GPX3 (glutathione peroxidase 3) - Rat Genome Database

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Gene: GPX3 (glutathione peroxidase 3) Homo sapiens
Analyze
Symbol: GPX3
Name: glutathione peroxidase 3
RGD ID: 1343858
HGNC Page HGNC:4555
Description: Enables glutathione peroxidase activity; identical protein binding activity; and selenium binding activity. Predicted to be involved in hydrogen peroxide catabolic process. Located in extracellular space. Implicated in several diseases, including Barrett's esophagus; cerebral infarction; gastrointestinal system cancer (multiple); multiple myeloma; and type 2 diabetes mellitus. Biomarker of several diseases, including cardiovascular system disease (multiple); colorectal adenoma; diabetes mellitus (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: extracellular glutathione peroxidase; glutathione peroxidase 3 (plasma); GPx-3; GPx-P; GSHPx-3; GSHPx-P; plasma glutathione peroxidase; selenoprotein GPX3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,020,591 - 151,028,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,020,591 - 151,028,988 (+)EnsemblGRCh38hg38GRCh38
GRCh375150,400,152 - 150,408,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,380,192 - 150,388,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 345150,380,111 - 150,388,741NCBI
Celera5146,481,339 - 146,489,894 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,545,808 - 145,554,363 (+)NCBIHuRef
CHM1_15149,832,791 - 149,841,346 (+)NCBICHM1_1
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (IEP)
acute kidney failure  (IEP)
acute myocardial infarction  (IEP)
adenocarcinoma  (EXP)
aortic valve disease  (HEP)
atherosclerosis  (ISO)
Barrett's adenocarcinoma  (IDA)
Barrett's esophagus  (IDA)
Binge Drinking  (ISO)
brain ischemia  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
cardiovascular system disease  (IEP)
Carotid Atherosclerosis  (IEP)
cerebral infarction  (IAGP)
cerebral venous thrombosis  (IAGP)
cerebrovascular disease  (IEP)
colon cancer  (ISO)
colorectal adenoma  (IEP)
colorectal carcinoma  (IEP)
congenital heart disease  (IGI)
coronary artery disease  (IEP)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IEP,ISO)
disease of cellular proliferation  (EXP)
endometrial adenocarcinoma  (ISO)
endometriosis  (EXP)
esophageal cancer  (IDA)
esophagus adenocarcinoma  (IAGP)
esophagus squamous cell carcinoma  (HDA,IDA)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial adenomatous polyposis 1  (IAGP)
Fanconi syndrome  (EXP)
gallbladder carcinoma  (IEP)
hepatocellular carcinoma  (IDA,IEP)
Hereditary Neoplastic Syndromes  (IAGP)
hypertension  (IAGP,ISO)
Hypertriglyceridemia  (IAGP)
hypoglycemia  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (EXP,ISO)
intracranial sinus thrombosis  (IAGP)
Kidney Reperfusion Injury  (ISO)
Liver Neoplasms  (EXP)
lung adenocarcinoma  (IEP)
lung cancer  (IEP)
lung carcinoma  (ISO)
lung disease  (ISO)
Lung Neoplasms  (EXP)
Lymphatic Metastasis  (IDA)
lymphoplasmacytic lymphoma  (IEP)
male infertility  (ISO)
meningioma  (HEP)
Mercury Poisoning  (ISO)
Metabolic Syndrome  (IEP)
mild pre-eclampsia  (IEP)
multiple myeloma  (IDA)
Myocardial Reperfusion Injury  (IEP)
nasal type extranodal NK/T-cell lymphoma  (IEP)
nephrotic syndrome  (IEP,ISO)
nephrotoxicity  (ISO)
neurodegenerative disease  (EXP)
obesity  (EXP,ISO)
Perinatal Asphyxia  (IEP)
polycystic ovary syndrome  (ISO)
Postoperative Atrial Fibrillation  (IEP)
pre-eclampsia  (IEP)
Pregnancy-Induced Hypertension  (IEP)
Primary Graft Dysfunction  (IMP)
Prostatic Neoplasms  (EXP)
Pulmonary Arterial Hypertension  (IEP)
Radiation Injuries  (ISO)
rectum cancer  (IAGP)
sciatic neuropathy  (ISO)
severe pre-eclampsia  (IEP)
spermatic cord torsion  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (HEP,IAGP,IDA)
Stroke  (IEP)
Subarachnoid Hemorrhage  (IEP)
Sudden Hearing Loss  (IAGP)
systemic scleroderma  (IEP)
transient cerebral ischemia  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (IDA,IEP)
Vascular Calcification  (ISO)
vitamin B12 deficiency  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (EXP)
(R)-lipoic acid  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,10-phenanthroline  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-hexylcinnamaldehyde  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apocynin  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atrazine  (ISO)
azathioprine  (EXP)
Azoxymethane  (ISO)
Bandrowski's base  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium dichloride  (ISO)
cannabidiol  (EXP)
captan  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (EXP)
chlordecone  (ISO)
chlorobenzene  (EXP)
choline  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (EXP)
ciguatoxin CTX1B  (ISO)
cinnamyl alcohol  (EXP)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cumene  (ISO)
Cuprizon  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP)
cyfluthrin  (EXP)
cylindrospermopsin  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
eugenol  (EXP)
fenofibrate  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
GW 7647  (EXP,ISO)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
ifosfamide  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (EXP)
isoeugenol  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
L-methionine  (ISO)
lanthanum trichloride  (EXP)
lead(0)  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lutein  (ISO)
lycopene  (ISO)
medroxyprogesterone acetate  (EXP)
melatonin  (ISO)
mercaptopurine  (EXP)
mercury dibromide  (EXP)
Mesaconitine  (ISO)
metam  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mitoxantrone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetylsphingosine  (EXP)
N-nitrosodiethylamine  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (EXP)
nicotine  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nutlin-3  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (EXP)
oltipraz  (EXP)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
PhIP  (ISO)
pioglitazone  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
purine-6-thiol  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (EXP,ISO)
Rebamipide  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (EXP)
selenium atom  (EXP,ISO)
selenium(2+)  (EXP)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulindac  (ISO)
sunitinib  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetradecane  (ISO)
tetrathiomolybdate(2-)  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trans-isoeugenol  (EXP)
Tributyltin oxide  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
undecane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Proteomic identification of novel differentiation plasma protein markers in hypobaric hypoxia-induced rat model. Ahmad Y, etal., PLoS One. 2014 May 19;9(5):e98027. doi: 10.1371/journal.pone.0098027. eCollection 2014.
2. Screening of the GPX3 gene identifies the "T" allele of the SNP -861A/T as a risk for ischemic stroke in young Asian Indians. Akhter MS, etal., J Stroke Cerebrovasc Dis. 2014 Sep;23(8):2060-2068. doi: 10.1016/j.jstrokecerebrovasdis.2014.03.010. Epub 2014 Aug 8.
3. Epigenetic and Glucocorticoid Receptor-Mediated Regulation of Glutathione Peroxidase 3 in Lung Cancer Cells. An BC, etal., Mol Cells. 2016 Aug 31;39(8):631-8. doi: 10.14348/molcells.2016.0164. Epub 2016 Aug 3.
4. Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats. Assayed ME, Immunopharmacol Immunotoxicol. 2010 Jun;32(2):284-96. doi: 10.3109/08923970903307552.
5. Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion. Ayvaz S, etal., J Pediatr Urol. 2014 Jun;10(3):550-8. doi: 10.1016/j.jpurol.2013.11.019. Epub 2013 Dec 27.
6. Glutathione peroxidase 3 serum levels and GPX3 gene polymorphisms in subjects with metabolic syndrome. Baez-Duarte BG, etal., Arch Med Res. 2014 Jul;45(5):375-82. doi: 10.1016/j.arcmed.2014.05.001. Epub 2014 May 10.
7. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Barrett CW, etal., Cancer Res. 2013 Feb 1;73(3):1245-55. doi: 10.1158/0008-5472.CAN-12-3150. Epub 2012 Dec 5.
8. Persistent oxidative stress following renal ischemia-reperfusion injury increases ANG II hemodynamic and fibrotic activity. Basile DP, etal., Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1494-502. doi: 10.1152/ajprenal.00691.2011. Epub 2012 Mar 21.
9. Cereal based diets modulate some markers of oxidative stress and inflammation in lean and obese Zucker rats. Belobrajdic DP, etal., Nutr Metab (Lond). 2011 May 3;8:27. doi: 10.1186/1743-7075-8-27.
10. Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's. Buijsse B, etal., PLoS One. 2012;7(6):e38901. doi: 10.1371/journal.pone.0038901. Epub 2012 Jun 15.
11. Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue. Cao S, etal., Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):198-204. doi: 10.1016/j.clinre.2014.09.003. Epub 2014 Oct 13.
12. Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss. Chien CY, etal., Kaohsiung J Med Sci. 2017 Jul;33(7):359-364. doi: 10.1016/j.kjms.2017.04.003. Epub 2017 May 9.
13. Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells. Chung SS, etal., Mol Cell Biol. 2009 Jan;29(1):20-30. Epub 2008 Oct 20.
14. Association of combined genetic variations in SOD3, GPX3, PON1, and GSTT1 with hypertension and severity of coronary artery disease. Decharatchakul N, etal., Heart Vessels. 2020 Jul;35(7):918-929. doi: 10.1007/s00380-020-01564-6. Epub 2020 Feb 8.
15. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
16. Acute hypoglycemia induces retinal cell death in mouse. Emery M, etal., PLoS One. 2011;6(6):e21586. doi: 10.1371/journal.pone.0021586. Epub 2011 Jun 27.
17. Microarray gene expression profiling in meningiomas: differential expression according to grade or histopathological subtype. Fèvre-Montange M, etal., Int J Oncol. 2009 Dec;35(6):1395-407. doi: 10.3892/ijo_00000457.
18. Baseline glutathione peroxidase activity affects prognosis after acute coronary syndromes. García-Pinilla JM, etal., Tex Heart Inst J. 2008;35(3):262-7.
19. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
20. Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis. Gong Y, etal., Life Sci. 2018 Apr 1;198:94-98. doi: 10.1016/j.lfs.2018.02.035. Epub 2018 Feb 26.
21. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
22. Gelatinases A and B and Antioxidant Enzyme Activity in the Early Phase of Acute Myocardial Infarction. Gopcevic K, etal., Folia Biol (Praha). 2017;63(1):20-26.
23. Impaired glomerular and tubular antioxidative defense mechanisms in nephrotic syndrome. Granqvist A, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F898-904. doi: 10.1152/ajprenal.00124.2010. Epub 2010 Aug 4.
24. Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves. Greene CL, etal., Genes (Basel). 2020 Jul 14;11(7):789. doi: 10.3390/genes11070789.
25. No association of the plasma glutathione peroxidase (GPx-3) gene with cerebral venous thrombosis in the German population. Grond-Ginsbach C, etal., Stroke. 2009 Feb;40(2):e24; author reply e25. doi: 10.1161/STROKEAHA.108.540062. Epub 2008 Dec 18.
26. Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China. Hao Y, etal., Chin Med J (Engl). 2011 Jul;124(14):2113-6.
27. Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer. Haug U, etal., Genes Chromosomes Cancer. 2012 Jun;51(6):598-605. doi: 10.1002/gcc.21946. Epub 2012 Feb 27.
28. Identification of GPX3 epigenetically silenced by CpG methylation in human esophageal squamous cell carcinoma. He Y, etal., Dig Dis Sci. 2011 Mar;56(3):681-8. doi: 10.1007/s10620-010-1369-0. Epub 2010 Aug 20.
29. NO2-induced acute and chronic lung injury cause imbalance of glutathione metabolism in type II pneumocytes. Hochscheid R, etal., Med Sci Monit. 2005 Aug;11(8):BR273-9. Epub 2005 Jul 25.
30. Glutathione peroxidase activity and expression levels are significantly increased in acute coronary syndromes. Holley A, etal., J Investig Med. 2017 Jun;65(5):919-925. doi: 10.1136/jim-2016-000361. Epub 2017 Mar 15.
31. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
32. Increased gene expression of glutathione peroxidase-3 in diabetic mouse heart. Iwata K, etal., Biol Pharm Bull. 2006 May;29(5):1042-5.
33. Increased glutathione utilization augments tumor cell proliferation in Waldenstrom Macroglobulinemia. Jalali S, etal., Redox Biol. 2020 Sep;36:101657. doi: 10.1016/j.redox.2020.101657. Epub 2020 Aug 1.
34. Clinical Prognosis for SAH Consistent with Redox Imbalance and Lipid Peroxidation. Jarocka-Karpowicz I, etal., Molecules. 2020 Apr 21;25(8):1921. doi: 10.3390/molecules25081921.
35. Xiaoyao Pills Ameliorate Depression-like Behaviors and Oxidative Stress Induced by Olfactory Bulbectomy in Rats via the Activation of the PIK3CA-AKT1-NFE2L2/BDNF Signaling Pathway. Ji Y, etal., Front Pharmacol. 2021 Apr 15;12:643456. doi: 10.3389/fphar.2021.643456. eCollection 2021.
36. Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia. Jin X, etal., Biochim Biophys Acta Proteins Proteom. 2017 Sep;1865(9):1207-1214. doi: 10.1016/j.bbapap.2017.07.003. Epub 2017 Jul 10.
37. High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. Jobgen W, etal., Amino Acids. 2009 May;37(1):187-98. Epub 2009 Feb 12.
38. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
39. Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization. Kaneko H, etal., Atherosclerosis. 2011 Aug;217(2):350-7. doi: 10.1016/j.atherosclerosis.2011.03.042. Epub 2011 Apr 8.
40. Gene expression profiling predicts a three-gene expression signature of endometrial adenocarcinoma in a rat model. Karlsson S, etal., Cancer Cell Int. 2009 May 8;9:12.
41. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Kenet G, etal., Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):2017-23. doi: 10.1161/01.atv.19.8.2017.
42. Glutathione Peroxidase 3 as a Biomarker of Recurrence after Lung Cancer Surgery. Kho BG, etal., J Clin Med. 2020 Nov 24;9(12). pii: jcm9123801. doi: 10.3390/jcm9123801.
43. Proteome analysis of serum from type 2 diabetics with nephropathy. Kim HJ, etal., J Proteome Res. 2007 Feb;6(2):735-43.
44. Oxidative stress in perinatal asphyxia. Kumar A, etal., Pediatr Neurol. 2008 Mar;38(3):181-5. doi: 10.1016/j.pediatrneurol.2007.10.008.
45. Biomarker Discovery by Mass Spectrometry in Cerebrospinal Fluid and Plasma after Global Hypoxia-Ischemia in Newborn Piglets. Kyng KJ, etal., Neonatology. 2018;114(4):307-314. doi: 10.1159/000490393. Epub 2018 Jul 19.
46. Cancer-induced Cardiac Atrophy Adversely Affects Myocardial Redox State and Mitochondrial Oxidative Characteristics. Lee DE, etal., JCSM Rapid Commun. 2021 Jan-Jun;4(1):3-15. doi: 10.1002/rco2.18. Epub 2020 Aug 7.
47. Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Lee OJ, etal., Neoplasia. 2005 Sep;7(9):854-61. doi: 10.1593/neo.05328.
48. Antioxidant and hepatoprotective activities of Cirsium setidens Nakai against CCl4-induced liver damage. Lee SH, etal., Am J Chin Med. 2008;36(1):107-14.
49. Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress. Lee YS, etal., Mol Endocrinol. 2008 Sep;22(9):2176-89. Epub 2008 Jun 18.
50. A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects. Li M, etal., Ann Hum Genet. 2016 Jan;80(1):20-31. doi: 10.1111/ahg.12139. Epub 2015 Nov 27.
51. Regulatory effects of sulfur dioxide on the development of atherosclerotic lesions and vascular hydrogen sulfide in atherosclerotic rats. Li W, etal., Atherosclerosis. 2011 Apr;215(2):323-30. doi: 10.1016/j.atherosclerosis.2010.12.037. Epub 2011 Jan 19.
52. Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis. Li X, etal., PLoS One. 2014 Jul 22;9(7):e103162. doi: 10.1371/journal.pone.0103162. eCollection 2014.
53. Preoperative plasma biomarkers associated with atrial fibrillation after coronary artery bypass surgery. Li XY, etal., J Thorac Cardiovasc Surg. 2021 Sep;162(3):851-863.e3. doi: 10.1016/j.jtcvs.2020.01.079. Epub 2020 Feb 19.
54. Gastrodin improves cognitive dysfunction and decreases oxidative stress in vascular dementia rats induced by chronic ischemia. Li Y and Zhang Z, Int J Clin Exp Pathol. 2015 Nov 1;8(11):14099-109. eCollection 2015.
55. Association between glutathione peroxidase-3 activity and carotid atherosclerosis in patients with type 2 diabetes mellitus. Ling P, etal., Brain Behav. 2020 Oct;10(10):e01773. doi: 10.1002/brb3.1773. Epub 2020 Aug 29.
56. Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. Lubieniecka JM, etal., PLoS One. 2011 Apr 29;6(4):e19247. doi: 10.1371/journal.pone.0019247.
57. Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2. Maciel-Dominguez A, etal., Mol Nutr Food Res. 2013 Dec;57(12):2195-205. doi: 10.1002/mnfr.201300168. Epub 2013 Aug 12.
58. Effects of Heracleum persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats. Majidi Z, etal., Iran J Med Sci. 2020 May;45(3):199-206. doi: 10.30476/ijms.2019.45805.
59. Circulating Lipopolysaccharides and Impaired Antioxidant Status in Patients With Atrial Fibrillation. Data From the ATHERO-AF Study. Menichelli D, etal., Front Cardiovasc Med. 2021 Nov 17;8:779503. doi: 10.3389/fcvm.2021.779503. eCollection 2021.
60. Prognostic significance of glutathione peroxidase 1 (GPX1) down-regulation and correlation with aberrant promoter methylation in human gastric cancer. Min SY, etal.
61. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Mistry HD, etal., Hypertension. 2008 Nov;52(5):881-8. doi: 10.1161/HYPERTENSIONAHA.108.116103. Epub 2008 Oct 13.
62. Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy. Mistry HD, etal., Placenta. 2010 May;31(5):401-8. doi: 10.1016/j.placenta.2010.02.011. Epub 2010 Mar 19.
63. Continuous vs interval training on glycemic control and macro- and microvascular reactivity in type 2 diabetic patients. Mitranun W, etal., Scand J Med Sci Sports. 2014 Apr;24(2):e69-76. doi: 10.1111/sms.12112. Epub 2013 Sep 17.
64. The nephroprotection exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy. Molina-Jijón E, etal., Biofactors. 2016 Nov 12;42(6):686-702. doi: 10.1002/biof.1313. Epub 2016 Jul 13.
65. Deferoxamine pretreatment prevents Cr(VI)-induced nephrotoxicity and oxidant stress: role of Cr(VI) chelation. Molina-Jijón E, etal., Toxicology. 2012 Jan 27;291(1-3):93-101. doi: 10.1016/j.tox.2011.11.003. Epub 2011 Nov 15.
66. Mangosteen (Garcinia mangostana) flesh supplementation attenuates biochemical and morphological changes in the liver and kidney of high fat diet-induced obese rats. Muhamad Adyab NS, etal., BMC Complement Altern Med. 2019 Dec 2;19(1):344. doi: 10.1186/s12906-019-2764-5.
67. Selective antioxidant enzymes during ischemia/reperfusion in myocardial infarction. Muzáková V, etal., Physiol Res. 2000;49(3):315-22.
68. Oxidative stress and adhesion molecules in children with type 1 diabetes mellitus: a possible link. Mylona-Karayanni C, etal., Pediatr Diabetes. 2006 Feb;7(1):51-9.
69. Sulforaphane attenuates gentamicin-induced nephrotoxicity: role of mitochondrial protection. Negrette-Guzmán M, etal., Evid Based Complement Alternat Med. 2013;2013:135314. doi: 10.1155/2013/135314. Epub 2013 Apr 4.
70. Plasma glutathione peroxidase in pediatric stroke families. Nowak-Göttl U, etal., J Thromb Haemost. 2011 Jan;9(1):33-8. doi: 10.1111/j.1538-7836.2010.04103.x.
71. Diagnostic value of serum glutathione peroxidase 3 levels in patients with lung cancer. Oh IJ, etal., Thorac Cancer. 2014 Sep;5(5):425-30. doi: 10.1111/1759-7714.12113. Epub 2014 Aug 25.
72. Binge drinking during adolescence disrupts Se homeostasis and its main hepatic selenoprotein expression. Ojeda ML, etal., Alcohol Clin Exp Res. 2015 May;39(5):818-26. doi: 10.1111/acer.12707. Epub 2015 Apr 10.
73. Aging-Related Decline of Glutathione Peroxidase 3 and Risk of Cardiovascular Events in Patients With Atrial Fibrillation. Pastori D, etal., J Am Heart Assoc. 2016 Sep 8;5(9):e003682. doi: 10.1161/JAHA.116.003682.
74. GPX3 and GSTT1 as biomarkers related to oxidative stress during renal ischemia reperfusion injuries and their relationship with immune infiltration. Pei J, etal., Front Immunol. 2023 Mar 22;14:1136146. doi: 10.3389/fimmu.2023.1136146. eCollection 2023.
75. Does bromocriptine play a role in decreasing oxidative stress for early weaned programmed obesity? Peixoto-Silva N, etal., Life Sci. 2014 Jan 24;95(1):14-21. doi: 10.1016/j.lfs.2013.12.013. Epub 2013 Dec 17.
76. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Peng DF, etal., Gut. 2009 Jan;58(1):5-15. doi: 10.1136/gut.2007.146290. Epub 2008 Jul 29.
77. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas. Peng DF, etal., PLoS One. 2012;7(10):e46214. doi: 10.1371/journal.pone.0046214. Epub 2012 Oct 10.
78. Vitamin E protection of obesity-enhanced vascular calcification in uremic rats. Peralta-Ramírez A, etal., Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F422-9. doi: 10.1152/ajprenal.00355.2013. Epub 2013 Dec 26.
79. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
80. Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma. Qi X, etal., Oncotarget. 2014 Nov 30;5(22):11103-20. doi: 10.18632/oncotarget.2549.
81. The Clinical Significance and Potential Therapeutic Role of GPx3 in Tumor Recurrence after Liver Transplantation. Qi X, etal., Theranostics. 2016 Aug 8;6(11):1934-46. doi: 10.7150/thno.16023. eCollection 2016.
82. Glutathione Peroxidase 3 Delivered by hiPSC-MSCs Ameliorated Hepatic IR Injury via Inhibition of Hepatic Senescence. Qi X, etal., Theranostics. 2018 Jan 1;8(1):212-222. doi: 10.7150/thno.21656. eCollection 2018.
83. Homocysteine and thiol metabolites in vitamin B12 deficiency. Ranganath LR, etal., Clin Sci (Lond). 2001 Jan;100(1):111-6.
84. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
85. Profiling and identification of cerebrospinal fluid proteins in a rat EAE model of multiple sclerosis. Rosenling T, etal., J Proteome Res. 2012 Apr 6;11(4):2048-60. Epub 2012 Feb 23.
86. Depot-specific overexpression of proinflammatory, redox, endothelial cell, and angiogenic genes in epicardial fat adjacent to severe stable coronary atherosclerosis. Sacks HS, etal., Metab Syndr Relat Disord. 2011 Dec;9(6):433-9. doi: 10.1089/met.2011.0024. Epub 2011 Jun 16.
87. The effect of leaf hydroalcoholic extract of Ephedra pachyclada infertility in male rats treated with cyclophosphamide: An experimental study. Saleh S, etal., Int J Reprod Biomed. 2023 May 8;21(4):285-294. doi: 10.18502/ijrm.v21i4.13268. eCollection 2023 May.
88. A DNA methylation-based test for esophageal cancer detection. Salta S, etal., Biomark Res. 2020 Nov 25;8(1):68. doi: 10.1186/s40364-020-00248-7.
89. Diabetes mellitus increases reactive oxygen species production in the thyroid of male rats. Santos MC, etal., Endocrinology. 2013 Mar;154(3):1361-72. doi: 10.1210/en.2012-1930. Epub 2013 Feb 13.
90. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
91. Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst. Shankar K, etal., Endocrinology. 2011 Nov;152(11):4158-70. Epub 2011 Aug 23.
92. Selenium and Copper as Biomarkers for Pulmonary Arterial Hypertension in Systemic Sclerosis. Sun Q, etal., Nutrients. 2020 Jun 25;12(6):1894. doi: 10.3390/nu12061894.
93. Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. Takata Y, etal., PLoS One. 2012;7(6):e38612. doi: 10.1371/journal.pone.0038612. Epub 2012 Jun 8.
94. Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Thomas MC, etal., Kidney Int. 2003 Jun;63(6):2152-61.
95. Pregnancy-induced hypertension is associated with changes in maternal and umbilical blood antioxidants. Uotila J, etal., Gynecol Obstet Invest. 1993;36(3):153-7. doi: 10.1159/000292616.
96. Findings on lipid peroxidation and antioxidant function in hypertensive complications of pregnancy. Uotila JT, etal., Br J Obstet Gynaecol. 1993 Mar;100(3):270-6. doi: 10.1111/j.1471-0528.1993.tb15242.x.
97. Hypericum perforatum L. supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats. Uslusoy F, etal., J Pharm Pharmacol. 2019 Jan;71(1):83-92. doi: 10.1111/jphp.12741. Epub 2017 May 16.
98. Decreased plasma thiol antioxidant barrier and selenoproteins as potential biomarkers for ongoing methylmercury intoxication and an individual protective capacity. Usuki F and Fujimura M, Arch Toxicol. 2016 Apr;90(4):917-26. doi: 10.1007/s00204-015-1528-3. Epub 2015 May 16.
99. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Voetsch B, etal., Stroke. 2007 Jan;38(1):41-9. doi: 10.1161/01.STR.0000252027.53766.2b. Epub 2006 Nov 22.
100. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Voetsch B, etal., Stroke. 2008 Feb;39(2):303-7. doi: 10.1161/STROKEAHA.107.490094. Epub 2007 Dec 20.
101. Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer. Wang JY, etal., Clin Chim Acta. 2010 Oct 9;411(19-20):1432-6. doi: 10.1016/j.cca.2010.05.026. Epub 2010 May 27.
102. Quercetin reduces oxidative stress and inhibits activation of c‑Jun N‑terminal kinase/activator protein‑1 signaling in an experimental mouse model of abdominal aortic aneurysm. Wang L, etal., Mol Med Rep. 2014 Feb;9(2):435-42. doi: 10.3892/mmr.2013.1846. Epub 2013 Dec 6.
103. Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3 as a novel lung cancer-related gene. Wu M, etal., BMC Cancer. 2013 Feb 1;13:44. doi: 10.1186/1471-2407-13-44.
104. Vitamin D-vitamin D receptor alleviates oxidative stress in ischemic acute kidney injury via upregulating glutathione peroxidase 3. Wu X, etal., FASEB J. 2023 Feb;37(2):e22738. doi: 10.1096/fj.202201400R.
105. Positive ALDH1A3 and negative GPX3 expressions are biomarkers for poor prognosis of gallbladder cancer. Yang ZL, etal., Dis Markers. 2013;35(3):163-72. doi: 10.1155/2013/187043. Epub 2013 Aug 25.
106. Decreased antioxidant activity in hypercholesterolemic children with nephrotic syndrome. Zachwieja J, etal., Med Sci Monit. 2003 Jun;9(6):CR235-9.
107. Association of Antioxidative Enzymes Polymorphisms with Efficacy of Platin and Fluorouracil-Based Adjuvant Therapy in Gastric Cancer. Zhang H, etal., Cell Physiol Biochem. 2018;48(6):2247-2257. doi: 10.1159/000492642. Epub 2018 Aug 16.
108. Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy. Zhang M, etal., Med Sci Monit. 2020 Jun 27;26:e924372. doi: 10.12659/MSM.924372.
109. An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. Zhang X, etal., Int J Oncol. 2010 Feb;36(2):405-14.
110. The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial. Zhao Z, etal., J Pineal Res. 2018 Nov;65(4):e12521. doi: 10.1111/jpi.12521. Epub 2018 Sep 30.
111. GPX3 hypermethylation in gastric cancer and its prognostic value in patients aged over 60. Zhou C, etal., Future Oncol. 2019 Apr;15(11):1279-1289. doi: 10.2217/fon-2018-0674. Epub 2019 Mar 29.
112. Rhamnocitrin Attenuates Ovarian Fibrosis in Rats with Letrozole-Induced Experimental Polycystic Ovary Syndrome. Zhou Y, etal., Oxid Med Cell Longev. 2022 May 26;2022:5558599. doi: 10.1155/2022/5558599. eCollection 2022.
113. GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma. Zhu X, etal., Am J Transl Res. 2018 Jun 15;10(6):1908-1920. eCollection 2018.
Additional References at PubMed
PMID:1339300   PMID:1897960   PMID:2229017   PMID:2491950   PMID:3619451   PMID:3693360   PMID:8056346   PMID:8262911   PMID:8287691   PMID:9501919   PMID:10652368   PMID:10970826  
PMID:11149894   PMID:11368344   PMID:11934214   PMID:11983108   PMID:12477932   PMID:12553559   PMID:12674495   PMID:12732844   PMID:15096516   PMID:15375613   PMID:15489334   PMID:15910762  
PMID:16937131   PMID:17804715   PMID:17937619   PMID:18483336   PMID:18676680   PMID:19020706   PMID:19161995   PMID:19170196   PMID:19199708   PMID:19219623   PMID:19375609   PMID:19573080  
PMID:19625176   PMID:19692168   PMID:19766714   PMID:19773279   PMID:19913121   PMID:20200426   PMID:20485444   PMID:20628086   PMID:20712757   PMID:20730571   PMID:20813000   PMID:21374652  
PMID:21684681   PMID:21873635   PMID:22461624   PMID:22508837   PMID:22981671   PMID:23132926   PMID:23376485   PMID:23436019   PMID:23533145   PMID:23837478   PMID:24186266   PMID:24279306  
PMID:24518545   PMID:24788695   PMID:24926085   PMID:25416956   PMID:25929866   PMID:26045745   PMID:26112936   PMID:26261521   PMID:26662676   PMID:27435875   PMID:27600457   PMID:27742442  
PMID:27891827   PMID:28931804   PMID:29100971   PMID:30118830   PMID:30153510   PMID:30260967   PMID:30509602   PMID:30537708   PMID:30600457   PMID:30898707   PMID:31085009   PMID:31310363  
PMID:31352088   PMID:31610903   PMID:31814699   PMID:32810779   PMID:32886395   PMID:33202543   PMID:33310051   PMID:33415437   PMID:33431801   PMID:33455417   PMID:33961781   PMID:34387669  
PMID:34563873   PMID:35042540   PMID:35176576   PMID:37087463   PMID:37310002   PMID:37629712   PMID:37633909   PMID:38003341   PMID:38299269   PMID:38322113   PMID:38420829   PMID:38927092  
PMID:39242582  


Genomics

Comparative Map Data
GPX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385151,020,591 - 151,028,988 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5151,020,591 - 151,028,988 (+)EnsemblGRCh38hg38GRCh38
GRCh375150,400,152 - 150,408,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365150,380,192 - 150,388,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 345150,380,111 - 150,388,741NCBI
Celera5146,481,339 - 146,489,894 (+)NCBICelera
Cytogenetic Map5q33.1NCBI
HuRef5145,545,808 - 145,554,363 (+)NCBIHuRef
CHM1_15149,832,791 - 149,841,346 (+)NCBICHM1_1
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBIT2T-CHM13v2.0
Gpx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,793,680 - 54,801,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,793,279 - 54,801,203 (+)EnsemblGRCm39 Ensembl
GRCm381154,902,854 - 54,910,387 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,902,453 - 54,910,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,716,355 - 54,723,889 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,746,373 - 54,753,800 (+)NCBIMGSCv36mm8
Celera1159,492,255 - 59,499,807 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
Gpx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81039,529,335 - 39,537,406 (+)NCBIGRCr8
mRatBN7.21039,028,624 - 39,036,695 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1039,028,570 - 39,037,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,717,089 - 43,725,159 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01043,207,165 - 43,215,235 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01038,710,877 - 38,718,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01040,247,436 - 40,255,423 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1040,247,436 - 40,255,422 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01040,019,704 - 40,027,691 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41040,311,094 - 40,319,382 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11040,324,744 - 40,333,004 (+)NCBI
Celera1038,366,821 - 38,374,734 (+)NCBICelera
Cytogenetic Map10q22NCBI
Gpx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554082,622,741 - 2,629,032 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554082,622,162 - 2,629,088 (-)NCBIChiLan1.0ChiLan1.0
GPX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24146,252,293 - 146,260,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15144,391,889 - 144,400,394 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05146,447,939 - 146,456,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15152,450,426 - 152,458,994 (+)NCBIpanpan1.1PanPan1.1panPan2
GPX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1458,200,671 - 58,209,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl458,200,672 - 58,209,010 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha457,952,390 - 57,960,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0458,638,793 - 58,647,136 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl458,638,795 - 58,647,137 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1458,456,392 - 58,464,733 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0458,555,078 - 58,563,407 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0459,058,428 - 59,066,768 (-)NCBIUU_Cfam_GSD_1.0
Gpx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,903,260 - 116,911,461 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366473,906,113 - 3,913,498 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366473,904,787 - 3,914,223 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1671,980,475 - 71,989,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11671,980,467 - 71,989,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21678,282,309 - 78,290,916 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12353,576,950 - 53,585,321 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603424,129,632 - 24,138,173 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473340,957,999 - 40,962,993 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473340,957,895 - 40,963,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GPX3
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q32-35.3(chr5:149714592-181272151)x3 copy number gain See cases [RCV000051863] Chr5:149714592..181272151 [GRCh38]
Chr5:149094155..180699152 [GRCh37]
Chr5:149074348..180631758 [NCBI36]
Chr5:5q32-35.3
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_002084.5(GPX3):c.538C>T (p.Arg180Cys) single nucleotide variant not specified [RCV004314162] Chr5:151027987 [GRCh38]
Chr5:150407548 [GRCh37]
Chr5:5q33.1
uncertain significance
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q32-35.3(chr5:149010383-180719789) copy number gain Hunter-McAlpine craniosynostosis [RCV002280612] Chr5:149010383..180719789 [GRCh37]
Chr5:5q32-35.3
pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
NM_002084.5(GPX3):c.20C>G (p.Ala7Gly) single nucleotide variant not specified [RCV004153909] Chr5:151020674 [GRCh38]
Chr5:150400235 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.392A>G (p.Asn131Ser) single nucleotide variant not specified [RCV004181593] Chr5:151027464 [GRCh38]
Chr5:150407025 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.80A>T (p.Lys27Met) single nucleotide variant not specified [RCV004153822] Chr5:151020734 [GRCh38]
Chr5:150400295 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.203A>G (p.Asn68Ser) single nucleotide variant not specified [RCV004240721] Chr5:151025455 [GRCh38]
Chr5:150405016 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.20C>A (p.Ala7Glu) single nucleotide variant not specified [RCV004205264] Chr5:151020674 [GRCh38]
Chr5:150400235 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.404T>G (p.Phe135Cys) single nucleotide variant not specified [RCV004206392] Chr5:151027476 [GRCh38]
Chr5:150407037 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.56T>A (p.Val19Asp) single nucleotide variant not specified [RCV004235177] Chr5:151020710 [GRCh38]
Chr5:150400271 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.284T>A (p.Val95Asp) single nucleotide variant not specified [RCV004323241] Chr5:151026942 [GRCh38]
Chr5:150406503 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.168C>A (p.Phe56Leu) single nucleotide variant not specified [RCV004349888] Chr5:151025420 [GRCh38]
Chr5:150404981 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.623A>G (p.Lys208Arg) single nucleotide variant not specified [RCV004393517] Chr5:151028072 [GRCh38]
Chr5:150407633 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.503G>A (p.Arg168His) single nucleotide variant not specified [RCV004393516] Chr5:151027952 [GRCh38]
Chr5:150407513 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.181G>A (p.Gly61Ser) single nucleotide variant not specified [RCV004632647] Chr5:151025433 [GRCh38]
Chr5:150404994 [GRCh37]
Chr5:5q33.1
uncertain significance
NM_002084.5(GPX3):c.619G>A (p.Val207Ile) single nucleotide variant not specified [RCV004632649] Chr5:151028068 [GRCh38]
Chr5:150407629 [GRCh37]
Chr5:5q33.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2628
Count of miRNA genes:867
Interacting mature miRNAs:1031
Transcripts:ENST00000388825, ENST00000517973, ENST00000519214, ENST00000520059, ENST00000520597, ENST00000521632, ENST00000521650, ENST00000521722
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597353860GWAS1449934_Hbody height QTL GWAS1449934 (human)0.0000002body height (VT:0001253)body height (CMO:0000106)5151023537151023538Human

Markers in Region
RH122357  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,400,817 - 150,401,158UniSTSGRCh37
Build 365150,381,010 - 150,381,351RGDNCBI36
Celera5146,482,157 - 146,482,498RGD
Cytogenetic Map5q23UniSTS
HuRef5145,546,626 - 145,546,967UniSTS
TNG Radiation Hybrid Map1265277.0UniSTS
GPX3_446  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,407,938 - 150,408,668UniSTSGRCh37
Build 365150,388,131 - 150,388,861RGDNCBI36
Celera5146,489,278 - 146,490,008RGD
HuRef5145,553,747 - 145,554,477UniSTS
D5S2783  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,400,511 - 150,400,910UniSTSGRCh37
Build 365150,380,704 - 150,381,103RGDNCBI36
Celera5146,481,851 - 146,482,250RGD
HuRef5145,546,320 - 145,546,719UniSTS
NIB1209  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,408,276 - 150,408,438UniSTSGRCh37
Build 365150,388,469 - 150,388,631RGDNCBI36
Celera5146,489,616 - 146,489,778RGD
Cytogenetic Map5q23UniSTS
HuRef5145,554,085 - 145,554,247UniSTS
GeneMap99-GB4 RH Map5580.51UniSTS
Whitehead-RH Map5497.6UniSTS
NCBI RH Map5891.6UniSTS
D5S2679  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375150,401,623 - 150,401,766UniSTSGRCh37
Build 365150,381,816 - 150,381,959RGDNCBI36
Celera5146,482,963 - 146,483,106RGD
Cytogenetic Map5q23UniSTS
HuRef5145,547,432 - 145,547,575UniSTS
GPX3  
Human AssemblyChrPosition (strand)SourceJBrowse
HuRef5145,554,110 - 145,554,330UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2423 2788 2253 4943 1720 2342 6 624 1892 464 2258 7232 6412 43 3715 1 851 1739 1609 174 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001329790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC008641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF217787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF285633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL036834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY310878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY552097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI522602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY069764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X58295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000388825   ⟹   ENSP00000373477
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,591 - 151,028,988 (+)Ensembl
Ensembl Acc Id: ENST00000517973   ⟹   ENSP00000429709
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,606 - 151,028,166 (+)Ensembl
Ensembl Acc Id: ENST00000519214   ⟹   ENSP00000430508
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,606 - 151,027,017 (+)Ensembl
Ensembl Acc Id: ENST00000520059   ⟹   ENSP00000429314
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,026,966 - 151,027,985 (+)Ensembl
Ensembl Acc Id: ENST00000520597
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,026,445 - 151,027,490 (+)Ensembl
Ensembl Acc Id: ENST00000521632   ⟹   ENSP00000430743
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,025,344 - 151,028,954 (+)Ensembl
Ensembl Acc Id: ENST00000521650   ⟹   ENSP00000427873
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,604 - 151,027,461 (+)Ensembl
Ensembl Acc Id: ENST00000521722
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,592 - 151,026,870 (+)Ensembl
Ensembl Acc Id: ENST00000614343   ⟹   ENSP00000483660
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,589 - 151,028,987 (+)Ensembl
Ensembl Acc Id: ENST00000622181   ⟹   ENSP00000484258
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,020,438 - 151,028,992 (+)Ensembl
Ensembl Acc Id: ENST00000625178
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5151,021,437 - 151,021,870 (+)Ensembl
RefSeq Acc Id: NM_001329790   ⟹   NP_001316719
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,020,591 - 151,028,988 (+)NCBI
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002084   ⟹   NP_002075
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,020,591 - 151,028,988 (+)NCBI
GRCh375150,399,999 - 150,408,554 (+)ENTREZGENE
Build 365150,380,192 - 150,388,747 (+)NCBI Archive
HuRef5145,545,808 - 145,554,363 (+)ENTREZGENE
CHM1_15149,832,791 - 149,841,346 (+)NCBI
T2T-CHM13v2.05151,557,070 - 151,565,467 (+)NCBI
Sequence:
RefSeq Acc Id: NP_002075   ⟸   NM_002084
- Peptide Label: isoform 1 precursor
- UniProtKB: P22352 (UniProtKB/Swiss-Prot),   Q9NZ74 (UniProtKB/Swiss-Prot),   Q86W78 (UniProtKB/Swiss-Prot),   O43787 (UniProtKB/Swiss-Prot),   Q9UEL1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001316719   ⟸   NM_001329790
- Peptide Label: isoform 2 precursor
- UniProtKB: P22352 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000429709   ⟸   ENST00000517973
Ensembl Acc Id: ENSP00000484258   ⟸   ENST00000622181
Ensembl Acc Id: ENSP00000430508   ⟸   ENST00000519214
Ensembl Acc Id: ENSP00000373477   ⟸   ENST00000388825
Ensembl Acc Id: ENSP00000429314   ⟸   ENST00000520059
Ensembl Acc Id: ENSP00000430743   ⟸   ENST00000521632
Ensembl Acc Id: ENSP00000427873   ⟸   ENST00000521650
Ensembl Acc Id: ENSP00000483660   ⟸   ENST00000614343

Promoters
RGD ID:6803232
Promoter ID:HG_KWN:51551
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:NM_002084,   UC003LTC.1,   UC003LTD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 365150,380,091 - 150,380,591 (+)MPROMDB
RGD ID:6852970
Promoter ID:EP74305
Type:initiation region
Name:HS_GPX3
Description:Glutathione peroxidase 3 (plasma).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 365150,380,362 - 150,380,422EPD
RGD ID:6871298
Promoter ID:EPDNEW_H8814
Type:initiation region
Name:GPX3_1
Description:glutathione peroxidase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385151,020,591 - 151,020,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4555 AgrOrtholog
COSMIC GPX3 COSMIC
Ensembl Genes ENSG00000211445 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000388825 ENTREZGENE
  ENST00000388825.9 UniProtKB/Swiss-Prot
  ENST00000517973.1 UniProtKB/TrEMBL
  ENST00000519214.5 UniProtKB/TrEMBL
  ENST00000520059.1 UniProtKB/TrEMBL
  ENST00000521632.1 UniProtKB/TrEMBL
  ENST00000521650.5 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000211445 GTEx
HGNC ID HGNC:4555 ENTREZGENE
Human Proteome Map GPX3 Human Proteome Map
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPX_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2878 UniProtKB/Swiss-Prot
NCBI Gene 2878 ENTREZGENE
OMIM 138321 OMIM
PANTHER GLUTATHIONE PEROXIDASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11592 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28951 PharmGKB
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A182DWH9_HUMAN UniProtKB/TrEMBL
  A0A182DWI0_HUMAN UniProtKB/TrEMBL
  E5RG32_HUMAN UniProtKB/TrEMBL
  GPX3_HUMAN UniProtKB/Swiss-Prot
  H0YBE4_HUMAN UniProtKB/TrEMBL
  H0YC19_HUMAN UniProtKB/TrEMBL
  O43787 ENTREZGENE
  P22352 ENTREZGENE
  Q6NXQ3_HUMAN UniProtKB/TrEMBL
  Q86W78 ENTREZGENE
  Q9NZ74 ENTREZGENE
  Q9UEL1 ENTREZGENE
UniProt Secondary O43787 UniProtKB/Swiss-Prot
  Q86W78 UniProtKB/Swiss-Prot
  Q9NZ74 UniProtKB/Swiss-Prot
  Q9UEL1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 GPX3  glutathione peroxidase 3  GPX3  glutathione peroxidase 3 (plasma)  Symbol and/or name change 5135510 APPROVED