MRGPRD (MAS related GPR family member D)

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Gene: MRGPRD (MAS related GPR family member D) Homo sapiens

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Symbol:

MRGPRD

Name:

MAS related GPR family member D

RGD ID:

1344076

HGNC Page

HGNC:29626

Description:

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in extracellular space.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

beta-alanine receptor; G-protein coupled receptor TGR7; mas-related G protein-coupled MRGD; mas-related G-protein coupled receptor member D; MAS-related GPR, member D; MRGD; TGR7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	68,980,021 - 68,980,986 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	68,980,021 - 68,980,986 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	68,747,490 - 68,748,455 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	68,504,066 - 68,505,031 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	68,504,065 - 68,505,031	NCBI
Celera	11	66,087,241 - 66,088,206 (-)	NCBI		Celera
Cytogenetic Map	11	q13.3	NCBI
HuRef	11	65,086,709 - 65,087,666 (-)	NCBI		HuRef
CHM1_1	11	68,630,734 - 68,631,699 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	68,990,212 - 68,991,177 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (IAGP)

dilated cardiomyopathy (ISS)

intellectual disability (IAGP)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2-palmitoylglycerol (EXP)

6-propyl-2-thiouracil (ISO)

aflatoxin B1 (EXP)

atrazine (EXP)

benzo[a]pyrene (EXP)

bisphenol A (ISO)

Cuprizon (ISO)

glycidol (ISO)

sodium arsenite (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IBA,IEA)

Cellular Component

extracellular space (HDA)

membrane (IEA)

plasma membrane (IBA,IEA)

Molecular Function

G protein-coupled receptor activity (IBA,IEA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Intellectual disability (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
2.	Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.	Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.

Additional References at PubMed

PMID:11551509	PMID:12044878	PMID:15037633	PMID:18636314	PMID:21873635	PMID:22664934	PMID:22715397	PMID:23446738	PMID:33891544	PMID:34948051	PMID:38338778

Genomics

Comparative Map Data

MRGPRD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	68,980,021 - 68,980,986 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	68,980,021 - 68,980,986 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	68,747,490 - 68,748,455 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	68,504,066 - 68,505,031 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	68,504,065 - 68,505,031	NCBI
Celera	11	66,087,241 - 66,088,206 (-)	NCBI		Celera
Cytogenetic Map	11	q13.3	NCBI
HuRef	11	65,086,709 - 65,087,666 (-)	NCBI		HuRef
CHM1_1	11	68,630,734 - 68,631,699 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	68,990,212 - 68,991,177 (-)	NCBI		T2T-CHM13v2.0

Mrgprd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	144,868,572 - 144,877,796 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	144,868,572 - 144,877,823 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	145,314,835 - 145,324,059 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	145,314,835 - 145,324,086 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	152,500,740 - 152,509,964 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	145,124,225 - 145,133,449 (+)	NCBI		MGSCv36	mm8
Celera	7	145,083,196 - 145,092,547 (+)	NCBI		Celera
Cytogenetic Map	7	F5	NCBI
cM Map	7	89.06	NCBI

Mrgprd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	209,908,487 - 209,917,183 (+)	NCBI		GRCr8
mRatBN7.2	1	200,479,204 - 200,487,902 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	200,485,189 - 200,486,148 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	208,860,568 - 208,861,527 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	215,947,137 - 215,948,096 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	208,621,341 - 208,622,300 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	218,481,146 - 218,491,910 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	218,487,824 - 218,488,783 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	225,348,996 - 225,358,326 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	205,771,612 - 205,772,571 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	205,925,064 - 205,926,024 (+)	NCBI
Celera	1	198,039,696 - 198,040,655 (+)	NCBI		Celera
Cytogenetic Map	1	q42	NCBI

Mrgprd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	16,980,932 - 16,981,903 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	16,980,896 - 16,981,906 (+)	NCBI	ChiLan1.0	ChiLan1.0

MRGPRD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	69,937,571 - 69,940,015 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	70,977,299 - 70,983,198 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	64,069,508 - 64,070,765 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	67,370,432 - 67,371,399 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	67,370,432 - 67,371,397 (-)	Ensembl	panpan1.1		panPan2

MRGPRD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	49,028,149 - 49,029,198 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	49,028,149 - 49,029,198 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	47,635,397 - 47,636,446 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	49,702,851 - 49,703,900 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	49,702,851 - 49,703,900 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	49,148,742 - 49,149,703 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	48,735,109 - 48,736,158 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	49,481,779 - 49,482,828 (+)	NCBI		UU_Cfam_GSD_1.0

Mrgprd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	4,941,988 - 4,942,947 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936599	1,384,216 - 1,385,296 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MRGPRD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	5,591,179 - 5,593,796 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	102,872,023 - 102,873,328 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mrgprd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624767	17,999,897 - 18,000,932 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in MRGPRD
17 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
Single allele	deletion	Intellectual disability [RCV001293382]	Chr11:118359328..118372573 [GRCh37] Chr11:11p15.3-q23.3	pathogenic
GRCh38/hg38 11q13.2-13.3(chr11:67217264-69448598)x1	copy number loss	See cases [RCV000135609]	Chr11:67217264..69448598 [GRCh38] Chr11:66984735..69263366 [GRCh37] Chr11:66741311..68972547 [NCBI36] Chr11:11q13.2-13.3	likely pathogenic
GRCh38/hg38 11q13.2-13.3(chr11:68205963-69580475)x3	copy number gain	See cases [RCV000137992]	Chr11:68205963..69580475 [GRCh38] Chr11:67973430..69395243 [GRCh37] Chr11:67730006..69104424 [NCBI36] Chr11:11q13.2-13.3	likely benign
GRCh38/hg38 11q13.2-13.4(chr11:68031693-71593495)x1	copy number loss	See cases [RCV000142138]	Chr11:68031693..71593495 [GRCh38] Chr11:67799160..71304541 [GRCh37] Chr11:67555736..70982189 [NCBI36] Chr11:11q13.2-13.4	likely pathogenic
GRCh37/hg19 11q13.3(chr11:68686958-69803426)x3	copy number gain	See cases [RCV000448627]	Chr11:68686958..69803426 [GRCh37] Chr11:11q13.3	uncertain significance
GRCh37/hg19 11q13.2-13.4(chr11:67799160-70701268)x1	copy number loss	See cases [RCV000510219]	Chr11:67799160..70701268 [GRCh37] Chr11:11q13.2-13.4	likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)	copy number gain	See cases [RCV000511729]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3	copy number gain	See cases [RCV000510881]	Chr11:230616..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
NM_198923.2(MRGPRD):c.799G>T (p.Val267Leu)	single nucleotide variant	not specified [RCV004294602]	Chr11:68980188 [GRCh38] Chr11:68747657 [GRCh37] Chr11:11q13.3	uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3	copy number gain	not provided [RCV000737348]	Chr11:198510..134934063 [GRCh37] Chr11:11p15.5-q25	pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3	copy number gain	not provided [RCV000749874]	Chr11:70864..134938470 [GRCh37] Chr11:11p15.5-q25	pathogenic
NM_198923.2(MRGPRD):c.548C>T (p.Ala183Val)	single nucleotide variant	not specified [RCV004304352]	Chr11:68980439 [GRCh38] Chr11:68747908 [GRCh37] Chr11:11q13.3	uncertain significance
NC_000011.9:g.(?_64973914)_(70052579_?)dup	duplication	Aicardi-Goutieres syndrome 3 [RCV003113322]\|FADD-related immunodeficiency [RCV003107753]	Chr11:64973914..70052579 [GRCh37] Chr11:11q13.1-13.3	uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3	copy number gain	MISSED ABORTION [RCV002282973]	Chr11:32799481..134938470 [GRCh37] Chr11:11p13-q25	pathogenic
NM_198923.2(MRGPRD):c.820G>A (p.Val274Ile)	single nucleotide variant	not specified [RCV004245685]	Chr11:68980167 [GRCh38] Chr11:68747636 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.641G>A (p.Arg214Gln)	single nucleotide variant	not specified [RCV004242665]	Chr11:68980346 [GRCh38] Chr11:68747815 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.940G>A (p.Val314Met)	single nucleotide variant	not specified [RCV004217933]	Chr11:68980047 [GRCh38] Chr11:68747516 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.865A>C (p.Thr289Pro)	single nucleotide variant	not specified [RCV004096585]	Chr11:68980122 [GRCh38] Chr11:68747591 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.251G>T (p.Ser84Ile)	single nucleotide variant	not specified [RCV004161393]	Chr11:68980736 [GRCh38] Chr11:68748205 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.845G>C (p.Arg282Pro)	single nucleotide variant	not specified [RCV004161436]	Chr11:68980142 [GRCh38] Chr11:68747611 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.904G>A (p.Glu302Lys)	single nucleotide variant	not specified [RCV004070862]	Chr11:68980083 [GRCh38] Chr11:68747552 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.520C>T (p.Arg174Trp)	single nucleotide variant	not specified [RCV004078793]	Chr11:68980467 [GRCh38] Chr11:68747936 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.58G>A (p.Gly20Arg)	single nucleotide variant	not specified [RCV004217538]	Chr11:68980929 [GRCh38] Chr11:68748398 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.811G>A (p.Ala271Thr)	single nucleotide variant	not specified [RCV004078978]	Chr11:68980176 [GRCh38] Chr11:68747645 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.953A>G (p.Glu318Gly)	single nucleotide variant	not specified [RCV004089873]	Chr11:68980034 [GRCh38] Chr11:68747503 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.913G>A (p.Glu305Lys)	single nucleotide variant	not specified [RCV004090141]	Chr11:68980074 [GRCh38] Chr11:68747543 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.368G>A (p.Arg123His)	single nucleotide variant	not specified [RCV004277209]	Chr11:68980619 [GRCh38] Chr11:68748088 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.562G>A (p.Gly188Arg)	single nucleotide variant	not specified [RCV004335287]	Chr11:68980425 [GRCh38] Chr11:68747894 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.410G>A (p.Arg137Gln)	single nucleotide variant	not specified [RCV004347591]	Chr11:68980577 [GRCh38] Chr11:68748046 [GRCh37] Chr11:11q13.3	likely benign
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3	copy number gain	not provided [RCV003484842]	Chr11:59923608..76272324 [GRCh37] Chr11:11q12.2-13.5	pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3	copy number gain	not specified [RCV003986944]	Chr11:56895955..69295402 [GRCh37] Chr11:11q12.1-13.3	likely pathogenic
NM_198923.2(MRGPRD):c.685G>C (p.Val229Leu)	single nucleotide variant	not specified [RCV004499202]	Chr11:68980302 [GRCh38] Chr11:68747771 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.467T>G (p.Met156Arg)	single nucleotide variant	not specified [RCV004499171]	Chr11:68980520 [GRCh38] Chr11:68747989 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.217C>T (p.Leu73Phe)	single nucleotide variant	not specified [RCV004499149]	Chr11:68980770 [GRCh38] Chr11:68748239 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.640C>T (p.Arg214Trp)	single nucleotide variant	not specified [RCV004499187]	Chr11:68980347 [GRCh38] Chr11:68747816 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.340A>G (p.Ser114Gly)	single nucleotide variant	not specified [RCV004499160]	Chr11:68980647 [GRCh38] Chr11:68748116 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.676T>G (p.Ser226Ala)	single nucleotide variant	not specified [RCV004499197]	Chr11:68980311 [GRCh38] Chr11:68747780 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.206C>T (p.Ala69Val)	single nucleotide variant	not specified [RCV004499144]	Chr11:68980781 [GRCh38] Chr11:68748250 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.806G>C (p.Ser269Thr)	single nucleotide variant	not specified [RCV004643552]	Chr11:68980181 [GRCh38] Chr11:68747650 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.577G>A (p.Val193Met)	single nucleotide variant	not specified [RCV004643547]	Chr11:68980410 [GRCh38] Chr11:68747879 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.242C>A (p.Ser81Tyr)	single nucleotide variant	not specified [RCV004643553]	Chr11:68980745 [GRCh38] Chr11:68748214 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.245C>T (p.Thr82Met)	single nucleotide variant	not specified [RCV004643554]	Chr11:68980742 [GRCh38] Chr11:68748211 [GRCh37] Chr11:11q13.3	likely benign
NM_198923.2(MRGPRD):c.895G>A (p.Ala299Thr)	single nucleotide variant	not specified [RCV004643548]	Chr11:68980092 [GRCh38] Chr11:68747561 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.362C>T (p.Thr121Ile)	single nucleotide variant	not specified [RCV004643549]	Chr11:68980625 [GRCh38] Chr11:68748094 [GRCh37] Chr11:11q13.3	uncertain significance
NM_198923.2(MRGPRD):c.760C>A (p.Gln254Lys)	single nucleotide variant	not specified [RCV004643551]	Chr11:68980227 [GRCh38] Chr11:68747696 [GRCh37] Chr11:11q13.3	likely benign
NM_198923.2(MRGPRD):c.845G>A (p.Arg282Gln)	single nucleotide variant	not specified [RCV004629120]	Chr11:68980142 [GRCh38] Chr11:68747611 [GRCh37] Chr11:11q13.3	likely benign

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	363
Count of miRNA genes:	344
Interacting mature miRNAs:	357
Transcripts:	ENST00000309106
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357380	BW64_H	Body weight QTL 64 (human)	2.2		Body weight	percent fat after exercise training	11	60978937	86978937	Human

Markers in Region

MRGPRD__7297

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	68,747,620 - 68,748,154	UniSTS	GRCh37
Build 36	11	68,504,196 - 68,504,730	RGD	NCBI36
Celera	11	66,087,371 - 66,087,905	RGD

UniSTS:482596

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	68,747,490 - 68,748,455	UniSTS	GRCh37
Celera	11	66,087,241 - 66,088,206	UniSTS
HuRef	11	65,086,709 - 65,087,666	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
971	1935	1929	1433	2150	465	970	164	560	104	1490	3537	3767	5	1610	448	1184	640	62

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_198923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB065786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB083627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB154410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AP000808	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY427820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068267	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000309106 ⟹ ENSP00000310631

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	11	68,980,021 - 68,980,986 (-)	Ensembl

RefSeq Acc Id:

NM_198923 ⟹ NP_944605

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	11	68,980,021 - 68,980,986 (-)	NCBI
GRCh37	11	68,747,490 - 68,748,455 (-)	RGD
Build 36	11	68,504,066 - 68,505,031 (-)	NCBI Archive
Celera	11	66,087,241 - 66,088,206 (-)	RGD
HuRef	11	65,086,709 - 65,087,666 (-)	ENTREZGENE
CHM1_1	11	68,630,734 - 68,631,699 (-)	NCBI
T2T-CHM13v2.0	11	68,990,212 - 68,991,177 (-)	NCBI

Sequence:

show sequence

ATGAACCAGACTTTGAATAGCAGTGGGACCGTGGAGTCAGCCCTAAACTATTCCAGAGGGAGCA
CAGTGCACACGGCCTACCTGGTGCTGAGCTCCCTGGCCATGTTCACCTGCCTGTGCGGGATGGC
AGGCAACAGCATGGTGATCTGGCTGCTGGGCTTTCGAATGCACAGGAACCCCTTCTGCATCTAT
ATCCTCAACCTGGCGGCAGCCGACCTCCTCTTCCTCTTCAGCATGGCTTCCACGCTCAGCCTGG
AAACCCAGCCCCTGGTCAATACCACTGACAAGGTCCACGAGCTGATGAAGAGACTGATGTACTT
TGCCTACACAGTGGGCCTGAGCCTGCTGACGGCCATCAGCACCCAGCGCTGTCTCTCTGTCCTC
TTCCCTATCTGGTTCAAGTGTCACCGGCCCAGGCACCTGTCAGCCTGGGTGTGTGGCCTGCTGT
GGACACTCTGTCTCCTGATGAACGGGTTGACCTCTTCCTTCTGCAGCAAGTTCTTGAAATTCAA
TGAAGATCGGTGCTTCAGGGTGGACATGGTCCAGGCCGCCCTCATCATGGGGGTCTTAACCCCA
GTGATGACTCTGTCCAGCCTGACCCTCTTTGTCTGGGTGCGGAGGAGCTCCCAGCAGTGGCGGC
GGCAGCCCACACGGCTGTTCGTGGTGGTCCTGGCCTCTGTCCTGGTGTTCCTCATCTGTTCCCT
GCCTCTGAGCATCTACTGGTTTGTGCTCTACTGGTTGAGCCTGCCGCCCGAGATGCAGGTCCTG
TGCTTCAGCTTGTCACGCCTCTCCTCGTCCGTAAGCAGCAGCGCCAACCCCGTCATCTACTTCC
TGGTGGGCAGCCGGAGGAGCCACAGGCTGCCCACCAGGTCCCTGGGGACTGTGCTCCAACAGGC
GCTTCGCGAGGAGCCCGAGCTGGAAGGTGGGGAGACGCCCACCGTGGGCACCAATGAGATGGGG
GCTTGA

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Protein Sequences


Protein RefSeqs	NP_944605	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAR05120	(Get FASTA)	NCBI Sequence Viewer
	BAB89340	(Get FASTA)	NCBI Sequence Viewer
	BAC06005	(Get FASTA)	NCBI Sequence Viewer
	BAD20638	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000310631
	ENSP00000310631.3
GenBank Protein	Q8TDS7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_944605 ⟸ NM_198923

- UniProtKB:

Q8NGK7 (UniProtKB/Swiss-Prot), Q8TDS7 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAGNSMVIWLLGFRMHRNPFCIY
ILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMKRLMYFAYTVGLSLLTAISTQRCLSVL
FPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLTSSFCSKFLKFNEDRCFRVDMVQAALIMGVLTP
VMTLSSLTLFVWVRRSSQQWRRQPTRLFVVVLASVLVFLICSLPLSIYWFVLYWLSLPPEMQVL
CFSLSRLSSSVSSSANPVIYFLVGSRRSHRLPTRSLGTVLQQALREEPELEGGETPTVGTNEMG
A

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Ensembl Acc Id:

ENSP00000310631 ⟸ ENST00000309106

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
MRGD	I-TASSER model	Q8TDS7	1-321	view protein structure
AF-Q8TDS7-F1-model_v2	AlphaFold	Q8TDS7	1-321	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:29626	AgrOrtholog
COSMIC	MRGPRD	COSMIC
Ensembl Genes	ENSG00000172938	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000309106	ENTREZGENE
	ENST00000309106.3	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
GTEx	ENSG00000172938	GTEx
HGNC ID	HGNC:29626	ENTREZGENE
Human Proteome Map	MRGPRD	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
	MRGPCRD	UniProtKB/Swiss-Prot
	MRGPCRFAMILY	UniProtKB/Swiss-Prot
KEGG Report	hsa:116512	UniProtKB/Swiss-Prot
NCBI Gene	116512	ENTREZGENE
OMIM	607231	OMIM
PANTHER	MAS-RELATED G-PROTEIN COUPLED RECEPTOR MEMBER D	UniProtKB/Swiss-Prot
	PTHR11334	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PharmGKB	PA134978563	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
	MRGPCRD	UniProtKB/Swiss-Prot
	MRGPCRFAMILY	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	MRGRD_HUMAN	UniProtKB/Swiss-Prot
	Q8NGK7	ENTREZGENE
	Q8TDS7	ENTREZGENE
UniProt Secondary	Q8NGK7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-01	MRGPRD	MAS related GPR family member D		MAS-related GPR, member D	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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