Lepr<sup>fa</sup> (leptin receptor; fa mutant)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Lepr^fa (leptin receptor; fa mutant) Rattus norvegicus

Analyze

Symbol:	Lepr^fa
Name:	leptin receptor; fa mutant
RGD ID:	13432153
Description:	A missense mutation (an A to C conversion at nucleotide position 806) was found in the extracellular domain of all the isoforms in Zucker fatty (fa/fa) rats, which resulted in an amino acid change from Gln to Pro at + 269 (the Gln269Pro mutation). ASSOCIATED WITH albuminuria; decreased survivor rate; hepatic steatosis; ASSOCIATED WITH Hyperphagia; Insulin Resistance; obesity
Type:	allele of Lepr
Previously known as:	Leprfa
Is Marker For:	Strains: F344.ZUC-Lepr^fa/Tj SS.ZUC-Lepr^fa-/-/Slc SS.ZUC-Lepr^fa-/+/Slc Ho:ZFDM-Lepr^fa Crl:ZUC-Lepr^fa ZUC-Lepr^fa Crl:ZUC(Orl)-Lepr^fa Crlj:ZUC-Lepr^fa Slc:ZUC-Lepr^fa-/- ZUC-Lepr^faSte-/- HsdHlr:ZUC-Lepr^fa BN.ZUC-Lepr^fa
Latest Assembly:	mRatBN7.2 - mRatBN7.2 Assembly
Position:	No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Hyperphagia (IAGP)

Insulin Resistance (IAGP)

obesity (IAGP)

proteinuria (IAGP)

type 2 diabetes mellitus (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

albuminuria (IAGP)

decreased survivor rate (IAGP)

hepatic steatosis (IAGP)

hyperlipidemia (IAGP)

increased body mass index (IAGP)

increased body weight (IAGP)

increased circulating alanine transaminase level (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating leptin level (IAGP)

increased circulating triglyceride level (IAGP)

increased epididymal fat pad weight (IAGP)

increased food intake (IAGP)

increased gonadal fat pad weight (IAGP)

increased inguinal fat pad weight (IAGP)

increased retroperitoneal fat pad weight (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

increased white fat cell number (IAGP)

obese (IAGP)

polyphagia (IAGP)

renal glomerulus fibrosis (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat.	Hattori T, etal., Nutr Diabetes. 2011 Jan 31;1:e1. doi: 10.1038/nutd.2010.1.
2.	Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats.	Kim K, etal., Physiol Genomics. 2010 Feb 16.
3.	Association of fat cell size and paracrine growth factors in development of hyperplastic obesity.	Marques BG, etal., Am J Physiol 1998 Dec;275(6 Pt 2):R1898-908.
4.	Hyperphagia as a mediator of renal disease initiation in obese Zucker rats.	Stevenson FT, etal., Obes Res 2001 Aug;9(8):492-9.
5.	Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats.	Takaya K, etal., Biochem Biophys Res Commun. 1996 Aug 5;225(1):75-83.
6.	Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat.	Wu-Peng XS, etal., Diabetes. 1997 Mar;46(3):513-8.

Genomics

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Leprfa-var1	chr5	116389200	116389200	A	C	point_mutation	mRatBN7.2
Leprfa-var1	chr5	120597857	120597857	A	C	point_mutation	Rnor_6.0

Related Rat Strains

The following Strains have been annotated to Lepr^fa

BN.ZUC-Lepr^fa Crl:ZUC(Orl)-Lepr^fa Crl:ZUC-Lepr^fa Crlj:ZUC-Lepr^fa F344.ZUC-Lepr^fa/Tj Ho:ZFDM-Lepr^fa HsdHlr:ZUC-Lepr^fa Slc:ZUC-Lepr^fa-/- SS.ZUC-Lepr^fa-/+/Slc SS.ZUC-Lepr^fa-/-/Slc ZUC-Lepr^fa ZUC-Lepr^faSte-/-

Expression

Sequence

Nucleotide Sequences

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Mammalian Phenotype