CCT3 (chaperonin containing TCP1 subunit 3) - Rat Genome Database

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Gene: CCT3 (chaperonin containing TCP1 subunit 3) Homo sapiens
Analyze
Symbol: CCT3
Name: chaperonin containing TCP1 subunit 3
RGD ID: 1342982
HGNC Page HGNC:1616
Description: Enables protein folding chaperone. Involved in chaperone mediated protein folding independent of cofactor and protein stabilization. Located in microtubule. Part of chaperonin-containing T-complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CCT-gamma; CCTG; chaperonin containing T-complex polypeptide 1 subunit 3; chaperonin containing TCP1, subunit 3 (gamma); hTRiC5; NEDSVH; PIG48; T-complex protein 1 subunit gamma; T-complex protein 1, gamma subunit; TCP-1-gamma; TCP1 (t-complex-1) ring complex, polypeptide 5; TRIC5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: CCT3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,308,968 - 156,338,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,308,968 - 156,367,873 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,278,759 - 156,308,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,545,376 - 154,574,819 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,091,832 - 153,121,121NCBI
Celera1129,351,733 - 129,381,131 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,638,812 - 127,668,494 (-)NCBIHuRef
CHM1_11157,674,664 - 157,704,561 (-)NCBICHM1_1
T2T-CHM13v2.01155,447,437 - 155,476,903 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dimethoxyphenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-nitrofluorene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
albendazole  (EXP)
all-trans-retinoic acid  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
beta-lapachone  (EXP)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
Brodifacoum  (ISO)
cadmium acetate  (EXP)
caffeine  (EXP)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
Cinobufagin  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
coumarin  (EXP)
CU-O LINKAGE  (EXP)
cyclophosphamide  (ISO)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP)
doxorubicin  (EXP)
enzyme inhibitor  (EXP)
fenvalerate  (ISO)
finasteride  (ISO)
flutamide  (ISO)
folic acid  (ISO)
FR900359  (EXP)
furfural  (EXP)
gentamycin  (ISO)
hydrogen peroxide  (EXP)
ivermectin  (EXP)
lead(0)  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
miconazole  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (ISO)
nimesulide  (ISO)
nitrates  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP)
sodium chloride  (EXP)
sodium dichromate  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
thiram  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7953530   PMID:8001976   PMID:8110840   PMID:8573069   PMID:10635329   PMID:11865071   PMID:12477932   PMID:12586295   PMID:12620389   PMID:14499622   PMID:14532270   PMID:15383276  
PMID:15489334   PMID:16009940   PMID:16085932   PMID:16169070   PMID:16189514   PMID:16196087   PMID:16497536   PMID:16710414   PMID:17110338   PMID:17314511   PMID:17550899   PMID:17643375  
PMID:18029348   PMID:18654987   PMID:18715871   PMID:18775504   PMID:18782753   PMID:19056867   PMID:19135240   PMID:19156129   PMID:19165527   PMID:19167051   PMID:19193609   PMID:19380743  
PMID:19738201   PMID:20139978   PMID:20193073   PMID:20458337   PMID:20467437   PMID:20516061   PMID:20562859   PMID:20634891   PMID:20936779   PMID:21081503   PMID:21081666   PMID:21145461  
PMID:21280222   PMID:21319273   PMID:21525035   PMID:21572988   PMID:21653829   PMID:21654808   PMID:21873635   PMID:21942715   PMID:22079093   PMID:22133715   PMID:22145905   PMID:22268729  
PMID:22304920   PMID:22399500   PMID:22586326   PMID:22589738   PMID:22623428   PMID:22681889   PMID:22810585   PMID:22863883   PMID:22939629   PMID:23011926   PMID:23022380   PMID:23349634  
PMID:23383273   PMID:23398456   PMID:23438482   PMID:23443559   PMID:23455922   PMID:23463506   PMID:23508102   PMID:23533145   PMID:23658844   PMID:23686814   PMID:23703321   PMID:23752268  
PMID:23868055   PMID:24189400   PMID:24244333   PMID:24366813   PMID:24457600   PMID:24647736   PMID:24711643   PMID:24755837   PMID:24981860   PMID:25144556   PMID:25147182   PMID:25192599  
PMID:25306918   PMID:25315684   PMID:25324306   PMID:25342745   PMID:25416956   PMID:25437307   PMID:25467444   PMID:25499913   PMID:25670202   PMID:25720964   PMID:25817432   PMID:25852190  
PMID:25900982   PMID:25921289   PMID:25940091   PMID:25959826   PMID:25963833   PMID:26186194   PMID:26217791   PMID:26229401   PMID:26344197   PMID:26414014   PMID:26460568   PMID:26472337  
PMID:26472760   PMID:26496610   PMID:26549023   PMID:26598607   PMID:26638075   PMID:26693507   PMID:26739059   PMID:26777405   PMID:26811472   PMID:26816005   PMID:26831064   PMID:26912792  
PMID:26972000   PMID:27025967   PMID:27107012   PMID:27114451   PMID:27375898   PMID:27462432   PMID:27545878   PMID:27576135   PMID:27591049   PMID:27609421   PMID:27634302   PMID:27684187  
PMID:27705803   PMID:27880917   PMID:28027390   PMID:28298427   PMID:28302793   PMID:28330616   PMID:28443643   PMID:28514442   PMID:28515276   PMID:28524877   PMID:28561026   PMID:28581483  
PMID:28685749   PMID:28700943   PMID:28902428   PMID:28977470   PMID:29053956   PMID:29117863   PMID:29229926   PMID:29298432   PMID:29331416   PMID:29395067   PMID:29467282   PMID:29490077  
PMID:29507755   PMID:29509190   PMID:29511261   PMID:29531219   PMID:29568061   PMID:29676528   PMID:29844126   PMID:29845934   PMID:29859926   PMID:29955894   PMID:29991511   PMID:30009671  
PMID:30021884   PMID:30196744   PMID:30209976   PMID:30258100   PMID:30340022   PMID:30352685   PMID:30442662   PMID:30455355   PMID:30463901   PMID:30517763   PMID:30559450   PMID:30575818  
PMID:30699358   PMID:30737378   PMID:30745168   PMID:30809309   PMID:30833792   PMID:30884312   PMID:30890647   PMID:30948266   PMID:30955883   PMID:30995489   PMID:31048545   PMID:31059266  
PMID:31067453   PMID:31091453   PMID:31180492   PMID:31239290   PMID:31300519   PMID:31324722   PMID:31353912   PMID:31405213   PMID:31409639   PMID:31501420   PMID:31536960   PMID:31586073  
PMID:31685992   PMID:31732153   PMID:31839598   PMID:31859543   PMID:31902948   PMID:31980649   PMID:31995728   PMID:32129710   PMID:32239614   PMID:32296183   PMID:32347575   PMID:32382008  
PMID:32416067   PMID:32529326   PMID:32552912   PMID:32687490   PMID:32698014   PMID:32707033   PMID:32786267   PMID:32807901   PMID:32850835   PMID:32877691   PMID:32929329   PMID:32994395  
PMID:33005030   PMID:33022573   PMID:33024031   PMID:33137104   PMID:33144677   PMID:33226137   PMID:33239621   PMID:33306668   PMID:33508424   PMID:33541421   PMID:33545068   PMID:33567341  
PMID:33644029   PMID:33658012   PMID:33729478   PMID:33762435   PMID:33863777   PMID:33916271   PMID:33961781   PMID:34079125   PMID:34189442   PMID:34316707   PMID:34349018   PMID:34373451  
PMID:34428256   PMID:34505628   PMID:34535262   PMID:34581821   PMID:34612768   PMID:34651664   PMID:34687317   PMID:34728620   PMID:34732716   PMID:34901782   PMID:35008187   PMID:35013218  
PMID:35063084   PMID:35102251   PMID:35140242   PMID:35235311   PMID:35256949   PMID:35271311   PMID:35338135   PMID:35366418   PMID:35446349   PMID:35509820   PMID:35530310   PMID:35545034  
PMID:35546148   PMID:35562734   PMID:35563538   PMID:35575683   PMID:35652658   PMID:35676659   PMID:35681168   PMID:35773623   PMID:35776542   PMID:35777956   PMID:35831314   PMID:35844135  
PMID:35944360   PMID:35973989   PMID:36055981   PMID:36057605   PMID:36114006   PMID:36129980   PMID:36168627   PMID:36180891   PMID:36199071   PMID:36215168   PMID:36282215   PMID:36414381  
PMID:36424410   PMID:36517590   PMID:36526897   PMID:36574265   PMID:36610398   PMID:36724073   PMID:36762613   PMID:36779763   PMID:36912080   PMID:36918801   PMID:36929488   PMID:37045861  
PMID:37059091   PMID:37071682   PMID:37092305   PMID:37108203   PMID:37120454   PMID:37167062   PMID:37223481   PMID:37249651   PMID:37314180   PMID:37314216   PMID:37317656   PMID:37448957  
PMID:37536630   PMID:37667382   PMID:37689310   PMID:37788672   PMID:37820061   PMID:37827155   PMID:37833621   PMID:37929963   PMID:38113892   PMID:38172120   PMID:38245532   PMID:38334954  
PMID:38360074   PMID:38569033   PMID:39231216   PMID:39358380   PMID:39422127   PMID:39501047  


Genomics

Comparative Map Data
CCT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,308,968 - 156,338,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,308,968 - 156,367,873 (-)EnsemblGRCh38hg38GRCh38
GRCh371156,278,759 - 156,308,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,545,376 - 154,574,819 (-)NCBINCBI36Build 36hg18NCBI36
Build 341153,091,832 - 153,121,121NCBI
Celera1129,351,733 - 129,381,131 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,638,812 - 127,668,494 (-)NCBIHuRef
CHM1_11157,674,664 - 157,704,561 (-)NCBICHM1_1
T2T-CHM13v2.01155,447,437 - 155,476,903 (-)NCBIT2T-CHM13v2.0
Cct3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,204,442 - 88,229,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,204,423 - 88,229,074 (+)EnsemblGRCm39 Ensembl
GRCm38388,297,135 - 88,321,766 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,297,116 - 88,321,767 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,101,057 - 88,125,688 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,383,062 - 88,407,693 (+)NCBIMGSCv36mm8
Celera388,336,705 - 88,361,340 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.79NCBI
Cct3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,063,529 - 176,088,180 (+)NCBIGRCr8
mRatBN7.22173,765,701 - 173,790,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,765,698 - 173,790,757 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,910,314 - 180,934,758 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02178,932,672 - 178,957,116 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,532,533 - 173,557,196 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,669,051 - 187,693,610 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,668,796 - 187,693,610 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,072,068 - 207,096,553 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,381,044 - 180,434,152 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,331,149 - 180,384,258 (+)NCBI
Celera2167,711,584 - 167,735,276 (+)NCBICelera
Cytogenetic Map2q34NCBI
Cct3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,444,988 - 2,461,113 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,444,988 - 2,460,976 (-)NCBIChiLan1.0ChiLan1.0
CCT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,508,565 - 93,536,333 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,240,518 - 93,268,250 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,652,058 - 131,679,802 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,482,012 - 135,508,983 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,481,427 - 135,508,983 (-)Ensemblpanpan1.1panPan2
CCT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,566,274 - 41,583,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,566,292 - 41,584,863 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,054,446 - 41,072,072 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,431,013 - 41,448,650 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,431,096 - 41,449,272 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,212,433 - 41,230,036 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,265,635 - 41,283,249 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,549,686 - 41,567,311 (+)NCBIUU_Cfam_GSD_1.0
Cct3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,506,956 - 26,523,883 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,537,015 - 5,554,384 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,537,338 - 5,554,384 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,733,918 - 93,753,340 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,733,967 - 93,753,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,435,570 - 102,453,406 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,518,729 - 7,545,296 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,518,846 - 7,545,677 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,819,515 - 6,846,680 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cct3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,575,562 - 1,592,594 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,575,560 - 1,592,540 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCT3
54 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001008800.2(CCT3):c.778+2T>G single nucleotide variant Malignant melanoma [RCV000059922] Chr1:156317413 [GRCh38]
Chr1:156287204 [GRCh37]
Chr1:154553828 [NCBI36]
Chr1:1q22		 not provided
GRCh38/hg38 1q22(chr1:155834419-156434205)x3 copy number gain See cases [RCV000138885] Chr1:155834419..156434205 [GRCh38]
Chr1:155804210..156403997 [GRCh37]
Chr1:154070834..154670621 [NCBI36]
Chr1:1q22		 uncertain significance
GRCh38/hg38 1q22-23.1(chr1:156256495-156681863)x1 copy number loss See cases [RCV000138561] Chr1:156256495..156681863 [GRCh38]
Chr1:156226286..156651655 [GRCh37]
Chr1:154492910..154918279 [NCBI36]
Chr1:1q22-23.1		 likely pathogenic
GRCh38/hg38 1q21.3-23.1(chr1:154566501-157624084)x3 copy number gain See cases [RCV000139902] Chr1:154566501..157624084 [GRCh38]
Chr1:154538977..157593874 [GRCh37]
Chr1:152805601..155860498 [NCBI36]
Chr1:1q21.3-23.1		 pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_005998.5(CCT3):c.562A>G (p.Asn188Asp) single nucleotide variant not specified [RCV004325643] Chr1:156320886 [GRCh38]
Chr1:156290677 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.556G>A (p.Glu186Lys) single nucleotide variant not specified [RCV004301261] Chr1:156320892 [GRCh38]
Chr1:156290683 [GRCh37]
Chr1:1q22		 uncertain significance
Single allele inversion Pediatric metastatic thyroid tumour [RCV000585807] Chr1:154130985..156843877 [GRCh37]
Chr1:1q21.3-23.1		 likely pathogenic
GRCh37/hg19 1q21.3-23.1(chr1:153751465-156660462)x3 copy number gain not provided [RCV000585385] Chr1:153751465..156660462 [GRCh37]
Chr1:1q21.3-23.1		 likely pathogenic
GRCh37/hg19 1q22-23.1(chr1:155636337-158024499)x1 copy number loss not provided [RCV000684658] Chr1:155636337..158024499 [GRCh37]
Chr1:1q22-23.1		 pathogenic
GRCh37/hg19 1q22-23.1(chr1:155999570-156844432)x3 copy number gain not provided [RCV000684659] Chr1:155999570..156844432 [GRCh37]
Chr1:1q22-23.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
LMNA-NTRK1 fusion fusion Congenital fibrosarcoma [RCV000754610] Chr1:156100565..156844697 [GRCh37]
Chr1:1q22-23.1		 pathogenic
NM_005998.5(CCT3):c.592T>A (p.Tyr198Asn) single nucleotide variant not specified [RCV004320356] Chr1:156320856 [GRCh38]
Chr1:156290647 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.94-3T>C single nucleotide variant not provided [RCV000893266] Chr1:156334921 [GRCh38]
Chr1:156304712 [GRCh37]
Chr1:1q22		 benign
GRCh37/hg19 1q22-23.1(chr1:155770505-156652136)x3 copy number gain not provided [RCV000848811] Chr1:155770505..156652136 [GRCh37]
Chr1:1q22-23.1		 uncertain significance
GRCh37/hg19 1q22(chr1:156037369-156463980)x3 copy number gain not provided [RCV000846254] Chr1:156037369..156463980 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.695A>G (p.Tyr232Cys) single nucleotide variant not specified [RCV004294435] Chr1:156318932 [GRCh38]
Chr1:156288723 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.337del (p.Leu113fs) deletion not provided [RCV004787252] Chr1:156325057 [GRCh38]
Chr1:156294848 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1552C>T (p.Arg518Ter) AND NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT single nucleotide variant NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION [RCV004998716]|See cases [RCV001196452] Chr1:156309285 [GRCh38]
Chr1:156279076 [GRCh37]
Chr1:1q22		 pathogenic|uncertain significance
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NC_000001.10:g.(?_155581953)_(156851434_?)del deletion Charcot-Marie-Tooth disease type 2 [RCV001983077] Chr1:155581953..156851434 [GRCh37]
Chr1:1q22-23.1		 pathogenic
NC_000001.10:g.(?_154141761)_(156851434_?)dup duplication Charcot-Marie-Tooth disease type 2 [RCV001990060] Chr1:154141761..156851434 [GRCh37]
Chr1:1q21.3-23.1		 uncertain significance
NC_000001.10:g.(?_149895434)_(156851434_?)dup duplication Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency [RCV001958273]|Congenital neutropenia-myelofibrosis-nephromegaly syndrome [RCV001958271]|Kostmann syndrome [RCV003120769]|MHC class II deficiency [RCV001992607] Chr1:149895434..156851434 [GRCh37]
Chr1:1q21.2-23.1		 uncertain significance
NM_005998.5(CCT3):c.274G>C (p.Gly92Arg) single nucleotide variant not specified [RCV004301502] Chr1:156333577 [GRCh38]
Chr1:156303368 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1109A>C (p.Lys370Thr) single nucleotide variant not specified [RCV004315537] Chr1:156312087 [GRCh38]
Chr1:156281878 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.208A>G (p.Ile70Val) single nucleotide variant not specified [RCV004207757] Chr1:156333643 [GRCh38]
Chr1:156303434 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1412C>T (p.Thr471Ile) single nucleotide variant not specified [RCV004238391] Chr1:156310679 [GRCh38]
Chr1:156280470 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.881A>G (p.Lys294Arg) single nucleotide variant not specified [RCV004177710] Chr1:156317426 [GRCh38]
Chr1:156287217 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.478A>G (p.Ile160Val) single nucleotide variant not specified [RCV004123944] Chr1:156320970 [GRCh38]
Chr1:156290761 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.631G>A (p.Asp211Asn) single nucleotide variant not specified [RCV004153899] Chr1:156318996 [GRCh38]
Chr1:156288787 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.689G>A (p.Arg230Gln) single nucleotide variant not specified [RCV004163322] Chr1:156318938 [GRCh38]
Chr1:156288729 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1553G>A (p.Arg518Gln) single nucleotide variant not specified [RCV004162147] Chr1:156309284 [GRCh38]
Chr1:156279075 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.46C>T (p.Arg16Cys) single nucleotide variant not specified [RCV004207406] Chr1:156335874 [GRCh38]
Chr1:156305665 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.938G>A (p.Arg313His) single nucleotide variant not specified [RCV004202005] Chr1:156317202 [GRCh38]
Chr1:156286993 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1262C>G (p.Ala421Gly) single nucleotide variant not specified [RCV004123004] Chr1:156311089 [GRCh38]
Chr1:156280880 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.83A>G (p.Asn28Ser) single nucleotide variant not specified [RCV004110467] Chr1:156335837 [GRCh38]
Chr1:156305628 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.919G>A (p.Ala307Thr) single nucleotide variant not specified [RCV004180147] Chr1:156317221 [GRCh38]
Chr1:156287012 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.35A>G (p.Gln12Arg) single nucleotide variant NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION [RCV004999890]|not specified [RCV004163526] Chr1:156335885 [GRCh38]
Chr1:156305676 [GRCh37]
Chr1:1q22		 pathogenic|uncertain significance
NM_005998.5(CCT3):c.500G>A (p.Arg167Gln) single nucleotide variant not specified [RCV004269251] Chr1:156320948 [GRCh38]
Chr1:156290739 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1346G>A (p.Arg449His) single nucleotide variant not specified [RCV004248892] Chr1:156311005 [GRCh38]
Chr1:156280796 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.77A>G (p.Asn26Ser) single nucleotide variant not specified [RCV004328783] Chr1:156335843 [GRCh38]
Chr1:156305634 [GRCh37]
Chr1:1q22		 uncertain significance
GRCh37/hg19 1q12-23.1(chr1:142535935-157648813)x3 copy number gain Chromosome 1q21.1 duplication syndrome [RCV003329522] Chr1:142535935..157648813 [GRCh37]
Chr1:1q12-23.1		 pathogenic
NM_005998.5(CCT3):c.1382G>A (p.Arg461His) single nucleotide variant not specified [RCV004341762] Chr1:156310969 [GRCh38]
Chr1:156280760 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.688C>T (p.Arg230Trp) single nucleotide variant not specified [RCV004347212] Chr1:156318939 [GRCh38]
Chr1:156288730 [GRCh37]
Chr1:1q22		 uncertain significance
GRCh37/hg19 1q21.1-23.1(chr1:144368497-158992086)x3 copy number gain not specified [RCV003986717] Chr1:144368497..158992086 [GRCh37]
Chr1:1q21.1-23.1		 pathogenic
GRCh37/hg19 1q21.3-23.1(chr1:154302443-156868186)x1 copy number loss not specified [RCV003986928] Chr1:154302443..156868186 [GRCh37]
Chr1:1q21.3-23.1		 pathogenic
GRCh37/hg19 1q21.1-23.1(chr1:146577511-157155587)x3 copy number gain not specified [RCV003987261] Chr1:146577511..157155587 [GRCh37]
Chr1:1q21.1-23.1		 pathogenic
NM_005998.5(CCT3):c.39C>A (p.Asn13Lys) single nucleotide variant not specified [RCV004433056] Chr1:156335881 [GRCh38]
Chr1:156305672 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.423T>A (p.Ser141Arg) single nucleotide variant not specified [RCV004433057] Chr1:156321025 [GRCh38]
Chr1:156290816 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.989G>A (p.Arg330Gln) single nucleotide variant not specified [RCV004433060] Chr1:156312207 [GRCh38]
Chr1:156281998 [GRCh37]
Chr1:1q22		 uncertain significance
GRCh37/hg19 1q22-23.2(chr1:155709113-159191078)x3 copy number gain not provided [RCV004577444] Chr1:155709113..159191078 [GRCh37]
Chr1:1q22-23.2		 likely pathogenic
NM_005998.5(CCT3):c.367A>G (p.Ile123Val) single nucleotide variant not specified [RCV004433055] Chr1:156325027 [GRCh38]
Chr1:156294818 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.799A>G (p.Ile267Val) single nucleotide variant not specified [RCV004433058] Chr1:156317508 [GRCh38]
Chr1:156287299 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.923A>G (p.Asn308Ser) single nucleotide variant not specified [RCV004433059] Chr1:156317217 [GRCh38]
Chr1:156287008 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.831G>C (p.Gln277His) single nucleotide variant not specified [RCV004606413] Chr1:156317476 [GRCh38]
Chr1:156287267 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.10C>T (p.His4Tyr) single nucleotide variant not specified [RCV004606415] Chr1:156338175 [GRCh38]
Chr1:156307966 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1603C>T (p.Arg535Trp) single nucleotide variant not specified [RCV004606414] Chr1:156309234 [GRCh38]
Chr1:156279025 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.14G>A (p.Arg5His) single nucleotide variant not specified [RCV004898702] Chr1:156338171 [GRCh38]
Chr1:156307962 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1186del (p.Gln396fs) AND NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT deletion NEURODEVELOPMENTAL DISORDER WITH SPEECH OR VISUAL IMPAIRMENT AND BRAIN HYPOMYELINATION [RCV005000611] Chr1:156311165 [GRCh38]
Chr1:156280956 [GRCh37]
Chr1:1q22		 pathogenic
NM_005998.5(CCT3):c.1196G>T (p.Arg399Leu) single nucleotide variant not specified [RCV004895145] Chr1:156311155 [GRCh38]
Chr1:156280946 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1154C>T (p.Ser385Leu) single nucleotide variant not specified [RCV004898699] Chr1:156312042 [GRCh38]
Chr1:156281833 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.724G>T (p.Asp242Tyr) single nucleotide variant not specified [RCV004898700] Chr1:156318903 [GRCh38]
Chr1:156288694 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.379C>T (p.Arg127Cys) single nucleotide variant not specified [RCV004898704] Chr1:156325015 [GRCh38]
Chr1:156294806 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.79A>C (p.Ile27Leu) single nucleotide variant not specified [RCV004898697] Chr1:156335841 [GRCh38]
Chr1:156305632 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.521A>G (p.Asn174Ser) single nucleotide variant not specified [RCV004898698] Chr1:156320927 [GRCh38]
Chr1:156290718 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.766A>G (p.Ile256Val) single nucleotide variant not specified [RCV004898701] Chr1:156317541 [GRCh38]
Chr1:156287332 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.452T>C (p.Met151Thr) single nucleotide variant not specified [RCV004898703] Chr1:156320996 [GRCh38]
Chr1:156290787 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.1357C>G (p.Gln453Glu) single nucleotide variant not specified [RCV004898705] Chr1:156310994 [GRCh38]
Chr1:156280785 [GRCh37]
Chr1:1q22		 uncertain significance
NM_005998.5(CCT3):c.218A>G (p.Gln73Arg) single nucleotide variant not specified [RCV004895147] Chr1:156333633 [GRCh38]
Chr1:156303424 [GRCh37]
Chr1:1q22		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3822
Count of miRNA genes:1014
Interacting mature miRNAs:1217
Transcripts:ENST00000295688, ENST00000368256, ENST00000368258, ENST00000368259, ENST00000368261, ENST00000368262, ENST00000413555, ENST00000415548, ENST00000446905, ENST00000463132, ENST00000472765, ENST00000478640, ENST00000489870, ENST00000490221, ENST00000496684, ENST00000533194
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597079952GWAS1176026_HRed cell distribution width QTL GWAS1176026 (human)6e-10Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156311180156311181Human
597615191GWAS1672051_HRed cell distribution width QTL GWAS1672051 (human)3e-43Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156311180156311181Human
597197522GWAS1293596_HHbA1c measurement QTL GWAS1293596 (human)9e-51HbA1c measurementblood hemoglobin A1c level (CMO:0002786)1156323415156323416Human
597615125GWAS1671985_HRed cell distribution width QTL GWAS1671985 (human)4e-39Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156311180156311181Human
596952539GWAS1072058_HRed cell distribution width QTL GWAS1072058 (human)6e-10Red cell distribution width1156311180156311181Human
597119768GWAS1215842_Hmonocyte count QTL GWAS1215842 (human)0.000002monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)1156326674156326675Human
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
597160134GWAS1256208_Herythrocyte count QTL GWAS1256208 (human)1e-22erythrocyte countred blood cell count (CMO:0000025)1156327497156327498Human
597131845GWAS1227919_Herythrocyte count QTL GWAS1227919 (human)6e-29erythrocyte countred blood cell count (CMO:0000025)1156330056156330057Human
597169035GWAS1265109_Hhemoglobin A1 measurement QTL GWAS1265109 (human)8e-13hemoglobin A1 measurement1156336310156336311Human
597343502GWAS1439576_HParkinson disease QTL GWAS1439576 (human)1e-15Parkinson disease1156330940156330941Human
597113421GWAS1209495_HRed cell distribution width QTL GWAS1209495 (human)8e-15Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156320865156320866Human
597113420GWAS1209494_HRed cell distribution width QTL GWAS1209494 (human)1e-11Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156311180156311181Human
597612988GWAS1669848_HRed cell distribution width QTL GWAS1669848 (human)5e-30Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156311180156311181Human
407081317GWAS730293_Hobsolete_red blood cell distribution width QTL GWAS730293 (human)8e-15obsolete_red blood cell distribution width1156320865156320866Human
407081316GWAS730292_Hobsolete_red blood cell distribution width QTL GWAS730292 (human)1e-11obsolete_red blood cell distribution width1156311180156311181Human
407385568GWAS1034544_Hobsolete_red blood cell distribution width QTL GWAS1034544 (human)7e-21obsolete_red blood cell distribution width1156311178156311179Human
407405029GWAS1054005_Hobsolete_red blood cell distribution width QTL GWAS1054005 (human)6e-10obsolete_red blood cell distribution width1156311180156311181Human
406987442GWAS636418_Hmean corpuscular hemoglobin concentration QTL GWAS636418 (human)5e-15mean corpuscular hemoglobin concentrationmean corpuscular hemoglobin concentration (CMO:0000291)1156311180156311181Human
597079783GWAS1175857_HRed cell distribution width QTL GWAS1175857 (human)7e-21Red cell distribution widthred blood cell distribution width- standard deviation (CMO:0003232)1156311178156311179Human
596979495GWAS1099014_HRed cell distribution width QTL GWAS1099014 (human)1e-11Red cell distribution width1156311180156311181Human
597057440GWAS1153514_Hbasophil count QTL GWAS1153514 (human)6e-11basophil quantity (VT:0002607)blood basophil count (CMO:0000034)1156322575156322576Human
596950243GWAS1069762_HRed cell distribution width QTL GWAS1069762 (human)7e-21Red cell distribution width1156311178156311179Human
597053291GWAS1149365_Hhousehold income QTL GWAS1149365 (human)7e-10household income1156320865156320866Human
596979496GWAS1099015_HRed cell distribution width QTL GWAS1099015 (human)8e-15Red cell distribution width1156320865156320866Human

Markers in Region
RH70900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371156,278,911 - 156,279,084UniSTSGRCh37
Build 361154,545,535 - 154,545,708RGDNCBI36
Celera1129,351,892 - 129,352,065RGD
Cytogenetic Map1q23UniSTS
HuRef1127,638,971 - 127,639,144UniSTS
GeneMap99-GB4 RH Map1562.17UniSTS
NCBI RH Map11405.1UniSTS
SHGC-132091  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371156,278,781 - 156,278,979UniSTSGRCh37
Build 361154,545,405 - 154,545,603RGDNCBI36
Celera1129,351,762 - 129,351,960RGD
Cytogenetic Map1q23UniSTS
HuRef1127,638,841 - 127,639,039UniSTS
TNG Radiation Hybrid Map170599.0UniSTS
CCT3_8687  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371156,278,572 - 156,279,094UniSTSGRCh37
Build 361154,545,196 - 154,545,718RGDNCBI36
Celera1129,351,553 - 129,352,075RGD
HuRef1127,638,632 - 127,639,154UniSTS
D1S3443  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371156,278,764 - 156,278,989UniSTSGRCh37
Build 361154,545,388 - 154,545,613RGDNCBI36
Celera1129,351,745 - 129,351,970RGD
Cytogenetic Map1q23UniSTS
HuRef1127,638,824 - 127,639,049UniSTS
Whitehead-YAC Contig Map1 UniSTS
GeneMap99-G3 RH Map16018.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_036564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_036565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB208882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK126400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL518070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL589685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL833197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY524046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG476176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG746513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000295688   ⟹   ENSP00000295688
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,308,968 - 156,338,292 (-)Ensembl
Ensembl Acc Id: ENST00000368256
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,332,653 - 156,338,311 (-)Ensembl
Ensembl Acc Id: ENST00000368258   ⟹   ENSP00000357241
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,308,969 - 156,338,263 (-)Ensembl
Ensembl Acc Id: ENST00000368259   ⟹   ENSP00000357242
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,308,969 - 156,338,245 (-)Ensembl
Ensembl Acc Id: ENST00000368261
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,308,992 - 156,325,089 (-)Ensembl
Ensembl Acc Id: ENST00000368262   ⟹   ENSP00000357245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,309,014 - 156,338,247 (-)Ensembl
Ensembl Acc Id: ENST00000413555   ⟹   ENSP00000413308
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,318,870 - 156,367,859 (-)Ensembl
Ensembl Acc Id: ENST00000415548   ⟹   ENSP00000413431
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,324,980 - 156,338,214 (-)Ensembl
Ensembl Acc Id: ENST00000446905   ⟹   ENSP00000388799
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,320,840 - 156,367,873 (-)Ensembl
Ensembl Acc Id: ENST00000463132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,320,839 - 156,367,837 (-)Ensembl
Ensembl Acc Id: ENST00000472765   ⟹   ENSP00000431543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,309,165 - 156,338,257 (-)Ensembl
Ensembl Acc Id: ENST00000478640   ⟹   ENSP00000435026
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,320,923 - 156,338,305 (-)Ensembl
Ensembl Acc Id: ENST00000489870
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,335,115 - 156,338,206 (-)Ensembl
Ensembl Acc Id: ENST00000490221
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,320,840 - 156,336,007 (-)Ensembl
Ensembl Acc Id: ENST00000496684   ⟹   ENSP00000434232
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,318,921 - 156,338,229 (-)Ensembl
Ensembl Acc Id: ENST00000533194   ⟹   ENSP00000434481
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1156,318,957 - 156,338,292 (-)Ensembl
RefSeq Acc Id: NM_001008800   ⟹   NP_001008800
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,308,968 - 156,338,292 (-)NCBI
GRCh371156,278,752 - 156,308,206 (-)NCBI
Build 361154,545,376 - 154,574,819 (-)NCBI Archive
HuRef1127,638,812 - 127,668,494 (-)ENTREZGENE
CHM1_11157,674,664 - 157,704,561 (-)NCBI
T2T-CHM13v2.01155,447,437 - 155,476,903 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005998   ⟹   NP_005989
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,308,968 - 156,338,292 (-)NCBI
GRCh371156,278,752 - 156,308,206 (-)NCBI
Build 361154,545,376 - 154,574,819 (-)NCBI Archive
HuRef1127,638,812 - 127,668,494 (-)ENTREZGENE
CHM1_11157,674,664 - 157,704,561 (-)NCBI
T2T-CHM13v2.01155,447,437 - 155,476,903 (-)NCBI
Sequence:
RefSeq Acc Id: NR_036564
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,308,968 - 156,338,292 (-)NCBI
GRCh371156,278,752 - 156,308,206 (-)ENTREZGENE
HuRef1127,638,812 - 127,668,494 (-)ENTREZGENE
CHM1_11157,674,664 - 157,704,561 (-)NCBI
T2T-CHM13v2.01155,447,437 - 155,476,903 (-)NCBI
Sequence:
RefSeq Acc Id: NR_036565
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,308,968 - 156,338,292 (-)NCBI
GRCh371156,278,752 - 156,308,206 (-)ENTREZGENE
HuRef1127,638,812 - 127,668,494 (-)ENTREZGENE
CHM1_11157,674,664 - 157,704,561 (-)NCBI
T2T-CHM13v2.01155,447,437 - 155,476,903 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001008800   ⟸   NM_001008800
- Peptide Label: isoform c
- UniProtKB: Q2TU64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_005989   ⟸   NM_005998
- Peptide Label: isoform a
- UniProtKB: Q5SZY1 (UniProtKB/Swiss-Prot),   A6NE14 (UniProtKB/Swiss-Prot),   Q9BR64 (UniProtKB/Swiss-Prot),   P49368 (UniProtKB/Swiss-Prot),   Q2TU64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000435026   ⟸   ENST00000478640
Ensembl Acc Id: ENSP00000295688   ⟸   ENST00000295688
Ensembl Acc Id: ENSP00000413308   ⟸   ENST00000413555
Ensembl Acc Id: ENSP00000413431   ⟸   ENST00000415548
Ensembl Acc Id: ENSP00000434481   ⟸   ENST00000533194
Ensembl Acc Id: ENSP00000434232   ⟸   ENST00000496684
Ensembl Acc Id: ENSP00000388799   ⟸   ENST00000446905
Ensembl Acc Id: ENSP00000357245   ⟸   ENST00000368262
Ensembl Acc Id: ENSP00000357242   ⟸   ENST00000368259
Ensembl Acc Id: ENSP00000357241   ⟸   ENST00000368258
Ensembl Acc Id: ENSP00000431543   ⟸   ENST00000472765

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49368-F1-model_v2 AlphaFold P49368 1-545 view protein structure

Promoters
RGD ID:6785342
Promoter ID:HG_KWN:5513
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000295688,   ENST00000368251,   ENST00000368252,   ENST00000368254,   ENST00000368256,   ENST00000368258,   NM_001008800,   NM_001008883,   NM_005998,   OTTHUMT00000060597,   OTTHUMT00000060599,   OTTHUMT00000060600,   OTTHUMT00000060604,   OTTHUMT00000060605,   OTTHUMT00000060608,   OTTHUMT00000099272,   UC001FOP.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361154,574,451 - 154,574,951 (+)MPROMDB
RGD ID:6851290
Promoter ID:EP73443
Type:initiation region
Name:HS_CCT3
Description:Chaperonin containing TCP1, subunit 3 (gamma).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361154,574,678 - 154,574,738EPD
RGD ID:6857578
Promoter ID:EPDNEW_H1954
Type:initiation region
Name:CCT3_1
Description:chaperonin containing TCP1 subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381156,338,257 - 156,338,317EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1616 AgrOrtholog
COSMIC CCT3 COSMIC
Ensembl Genes ENSG00000163468 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000295688 ENTREZGENE
  ENST00000295688.8 UniProtKB/Swiss-Prot
  ENST00000368259 ENTREZGENE
  ENST00000368259.6 UniProtKB/Swiss-Prot
  ENST00000368262 ENTREZGENE
  ENST00000472765 ENTREZGENE
Gene3D-CATH 1.10.560.10 UniProtKB/Swiss-Prot
  3.30.260.10 UniProtKB/Swiss-Prot
  3.50.7.10 UniProtKB/Swiss-Prot
GTEx ENSG00000163468 GTEx
HGNC ID HGNC:1616 ENTREZGENE
Human Proteome Map CCT3 Human Proteome Map
InterPro Chap_CCT_gamma UniProtKB/Swiss-Prot
  Chaperone_TCP-1 UniProtKB/Swiss-Prot
  Chaperonin_TCP-1_CS UniProtKB/Swiss-Prot
  Cpn60/TCP-1 UniProtKB/Swiss-Prot
  GroEL-like_apical_dom_sf UniProtKB/Swiss-Prot
  GROEL-like_equatorial_sf UniProtKB/Swiss-Prot
  TCP-1-like_intermed_sf UniProtKB/Swiss-Prot
  TCP-1_chaperonin UniProtKB/Swiss-Prot
  thermosome_alpha UniProtKB/Swiss-Prot
KEGG Report hsa:7203 UniProtKB/Swiss-Prot
NCBI Gene 7203 ENTREZGENE
OMIM 600114 OMIM
PANTHER PTHR11353 UniProtKB/Swiss-Prot
Pfam Cpn60_TCP1 UniProtKB/Swiss-Prot
PharmGKB PA26180 PharmGKB
PRINTS TCOMPLEXTCP1 UniProtKB/Swiss-Prot
PROSITE TCP1_1 UniProtKB/Swiss-Prot
  TCP1_2 UniProtKB/Swiss-Prot
  TCP1_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48592 UniProtKB/Swiss-Prot
  SSF52029 UniProtKB/Swiss-Prot
  SSF54849 UniProtKB/Swiss-Prot
UniProt A6NE14 ENTREZGENE
  B3KX11_HUMAN UniProtKB/TrEMBL
  B4DUR8_HUMAN UniProtKB/TrEMBL
  E9PM09_HUMAN UniProtKB/TrEMBL
  E9PQ35_HUMAN UniProtKB/TrEMBL
  E9PRC8_HUMAN UniProtKB/TrEMBL
  E9PRM9_HUMAN UniProtKB/TrEMBL
  E9PRN0_HUMAN UniProtKB/TrEMBL
  P49368 ENTREZGENE
  Q2TU64 ENTREZGENE, UniProtKB/TrEMBL
  Q59H77_HUMAN UniProtKB/TrEMBL
  Q5SZW8_HUMAN UniProtKB/TrEMBL
  Q5SZX6_HUMAN UniProtKB/TrEMBL
  Q5SZX9_HUMAN UniProtKB/TrEMBL
  Q5SZY1 ENTREZGENE
  Q9BR64 ENTREZGENE
  TCPG_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6NE14 UniProtKB/Swiss-Prot
  Q5SZY1 UniProtKB/Swiss-Prot
  Q9BR64 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-12 CCT3  chaperonin containing TCP1 subunit 3    chaperonin containing TCP1, subunit 3 (gamma)  Symbol and/or name change 5135510 APPROVED