IFIT1B (interferon induced protein with tetratricopeptide repeats 1B) - Rat Genome Database

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Gene: IFIT1B (interferon induced protein with tetratricopeptide repeats 1B) Homo sapiens
Analyze
Symbol: IFIT1B
Name: interferon induced protein with tetratricopeptide repeats 1B
RGD ID: 1344579
HGNC Page HGNC:23442
Description: Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to act upstream of or within cellular response to interferon-alpha; cellular response to interferon-beta; and response to bacterium. Predicted to be located in cytoplasm. Predicted to be active in cytosol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bA149I23.6; DKFZp781M1841; IFIT1L; interferon-induced protein with tetratricopeptide repeats 1-like protein; interferon-induced protein with tetratricopeptide repeats 1B
RGD Orthologs
Mouse
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Related Pseudogenes: IFIT6P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,378,056 - 89,385,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,378,056 - 89,385,205 (+)EnsemblGRCh38hg38GRCh38
GRCh371091,137,813 - 91,144,962 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361091,127,793 - 91,134,942 (+)NCBINCBI36Build 36hg18NCBI36
Build 341091,127,792 - 91,134,941NCBI
Celera1084,884,634 - 84,891,783 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,771,999 - 84,779,148 (+)NCBIHuRef
CHM1_11091,419,874 - 91,427,023 (+)NCBICHM1_1
T2T-CHM13v2.01090,261,914 - 90,269,063 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dexamethasone  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fructose  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
mercaptopurine  (ISO)
metam  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
purine-6-thiol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
Triptolide  (ISO)
trovafloxacin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
High myopia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:3175763   PMID:12477932   PMID:21642987   PMID:21873635   PMID:23237964   PMID:28514442   PMID:32296183   PMID:33961781   PMID:36724073  


Genomics

Comparative Map Data
IFIT1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,378,056 - 89,385,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,378,056 - 89,385,205 (+)EnsemblGRCh38hg38GRCh38
GRCh371091,137,813 - 91,144,962 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361091,127,793 - 91,134,942 (+)NCBINCBI36Build 36hg18NCBI36
Build 341091,127,792 - 91,134,941NCBI
Celera1084,884,634 - 84,891,783 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,771,999 - 84,779,148 (+)NCBIHuRef
CHM1_11091,419,874 - 91,427,023 (+)NCBICHM1_1
T2T-CHM13v2.01090,261,914 - 90,269,063 (+)NCBIT2T-CHM13v2.0
Ifit1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,618,289 - 34,627,409 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,618,271 - 34,627,409 (+)EnsemblGRCm39 Ensembl
GRCm381934,640,889 - 34,650,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,640,871 - 34,650,009 (+)EnsemblGRCm38mm10GRCm38
MGSCv371934,715,379 - 34,724,499 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361934,706,911 - 34,715,477 (+)NCBIMGSCv36mm8
Celera1935,415,203 - 35,424,323 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.78NCBI
Ifit1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,565,197 - 241,567,262 (+)NCBIGRCr8
mRatBN7.21232,152,038 - 232,154,103 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,127,170 - 232,154,435 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,538,339 - 240,547,748 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,464,818 - 247,466,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,303,024 - 240,305,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,944,105 - 252,946,170 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,944,103 - 252,946,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,165,590 - 260,167,655 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,609,171 - 238,611,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,773,058 - 238,775,125 (+)NCBI
Celera1229,265,082 - 229,267,147 (+)NCBICelera
Cytogenetic Map1q53NCBI
LOC100977291
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,393,967 - 101,403,509 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,399,281 - 101,408,823 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01086,094,636 - 86,109,924 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,634,232 - 89,649,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,648,070 - 89,649,517 (+)Ensemblpanpan1.1panPan2
IFIT1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,771,077 - 82,778,696 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604843,445,035 - 43,453,357 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in IFIT1B
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.31(chr10:89095288-89633544)x3 copy number gain See cases [RCV000141185] Chr10:89095288..89633544 [GRCh38]
Chr10:90855045..91393301 [GRCh37]
Chr10:90845025..91383281 [NCBI36]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.407T>C (p.Met136Thr) single nucleotide variant not specified [RCV004296117] Chr10:89383720 [GRCh38]
Chr10:91143477 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q23.1-23.31(chr10:86766571-92609514)x1 copy number loss See cases [RCV000447104] Chr10:86766571..92609514 [GRCh37]
Chr10:10q23.1-23.31		 pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1		 pathogenic|drug response
GRCh37/hg19 10q23.2-23.31(chr10:88615516-92032083)x3 copy number gain See cases [RCV000448638] Chr10:88615516..92032083 [GRCh37]
Chr10:10q23.2-23.31		 uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
NM_001010987.2(IFIT1B):c.436G>C (p.Gly146Arg) single nucleotide variant not specified [RCV004320863] Chr10:89383749 [GRCh38]
Chr10:91143506 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32		 pathogenic
GRCh37/hg19 10q23.1-23.32(chr10:83379241-93219169)x1 copy number loss not provided [RCV000683284] Chr10:83379241..93219169 [GRCh37]
Chr10:10q23.1-23.32		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_001010987.2(IFIT1B):c.563T>C (p.Leu188Pro) single nucleotide variant not provided [RCV000893246] Chr10:89383876 [GRCh38]
Chr10:91143633 [GRCh37]
Chr10:10q23.31		 benign
NM_001010987.2(IFIT1B):c.1153G>A (p.Gly385Ser) single nucleotide variant High myopia [RCV000785681] Chr10:89384466 [GRCh38]
Chr10:91144223 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.899T>C (p.Ile300Thr) single nucleotide variant not specified [RCV004294434] Chr10:89384212 [GRCh38]
Chr10:91143969 [GRCh37]
Chr10:10q23.31		 uncertain significance
NC_000010.11:g.(?_89338661)_(89612048_?)del deletion not provided [RCV001031694] Chr10:91098418..91371805 [GRCh37]
Chr10:10q23.31		 pathogenic
GRCh37/hg19 10q23.2-23.31(chr10:88685387-92144296)x1 copy number loss not provided [RCV001258457] Chr10:88685387..92144296 [GRCh37]
Chr10:10q23.2-23.31		 pathogenic
NC_000010.10:g.(?_90974585)_(91222335_?)dup duplication Wolman disease [RCV003122214] Chr10:90974585..91222335 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q23.1-23.31(chr10:83533660-91913077)x1 copy number loss See cases [RCV002287561] Chr10:83533660..91913077 [GRCh37]
Chr10:10q23.1-23.31		 pathogenic
GRCh37/hg19 10q23.1-23.32(chr10:82595472-93542416)x1 copy number loss not provided [RCV002472429] Chr10:82595472..93542416 [GRCh37]
Chr10:10q23.1-23.32		 pathogenic
GRCh37/hg19 10q23.31-23.33(chr10:89823147-96056941)x1 copy number loss not provided [RCV002472645] Chr10:89823147..96056941 [GRCh37]
Chr10:10q23.31-23.33		 pathogenic
GRCh37/hg19 10q23.31(chr10:90672265-91165763)x3 copy number gain not provided [RCV002474877] Chr10:90672265..91165763 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q23.31(chr10:90874051-91291188)x3 copy number gain not provided [RCV002474794] Chr10:90874051..91291188 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1223T>G (p.Ile408Arg) single nucleotide variant not specified [RCV004085522] Chr10:89384536 [GRCh38]
Chr10:91144293 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.559C>T (p.Arg187Cys) single nucleotide variant not specified [RCV004206973] Chr10:89383872 [GRCh38]
Chr10:91143629 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1138A>T (p.Ile380Phe) single nucleotide variant not specified [RCV004111916] Chr10:89384451 [GRCh38]
Chr10:91144208 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.149A>G (p.Tyr50Cys) single nucleotide variant not specified [RCV004234009] Chr10:89383462 [GRCh38]
Chr10:91143219 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.871A>G (p.Met291Val) single nucleotide variant not specified [RCV004199005] Chr10:89384184 [GRCh38]
Chr10:91143941 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.625G>T (p.Ala209Ser) single nucleotide variant not specified [RCV004142997] Chr10:89383938 [GRCh38]
Chr10:91143695 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1381G>A (p.Glu461Lys) single nucleotide variant not specified [RCV004194044] Chr10:89384694 [GRCh38]
Chr10:91144451 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.578C>T (p.Thr193Ile) single nucleotide variant not specified [RCV004214744] Chr10:89383891 [GRCh38]
Chr10:91143648 [GRCh37]
Chr10:10q23.31		 likely benign
NM_001010987.2(IFIT1B):c.921C>G (p.Asn307Lys) single nucleotide variant not specified [RCV004280849] Chr10:89384234 [GRCh38]
Chr10:91143991 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1157G>A (p.Arg386His) single nucleotide variant not specified [RCV004316381] Chr10:89384470 [GRCh38]
Chr10:91144227 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
NM_001010987.2(IFIT1B):c.1177A>C (p.Lys393Gln) single nucleotide variant not specified [RCV004363736] Chr10:89384490 [GRCh38]
Chr10:91144247 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.781T>C (p.Tyr261His) single nucleotide variant not specified [RCV004363737] Chr10:89384094 [GRCh38]
Chr10:91143851 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.934G>A (p.Gly312Arg) single nucleotide variant not specified [RCV004358395] Chr10:89384247 [GRCh38]
Chr10:91144004 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
GRCh37/hg19 10q23.31(chr10:90948076-91395072)x3 copy number gain not specified [RCV003986858] Chr10:90948076..91395072 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q23.31-24.2(chr10:90796994-100067505)x1 copy number loss not specified [RCV003986861] Chr10:90796994..100067505 [GRCh37]
Chr10:10q23.31-24.2		 pathogenic
GRCh37/hg19 10q23.31-23.32(chr10:89950990-92959893)x3 copy number gain not specified [RCV003986875] Chr10:89950990..92959893 [GRCh37]
Chr10:10q23.31-23.32		 uncertain significance
GRCh37/hg19 10q23.2-23.32(chr10:88121043-93641582)x1 copy number loss not specified [RCV003986869] Chr10:88121043..93641582 [GRCh37]
Chr10:10q23.2-23.32		 pathogenic
NM_001010987.2(IFIT1B):c.1283G>T (p.Arg428Ile) single nucleotide variant not specified [RCV004400076] Chr10:89384596 [GRCh38]
Chr10:91144353 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1333C>T (p.Leu445Phe) single nucleotide variant not specified [RCV004400078] Chr10:89384646 [GRCh38]
Chr10:91144403 [GRCh37]
Chr10:10q23.31		 likely benign
NM_001010987.2(IFIT1B):c.181G>T (p.Val61Leu) single nucleotide variant not specified [RCV004400080] Chr10:89383494 [GRCh38]
Chr10:91143251 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.334G>A (p.Ala112Thr) single nucleotide variant not specified [RCV004400081] Chr10:89383647 [GRCh38]
Chr10:91143404 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1309G>A (p.Val437Met) single nucleotide variant not specified [RCV004400077] Chr10:89384622 [GRCh38]
Chr10:91144379 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1352G>A (p.Gly451Glu) single nucleotide variant not specified [RCV004400079] Chr10:89384665 [GRCh38]
Chr10:91144422 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.411G>C (p.Glu137Asp) single nucleotide variant not specified [RCV004400082] Chr10:89383724 [GRCh38]
Chr10:91143481 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1166A>C (p.Glu389Ala) single nucleotide variant not specified [RCV004400075] Chr10:89384479 [GRCh38]
Chr10:91144236 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.1003T>A (p.Leu335Ile) single nucleotide variant not specified [RCV004400074] Chr10:89384316 [GRCh38]
Chr10:91144073 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.492T>G (p.Phe164Leu) single nucleotide variant not specified [RCV004400083] Chr10:89383805 [GRCh38]
Chr10:91143562 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.545C>T (p.Ala182Val) single nucleotide variant not specified [RCV004400084] Chr10:89383858 [GRCh38]
Chr10:91143615 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010987.2(IFIT1B):c.832T>G (p.Leu278Val) single nucleotide variant not specified [RCV004400086] Chr10:89384145 [GRCh38]
Chr10:91143902 [GRCh37]
Chr10:10q23.31		 uncertain significance
NC_000010.10:g.(?_90332640)_(91222335_?)dup duplication Autoimmune lymphoproliferative syndrome type 1 [RCV004580419] Chr10:90332640..91222335 [GRCh37]
Chr10:10q23.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:137
Interacting mature miRNAs:139
Transcripts:ENST00000371809
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2314551GLUCO52_HGlucose level QTL 52 (human)1.4Glucose level1077605006103605006Human

Markers in Region
WI-11615  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371091,144,824 - 91,144,950UniSTSGRCh37
Build 361091,134,804 - 91,134,930RGDNCBI36
Celera1084,891,645 - 84,891,771RGD
Cytogenetic Map10q23.31UniSTS
HuRef1084,779,010 - 84,779,136UniSTS
GeneMap99-GB4 RH Map10433.13UniSTS
Whitehead-RH Map10519.0UniSTS
NCBI RH Map101033.9UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
774 1057 1250 1168 2653 938 1241 3 264 1316 216 867 3834 3835 16 2497 410 903 900 58 1

Sequence


Ensembl Acc Id: ENST00000371809   ⟹   ENSP00000360874
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1089,378,056 - 89,385,205 (+)Ensembl
RefSeq Acc Id: NM_001010987   ⟹   NP_001010987
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381089,378,056 - 89,385,205 (+)NCBI
GRCh371091,137,813 - 91,144,962 (+)RGD
Build 361091,127,793 - 91,134,942 (+)NCBI Archive
Celera1084,884,634 - 84,891,783 (+)RGD
HuRef1084,771,999 - 84,779,148 (+)ENTREZGENE
CHM1_11091,419,874 - 91,427,023 (+)NCBI
T2T-CHM13v2.01090,261,914 - 90,269,063 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001010987 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI37369 (Get FASTA)   NCBI Sequence Viewer  
  AAI37370 (Get FASTA)   NCBI Sequence Viewer  
  AAI50190 (Get FASTA)   NCBI Sequence Viewer  
  EAW50139 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000360874
  ENSP00000360874.3
GenBank Protein Q5T764 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001010987   ⟸   NM_001010987
- UniProtKB: Q5T764 (UniProtKB/Swiss-Prot),   A7E245 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000360874   ⟸   ENST00000371809

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5T764-F1-model_v2 AlphaFold Q5T764 1-474 view protein structure

Promoters
RGD ID:7218105
Promoter ID:EPDNEW_H14798
Type:multiple initiation site
Name:IFIT1B_1
Description:interferon induced protein with tetratricopeptide repeats 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381089,378,056 - 89,378,116EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23442 AgrOrtholog
COSMIC IFIT1B COSMIC
Ensembl Genes ENSG00000204010 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000371809 ENTREZGENE
  ENST00000371809.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000204010 GTEx
HGNC ID HGNC:23442 ENTREZGENE
Human Proteome Map IFIT1B Human Proteome Map
InterPro TPR-like_helical_dom_sf UniProtKB/Swiss-Prot
  TPR_repeat UniProtKB/Swiss-Prot
KEGG Report hsa:439996 UniProtKB/Swiss-Prot
NCBI Gene IFIT1B ENTREZGENE
PANTHER INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS UniProtKB/Swiss-Prot
  INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 1B UniProtKB/Swiss-Prot
Pfam TPR_7 UniProtKB/Swiss-Prot
  TPR_8 UniProtKB/Swiss-Prot
PharmGKB PA165548753 PharmGKB
PROSITE TPR UniProtKB/Swiss-Prot
  TPR_REGION UniProtKB/Swiss-Prot
SMART TPR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot
UniProt A7E245 ENTREZGENE
  IFT1B_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A7E245 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 IFIT1B  interferon induced protein with tetratricopeptide repeats 1B    interferon-induced protein with tetratricopeptide repeats 1B  Symbol and/or name change 5135510 APPROVED
2011-07-27 IFIT1B  interferon-induced protein with tetratricopeptide repeats 1B  IFIT1L  interferon-induced protein with tetratricopeptide repeats 1-like  Symbol and/or name change 5135510 APPROVED