MIR324 (microRNA 324) - Rat Genome Database

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Gene: MIR324 (microRNA 324) Homo sapiens
Analyze
Symbol: MIR324
Name: microRNA 324
RGD ID: 1343418
HGNC Page HGNC:31767
Description: Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; long-term synaptic potentiation; and regulation of gene expression. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-324; mir-324; MIRN324
RGD Orthologs
Mouse
Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,223,297 - 7,223,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,223,297 - 7,223,379 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,126,616 - 7,126,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,067,339 - 7,067,421 (-)NCBINCBI36Build 36hg18NCBI36
Celera177,151,250 - 7,151,332 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,018,606 - 7,018,688 (-)NCBIHuRef
CHM1_1177,135,364 - 7,135,446 (-)NCBICHM1_1
T2T-CHM13v2.0177,124,208 - 7,124,290 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15634332   PMID:15800047   PMID:16381832   PMID:17604727   PMID:17616659   PMID:21037258   PMID:26177288   PMID:26390174   PMID:27057006   PMID:27517633   PMID:27798879  
PMID:28905994   PMID:29103082   PMID:29386086   PMID:29559644   PMID:29956723   PMID:30045983   PMID:30159900   PMID:30193893   PMID:30337605   PMID:30969074   PMID:31003776   PMID:31066044  
PMID:31527801   PMID:31858815   PMID:31960744   PMID:32132543   PMID:32151175   PMID:32353552   PMID:32688371   PMID:32757457   PMID:33017570   PMID:33169939   PMID:33183906   PMID:33191336  
PMID:33191361   PMID:33378033   PMID:33430926   PMID:33522578   PMID:33982764   PMID:34147937   PMID:34155128   PMID:34257080   PMID:34373133   PMID:34483139   PMID:34976325   PMID:34980214  
PMID:35413678   PMID:35549643   PMID:35579772   PMID:35689709   PMID:35735238   PMID:36462499   PMID:36880587  


Genomics

Comparative Map Data
MIR324
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,223,297 - 7,223,379 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,223,297 - 7,223,379 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,126,616 - 7,126,698 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,067,339 - 7,067,421 (-)NCBINCBI36Build 36hg18NCBI36
Celera177,151,250 - 7,151,332 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,018,606 - 7,018,688 (-)NCBIHuRef
CHM1_1177,135,364 - 7,135,446 (-)NCBICHM1_1
T2T-CHM13v2.0177,124,208 - 7,124,290 (-)NCBIT2T-CHM13v2.0
Mir324
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,902,869 - 69,902,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,902,869 - 69,902,957 (+)EnsemblGRCm39 Ensembl
GRCm381170,012,043 - 70,012,131 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,012,043 - 70,012,131 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,825,545 - 69,825,633 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1177,559,995 - 77,560,083 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.96NCBI
Mir324
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,233,363 - 55,233,445 (+)NCBIGRCr8
mRatBN7.21054,734,680 - 54,734,762 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,734,678 - 54,734,766 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,396,826 - 59,396,908 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,885,406 - 58,885,488 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,392,696 - 54,392,778 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,621,126 - 56,621,208 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,621,124 - 56,621,212 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,366,245 - 56,366,327 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1053,888,264 - 53,888,346 (+)NCBICelera
Cytogenetic Map10q24NCBI

Variants

.
Variants in MIR324
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_004422.2(DVL2):c.2009C>T (p.Pro670Leu) single nucleotide variant Malignant melanoma [RCV000071665] Chr17:7226067 [GRCh38]
Chr17:7129386 [GRCh37]
Chr17:7070110 [NCBI36]
Chr17:17p13.1		 not provided
GRCh38/hg38 17p13.1(chr17:6958978-7491129)x3 copy number gain See cases [RCV000133763] Chr17:6958978..7491129 [GRCh38]
Chr17:6862297..7394448 [GRCh37]
Chr17:6803021..7335172 [NCBI36]
Chr17:17p13.1		 uncertain significance
GRCh38/hg38 17p13.2-12(chr17:5732953-12095349)x3 copy number gain See cases [RCV000134851] Chr17:5732953..12095349 [GRCh38]
Chr17:5636273..11998666 [GRCh37]
Chr17:5576997..11939391 [NCBI36]
Chr17:17p13.2-12		 pathogenic
GRCh38/hg38 17p13.3-13.1(chr17:198748-7491129)x3 copy number gain See cases [RCV000134970] Chr17:198748..7491129 [GRCh38]
Chr17:50690..7394448 [GRCh37]
Chr17:48539..7335172 [NCBI36]
Chr17:17p13.3-13.1		 pathogenic
GRCh38/hg38 17p13.3-13.1(chr17:162016-7697012)x1 copy number loss See cases [RCV000138214] Chr17:162016..7697012 [GRCh38]
Chr17:45835..7600330 [GRCh37]
Chr17:11807..7541055 [NCBI36]
Chr17:17p13.3-13.1		 pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:6361393-7750863)x3 copy number gain See cases [RCV000138220] Chr17:6361393..7750863 [GRCh38]
Chr17:6264713..7654181 [GRCh37]
Chr17:6205437..7594906 [NCBI36]
Chr17:17p13.2-13.1		 likely pathogenic
GRCh38/hg38 17p13.3-12(chr17:162016-12343901)x3 copy number gain See cases [RCV000138531] Chr17:162016..12343901 [GRCh38]
Chr17:45835..12247218 [GRCh37]
Chr17:11807..12187943 [NCBI36]
Chr17:17p13.3-12		 pathogenic
GRCh38/hg38 17p13.1(chr17:6891357-7264234)x3 copy number gain See cases [RCV000139216] Chr17:6891357..7264234 [GRCh38]
Chr17:6794676..7167553 [GRCh37]
Chr17:6735400..7108277 [NCBI36]
Chr17:17p13.1		 uncertain significance
GRCh38/hg38 17p13.3-12(chr17:150732-14764202)x3 copy number gain See cases [RCV000142236] Chr17:150732..14764202 [GRCh38]
Chr17:525..14667519 [GRCh37]
Chr17:525..14608244 [NCBI36]
Chr17:17p13.3-12		 pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:5732977-8038822)x1 copy number loss See cases [RCV000051043] Chr17:5732977..8038822 [GRCh38]
Chr17:5636297..7942140 [GRCh37]
Chr17:5577021..7882865 [NCBI36]
Chr17:17p13.2-13.1		 pathogenic
GRCh38/hg38 17p13.1(chr17:6958978-8335684)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052457]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052457]|See cases [RCV000052457] Chr17:6958978..8335684 [GRCh38]
Chr17:6862297..8239002 [GRCh37]
Chr17:6803021..8179727 [NCBI36]
Chr17:17p13.1		 pathogenic
GRCh38/hg38 17p13.2-13.1(chr17:6307904-8842949)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053407]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053407]|See cases [RCV000053407] Chr17:6307904..8842949 [GRCh38]
Chr17:6211224..8746266 [GRCh37]
Chr17:6151948..8686991 [NCBI36]
Chr17:17p13.2-13.1		 pathogenic
GRCh38/hg38 17p13.1(chr17:7210345-7496934)x1 copy number loss See cases [RCV000053425] Chr17:7210345..7496934 [GRCh38]
Chr17:7113664..7400253 [GRCh37]
Chr17:7054388..7340977 [NCBI36]
Chr17:17p13.1		 pathogenic
NM_000018.4(ACADVL):c.1182+142G>C single nucleotide variant not provided [RCV001560959] Chr17:7223379 [GRCh38]
Chr17:7126698 [GRCh37]
Chr17:17p13.1		 likely benign
GRCh38/hg38 17p13.3-12(chr17:165730-11404096)x3 copy number gain Chromosome 17p13.3 duplication syndrome [RCV003327726] Chr17:165730..11404096 [GRCh38]
Chr17:17p13.3-12		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
SMOhsa-miR-324-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
SMOhsa-miR-324-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18756266
GLI1hsa-miR-324-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18756266
TNKShsa-miR-324-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
GLI1hsa-miR-324-5pMirecordsexternal_infoNANA18756266
SMOhsa-miR-324-5pMirecordsexternal_info{changed}NA18756266
WNT9Bhsa-miR-324-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19478946
PIKFYVEhsa-miR-324-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248

Predicted Targets
Summary Value
Count of predictions:59663
Count of gene targets:18943
Count of transcripts:47629
Interacting mature miRNAs:hsa-miR-324-3p, hsa-miR-324-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH11576  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37177,127,310 - 7,127,693UniSTSGRCh37
Build 36177,068,034 - 7,068,417RGDNCBI36
Celera177,151,944 - 7,152,327RGD
Cytogenetic Map17p13.1UniSTS
HuRef177,019,300 - 7,019,683UniSTS
GeneMap99-GB4 RH Map1753.5UniSTS
NCBI RH Map17109.3UniSTS
SHGC-35547  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37177,128,429 - 7,128,581UniSTSGRCh37
Build 36177,069,153 - 7,069,305RGDNCBI36
Celera177,153,063 - 7,153,215RGD
Cytogenetic Map17p13.1UniSTS
HuRef177,020,419 - 7,020,571UniSTS
Stanford-G3 RH Map17433.0UniSTS
GeneMap99-GB4 RH Map1753.5UniSTS
Whitehead-RH Map1777.9UniSTS
NCBI RH Map17186.2UniSTS
GeneMap99-G3 RH Map17433.0UniSTS


Sequence


Ensembl Acc Id: ENST00000362183
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl177,223,297 - 7,223,379 (-)Ensembl
RefSeq Acc Id: NR_029896
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38177,223,297 - 7,223,379 (-)NCBI
GRCh37177,126,616 - 7,126,698 (-)RGD
Celera177,151,250 - 7,151,332 (-)RGD
HuRef177,018,606 - 7,018,688 (-)RGD
CHM1_1177,135,364 - 7,135,446 (-)NCBI
T2T-CHM13v2.0177,124,208 - 7,124,290 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31767 AgrOrtholog
COSMIC MIR324 COSMIC
Ensembl Genes ENSG00000199053 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362183 ENTREZGENE
GTEx ENSG00000199053 GTEx
HGNC ID HGNC:31767 ENTREZGENE
Human Proteome Map MIR324 Human Proteome Map
miRBase MI0000813 ENTREZGENE
NCBI Gene 442898 ENTREZGENE
PharmGKB PA164722657 PharmGKB
RNAcentral URS000075BEBE RNACentral
  URS000075CFD7 RNACentral
  URS0000D50706 RNACentral