTTTCCAGCCGTTCCAGAGGAGCATATCTGCTGATGATGACCTG
CAAGAGTCATCCAGACGTCCCCAGAGGAAATCTCTGTATGAGAGCTTTGTGTCTTCTAGTGATC
GACTTCGAGAACTAGGACCAGATGGAGAAGAGGCAGAGGGCCCAGGGGCTGGTGATGGTCCCCC
TCGAAGCTTTGACTGGGGCTATGAAGAACGCAGTGGTGCCCACTCCTCAGCCTCCCCTCCCCGA
AGCCGCAGCCGGGACCGCAGCCATGAGAGGAACCGGGACAGAGACCGAGATCGGGAGCGGGATC
GAGACCGGGATCGAGACAGAGACAGAGAGCGGGACAGGGATCGGGATCGGGATCGAGATCGAGA
CCGGGAACGGGACAGGGATCGGGAGCGGGATCGAGACCGAGACCGAGAGGGTCCTTTCCGCAGG
TCGGATTCATTCCCTGAACGGCGAGCCCCTAGGAAAGGGAATACTCTCTATGTATATGGAGAAG
ACATGACACCCACCCTTCTCCGTGGGGCCTTCTCTCCTTTTGGAAACATCATTGACCTCTCCAT
GGACCCACCCAGAAACTGTGCCTTCGTCACCTATGAAAAGATGGAGTCAGCAGATCAGGCCGTT
GCTGAGCTCAACGGGACCCAGGTGGAGTCTGTACAGCTCAAAGTCAACATAGCCCGAAAACAGC
CCATGCTGGATGCCGCTACTGGCAAGTCTGTCTGGGGCTCCCTCGCTGTCCAGAACAGCCCTAA
GGGTTGCCACCGGGACAAGAGGACCCAGATTGTCTACAGTGATGACGTCTACAAGGAAAACCTT
GTGGATGGCTTCTAGGGAACAGAGCTGGATTCCTTGTGCCTCATATGCCCCAATGCTGGTCTCA
GTAAAACACTGAGGTGGAAGCTTACACATCTCCCTCAGCCTCTGGTTTTTCAGCACTTGGGATT
GGGGTTAAACCTTTAAAAACGGCTGTCAGGTTTGATCTCAGTGTAACAACATGGCCAGTGCCTG
TTCCCCACTCCCTTGCCCCAAAAGGATCTGGAACACA

hide sequence

RefSeq Acc Id:

XM_006715205 ⟹ XP_006715268

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI

Sequence:

show sequence

GTCATCGTTGTGAGCCCGCTATCAGCGGCCAGCGCGGGCGCGGCCGGAGACCGTGGGGCCCCCG
GTTGCCGCCCCCTCGGGAGCCACCATGTTGGTGATACCCCCCGGACTGAGCGAGGAAGAGGAGG
CTCTGCAGAAGAAATTCAACAAGCTCAAGAAAAAGAAAAAGGCATTGCTGGCTCTGAAGAAGCA
AAGTAGCAGCAGCACAACCAGCCAAGGTGGTGTCAAACGCTCACTATCAGAGCAGCCTGTCATG
GACACAGCCACAGCAACAGAGCAGGCAAAGCAGCTGGTGAAGTCAGGAGCCATCAGTGCCATCA
AGGCTGAGACCAAGAACTCAGGCTTCAAGCGTTCTCGAACCCTTGAGGGGAAGTTAAAGGACCC
CGAGAAGGGACCAGTCCCCACTTTCCAGCCGTTCCAGAGGAGCATATCTGCTGATGATGACCTG
CAAGAGTCATCCAGACGTCCCCAGAGGAAATCTCTGTATGAGAGTGATCGACTTCGAGAACTAG
GACCAGATGGAGAAGAGGCAGAGGGCCCAGGGGCTGGTGATGGTCCCCCTCGAAGCTTTGACTG
GGGCTATGAAGAACGCAGTGGTGCCCACTCCTCAGCCTCCCCTCCCCGAAGCCGCAGCCGGGAC
CGCAGCCATGAGAGGAACCGGGACAGAGACCGAGATCGGGAGCGGGATCGAGACCGGGATCGAG
ACAGAGACAGAGAGCGGGACAGGGATCGGGATCGGGATCGAGATCGAGACCGGGAACGGGACAG
GGATCGGGAGCGGGATCGAGACCGAGACCGAGAGGGTCCTTTCCGCAGGTCGGATTCATTCCCT
GAACGGCGAGCCCCTAGGAAAGGGAATACTCTCTATGTATATGGAGAAGACATGACACCCACCC
TTCTCCGTGGGGCCTTCTCTCCTTTTGGAAACATCATTGACCTCTCCATGGACCCACCCAGAAA
CTGTGCCTTCGTCACCTATGAAAAGATGGAGTCAGCAGATCAGGCCGTTGCTGAGCTCAACGGG
ACCCAGGTGGAGTCTGTACAGCTCAAAGTCAACATAGCCCGAAAACAGCCCATGCTGGATGCCG
CTACTGGCAAGTCTGTCTGGGGCTCCCTCGCTGTCCAGAACAGCCCTAAGGGTTGCCACCGGGA
CAAGAGGACCCAGATTGTCTACAGTGATGACGTCTACAAGGAAAACCTTGTGGATGGCTTCTAG
GGAACAGAGCTGGATTCCTTGTGCCTCATATGCCCCAATGCTGGTCTCAGTAAAACACTGAGGT
GGAAGCTTACA

hide sequence

RefSeq Acc Id:

XM_011514913 ⟹ XP_011513215

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,952,087 - 31,958,444 (-)	NCBI

Sequence:

show sequence

CGGTGGAAGGCCGGGCGGAAGTGCGCGCCTGGGGCCGCCTTGGTTACCGCGTTTTCCGCTCCTC
GCTACGTCATCGTTGTGAGCCCGCTATCAGCGGCCAGCGCGGGCGCGGCCGGAGACCGTGGGGC
CCCCGGTTGCCGCCCCCTCGGGAGCCACCATGTTGGTGATACCCCCCGGACTGAGCGAGGAAGA
GGAGGCTCTGCAGAAGAAATTCAACAAGCTCAAGAAAAAGGTGAGGGACTGTGTGTGGACATGG
CCTAACCTTTCACAGACTCTGCACTCTGAGAAGATATGGGAAAAAGGCATTGCTGGCTCTGAAG
AAGCAAAGTAGCAGCAGCACAACCAGCCAAGGTGGTGTCAAACGCTCACTATCAGAGCAGCCTG
TCATGGACACAGCCACAGCAACAGAGCAGGCAAAGCAGCTGGTGAAGTCAGGAGCCATCAGTGC
CATCAAGGCTGAGACCAAGAACTCAGGCTTCAAGCGTTCTCGAACCCTTGAGGGGAAGTTAAAG
GACCCCGAGAAGGGACCAGTCCCCACTTTCCAGCCGTTCCAGAGGAGCATATCTGCTGATGATG
ACCTGCAAGAGTCATCCAGACGTCCCCAGAGGAAATCTCTGTATGAGAGCTTTGTGTCTTCTAG
TGATCGACTTCGAGAACTAGGACCAGATGGAGAAGAGGCAGAGGGCCCAGGGGCTGGTGATGGT
CCCCCTCGAAGCTTTGACTGGGGCTATGAAGAACGCAGTGGTGCCCACTCCTCAGCCTCCCCTC
CCCGAAGCCGCAGCCGGGACCGCAGCCATGAGAGGAACCGGGACAGAGACCGAGATCGGGAGCG
GGATCGAGACCGGGATCGAGACAGAGACAGAGAGCGGGACAGGGATCGGGATCGGGATCGAGAT
CGAGACCGGGAACGGGACAGGGATCGGGAGCGGGATCGAGACCGAGACCGAGAGGGTCCTTTCC
GCAGGTCGGATTCATTCCCTGAACGGCGAGCCCCTAGGAAAGGGAATACTCTCTATGTATATGG
AGAAGACATGACACCCACCCTTCTCCGTGGGGCCTTCTCTCCTTTTGGAAACATCATTGACCTC
TCCATGGACCCACCCAGAAACTGTGCCTTCGTCACCTATGAAAAGATGGAGTCAGCAGATCAGG
CCGTTGCTGAGCTCAACGGGACCCAGGTGGAGTCTGTACAGCTCAAAGTCAACATAGCCCGAAA
ACAGCCCATGCTGGATGCCGCTACTGGCAAGTCTGTCTGGGGCTCCCTCGCTGTCCAGAACAGC
CCTAAGGGTTGCCACCGGGACAAGAGGACCCAGATTGTCTACAGTGATGACGTCTACAAGGAAA
ACCTTGTGGATGGCTTCTAGGGAACAGAGCTGGATTCCTTGTGCCTCATATGCCCCAATGCTGG
TCTCAGTAAAACACTGAGGTGGAAGCTTACA

hide sequence

RefSeq Acc Id:

XM_047419354 ⟹ XP_047275310

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI

RefSeq Acc Id:

XM_047419355 ⟹ XP_047275311

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI

RefSeq Acc Id:

XM_047419356 ⟹ XP_047275312

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,952,087 - 31,958,971 (-)	NCBI

RefSeq Acc Id:

XM_054356409 ⟹ XP_054212384

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI

RefSeq Acc Id:

XM_054356410 ⟹ XP_054212385

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI

RefSeq Acc Id:

XM_054356411 ⟹ XP_054212386

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	6	31,805,292 - 31,812,176 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_002895	(Get FASTA)	NCBI Sequence Viewer
	XP_006715268	(Get FASTA)	NCBI Sequence Viewer
	XP_011513215	(Get FASTA)	NCBI Sequence Viewer
	XP_047275310	(Get FASTA)	NCBI Sequence Viewer
	XP_047275311	(Get FASTA)	NCBI Sequence Viewer
	XP_047275312	(Get FASTA)	NCBI Sequence Viewer
	XP_054185880	(Get FASTA)	NCBI Sequence Viewer
	XP_054185881	(Get FASTA)	NCBI Sequence Viewer
	XP_054185882	(Get FASTA)	NCBI Sequence Viewer
	XP_054186372	(Get FASTA)	NCBI Sequence Viewer
	XP_054186373	(Get FASTA)	NCBI Sequence Viewer
	XP_054186374	(Get FASTA)	NCBI Sequence Viewer
	XP_054186864	(Get FASTA)	NCBI Sequence Viewer
	XP_054186865	(Get FASTA)	NCBI Sequence Viewer
	XP_054186866	(Get FASTA)	NCBI Sequence Viewer
	XP_054187148	(Get FASTA)	NCBI Sequence Viewer
	XP_054187149	(Get FASTA)	NCBI Sequence Viewer
	XP_054187150	(Get FASTA)	NCBI Sequence Viewer
	XP_054187387	(Get FASTA)	NCBI Sequence Viewer
	XP_054187388	(Get FASTA)	NCBI Sequence Viewer
	XP_054187389	(Get FASTA)	NCBI Sequence Viewer
	XP_054212384	(Get FASTA)	NCBI Sequence Viewer
	XP_054212385	(Get FASTA)	NCBI Sequence Viewer
	XP_054212386	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA36308	(Get FASTA)	NCBI Sequence Viewer
	AAB67979	(Get FASTA)	NCBI Sequence Viewer
	AAC37523	(Get FASTA)	NCBI Sequence Viewer
	AAH25235	(Get FASTA)	NCBI Sequence Viewer
	AAH50617	(Get FASTA)	NCBI Sequence Viewer
	AAK29466	(Get FASTA)	NCBI Sequence Viewer
	AFH41798	(Get FASTA)	NCBI Sequence Viewer
	AQY76952	(Get FASTA)	NCBI Sequence Viewer
	AQY76953	(Get FASTA)	NCBI Sequence Viewer
	BAG62393	(Get FASTA)	NCBI Sequence Viewer
	BAG63891	(Get FASTA)	NCBI Sequence Viewer
	BAG64255	(Get FASTA)	NCBI Sequence Viewer
	BAH13370	(Get FASTA)	NCBI Sequence Viewer
	CAA34231	(Get FASTA)	NCBI Sequence Viewer
	CAB89308	(Get FASTA)	NCBI Sequence Viewer
	EAX03551	(Get FASTA)	NCBI Sequence Viewer
	EAX03552	(Get FASTA)	NCBI Sequence Viewer
	EAX03553	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000364574
	ENSP00000364574.5
	ENSP00000364578
	ENSP00000364578.3
	ENSP00000372660.4
	ENSP00000372834.4
	ENSP00000388400
	ENSP00000388400.2
	ENSP00000390689.1
	ENSP00000393005.2
	ENSP00000393103.1
	ENSP00000393793.1
	ENSP00000393794.1
	ENSP00000394340.1
	ENSP00000394879.2
	ENSP00000395175.1
	ENSP00000396604.1
	ENSP00000396971.1
	ENSP00000397565.1
	ENSP00000397914.1
	ENSP00000401342.1
	ENSP00000401745.1
	ENSP00000403623.2
	ENSP00000403630.1
	ENSP00000407528.1
	ENSP00000407630.1
	ENSP00000409139.1
	ENSP00000409269.1
	ENSP00000409389.1
	ENSP00000410872.1
	ENSP00000411487.1
	ENSP00000411724.1
	ENSP00000414014.1
	ENSP00000414029.2
	ENSP00000415567.1
	ENSP00000419183.1
	ENSP00000420205.1
	ENSP00000486074.1
	ENSP00000486432.1
	ENSP00000486647.1
	ENSP00000486884.1
	ENSP00000487225.1
	ENSP00000487402.1
GenBank Protein	P18615	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_002895 ⟸ NM_002904
- UniProtKB:	Q96F56 (UniProtKB/Swiss-Prot), Q5JP75 (UniProtKB/Swiss-Prot), Q5JP74 (UniProtKB/Swiss-Prot), B4DYX9 (UniProtKB/Swiss-Prot), B4DUN1 (UniProtKB/Swiss-Prot), A2BE08 (UniProtKB/Swiss-Prot), Q9NPK2 (UniProtKB/Swiss-Prot), P18615 (UniProtKB/Swiss-Prot), A0A1U9X830 (UniProtKB/TrEMBL), A0A1U9X839 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQ AKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQ RKSLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSH ERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERR APRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQV ESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF hide sequence

RefSeq Acc Id:	XP_006715268 ⟸ XM_006715205
- Peptide Label:	isoform X2
- UniProtKB:	A0A1U9X839 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQ AKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQ RKSLYESDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSHERNRD RDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERRAPRKG NTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQL KVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF hide sequence

RefSeq Acc Id:	XP_011513215 ⟸ XM_011514913
- Peptide Label:	isoform X3
- UniProtKB:	A0A1U9X839 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDD LQESSRRPQRKSLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPP RSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFR RSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQA VAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKEN LVDGF hide sequence

Ensembl Acc Id:

ENSP00000394340 ⟸ ENST00000426722

Ensembl Acc Id:

ENSP00000419183 ⟸ ENST00000492539

Ensembl Acc Id:

ENSP00000486884 ⟸ ENST00000625905

Ensembl Acc Id:

ENSP00000364574 ⟸ ENST00000375425

Ensembl Acc Id:

ENSP00000364578 ⟸ ENST00000375429

Ensembl Acc Id:

ENSP00000409389 ⟸ ENST00000454913

Ensembl Acc Id:

ENSP00000420205 ⟸ ENST00000494956

Ensembl Acc Id:

ENSP00000397914 ⟸ ENST00000441998

Ensembl Acc Id:

ENSP00000388400 ⟸ ENST00000444811

Ensembl Acc Id:

ENSP00000414029 ⟸ ENST00000436289

RefSeq Acc Id:	XP_047275312 ⟸ XM_047419356
- Peptide Label:	isoform X2
- UniProtKB:	A0A1U9X839 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_047275310 ⟸ XM_047419354
- Peptide Label:	isoform X1
- UniProtKB:	Q96F56 (UniProtKB/Swiss-Prot), Q5JP75 (UniProtKB/Swiss-Prot), Q5JP74 (UniProtKB/Swiss-Prot), P18615 (UniProtKB/Swiss-Prot), B4DYX9 (UniProtKB/Swiss-Prot), B4DUN1 (UniProtKB/Swiss-Prot), A2BE08 (UniProtKB/Swiss-Prot), Q9NPK2 (UniProtKB/Swiss-Prot), A0A1U9X830 (UniProtKB/TrEMBL), A0A1U9X839 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_047275311 ⟸ XM_047419355
- Peptide Label:	isoform X1
- UniProtKB:	Q96F56 (UniProtKB/Swiss-Prot), Q5JP75 (UniProtKB/Swiss-Prot), Q5JP74 (UniProtKB/Swiss-Prot), P18615 (UniProtKB/Swiss-Prot), B4DYX9 (UniProtKB/Swiss-Prot), B4DUN1 (UniProtKB/Swiss-Prot), A2BE08 (UniProtKB/Swiss-Prot), Q9NPK2 (UniProtKB/Swiss-Prot), A0A1U9X830 (UniProtKB/TrEMBL), A0A1U9X839 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054212385 ⟸ XM_054356410
- Peptide Label:	isoform X2
- UniProtKB:	A0A1U9X839 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054212386 ⟸ XM_054356411
- Peptide Label:	isoform X2
- UniProtKB:	A0A1U9X839 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054212384 ⟸ XM_054356409
- Peptide Label:	isoform X1
- UniProtKB:	Q96F56 (UniProtKB/Swiss-Prot), Q5JP75 (UniProtKB/Swiss-Prot), Q5JP74 (UniProtKB/Swiss-Prot), P18615 (UniProtKB/Swiss-Prot), B4DYX9 (UniProtKB/Swiss-Prot), B4DUN1 (UniProtKB/Swiss-Prot), A2BE08 (UniProtKB/Swiss-Prot), Q9NPK2 (UniProtKB/Swiss-Prot), A0A1U9X830 (UniProtKB/TrEMBL), A0A1U9X839 (UniProtKB/TrEMBL)

Protein Domains

RRM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P18615-F1-model_v2	AlphaFold	P18615	1-380	view protein structure

Promoters

RGD ID:

6872692

Promoter ID:

EPDNEW_H9511

Type:

initiation region

Name:

NELFE_1

Description:

negative elongation factor complex member E

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	31,958,962 - 31,959,022	EPDNEW

RGD ID:

6804603

Promoter ID:

HG_KWN:53029

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000375425, OTTHUMT00000076047, OTTHUMT00000076049, OTTHUMT00000076050, OTTHUMT00000076051, OTTHUMT00000268584, OTTHUMT00000268585, OTTHUMT00000268586, OTTHUMT00000268587, OTTHUMT00000268588, OTTHUMT00000268589, OTTHUMT00000268626, UC003NYL.1, UC003NYM.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	6	32,034,619 - 32,035,119 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:13974	AgrOrtholog
COSMIC	NELFE	COSMIC
Ensembl Genes	ENSG00000204356	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000206268	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000206357	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000229363	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000231044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSG00000233801	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000375425	ENTREZGENE
	ENST00000375425.9	UniProtKB/Swiss-Prot
	ENST00000375429	ENTREZGENE
	ENST00000375429.8	UniProtKB/Swiss-Prot
	ENST00000383174.8	UniProtKB/Swiss-Prot
	ENST00000383343.8	UniProtKB/Swiss-Prot
	ENST00000411745.5	UniProtKB/TrEMBL
	ENST00000418059.1	UniProtKB/TrEMBL
	ENST00000418423.5	UniProtKB/TrEMBL
	ENST00000420039.1	UniProtKB/TrEMBL
	ENST00000420837.1	UniProtKB/TrEMBL
	ENST00000424762.5	UniProtKB/TrEMBL
	ENST00000424967.5	UniProtKB/TrEMBL
	ENST00000425721.5	UniProtKB/TrEMBL
	ENST00000425810.5	UniProtKB/TrEMBL
	ENST00000426722.5	UniProtKB/TrEMBL
	ENST00000429857.6	UniProtKB/Swiss-Prot
	ENST00000434518.5	UniProtKB/TrEMBL
	ENST00000435435.5	UniProtKB/TrEMBL
	ENST00000436289.6	UniProtKB/TrEMBL
	ENST00000437732.5	UniProtKB/TrEMBL
	ENST00000440478.5	UniProtKB/TrEMBL
	ENST00000441998.5	UniProtKB/TrEMBL
	ENST00000443464.5	UniProtKB/TrEMBL
	ENST00000444811	ENTREZGENE
	ENST00000444811.6	UniProtKB/Swiss-Prot
	ENST00000448628.6	UniProtKB/Swiss-Prot
	ENST00000449057.5	UniProtKB/TrEMBL
	ENST00000452147.5	UniProtKB/TrEMBL
	ENST00000453084.5	UniProtKB/TrEMBL
	ENST00000454913.5	UniProtKB/TrEMBL
	ENST00000456263.1	UniProtKB/TrEMBL
	ENST00000456281.5	UniProtKB/TrEMBL
	ENST00000457397.6	UniProtKB/Swiss-Prot
	ENST00000458622.1	UniProtKB/TrEMBL
	ENST00000492539.5	UniProtKB/TrEMBL
	ENST00000494956.1	UniProtKB/TrEMBL
	ENST00000625436.1	UniProtKB/TrEMBL
	ENST00000625545.1	UniProtKB/TrEMBL
	ENST00000625905.1	UniProtKB/TrEMBL
	ENST00000625993.1	UniProtKB/TrEMBL
	ENST00000628497.1	UniProtKB/TrEMBL
	ENST00000629797.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000204356	GTEx
	ENSG00000206268	GTEx
	ENSG00000206357	GTEx
	ENSG00000229363	GTEx
	ENSG00000231044	GTEx
	ENSG00000233801	GTEx
HGNC ID	HGNC:13974	ENTREZGENE
Human Proteome Map	NELFE	Human Proteome Map
InterPro	NELFE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NELFE_RRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RRM_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:7936	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	7936	ENTREZGENE
OMIM	154040	OMIM
PANTHER	NEGATIVE ELONGATION FACTOR E	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR17250	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA134974984	PharmGKB
PROSITE	RRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RNAcentral	URS00008C0FEA	RNACentral
	URS00008C279B	RNACentral
SMART	RRM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0A0MSN9_HUMAN	UniProtKB/TrEMBL
	A0A0A0MT02_HUMAN	UniProtKB/TrEMBL
	A0A0G2JI50_HUMAN	UniProtKB/TrEMBL
	A0A1U9X830	ENTREZGENE, UniProtKB/TrEMBL
	A0A1U9X839	ENTREZGENE, UniProtKB/TrEMBL
	A2ABK4_HUMAN	UniProtKB/TrEMBL
	A2BE08	ENTREZGENE
	B4DUN1	ENTREZGENE
	B4DYX9	ENTREZGENE
	E7ENC7_HUMAN	UniProtKB/TrEMBL
	E7EWR7_HUMAN	UniProtKB/TrEMBL
	E9PD43_HUMAN	UniProtKB/TrEMBL
	NELFE_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5JP74	ENTREZGENE
	Q5JP75	ENTREZGENE
	Q96F56	ENTREZGENE
	Q9NPK2	ENTREZGENE
UniProt Secondary	A2BE08	UniProtKB/Swiss-Prot
	B4DUN1	UniProtKB/Swiss-Prot
	B4DYX9	UniProtKB/Swiss-Prot
	Q5JP74	UniProtKB/Swiss-Prot
	Q5JP75	UniProtKB/Swiss-Prot
	Q96F56	UniProtKB/Swiss-Prot
	Q9NPK2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-06	NELFE	negative elongation factor complex member E	RDBP	RD RNA binding protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

RGD Manual Annotations