KRT26 (keratin 26) - Rat Genome Database

Name: KRT26
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: KRT26 (keratin 26) Homo sapiens

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Symbol:

KRT26

Name:

keratin 26

RGD ID:

1343053

HGNC Page

HGNC:30840

Description:

Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Located in extracellular exosome.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

CK-26; CK26; cytokeratin-26; K25; K25B; K25IRS2; K26; keratin 25B; keratin 26, type I; keratin, type I cytoskeletal 26; keratin-25B; keratin-26; KRT25B; type I inner root sheath specific keratin 25 irs2; type I inner root sheath-specific keratin-K25irs2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Krt26 (keratin 26)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Krt26 (keratin 26)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Chinchilla lanigera (long-tailed chinchilla):	Krt26 (keratin 26)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	KRT26 (keratin 26)	NCBI	Ortholog
Canis lupus familiaris (dog):	KRT26 (keratin 26)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Krt26 (keratin 26)	NCBI	Ortholog
Sus scrofa (pig):	KRT26 (keratin 26)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	KRT26 (keratin 26)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Krt25 (keratin 25)	HGNC	OrthoMCL
Mus musculus (house mouse):	Krt27 (keratin 27)	HGNC	OrthoMCL
Mus musculus (house mouse):	Krt28 (keratin 28)	HGNC	OrthoMCL
Rattus norvegicus (Norway rat):	Pld3 (phospholipase D family, member 3)	HGNC	OMA
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Krt26 (keratin 26)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Krt26 (keratin 26)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ifd-2	Alliance	DIOPT (Ensembl Compara\|OMA)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	40,766,238 - 40,772,201 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	40,766,238 - 40,772,201 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	38,922,490 - 38,928,453 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	36,176,016 - 36,181,937 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	36,157,799 - 36,181,937	NCBI
Celera	17	35,584,037 - 35,589,958 (-)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	34,716,863 - 34,722,780 (-)	NCBI		HuRef
CHM1_1	17	39,157,819 - 39,163,738 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	41,630,552 - 41,636,512 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

4,4'-sulfonyldiphenol (EXP)

alpha-Zearalanol (ISO)

benzo[a]pyrene (EXP)

bisphenol A (ISO)

CGP 52608 (EXP)

fulvestrant (EXP)

genistein (ISO)

glyphosate (ISO)

perfluorooctanoic acid (ISO)

sodium arsenite (EXP)

trichloroethene (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epithelial cell differentiation (IBA)

intermediate filament organization (IBA)

Cellular Component

cytoskeleton (IBA)

cytosol (TAS)

extracellular exosome (HDA)

intermediate filament (IEA)

Molecular Function

protein binding (IPI)

structural molecule activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15617563	PMID:16831889	PMID:16874310	PMID:21800051	PMID:21873635	PMID:23533145	PMID:29676528	PMID:29845934	PMID:32296183	PMID:36949045

Genomics

Comparative Map Data

KRT26
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	40,766,238 - 40,772,201 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	40,766,238 - 40,772,201 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	38,922,490 - 38,928,453 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	36,176,016 - 36,181,937 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	36,157,799 - 36,181,937	NCBI
Celera	17	35,584,037 - 35,589,958 (-)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	34,716,863 - 34,722,780 (-)	NCBI		HuRef
CHM1_1	17	39,157,819 - 39,163,738 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	41,630,552 - 41,636,512 (-)	NCBI		T2T-CHM13v2.0

Krt26
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	99,219,310 - 99,228,791 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	99,219,376 - 99,228,792 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	99,328,484 - 99,337,965 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	99,328,550 - 99,337,966 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	99,189,798 - 99,199,279 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	100,103,480 - 100,112,965 (-)	NCBI		MGSCv36	mm8
MGSCv36	11	99,144,572 - 99,154,057 (-)	NCBI		MGSCv36	mm8
Cytogenetic Map	11	D	NCBI
cM Map	11	62.92	NCBI

Krt26
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	84,777,137 - 84,791,756 (-)	NCBI		GRCr8
mRatBN7.2	10	84,280,965 - 84,295,575 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	84,281,162 - 84,292,466 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	89,225,468 - 89,234,501 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	88,723,585 - 88,732,619 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	84,115,575 - 84,124,603 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	87,239,722 - 87,248,589 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	87,238,723 - 87,248,632 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	87,035,420 - 87,044,512 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	88,232,055 - 88,240,699 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	88,246,424 - 88,255,069 (-)	NCBI
Celera	10	83,021,282 - 83,029,760 (-)	NCBI		Celera
Cytogenetic Map	10	q31	NCBI

Krt26
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	15,230,780 - 15,236,784 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	15,230,834 - 15,236,699 (-)	NCBI	ChiLan1.0	ChiLan1.0

KRT26
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	24,176,817 - 24,186,349 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	26,067,258 - 26,076,789 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	16,512,055 - 16,517,973 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	16,737,108 - 16,743,025 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	16,737,108 - 16,743,025 (+)	Ensembl	panpan1.1		panPan2

KRT26
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	21,924,248 - 21,929,809 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	21,924,248 - 21,929,809 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	21,397,517 - 21,402,890 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	22,717,338 - 22,722,912 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	22,717,338 - 22,722,912 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	21,492,178 - 21,497,521 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	21,750,781 - 21,756,349 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	21,875,167 - 21,880,734 (+)	NCBI		UU_Cfam_GSD_1.0

Krt26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	21,326,477 - 21,332,961 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	15,742,328 - 15,748,494 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	15,742,328 - 15,748,494 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KRT26
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	21,689,145 - 21,695,847 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	21,689,150 - 21,696,096 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	21,792,911 - 21,799,834 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KRT26
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	65,412,225 - 65,413,931 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	65,412,753 - 65,418,344 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	36,294,422 - 36,300,065 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in KRT26
29 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3	copy number gain	See cases [RCV000050957]	Chr17:36449220..68170214 [GRCh38] Chr17:48563237..65936105 [GRCh37] Chr17:45918236..63677950 [NCBI36] Chr17:17q21.33-24.2	pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]\|See cases [RCV000052483]	Chr17:36449220..83086677 [GRCh38] Chr17:58617905..81044553 [GRCh37] Chr17:55972687..78637842 [NCBI36] Chr17:17q23.2-25.3	pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3	copy number gain	See cases [RCV000052479]	Chr17:39199873..45629579 [GRCh38] Chr17:37356126..43706945 [GRCh37] Chr17:34609652..41062728 [NCBI36] Chr17:17q12-21.31	pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3	copy number gain	See cases [RCV000137437]	Chr17:36449220..75053130 [GRCh38] Chr17:57595736..73049225 [GRCh37] Chr17:54950518..70560820 [NCBI36] Chr17:17q23.1-25.1	pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)	copy number gain	See cases [RCV000511439]	Chr17:526..81041938 [GRCh37] Chr17:17p13.3-q25.3	pathogenic
NM_181539.5(KRT26):c.313G>A (p.Glu105Lys)	single nucleotide variant	not specified [RCV004332088]	Chr17:40771801 [GRCh38] Chr17:38928053 [GRCh37] Chr17:17q21.2	uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3	copy number gain	See cases [RCV000512441]	Chr17:526..81041938 [GRCh37] Chr17:17p13.3-q25.3	pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3	copy number gain	not provided [RCV000739324]	Chr17:8547..81060040 [GRCh37] Chr17:17p13.3-q25.3	pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3	copy number gain	not provided [RCV000739320]	Chr17:7214..81058310 [GRCh37] Chr17:17p13.3-q25.3	pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3	copy number gain	not provided [RCV000739325]	Chr17:12344..81057996 [GRCh37] Chr17:17p13.3-q25.3	pathogenic
NM_181539.5(KRT26):c.616G>A (p.Asp206Asn)	single nucleotide variant	not specified [RCV004291192]	Chr17:40770318 [GRCh38] Chr17:38926570 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.380C>T (p.Ser127Phe)	single nucleotide variant	not specified [RCV004126621]	Chr17:40771734 [GRCh38] Chr17:38927986 [GRCh37] Chr17:17q21.2	likely benign
NM_181539.5(KRT26):c.989C>T (p.Ser330Phe)	single nucleotide variant	not specified [RCV004120498]	Chr17:40769077 [GRCh38] Chr17:38925329 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.44G>A (p.Arg15Gln)	single nucleotide variant	not specified [RCV004070032]	Chr17:40772070 [GRCh38] Chr17:38928322 [GRCh37] Chr17:17q21.2	likely benign
NM_181539.5(KRT26):c.97G>C (p.Val33Leu)	single nucleotide variant	not specified [RCV004087888]	Chr17:40772017 [GRCh38] Chr17:38928269 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1169T>C (p.Leu390Ser)	single nucleotide variant	not specified [RCV004139429]	Chr17:40768897 [GRCh38] Chr17:38925149 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1217A>G (p.Lys406Arg)	single nucleotide variant	not specified [RCV004134393]	Chr17:40767624 [GRCh38] Chr17:38923876 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.871G>A (p.Asp291Asn)	single nucleotide variant	not specified [RCV004097383]	Chr17:40769852 [GRCh38] Chr17:38926104 [GRCh37] Chr17:17q21.2	likely benign
NM_181539.5(KRT26):c.1360A>C (p.Ile454Leu)	single nucleotide variant	not specified [RCV004100660]	Chr17:40766562 [GRCh38] Chr17:38922814 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.338A>G (p.Gln113Arg)	single nucleotide variant	not specified [RCV004225855]	Chr17:40771776 [GRCh38] Chr17:38928028 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1352C>A (p.Ser451Tyr)	single nucleotide variant	not specified [RCV004160805]	Chr17:40766570 [GRCh38] Chr17:38922822 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.656C>G (p.Thr219Ser)	single nucleotide variant	not specified [RCV004079422]	Chr17:40770278 [GRCh38] Chr17:38926530 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.387A>T (p.Glu129Asp)	single nucleotide variant	not specified [RCV004157034]	Chr17:40771727 [GRCh38] Chr17:38927979 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.16T>A (p.Ser6Thr)	single nucleotide variant	not specified [RCV004115622]	Chr17:40772098 [GRCh38] Chr17:38928350 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.323A>G (p.Asn108Ser)	single nucleotide variant	not specified [RCV004225260]	Chr17:40771791 [GRCh38] Chr17:38928043 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.422T>C (p.Ile141Thr)	single nucleotide variant	not specified [RCV004185689]	Chr17:40771692 [GRCh38] Chr17:38927944 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.382C>T (p.Arg128Trp)	single nucleotide variant	not specified [RCV004103261]	Chr17:40771732 [GRCh38] Chr17:38927984 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.67G>A (p.Gly23Ser)	single nucleotide variant	not specified [RCV004120989]	Chr17:40772047 [GRCh38] Chr17:38928299 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.945A>G (p.Ile315Met)	single nucleotide variant	not specified [RCV004115012]	Chr17:40769778 [GRCh38] Chr17:38926030 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.868T>C (p.Ser290Pro)	single nucleotide variant	not specified [RCV004184995]	Chr17:40769855 [GRCh38] Chr17:38926107 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.170G>A (p.Cys57Tyr)	single nucleotide variant	not specified [RCV004223346]	Chr17:40771944 [GRCh38] Chr17:38928196 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.497G>A (p.Arg166Lys)	single nucleotide variant	not specified [RCV004276635]	Chr17:40771181 [GRCh38] Chr17:38927433 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.14T>C (p.Leu5Pro)	single nucleotide variant	not specified [RCV004269619]	Chr17:40772100 [GRCh38] Chr17:38928352 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.581G>C (p.Arg194Pro)	single nucleotide variant	not specified [RCV004260535]	Chr17:40770353 [GRCh38] Chr17:38926605 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.390C>G (p.His130Gln)	single nucleotide variant	not specified [RCV004257075]	Chr17:40771724 [GRCh38] Chr17:38927976 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1240G>A (p.Gly414Arg)	single nucleotide variant	not specified [RCV004306686]	Chr17:40767601 [GRCh38] Chr17:38923853 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.250A>C (p.Lys84Gln)	single nucleotide variant	not specified [RCV004363794]	Chr17:40771864 [GRCh38] Chr17:38928116 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.851C>G (p.Thr284Arg)	single nucleotide variant	not specified [RCV004354975]	Chr17:40769872 [GRCh38] Chr17:38926124 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1024C>T (p.Leu342Phe)	single nucleotide variant	not specified [RCV004412272]	Chr17:40769042 [GRCh38] Chr17:38925294 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1105G>C (p.Glu369Gln)	single nucleotide variant	not specified [RCV004412273]	Chr17:40768961 [GRCh38] Chr17:38925213 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.753C>A (p.Asp251Glu)	single nucleotide variant	not specified [RCV004412274]	Chr17:40770051 [GRCh38] Chr17:38926303 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.85G>A (p.Val29Met)	single nucleotide variant	not specified [RCV004412275]	Chr17:40772029 [GRCh38] Chr17:38928281 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.961A>G (p.Met321Val)	single nucleotide variant	not specified [RCV004412277]	Chr17:40769762 [GRCh38] Chr17:38926014 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.581G>A (p.Arg194His)	single nucleotide variant	not specified [RCV004644464]	Chr17:40770353 [GRCh38] Chr17:38926605 [GRCh37] Chr17:17q21.2	likely benign
NM_181539.5(KRT26):c.607T>C (p.Cys203Arg)	single nucleotide variant	not specified [RCV004644465]	Chr17:40770327 [GRCh38] Chr17:38926579 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.1349A>T (p.Lys450Met)	single nucleotide variant	not specified [RCV004644462]	Chr17:40766573 [GRCh38] Chr17:38922825 [GRCh37] Chr17:17q21.2	uncertain significance
NM_181539.5(KRT26):c.848C>G (p.Ala283Gly)	single nucleotide variant	not specified [RCV004644463]	Chr17:40769875 [GRCh38] Chr17:38926127 [GRCh37] Chr17:17q21.2	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	147
Count of miRNA genes:	123
Interacting mature miRNAs:	135
Transcripts:	ENST00000335552
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298406	BP16_H	Blood pressure QTL 16 (human)		0.0004	Blood pressure	hypertension susceptibility	17	14778647	40778647	Human

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system
548	637	1489	637	1735	363	491	120	254	48	1529	1585	1793	890	241	755	367	72

Sequence

Nucleotide Sequences


RefSeq Transcripts	NG_012487	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_181539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC090283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AJ564205	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC132951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC136896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000335552 ⟹ ENSP00000334798

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	17	40,766,238 - 40,772,201 (-)	Ensembl

RefSeq Acc Id:

NM_181539 ⟹ NP_853517

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	17	40,766,238 - 40,772,201 (-)	NCBI
GRCh37	17	38,922,490 - 38,928,411 (-)	RGD
Build 36	17	36,176,016 - 36,181,937 (-)	NCBI Archive
Celera	17	35,584,037 - 35,589,958 (-)	RGD
HuRef	17	34,716,863 - 34,722,780 (-)	ENTREZGENE
CHM1_1	17	39,157,819 - 39,163,738 (-)	NCBI
T2T-CHM13v2.0	17	41,630,552 - 41,636,512 (-)	NCBI

Sequence:

show sequence

CTTTGCTCCTCTTTCTGGGAAGGGGTTGCCCGGCTGTGCTGCCACCATGTCTTTTCGACTTTCT
GGTGGATCCAGGAGGATCTGCTCGCGAACTGGGTCTGGTAGGCTGTCCGGTGGAGGAACAGGCT
TCGTGGCTGGGAATGTGTGTGTTGGATCGGGAGCAAGAAGCAGCTTTTCTTGTACTCTTGAGGG
CATCTCTTCTGGAGGAAGCTTCTGCAATAGCGGTGGAGGGTTGGGAAGTGGTGCCTGTGCTGGT
TTTCTTGGCAATGAGCACAGCCTCCTCTCTGGGAATGAAAAGGTGACCATGCAGAATCTCAACG
ACCGCCTGGCATCCTACCTGGACCATGTGCATGCTCTAGAGGAGGCCAACGCAGACCTGGAGCA
GAAGATCAAGGGCTGGTACGAGAAATGTGAGCCTGGCTCTTCCCGGGAACACGATCATGACTAT
AGCAGATACTTCTCAGTCATAGAAGATCTTAAAAGGCAGATTATTTCTGCGACCATCTGCAATG
CCAGCATTGTTCTACAAAATGACAATGCCAGACTGACCGCTGATGACTTCAGGCTGAAGTATGA
AAATGAGCTGGCTCTGCACCACAGTGTTGAGGCCGACACCAGTGGTCTTCGCAGAGTGTTGGAT
GAACTGACCCTTTGTACAACCGACCTGGAGATACAGTGTGAGACCCTCAGTGAGGAATTGACCT
ACCTCAAAAAAAGTCATGAGGAGGAAATGGAAGTCTTGCAATATACAGCTGGGGGGAACGTGAA
CGTGGAGATGAATGCAACCCCAGGAGTGGACCTAACTGTCCTGTTGAACAACATGAGGGCTGAG
TATGAGGACTTGGCTGAGCAGAACCGCAAAGATGCTGAAGCCTGGTTCAACGAGAGGAGTGCAA
CGCTGCAACAACAGATTTCCGATCATGAGGGAGCAGCCACAGCAGCCAGAAATGAGCTGACCGA
ATTAAAACGCAATCTGCAAACCCTGGAAATAGAACTTCAGTCCCTCATGGCTGTGAAACATTCC
TATGAATGCTCCTTGGCTGAGACTGAAGGAAATTACTGCAATCAACTCCAGCAAATTCAGGATC
AGATAGGGGTGATGGAGGAACAACTGCAACAGATTCGAACAGAAACAGAAGGCCAGAAGCTGGA
GTATGAACAGCTTCTTGATGTAAAAATATTTTTAGAAAAAGAAATTGACATTTATTGCAACTTA
CTAGATGGAGAAGAAAGAAAAAGCAAATCCACATGTTACAAATCAAAAGGATACAGGCCTGTGA
ATTCTGGAAATCAAGCCAAAGACTCAACAGAAGAAACTATTGTTAAAACAGTGGTTGAGGAACT
GGATCAAATTGGCAATCTCCTTTCACTGAGAGTCCACTCAGTTGAAGAAAAGTCCTCTAAAATA
AGCAACATTACAGTAGAGCAACGAGTACCTTCTAAAGCACCATAATGAGGAAAAAGTTATTTGG
AAAGAAAGAAAGAAAGAGAGAGAGAGAGAAAGAAAGAAAGAAAGGCTGCCTTTGCAAAAATCCT
ACTGGTCAAATAACCTAAGGAAATTATTCATTTCTGTTCTTAAAAGGGCTAGAATTTGTTCTCC
TTCTCTTCCTTTTCTCATGTTCTATGCATGTAATCCTTTTCCAGAGTAGAAAAATCCTGCTCTG
TCCCTAATTTTTGTTTTTATTTTGGGGGCCTTTTTTGACATTTCATTAAAAATTCTTCTATTGC
AAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_853517	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI32952	(Get FASTA)	NCBI Sequence Viewer
	AAI36897	(Get FASTA)	NCBI Sequence Viewer
	CAD91905	(Get FASTA)	NCBI Sequence Viewer
	EAW60677	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000334798
	ENSP00000334798.4
GenBank Protein	Q7Z3Y9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_853517 ⟸ NM_181539

- UniProtKB:

A2RUL2 (UniProtKB/Swiss-Prot), B2RNH8 (UniProtKB/Swiss-Prot), Q7Z3Y9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSFRLSGGSRRICSRTGSGRLSGGGTGFVAGNVCVGSGARSSFSCTLEGISSGGSFCNSGGGLG
SGACAGFLGNEHSLLSGNEKVTMQNLNDRLASYLDHVHALEEANADLEQKIKGWYEKCEPGSSR
EHDHDYSRYFSVIEDLKRQIISATICNASIVLQNDNARLTADDFRLKYENELALHHSVEADTSG
LRRVLDELTLCTTDLEIQCETLSEELTYLKKSHEEEMEVLQYTAGGNVNVEMNATPGVDLTVLL
NNMRAEYEDLAEQNRKDAEAWFNERSATLQQQISDHEGAATAARNELTELKRNLQTLEIELQSL
MAVKHSYECSLAETEGNYCNQLQQIQDQIGVMEEQLQQIRTETEGQKLEYEQLLDVKIFLEKEI
DIYCNLLDGEERKSKSTCYKSKGYRPVNSGNQAKDSTEETIVKTVVEELDQIGNLLSLRVHSVE
EKSSKISNITVEQRVPSKAP

hide sequence

Ensembl Acc Id:

ENSP00000334798 ⟸ ENST00000335552

Protein Domains

IF rod

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7Z3Y9-F1-model_v2	AlphaFold	Q7Z3Y9	1-468	view protein structure

Promoters

RGD ID:

7234951

Promoter ID:

EPDNEW_H23221

Type:

single initiation site

Name:

KRT26_1

Description:

keratin 26

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.; Paired-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	17	40,772,201 - 40,772,261	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:30840	AgrOrtholog
COSMIC	KRT26	COSMIC
Ensembl Genes	ENSG00000186393	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000335552	ENTREZGENE
	ENST00000335552.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.5.170	UniProtKB/Swiss-Prot
	Single helix bin	UniProtKB/Swiss-Prot
	Vasodilator-stimulated phosphoprotein	UniProtKB/Swiss-Prot
GTEx	ENSG00000186393	GTEx
HGNC ID	HGNC:30840	ENTREZGENE
Human Proteome Map	KRT26	Human Proteome Map
InterPro	IF_rod_dom	UniProtKB/Swiss-Prot
	Keratin_I	UniProtKB/Swiss-Prot
KEGG Report	hsa:353288	UniProtKB/Swiss-Prot
NCBI Gene	353288	ENTREZGENE
OMIM	616675	OMIM
PANTHER	KERATIN, TYPE I CYTOSKELETAL 26	UniProtKB/Swiss-Prot
	PTHR23239	UniProtKB/Swiss-Prot
Pfam	Filament	UniProtKB/Swiss-Prot
PharmGKB	PA134863261	PharmGKB
PRINTS	TYPE1KERATIN	UniProtKB/Swiss-Prot
PROSITE	IF_ROD_2	UniProtKB/Swiss-Prot
SMART	Filament	UniProtKB/Swiss-Prot
Superfamily-SCOP	Intermediate filament protein, coiled coil region	UniProtKB/Swiss-Prot
UniProt	A2RUL2	ENTREZGENE
	B2RNH8	ENTREZGENE
	K1C26_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A2RUL2	UniProtKB/Swiss-Prot
	B2RNH8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-14	KRT26	keratin 26	KRT26	keratin 26, type I	Symbol and/or name change	5135510	APPROVED
2015-01-27	KRT26	keratin 26, type I	KRT26	keratin 26	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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