MIR146A (microRNA 146a) - Rat Genome Database

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Gene: MIR146A (microRNA 146a) Homo sapiens
Analyze
Symbol: MIR146A
Name: microRNA 146a
RGD ID: 1344673
HGNC Page HGNC:31533
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of cell migration involved in sprouting angiogenesis; and regulation of endothelial cell proliferation. Located in extracellular exosome. Implicated in atrophic gastritis; carcinoma (multiple); coronary artery disease; fatal familial insomnia; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); arthritis (multiple); bacterial gastritis; hepatitis C; and systemic lupus erythematosus.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microrna 146; miR-146a; MIRN146; MIRN146A; miRNA146A
RGD Orthologs
Mouse
Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,485,352 - 160,485,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5160,485,352 - 160,485,450 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,912,359 - 159,912,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,844,936 - 159,845,034 (+)NCBINCBI36Build 36hg18NCBI36
Celera5155,944,832 - 155,944,930 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5155,005,782 - 155,005,880 (+)NCBIHuRef
CHM1_15159,345,261 - 159,345,359 (+)NCBICHM1_1
T2T-CHM13v2.05161,013,850 - 161,013,948 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,3-benzothiazole-2-thiol  (EXP)
17beta-estradiol  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
alpha-hexylcinnamaldehyde  (EXP)
aluminium sulfate (anhydrous)  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP)
atrazine  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (EXP)
benzene  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
captopril  (ISO)
carbon atom  (EXP)
catechol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP,ISO)
curcumin  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (ISO)
diarsenic trioxide  (EXP)
elemental carbon  (EXP)
enalapril  (EXP)
eugenol  (EXP)
folic acid  (EXP)
furan  (ISO)
glucose  (EXP)
glyburide  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
imidacloprid  (ISO)
ionomycin  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
lead(0)  (EXP)
Licochalcone B  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
mechlorethamine  (ISO)
metformin  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
ochratoxin A  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
progesterone  (EXP,ISO)
propofol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
silicon dioxide  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
stanozolol  (ISO)
streptozocin  (ISO)
tacrolimus hydrate  (ISO)
telmisartan  (EXP,ISO)
thiabendazole  (ISO)
titanium dioxide  (EXP)
tributyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
tropisetron  (ISO)
urethane  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical NF-kappaB signal transduction  (IMP)
cellular response to amyloid-beta  (IMP)
cellular response to cytokine stimulus  (IDA)
cellular response to decreased oxygen levels  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to glucose stimulus  (IDA)
cellular response to hypoxia  (IMP)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IDA,ISO,ISS)
cellular response to oxidised low-density lipoprotein particle stimulus  (IDA)
cellular response to virus  (IDA)
innate immune response  (IDA)
interleukin-1-mediated signaling pathway  (IMP)
miRNA-mediated gene silencing by inhibition of translation  (IDA)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA,IMP,ISO)
myeloid cell differentiation  (ISO)
negative regulation of angiogenesis  (IMP)
negative regulation of apoptotic DNA fragmentation  (IDA)
negative regulation of canonical NF-kappaB signal transduction  (IDA)
negative regulation of cell adhesion molecule production  (IDA)
negative regulation of cell migration involved in sprouting angiogenesis  (IMP,ISS)
negative regulation of chemokine (C-X-C motif) ligand 2 production  (IDA)
negative regulation of cholesterol storage  (IDA)
negative regulation of cytokine production involved in inflammatory response  (IDA)
negative regulation of dephosphorylation  (IDA)
negative regulation of endothelial cell proliferation  (IDA)
negative regulation of gene expression  (IDA)
negative regulation of glial cell proliferation  (IDA)
negative regulation of inflammatory response  (IMP)
negative regulation of interleukin-6 production  (IDA)
negative regulation of interleukin-8 production  (IDA)
negative regulation of intracellular signal transduction  (IDA)
negative regulation of leukocyte adhesion to vascular endothelial cell  (IDA)
negative regulation of matrix metallopeptidase secretion  (IDA)
negative regulation of membrane permeability  (IDA)
negative regulation of monocyte extravasation  (IDA)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IGI)
negative regulation of SMAD protein signal transduction  (IMP)
negative regulation of toll-like receptor 4 signaling pathway  (IC)
negative regulation of tyrosine phosphorylation of STAT protein  (IDA)
negative regulation of vascular endothelial growth factor production  (IDA)
positive regulation of apoptotic process  (IGI)
positive regulation of apoptotic process in bone marrow cell  (ISS)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
positive regulation of cell migration involved in sprouting angiogenesis  (IDA,IMP)
positive regulation of cellular senescence  (ISS)
positive regulation of fibroblast growth factor receptor signaling pathway  (IDA)
positive regulation of gene expression  (IDA)
positive regulation of neuron differentiation  (IC)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of gene expression  (ISO)
regulation of stem cell differentiation  (IDA)
regulation of toll-like receptor signaling pathway  (IDA)
response to Gram-positive bacterium  (ISO)
response to ischemia  (ISO)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Up-regulation of circulating miRNA146a correlates with viral load via IRAK1 and TRAF6 in hepatitis C virus-infected patients. Abdel Motaleb FI, etal., Virus Res. 2017 Jun 15;238:24-28. doi: 10.1016/j.virusres.2017.05.026. Epub 2017 Jun 3.
2. MicroRNA-146a-deficient mice develop immune complex glomerulonephritis. Amrouche L, etal., Sci Rep. 2019 Oct 30;9(1):15597. doi: 10.1038/s41598-019-51985-1.
3. Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. Assmann TS, etal., Acta Diabetol. 2017 May;54(5):433-441. doi: 10.1007/s00592-016-0961-y. Epub 2017 Jan 19.
4. Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis. Bandiera S, etal., J Virol. 2016 Jun 24;90(14):6387-6400. doi: 10.1128/JVI.00619-16. Print 2016 Jul 15.
5. MiRNA-Related Polymorphisms in miR-146a and TCF21 Are Associated with Increased Susceptibility to Coronary Artery Disease in an Iranian Population. Bastami M, etal., Genet Test Mol Biomarkers. 2016 May;20(5):241-8. doi: 10.1089/gtmb.2015.0253. Epub 2016 Feb 24.
6. Anti-Inflammatory Role of MicroRNA-146a in the Pathogenesis of Diabetic Nephropathy. Bhatt K, etal., J Am Soc Nephrol. 2016 Aug;27(8):2277-88. doi: 10.1681/ASN.2015010111. Epub 2015 Dec 8.
7. Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis. Cai P, etal., Int J Mol Sci. 2020 May 18;21(10). pii: ijms21103560. doi: 10.3390/ijms21103560.
8. miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain. Cannella D, etal., Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27.
9. miR-146a G>C polymorphisms and risk of hepatocellular carcinoma in a Chinese population. Cong N, etal., Tumour Biol. 2014 Jun;35(6):5669-73. doi: 10.1007/s13277-014-1750-2. Epub 2014 Mar 11.
10. MicroRNA-146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota. Du CT, etal., Int J Mol Sci. 2018 Mar 26;19(4). pii: ijms19040993. doi: 10.3390/ijms19040993.
11. Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection. Fu Y, etal., PLoS Pathog. 2017 Sep 14;13(9):e1006611. doi: 10.1371/journal.ppat.1006611. eCollection 2017 Sep.
12. The associations of two SNPs in miRNA-146a and one SNP in ZBTB38-RASA2 with the disease susceptibility and the clinical features of the Chinese patients of sCJD and FFI. Gao C, etal., Prion. 2018 Jan 2;12(1):34-41. doi: 10.1080/19336896.2017.1405885. Epub 2018 Jan 2.
13. Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression. Gao M, etal., J Immunol. 2015 Jul 15;195(2):672-82. doi: 10.4049/jimmunol.1403155. Epub 2015 Jun 5.
14. Systemic Treatment with a miR-146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft-versus-Host Disease. Gartner JG, etal., Scand J Immunol. 2017 Nov;86(5):368-376. doi: 10.1111/sji.12597. Epub 2017 Sep 29.
15. NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease. Ghorpade DS, etal., J Biol Chem. 2013 Nov 15;288(46):33037-48. doi: 10.1074/jbc.M113.492496. Epub 2013 Oct 3.
16. Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. Güçlü A, etal., Ren Fail. 2016 Oct;38(9):1468-1475. doi: 10.1080/0886022X.2016.1227915. Epub 2016 Oct 19.
17. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis. He X, etal., EBioMedicine. 2016 Nov;13:339-347. doi: 10.1016/j.ebiom.2016.10.024. Epub 2016 Oct 19.
18. Activation of nuclear factor kappa B in the hepatic stellate cells of mice with schistosomiasis japonica. He X, etal., PLoS One. 2014 Aug 12;9(8):e104323. doi: 10.1371/journal.pone.0104323. eCollection 2014.
19. Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese. Hishida A, etal., Dig Dis Sci. 2011 Apr;56(4):1131-7. doi: 10.1007/s10620-010-1376-1. Epub 2010 Aug 19.
20. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Ho BC, etal., Nat Commun. 2014;5:3344. doi: 10.1038/ncomms4344.
21. Hepatitis B virus inhibits intrinsic RIG-I and RIG-G immune signaling via inducing miR146a. Hou Z, etal., Sci Rep. 2016 May 23;6:26150. doi: 10.1038/srep26150.
22. Acute meningitis in rats is associated with decreased levels of miR132 and miR146a. Jagoo M, etal., Cent Eur J Immunol. 2014;39(3):316-22. doi: 10.5114/ceji.2014.45941. Epub 2014 Oct 14.
23. Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure. Jiang H, etal., Immunogenetics. 2013 Apr;65(4):257-63. doi: 10.1007/s00251-012-0675-4. Epub 2013 Jan 6.
24. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis. Li H, etal., Life Sci. 2020 Aug 1;254:116801. doi: 10.1016/j.lfs.2019.116801. Epub 2019 Aug 28.
25. Upregulation of microRNA-146a by hepatitis B virus X protein contributes to hepatitis development by downregulating complement factor H. Li JF, etal., mBio. 2015 Mar 24;6(2). pii: mBio.02459-14. doi: 10.1128/mBio.02459-14.
26. microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production. Li M, etal., Sci Rep. 2016 Mar 30;6:23351. doi: 10.1038/srep23351.
27. MicroRNA‑146a inhibits the inflammatory responses induced by interleukin‑17A during the infection of Helicobacter pylori. Li N, etal., Mol Med Rep. 2019 Feb;19(2):1388-1395. doi: 10.3892/mmr.2018.9725. Epub 2018 Dec 5.
28. Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a. Li R and Wang L, Mol Med Rep. 2019 Dec;20(6):5041-5049. doi: 10.3892/mmr.2019.10743. Epub 2019 Oct 15.
29. MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2. Li YL, etal., Oncotarget. 2016 Sep 13;7(37):59287-59298. doi: 10.18632/oncotarget.11040.
30. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. Lochhead RB, etal., PLoS Pathog. 2014 Jun 26;10(6):e1004212. doi: 10.1371/journal.ppat.1004212. eCollection 2014 Jun.
31. Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity. Okoye IS, etal., Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3081-90. doi: 10.1073/pnas.1406322111. Epub 2014 Jul 14.
32. Dysregulated Serum MiRNA Profile and Promising Biomarkers in Dengue-infected Patients. Ouyang X, etal., Int J Med Sci. 2016 Feb 18;13(3):195-205. doi: 10.7150/ijms.13996. eCollection 2016.
33. Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a. Paik S, etal., Sci Rep. 2019 Mar 13;9(1):4342. doi: 10.1038/s41598-019-40690-8.
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. Saba R, etal., PLoS One. 2012;7(2):e30832. doi: 10.1371/journal.pone.0030832. Epub 2012 Feb 17.
36. MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1. Schmolka N, etal., Sci Immunol. 2018 May 4;3(23). pii: 3/23/eaao1392. doi: 10.1126/sciimmunol.aao1392.
37. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
38. MiRNA-146a polymorphism increases the odds of malaria in pregnancy. van Loon W, etal., Malar J. 2019 Jan 14;18(1):7. doi: 10.1186/s12936-019-2643-z.
39. [Expression characteristics of microRNA in mice with schistosomiasis and praziquantel treatment]. Wang CY, etal., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2014 Apr;26(2):165-8, 174.
40. MicroRNA-146a feedback suppresses T cell immune function by targeting Stat1 in patients with chronic hepatitis B. Wang S, etal., J Immunol. 2013 Jul 1;191(1):293-301. doi: 10.4049/jimmunol.1202100. Epub 2013 May 22.
41. MicroRNA-146a enhances Helicobacter pylori induced cell apoptosis in human gastric cancer epithelial cells. Wu K, etal., Asian Pac J Cancer Prev. 2014;15(14):5583-6. doi: 10.7314/apjcp.2014.15.14.5583.
42. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Xu T, etal., Carcinogenesis. 2008 Nov;29(11):2126-31. doi: 10.1093/carcin/bgn195. Epub 2008 Aug 18.
43. Association of genetic variations in miR-146a rs2910164 and miR-149 rs11614913 with the development of classic Kaposi sarcoma. Yang H, etal., Genet Mol Res. 2016 Nov 3;15(4). pii: gmr-15-gmr15048855. doi: 10.4238/gmr15048855.
44. Downregulation of microRNA-196a inhibits human liver cancer cell proliferation and invasion by targeting FOXO1. Yang L, etal., Oncol Rep. 2017 Oct;38(4):2148-2154. doi: 10.3892/or.2017.5873. Epub 2017 Aug 3.
45. MicroRNA-146a regulates the transformation from liver fibrosis to cirrhosis in patients with hepatitis B via interleukin-6. Yang Z, etal., Exp Ther Med. 2019 Jun;17(6):4670-4676. doi: 10.3892/etm.2019.7490. Epub 2019 Apr 16.
46. Downregulation of miR-146a inhibits influenza A virus replication by enhancing the type I interferon response in vitro and in vivo. Zhang F, etal., Biomed Pharmacother. 2019 Mar;111:740-750. doi: 10.1016/j.biopha.2018.12.103. Epub 2019 Jan 3.
47. Involvement of TLR2-MyD88 in abnormal expression of miR-146a in peripheral blood monocytes of patients with chronic hepatitis C. Zhang WJ, etal., J Huazhong Univ Sci Technolog Med Sci. 2015 Apr;35(2):219-224. doi: 10.1007/s11596-015-1414-5. Epub 2015 Apr 16.
48. Association between miR-146aG>C and miR-196a2C>T polymorphisms and the risk of hepatocellular carcinoma in a Chinese population. Zhou B, etal., Tumour Biol. 2014 Aug;35(8):7775-80. doi: 10.1007/s13277-014-2020-z. Epub 2014 May 10.
49. Inflammation-Related MicroRNAs Are Associated with Plaque Stability Calculated by IVUS in Coronary Heart Disease Patients. Zhu GF, etal., J Interv Cardiol. 2019 Dec 1;2019:9723129. doi: 10.1155/2019/9723129. eCollection 2019.
50. The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Zhu S, etal., Nat Med. 2012 Jul;18(7):1077-86. doi: 10.1038/nm.2815.
51. PECULIARITIES OF MIR-146A AND MIR-155 EXPRESSION IN PATIENTS WITH ALLERGOPATHY IN COMBINATION WITH CHRONIC EPSTEIN-BARR VIRUS INFECTION IN LATENT AND ACTIVE PHASES. Zubchenko S, etal., Georgian Med News. 2019 May;(290):69-73.
Additional References at PubMed
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PMID:20810544   PMID:20842445   PMID:20845080   PMID:20848167   PMID:20934487   PMID:20937840   PMID:20952466   PMID:21037258   PMID:21073609   PMID:21178010   PMID:21236257   PMID:21249428  
PMID:21263019   PMID:21329689   PMID:21345130   PMID:21347720   PMID:21354921   PMID:21469088   PMID:21472990   PMID:21511256   PMID:21529448   PMID:21529907   PMID:21555486   PMID:21591024  
PMID:21610143   PMID:21624236   PMID:21632853   PMID:21637771   PMID:21640790   PMID:21738483   PMID:21744077   PMID:21773870   PMID:21807077   PMID:21810022   PMID:21861697   PMID:21885871  
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PMID:24781267   PMID:24796653   PMID:24800242   PMID:24802714   PMID:24803388   PMID:24805774   PMID:24824381   PMID:24839931   PMID:24860819   PMID:24863965   PMID:24885368   PMID:24892945  
PMID:24895573   PMID:24910152   PMID:24930753   PMID:24939082   PMID:24952884   PMID:24978643   PMID:24996260   PMID:25008481   PMID:25047043   PMID:25052989   PMID:25053223   PMID:25077922  
PMID:25081906   PMID:25084752   PMID:25100151   PMID:25108400   PMID:25123132   PMID:25154761   PMID:25161335   PMID:25182190   PMID:25183503   PMID:25187983   PMID:25209759   PMID:25214035  
PMID:25217662   PMID:25218914   PMID:25269878   PMID:25283877   PMID:25291868   PMID:25308712   PMID:25319229   PMID:25326754   PMID:25331734   PMID:25349113   PMID:25370733   PMID:25386093  
PMID:25417703   PMID:25445498   PMID:25448133   PMID:25455160   PMID:25469565   PMID:25483824   PMID:25490205   PMID:25500583   PMID:25505246   PMID:25515214   PMID:25523239   PMID:25524940  
PMID:25524943   PMID:25526182   PMID:25537514   PMID:25546664   PMID:25555557   PMID:25591770   PMID:25596948   PMID:25607648   PMID:25608619   PMID:25614225   PMID:25630616   PMID:25646371  
PMID:25658319   PMID:25673459   PMID:25693929   PMID:25705792   PMID:25727911   PMID:25740880   PMID:25755772   PMID:25757558   PMID:25767384   PMID:25815338   PMID:25830862   PMID:25836258  
PMID:25865299   PMID:25867338   PMID:25891929   PMID:25896300   PMID:25958310   PMID:25959385   PMID:25986346   PMID:25987052   PMID:26008204   PMID:26033453   PMID:26044809   PMID:26045293  
PMID:26078942   PMID:26095531   PMID:26112171   PMID:26114385   PMID:26122011   PMID:26125831   PMID:26151128   PMID:26165231   PMID:26165719   PMID:26202355   PMID:26202478   PMID:26214448  
PMID:26214637   PMID:26235181   PMID:26238771   PMID:26306811   PMID:26323945   PMID:26337564   PMID:26337652   PMID:26341226   PMID:26345457   PMID:26345764   PMID:26345790   PMID:26352740  
PMID:26366721   PMID:26406414   PMID:26406571   PMID:26418898   PMID:26426696   PMID:26458899   PMID:26464690   PMID:26476291   PMID:26505653   PMID:26505665   PMID:26508028   PMID:26526003  
PMID:26529280   PMID:26537765   PMID:26549232   PMID:26608782   PMID:26621153   PMID:26646931   PMID:26673617   PMID:26689540   PMID:26718614   PMID:26722556   PMID:26752469   PMID:26785832  
PMID:26794279   PMID:26818976   PMID:26835710   PMID:26852168   PMID:26855180   PMID:26861135   PMID:26875519   PMID:26896831   PMID:26916895   PMID:26968172   PMID:26984146   PMID:26996068  
PMID:26997512   PMID:27004559   PMID:27011326   PMID:27013199   PMID:27014996   PMID:27015561   PMID:27060458   PMID:27077822   PMID:27079198   PMID:27093470   PMID:27098222   PMID:27102001  
PMID:27105532   PMID:27109937   PMID:27121396   PMID:27131313   PMID:27156151   PMID:27157639   PMID:27163405   PMID:27164084   PMID:27175941   PMID:27221467   PMID:27241555   PMID:27256622  
PMID:27267319   PMID:27268610   PMID:27297392   PMID:27310665   PMID:27311960   PMID:27323019   PMID:27339100   PMID:27342690   PMID:27351285   PMID:27378744   PMID:27379568   PMID:27430349  
PMID:27431205   PMID:27434289   PMID:27438138   PMID:27444565   PMID:27449900   PMID:27468194   PMID:27477122   PMID:27494344   PMID:27497395   PMID:27525378   PMID:27541693   PMID:27546538  
PMID:27562321   PMID:27568078   PMID:27573045   PMID:27636999   PMID:27706635   PMID:27706712   PMID:27762791   PMID:27769860   PMID:27794184   PMID:27818285   PMID:27824903   PMID:27832663  
PMID:27864711   PMID:27880723   PMID:27886162   PMID:27888401   PMID:27889748   PMID:27893422   PMID:27901485   PMID:27911870   PMID:27922090   PMID:27943367   PMID:28050558   PMID:28083614  
PMID:28101571   PMID:28103790   PMID:28127562   PMID:28131813   PMID:28145491   PMID:28161709   PMID:28164567   PMID:28164605   PMID:28186967   PMID:28202053   PMID:28202285   PMID:28218896  
PMID:28288804   PMID:28301595   PMID:28319200   PMID:28383548   PMID:28387985   PMID:28397233   PMID:28399410   PMID:28407626   PMID:28427206   PMID:28433754   PMID:28443377   PMID:28454101  
PMID:28489066   PMID:28514293   PMID:28527151   PMID:28530238   PMID:28545737   PMID:28546273   PMID:28549054   PMID:28560435   PMID:28569050   PMID:28573480   PMID:28609461   PMID:28647559  
PMID:28654546   PMID:28662100   PMID:28674224   PMID:28720071   PMID:28727754   PMID:28733034   PMID:28741852   PMID:28748483   PMID:28771774   PMID:28801378   PMID:28825144   PMID:28841705  
PMID:28870579   PMID:28886326   PMID:28990079   PMID:29037553   PMID:29048658   PMID:29048684   PMID:29049342   PMID:29058209   PMID:29095255   PMID:29101123   PMID:29115409   PMID:29127520  
PMID:29127522   PMID:29128203   PMID:29145150   PMID:29208766   PMID:29229881   PMID:29250766   PMID:29276184   PMID:29279330   PMID:29292727   PMID:29328400   PMID:29357324   PMID:29384235  
PMID:29402939   PMID:29437577   PMID:29442046   PMID:29443743   PMID:29461602   PMID:29467762   PMID:29484780   PMID:29495389   PMID:29521182   PMID:29578157   PMID:29587639   PMID:29593706  
PMID:29594807   PMID:29635981   PMID:29658581   PMID:29678844   PMID:29685157   PMID:29693168   PMID:29700729   PMID:29702190   PMID:29715515   PMID:29717615   PMID:29734142   PMID:29749487  
PMID:29754557   PMID:29844486   PMID:29863307   PMID:29889802   PMID:29896267   PMID:29896975   PMID:29902229   PMID:29902868   PMID:29903729   PMID:29915929   PMID:29946002   PMID:29951184  
PMID:29954239   PMID:29956871   PMID:29965793   PMID:29987428   PMID:30018336   PMID:30043989   PMID:30054544   PMID:30056535   PMID:30060033   PMID:30066863   PMID:30077189   PMID:30107841  
PMID:30121885   PMID:30123065   PMID:30125971   PMID:30125982   PMID:30176290   PMID:30184528   PMID:30208330   PMID:30212608   PMID:30224945   PMID:30242879   PMID:30254431   PMID:30278502  
PMID:30287978   PMID:30291383   PMID:30297336   PMID:30308218   PMID:30321140   PMID:30328616   PMID:30355233   PMID:30366049   PMID:30411131   PMID:30414370   PMID:30419656   PMID:30421783  
PMID:30425059   PMID:30462539   PMID:30478292   PMID:30484703   PMID:30537266   PMID:30576465   PMID:30582225   PMID:30599464   PMID:30611259   PMID:30624803   PMID:30637557   PMID:30642078  
PMID:30657551   PMID:30700845   PMID:30710793   PMID:30711634   PMID:30732186   PMID:30779466   PMID:30801535   PMID:30816543   PMID:30820968   PMID:30864722   PMID:30872409   PMID:30880764  
PMID:30887564   PMID:30904593   PMID:30914680   PMID:30934838   PMID:30963551   PMID:30980673   PMID:30989711   PMID:31018043   PMID:31030445   PMID:31071307   PMID:31077718   PMID:31092195  
PMID:31095782   PMID:31123171   PMID:31156641   PMID:31183875   PMID:31216106   PMID:31223622   PMID:31252530   PMID:31264164   PMID:31298396   PMID:31299195   PMID:31330207   PMID:31355469  
PMID:31425002   PMID:31428639   PMID:31437718   PMID:31466461   PMID:31470144   PMID:31484042   PMID:31522559   PMID:31538427   PMID:31545496   PMID:31560641   PMID:31570669   PMID:31588496  
PMID:31598678   PMID:31609675   PMID:31612476   PMID:31612500   PMID:31630447   PMID:31635187   PMID:31638178   PMID:31638185   PMID:31646827   PMID:31672084   PMID:31693774   PMID:31698144  
PMID:31727077   PMID:31738890   PMID:31791577   PMID:31813598   PMID:31827152   PMID:31872268   PMID:31889417   PMID:31894531   PMID:31898522   PMID:31908003   PMID:31910330   PMID:31918067  
PMID:31926946   PMID:31960423   PMID:31999471   PMID:32031872   PMID:32097101   PMID:32107471   PMID:32108040   PMID:32124721   PMID:32125286   PMID:32132049   PMID:32138469   PMID:32153557  
PMID:32155539   PMID:32210951   PMID:32223661   PMID:32226532   PMID:32255285   PMID:32268136   PMID:32300104   PMID:32308092   PMID:32314378   PMID:32316600   PMID:32319375   PMID:32323801  
PMID:32326527   PMID:32328683   PMID:32329848   PMID:32331943   PMID:32342557   PMID:32384151   PMID:32438863   PMID:32452829   PMID:32469461   PMID:32481361   PMID:32485219   PMID:32552942  
PMID:32554962   PMID:32569501   PMID:32572893   PMID:32582192   PMID:32592352   PMID:32596945   PMID:32629683   PMID:32640303   PMID:32659369   PMID:32770182   PMID:32798394   PMID:32803682  
PMID:32812451   PMID:32826242   PMID:32854478   PMID:32863945   PMID:32894083   PMID:32927965   PMID:32929657   PMID:32931869   PMID:32935891   PMID:32938348   PMID:32948076   PMID:32949355  
PMID:32954867   PMID:32967672   PMID:32993109   PMID:33003976   PMID:33021154   PMID:33059199   PMID:33095833   PMID:33124182   PMID:33131113   PMID:33161770   PMID:33172871   PMID:33198870  
PMID:33238873   PMID:33248456   PMID:33259730   PMID:33289522   PMID:33294082   PMID:33297927   PMID:33317606   PMID:33327874   PMID:33338955   PMID:33340248   PMID:33376728   PMID:33378026  
PMID:33382018   PMID:33396906   PMID:33403895   PMID:33420081   PMID:33446013   PMID:33447879   PMID:33459883   PMID:33463131   PMID:33478974   PMID:33554246   PMID:33569722   PMID:33583336  
PMID:33590413   PMID:33605830   PMID:33629312   PMID:33660812   PMID:33754051   PMID:33754922   PMID:33792241   PMID:33830627   PMID:33867821   PMID:33877886   PMID:33897883   PMID:33925232  
PMID:33937970   PMID:33941959   PMID:34002665   PMID:34022359   PMID:34030136   PMID:34030497   PMID:34052997   PMID:34077450   PMID:34095322   PMID:34134454   PMID:34146927   PMID:34185416  
PMID:34199767   PMID:34232111   PMID:34238177   PMID:34243103   PMID:34269309   PMID:34282692   PMID:34293926   PMID:34313201   PMID:34315248   PMID:34403295   PMID:34437653   PMID:34448795  
PMID:34463887   PMID:34502105   PMID:34517910   PMID:34543271   PMID:34584188   PMID:34601384   PMID:34645448   PMID:34656082   PMID:34659590   PMID:34716993   PMID:34727826   PMID:34728702  
PMID:34742341   PMID:34796909   PMID:34798192   PMID:34815474   PMID:34823560   PMID:34837916   PMID:34893101   PMID:34906298   PMID:34917199   PMID:34968770   PMID:34969353   PMID:34975837  
PMID:34981334   PMID:35091706   PMID:35112981   PMID:35171545   PMID:35210329   PMID:35227165   PMID:35240920   PMID:35270805   PMID:35278613   PMID:35315037   PMID:35349375   PMID:35406750  
PMID:35477552   PMID:35499218   PMID:35535334   PMID:35604113   PMID:35605149   PMID:35689735   PMID:35690236   PMID:35751569   PMID:35764020   PMID:35764071   PMID:36002591   PMID:36028828  
PMID:36075029   PMID:36078154   PMID:36099375   PMID:36155522   PMID:36227679   PMID:36237193   PMID:36239723   PMID:36243928   PMID:36303006   PMID:36420648   PMID:36434576   PMID:36540006  
PMID:36541377   PMID:36613718   PMID:36740569   PMID:36786137   PMID:36833398   PMID:36840403   PMID:36899831   PMID:36902041   PMID:36911496   PMID:36961677   PMID:37044033   PMID:37142567  
PMID:37189131   PMID:37231940   PMID:37364699   PMID:37369185   PMID:37511371   PMID:37545224   PMID:37591448   PMID:37628949   PMID:37728419   PMID:37783052   PMID:37903473   PMID:37904010  
PMID:37917636   PMID:37957714   PMID:38018996   PMID:38063120   PMID:38165852   PMID:38278065   PMID:38301106   PMID:38341771   PMID:38355214   PMID:38428111   PMID:38457157   PMID:38490506  
PMID:38775532  


Genomics

Comparative Map Data
MIR146A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385160,485,352 - 160,485,450 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5160,485,352 - 160,485,450 (+)EnsemblGRCh38hg38GRCh38
GRCh375159,912,359 - 159,912,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365159,844,936 - 159,845,034 (+)NCBINCBI36Build 36hg18NCBI36
Celera5155,944,832 - 155,944,930 (+)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5155,005,782 - 155,005,880 (+)NCBIHuRef
CHM1_15159,345,261 - 159,345,359 (+)NCBICHM1_1
T2T-CHM13v2.05161,013,850 - 161,013,948 (+)NCBIT2T-CHM13v2.0
Mir146
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,265,224 - 43,265,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,265,224 - 43,265,288 (-)EnsemblGRCm39 Ensembl
GRCm381143,374,397 - 43,374,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,374,397 - 43,374,461 (-)EnsemblGRCm38mm10GRCm38
MGSCv371143,187,899 - 43,187,963 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1148,002,809 - 48,002,873 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1125.68NCBI
Mir146a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81028,349,996 - 28,350,090 (-)NCBIGRCr8
mRatBN7.21027,848,516 - 27,848,610 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1027,848,516 - 27,848,610 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1032,609,206 - 32,609,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0101,147,600 - 1,147,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01027,581,111 - 27,581,205 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01028,962,476 - 28,962,570 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1028,962,476 - 28,962,570 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01028,806,739 - 28,806,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1027,342,093 - 27,342,187 (-)NCBICelera
Cytogenetic Map10q21NCBI


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3
pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:160029980-181269805)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051865]|See cases [RCV000051865] Chr5:160029980..181269805 [GRCh38]
Chr5:159456987..180696806 [GRCh37]
Chr5:159389565..180629412 [NCBI36]
Chr5:5q33.3-35.3
pathogenic
GRCh38/hg38 5q33.1-34(chr5:152761187-167248053)x1 copy number loss See cases [RCV000052144] Chr5:152761187..167248053 [GRCh38]
Chr5:152140747..166675058 [GRCh37]
Chr5:152120940..166607636 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q33.1-34(chr5:153195314-164014005)x1 copy number loss See cases [RCV000052145] Chr5:153195314..164014005 [GRCh38]
Chr5:152574874..163441011 [GRCh37]
Chr5:152555067..163373589 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q33.3-35.3(chr5:156825512-181269805)x3 copy number gain See cases [RCV000133847] Chr5:156825512..181269805 [GRCh38]
Chr5:156252523..180696806 [GRCh37]
Chr5:156185101..180629412 [NCBI36]
Chr5:5q33.3-35.3
pathogenic
GRCh38/hg38 5q33.1-34(chr5:152443869-166104392)x1 copy number loss See cases [RCV000138282] Chr5:152443869..166104392 [GRCh38]
Chr5:151823430..165531397 [GRCh37]
Chr5:151803623..165463975 [NCBI36]
Chr5:5q33.1-34
pathogenic
GRCh38/hg38 5q33.3-34(chr5:158941354-164386760)x1 copy number loss See cases [RCV000138895] Chr5:158941354..164386760 [GRCh38]
Chr5:158368362..163813766 [GRCh37]
Chr5:158300940..163746344 [NCBI36]
Chr5:5q33.3-34
pathogenic
GRCh37/hg19 5q33.2-35.1(chr5:154886174-169757448)x1 copy number loss See cases [RCV000240059] Chr5:154886174..169757448 [GRCh37]
Chr5:5q33.2-35.1
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q33.3-34(chr5:159694389-160048347)x1 copy number loss not provided [RCV000682605] Chr5:159694389..160048347 [GRCh37]
Chr5:5q33.3-34
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q33.2-35.3(chr5:155344802-180693344)x3 copy number gain not provided [RCV000745284] Chr5:155344802..180693344 [GRCh37]
Chr5:5q33.2-35.3
pathogenic
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3
pathogenic
GRCh37/hg19 5q33.3-35.1(chr5:156597181-171166353)x3 copy number gain not provided [RCV000845588] Chr5:156597181..171166353 [GRCh37]
Chr5:5q33.3-35.1
pathogenic
GRCh37/hg19 5q33.3-35.1(chr5:156347980-169959880)x1 copy number loss not provided [RCV001005746] Chr5:156347980..169959880 [GRCh37]
Chr5:5q33.3-35.1
pathogenic
GRCh37/hg19 5q33.3-34(chr5:159714197-161313217)x1 copy number loss not provided [RCV001005749] Chr5:159714197..161313217 [GRCh37]
Chr5:5q33.3-34
likely pathogenic
GRCh37/hg19 5q33.3-34(chr5:157801321-162780186)x1 copy number loss not provided [RCV001005747] Chr5:157801321..162780186 [GRCh37]
Chr5:5q33.3-34
pathogenic
GRCh37/hg19 5q33.3-34(chr5:159623973-160000962)x3 copy number gain not provided [RCV001005748] Chr5:159623973..160000962 [GRCh37]
Chr5:5q33.3-34
uncertain significance
GRCh37/hg19 5q33.3-34(chr5:155970607-162450579)x1 copy number loss not provided [RCV001825167] Chr5:155970607..162450579 [GRCh37]
Chr5:5q33.3-34
not provided
Single allele duplication not specified [RCV002286367] Chr5:158887731..164722046 [GRCh38]
Chr5:5q33.3-34
uncertain significance
GRCh37/hg19 5q33.1-35.2(chr5:150535183-172906793)x3 copy number gain not provided [RCV002474507] Chr5:150535183..172906793 [GRCh37]
Chr5:5q33.1-35.2
pathogenic
GRCh37/hg19 5q33.3-34(chr5:159535230-161656766)x3 copy number gain not provided [RCV002474838] Chr5:159535230..161656766 [GRCh37]
Chr5:5q33.3-34
uncertain significance
GRCh37/hg19 5q33.3-34(chr5:156786013-162945369)x1 copy number loss not provided [RCV002512289] Chr5:156786013..162945369 [GRCh37]
Chr5:5q33.3-34
likely pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)18759964
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoImmunoprecipitaion//Western blot//CommunoprecipitaFunctional MTI19898489
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//Western blot//ImmunofluorescenceFunctional MTI19918258
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI16885212
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//Northern blot//qFunctional MTI20542134
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI21178010
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22593544
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoWestern blotFunctional MTI20110513
IRAK1hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21632853
ROCK1hsa-miR-146a-5pMirtarbaseexternal_infoflow//Western blot//Northern blot//Luciferase repoFunctional MTI18174313
BRCA2hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18660546
BRCA1hsa-miR-146a-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI19944095
TLR4hsa-miR-146a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//Microarray//qRT-Functional MTI21329689
FAF1hsa-miR-146a-5pMirtarbaseexternal_infoGFP reporter assay//qRT-PCRFunctional MTI20459811
CXCL8hsa-miR-146a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20124483
NFKB1hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18504431
NFKB1hsa-miR-146a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18660546
CDKN1Ahsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayNon-Functional MTI20101223
EGFRhsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22161865
EGFRhsa-miR-146a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19190326
CD40LGhsa-miR-146a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCR//WesternFunctional MTI21236257
FAShsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20656888
CDKN3hsa-miR-146a-5pMirtarbaseexternal_infoWestern blotNon-Functional MTI19944095
ERBB4hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
SMAD4hsa-miR-146a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//MFunctional MTI22507670
SMAD4hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21968601
WASF2hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23435376
IRF7hsa-miR-146a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18057241
BGLAPhsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20110513
STAT1hsa-miR-146a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20110513
SLPIhsa-miR-146a-5pMirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI20110513
MSChsa-miR-146a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
EPSTI1hsa-miR-146a-5pTarbaseexternal_infoMicroarrayPOSITIVE
IRAK1hsa-miR-146a-5pTarbaseexternal_infoWesternblitPOSITIVE
TLR2hsa-miR-146a-5pTarbaseexternal_infoqPCRPOSITIVE
CD83hsa-miR-146a-5pTarbaseexternal_infoOtherPOSITIVE
WASF2hsa-miR-146a-5pOncomiRDBexternal_infoNANA23435376
CARD10hsa-miR-146a-5pOncomiRDBexternal_infoNANA22992343
L1CAMhsa-miR-146a-5pOncomiRDBexternal_infoNANA22711166
L1CAMhsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22711166
MMP16hsa-miR-146a-5pOncomiRDBexternal_infoNANA22348245
TRAF2hsa-miR-146a-5pOncomiRDBexternal_infoNANA22167321
EGFRhsa-miR-146a-5pOncomiRDBexternal_infoNANA22161865
SMAD4hsa-miR-146a-5pOncomiRDBexternal_infoNANA22020746
NOTCH1hsa-miR-146a-5pOncomiRDBexternal_infoNANA21730286
EGFRhsa-miR-146a-5pOncomiRDBexternal_infoNANA21632853
BRCA1hsa-miR-146a-5pOncomiRDBexternal_infoNANA21472990
THRBhsa-miR-146a-5pOncomiRDBexternal_infoNANA21159845
SMAD4hsa-miR-146a-5pOncomiRDBexternal_infoNANA20577838
CXCR4hsa-miR-146a-5pOncomiRDBexternal_infoNANA20023696
PLXNA1hsa-miR-146a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
IRAK1hsa-miR-146a-3pMirecordsexternal_info{changed}NA18759964
BRCA2hsa-miR-146a-3pMirecordsexternal_infoNANA18660546
CXCR4hsa-miR-146a-3pMirecordsexternal_infoNANA18568019
TBPhsa-miR-146a-3pMirecordsexternal_info{changed}NA20451497
CCL8hsa-miR-146a-3pMirecordsexternal_infoNANA20181935
CCNA2hsa-miR-146a-3pMirecordsexternal_info{changed}NA19944095
FADDhsa-miR-146a-3pMirecordsexternal_infoNANA19965651
IRF5hsa-miR-146a-3pMirecordsexternal_infoNANA19333922
CXCR4hsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18568019
CXCR4hsa-miR-146a-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20375304
CFHhsa-miR-146a-5pMirtarbaseexternal_infoWestern blotFunctional MTI19540598
CFHhsa-miR-146a-5pMirtarbaseexternal_infoWestern blotFunctional MTI18801740
IRAK2hsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI20124483
TLR2hsa-miR-146a-5pMirtarbaseexternal_infoqRT-PCR//flow//Luciferase reporter assay//Western Functional MTI20375304
FADDhsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19965651
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoWestern blot//Northern blotFunctional MTI18504431
TRAF6hsa-miR-146a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20061417

Predicted Targets
Summary Value
Count of predictions:33838
Count of gene targets:11129
Count of transcripts:22949
Interacting mature miRNAs:hsa-miR-146a-3p, hsa-miR-146a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


RefSeq Acc Id: ENST00000385201
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5160,485,352 - 160,485,450 (+)Ensembl
RefSeq Acc Id: NR_029701
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385160,485,352 - 160,485,450 (+)NCBI
GRCh375159,912,359 - 159,912,457 (+)ENTREZGENE
HuRef5155,005,782 - 155,005,880 (+)ENTREZGENE
CHM1_15159,345,261 - 159,345,359 (+)NCBI
T2T-CHM13v2.05161,013,850 - 161,013,948 (+)NCBI
Sequence:
Promoters
RGD ID:6814754
Promoter ID:HG_XEF:6603
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:NR_029558,   NR_031031,   NR_031459,   NR_031892,   NR_032416,   NR_032937
Position:
Human AssemblyChrPosition (strand)Source
Build 365159,844,661 - 159,845,161 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31533 AgrOrtholog
COSMIC MIR146A COSMIC
Ensembl Genes ENSG00000283733 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385201 ENTREZGENE
GTEx ENSG00000283733 GTEx
HGNC ID HGNC:31533 ENTREZGENE
Human Proteome Map MIR146A Human Proteome Map
miRBase MI0000477 ENTREZGENE
NCBI Gene 406938 ENTREZGENE
OMIM 610566 OMIM
PharmGKB PA164722497 PharmGKB
RNAcentral URS00001EFBE3 RNACentral
  URS000050B527 RNACentral
  URS000075D8A0 RNACentral