GNLY (granulysin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: GNLY (granulysin) Homo sapiens
Analyze
Symbol: GNLY
Name: granulysin
RGD ID: 1342846
HGNC Page HGNC:4414
Description: Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and cellular defense response. Located in cytolytic granule.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 519; D2S69E; LAG-2; LAG2; lymphocyte-activation gene 2; lymphokine LAG-2; NKG5; T-cell activation protein 519; T-lymphocyte activation gene 519; TLA519
RGD Orthologs
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,694,358 - 85,698,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,685,175 - 85,698,852 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,921,481 - 85,925,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,774,925 - 85,779,386 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,833,206 - 85,837,538NCBI
Celera285,749,716 - 85,754,178 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,818,624 - 85,823,086 (+)NCBIHuRef
CHM1_1285,851,219 - 85,855,682 (+)NCBICHM1_1
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2209093   PMID:2212946   PMID:2434598   PMID:8423048   PMID:9058801   PMID:9194222   PMID:9756476   PMID:10449094   PMID:10644038   PMID:11418670   PMID:12145461   PMID:12421959  
PMID:12477932   PMID:12483306   PMID:12488100   PMID:12626573   PMID:12884856   PMID:15223905   PMID:15489334   PMID:15778384   PMID:15843520   PMID:16344560   PMID:16980658   PMID:17038537  
PMID:17596262   PMID:17703412   PMID:18192122   PMID:18490721   PMID:18584314   PMID:18688023   PMID:19029983   PMID:19106590   PMID:19111751   PMID:19243819   PMID:19258923   PMID:19454696  
PMID:19687290   PMID:19861007   PMID:20237496   PMID:20503287   PMID:20660289   PMID:20889547   PMID:21296981   PMID:21501511   PMID:21623991   PMID:21819408   PMID:21832049   PMID:21873635  
PMID:21967803   PMID:22045985   PMID:22216262   PMID:22586033   PMID:22788687   PMID:22890551   PMID:23399514   PMID:23801887   PMID:24035442   PMID:24269628   PMID:24906149   PMID:25644528  
PMID:25921628   PMID:26225678   PMID:26314314   PMID:26751807   PMID:26752517   PMID:27276051   PMID:27503909   PMID:27756230   PMID:29896906   PMID:30151671   PMID:30658247   PMID:31449312  
PMID:31642954   PMID:32066596   PMID:32271478   PMID:32296183   PMID:32511236   PMID:32822574   PMID:32913355   PMID:32929333   PMID:33560872   PMID:33961781   PMID:34093532   PMID:34445098  
PMID:34691030   PMID:35066979   PMID:38471344  


Genomics

Comparative Map Data
GNLY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38285,694,358 - 85,698,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl285,685,175 - 85,698,852 (+)EnsemblGRCh38hg38GRCh38
GRCh37285,921,481 - 85,925,975 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,774,925 - 85,779,386 (+)NCBINCBI36Build 36hg18NCBI36
Build 34285,833,206 - 85,837,538NCBI
Celera285,749,716 - 85,754,178 (+)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef285,818,624 - 85,823,086 (+)NCBIHuRef
CHM1_1285,851,219 - 85,855,682 (+)NCBICHM1_1
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBIT2T-CHM13v2.0
GNLY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21240,686,798 - 40,691,543 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A40,689,559 - 40,694,310 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A85,743,909 - 85,748,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A87,293,337 - 87,297,805 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,293,337 - 87,297,805 (+)Ensemblpanpan1.1panPan2
LOC111090436
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,326,018 - 39,329,859 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1739,010,489 - 39,014,374 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01740,085,242 - 40,089,129 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.01739,287,437 - 39,291,319 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01739,674,340 - 39,678,200 (-)NCBIUU_Cfam_GSD_1.0
GNLY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl359,067,221 - 59,072,045 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1359,067,327 - 59,072,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2361,953,109 - 61,957,816 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNLY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,459,086 - 21,463,941 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604591,004,779 - 91,010,433 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in GNLY
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p12-11.2(chr2:77025216-90282666)x3 copy number gain See cases [RCV000134786] Chr2:77025216..90282666 [GRCh38]
Chr2:77252342..91619262 [GRCh37]
Chr2:77105850..90982989 [NCBI36]
Chr2:2p12-11.2		 pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p11.2(chr2:85014686-88826619)x1 copy number loss See cases [RCV000141948] Chr2:85014686..88826619 [GRCh38]
Chr2:85241809..89126132 [GRCh37]
Chr2:85095320..88907247 [NCBI36]
Chr2:2p11.2		 pathogenic
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p13.1-11.2(chr2:74365484-89129064)x1 copy number loss See cases [RCV000510763] Chr2:74365484..89129064 [GRCh37]
Chr2:2p13.1-11.2		 pathogenic
NM_006433.5(GNLY):c.290G>A (p.Arg97Lys) single nucleotide variant not specified [RCV004323084] Chr2:85697540 [GRCh38]
Chr2:85924663 [GRCh37]
Chr2:2p11.2		 uncertain significance
GRCh37/hg19 2p12-11.2(chr2:82517612-86262705)x3 copy number gain not provided [RCV000682150] Chr2:82517612..86262705 [GRCh37]
Chr2:2p12-11.2		 uncertain significance
GRCh37/hg19 2p13.1-11.2(chr2:74527522-89125488)x1 copy number loss not provided [RCV000682167] Chr2:74527522..89125488 [GRCh37]
Chr2:2p13.1-11.2		 pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
NM_006433.5(GNLY):c.8C>T (p.Thr3Ile) single nucleotide variant not provided [RCV000903509] Chr2:85694426 [GRCh38]
Chr2:85921549 [GRCh37]
Chr2:2p11.2		 benign
NM_006433.5(GNLY):c.78T>C (p.Pro26=) single nucleotide variant not provided [RCV000968983] Chr2:85695345 [GRCh38]
Chr2:85922468 [GRCh37]
Chr2:2p11.2		 benign
NM_006433.5(GNLY):c.11G>A (p.Trp4Ter) single nucleotide variant not provided [RCV000961966] Chr2:85694429 [GRCh38]
Chr2:85921552 [GRCh37]
Chr2:2p11.2		 benign
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p12-11.2(chr2:77907114-87330965)x1 copy number loss not provided [RCV000846587] Chr2:77907114..87330965 [GRCh37]
Chr2:2p12-11.2		 pathogenic
GRCh37/hg19 2p11.2(chr2:85786006-86559358)x3 copy number gain not provided [RCV001259609] Chr2:85786006..86559358 [GRCh37]
Chr2:2p11.2		 uncertain significance
GRCh37/hg19 2p12-11.2(chr2:81209244-86688030)x1 copy number loss not provided [RCV001537915] Chr2:81209244..86688030 [GRCh37]
Chr2:2p12-11.2		 pathogenic
GRCh37/hg19 2p12-11.2(chr2:82486900-87322042) copy number loss not specified [RCV002053172] Chr2:82486900..87322042 [GRCh37]
Chr2:2p12-11.2		 pathogenic
NC_000002.11:g.(?_85766411)_(86564633_?)del deletion Hereditary spastic paraplegia 31 [RCV003111516] Chr2:85766411..86564633 [GRCh37]
Chr2:2p11.2		 pathogenic
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13		 pathogenic
NM_006433.5(GNLY):c.114T>G (p.Asp38Glu) single nucleotide variant not specified [RCV004327283] Chr2:85695381 [GRCh38]
Chr2:85922504 [GRCh37]
Chr2:2p11.2		 uncertain significance
GRCh37/hg19 2p11.2(chr2:85786007-86559358)x3 copy number gain not provided [RCV002475677] Chr2:85786007..86559358 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.14C>T (p.Ala5Val) single nucleotide variant not specified [RCV004174898] Chr2:85694432 [GRCh38]
Chr2:85921555 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.131C>T (p.Pro44Leu) single nucleotide variant not specified [RCV004183759] Chr2:85695398 [GRCh38]
Chr2:85922521 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.158G>T (p.Gly53Val) single nucleotide variant not specified [RCV004184635] Chr2:85695959 [GRCh38]
Chr2:85923082 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.383C>T (p.Ala128Val) single nucleotide variant not specified [RCV004335980] Chr2:85697633 [GRCh38]
Chr2:85924756 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.89A>G (p.Asp30Gly) single nucleotide variant not specified [RCV004395537] Chr2:85695356 [GRCh38]
Chr2:85922479 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.215T>C (p.Ile72Thr) single nucleotide variant not specified [RCV004395536] Chr2:85696016 [GRCh38]
Chr2:85923139 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.383C>G (p.Ala128Gly) single nucleotide variant not specified [RCV004919846] Chr2:85697633 [GRCh38]
Chr2:85924756 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.146A>T (p.Glu49Val) single nucleotide variant not specified [RCV004919847] Chr2:85695413 [GRCh38]
Chr2:85922536 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.79G>A (p.Glu27Lys) single nucleotide variant not specified [RCV004919848] Chr2:85695346 [GRCh38]
Chr2:85922469 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.81G>C (p.Glu27Asp) single nucleotide variant not specified [RCV004919849] Chr2:85695348 [GRCh38]
Chr2:85922471 [GRCh37]
Chr2:2p11.2		 uncertain significance
NM_006433.5(GNLY):c.65C>G (p.Ser22Cys) single nucleotide variant not specified [RCV004932766] Chr2:85695332 [GRCh38]
Chr2:85922455 [GRCh37]
Chr2:2p11.2		 uncertain significance
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:3162
Count of miRNA genes:886
Interacting mature miRNAs:1070
Transcripts:ENST00000263863, ENST00000409696, ENST00000464298, ENST00000470974, ENST00000482900, ENST00000488945, ENST00000489214, ENST00000489980, ENST00000491234, ENST00000524600, ENST00000526018, ENST00000531685, ENST00000533041, ENST00000534351
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
597273832GWAS1369906_Hgranulysin measurement QTL GWAS1369906 (human)4e-34granulysin measurement28569604685696047Human
597398628GWAS1494702_Hgranulysin measurement QTL GWAS1494702 (human)1e-16granulysin measurement28569720385697204Human

Markers in Region
STS-M85276  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37285,925,700 - 85,925,817UniSTSGRCh37
Build 36285,779,211 - 85,779,328RGDNCBI36
Celera285,754,003 - 85,754,120RGD
Cytogenetic Map2p11.2UniSTS
HuRef285,822,911 - 85,823,028UniSTS
NCBI RH Map2460.4UniSTS
D10S275  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map13q12.13UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map2q11.2UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map6q22UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map20q11UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map3p22.1UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map14q24UniSTS
Cytogenetic Map14q22-q24UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map20q13.31UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map16q24UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map22q12.3UniSTS
Cytogenetic Map6p21.33UniSTS
Cytogenetic Map10p11UniSTS
Cytogenetic Map1p13.1UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic MapXq22.1UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map3q12.3UniSTS
Cytogenetic Map6q24UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9q13-q21UniSTS
Cytogenetic Map3p25UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map9q22UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map20q13UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic MapXp22.2-p22.1UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map20pter-q11.23UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map10p12.3UniSTS
Cytogenetic Map12p13.3UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map3q26.3UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q22UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map10q24.31UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map12p12UniSTS
Cytogenetic Map3q13.31UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map1q24-q25.3UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map2q32.1UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map1q21.2-q21.3UniSTS
Cytogenetic Map6q25.2-q27UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12q24.32UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map13q12-q14UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map2p11.2UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map17q23.2UniSTS
Cytogenetic Map11p14.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map4q13UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map2p25.3UniSTS
Cytogenetic Map1q41UniSTS
Cytogenetic Map5q14.1UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map7p14.2UniSTS
Cytogenetic Map6q24.3UniSTS
Cytogenetic Map22q13.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map6q12-q13UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map18q23UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map1q43UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic MapXp22UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map3p25.2UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map2p14UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2342 2787 2227 4830 1698 2217 3 604 1612 443 2190 6839 6113 31 3667 813 1671 1508 165

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001302758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005264084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005264085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005264087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054340197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054340198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054340199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A00142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  A07389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA883466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC012454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ015680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA932688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GN344067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M85276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000263863   ⟹   ENSP00000263863
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,358 - 85,698,852 (+)Ensembl
Ensembl Acc Id: ENST00000409696   ⟹   ENSP00000387116
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,426 - 85,698,757 (+)Ensembl
Ensembl Acc Id: ENST00000464298
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,328 - 85,696,494 (+)Ensembl
Ensembl Acc Id: ENST00000470974
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,332 - 85,696,106 (+)Ensembl
Ensembl Acc Id: ENST00000482900
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,302 - 85,696,435 (+)Ensembl
Ensembl Acc Id: ENST00000488945
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,685,175 - 85,696,730 (+)Ensembl
Ensembl Acc Id: ENST00000489214
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,293 - 85,696,391 (+)Ensembl
Ensembl Acc Id: ENST00000489980
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,342 - 85,698,747 (+)Ensembl
Ensembl Acc Id: ENST00000491234
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,904 - 85,696,532 (+)Ensembl
Ensembl Acc Id: ENST00000524600   ⟹   ENSP00000436423
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,358 - 85,698,744 (+)Ensembl
Ensembl Acc Id: ENST00000526018   ⟹   ENSP00000434467
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,695,368 - 85,698,747 (+)Ensembl
Ensembl Acc Id: ENST00000531685
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,695,137 - 85,696,393 (+)Ensembl
Ensembl Acc Id: ENST00000533041
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,380 - 85,696,797 (+)Ensembl
Ensembl Acc Id: ENST00000534351
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl285,694,426 - 85,697,101 (+)Ensembl
RefSeq Acc Id: NM_001302758   ⟹   NP_001289687
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,698,852 (+)NCBI
CHM1_1285,851,219 - 85,855,781 (+)NCBI
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006433   ⟹   NP_006424
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,698,852 (+)NCBI
GRCh37285,921,414 - 85,925,967 (+)NCBI
Build 36285,774,925 - 85,779,386 (+)NCBI Archive
HuRef285,818,624 - 85,823,086 (+)ENTREZGENE
CHM1_1285,851,219 - 85,855,781 (+)NCBI
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBI
Sequence:
RefSeq Acc Id: NM_012483   ⟹   NP_036615
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,698,852 (+)NCBI
GRCh37285,921,414 - 85,925,967 (+)NCBI
Build 36285,774,925 - 85,779,386 (+)NCBI Archive
HuRef285,818,624 - 85,823,086 (+)ENTREZGENE
CHM1_1285,851,219 - 85,855,781 (+)NCBI
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005264084   ⟹   XP_005264141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,698,852 (+)NCBI
GRCh37285,921,414 - 85,925,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005264085   ⟹   XP_005264142
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,698,852 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047442947   ⟹   XP_047298903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,697,384 (+)NCBI
RefSeq Acc Id: XM_054340197   ⟹   XP_054196172
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBI
RefSeq Acc Id: XM_054340198   ⟹   XP_054196173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,696,414 - 85,700,909 (+)NCBI
RefSeq Acc Id: XM_054340199   ⟹   XP_054196174
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0285,696,414 - 85,699,434 (+)NCBI
RefSeq Acc Id: NP_036615   ⟸   NM_012483
- Peptide Label: isoform 3
- UniProtKB: P22749 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_006424   ⟸   NM_006433
- Peptide Label: isoform 2 precursor
- UniProtKB: P09325 (UniProtKB/Swiss-Prot),   Q6GU08 (UniProtKB/Swiss-Prot),   P22749 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005264142   ⟸   XM_005264085
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005264141   ⟸   XM_005264084
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001289687   ⟸   NM_001302758
- Peptide Label: isoform 1 precursor
- UniProtKB: B4E3H9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000436423   ⟸   ENST00000524600
Ensembl Acc Id: ENSP00000434467   ⟸   ENST00000526018
Ensembl Acc Id: ENSP00000387116   ⟸   ENST00000409696
Ensembl Acc Id: ENSP00000263863   ⟸   ENST00000263863
RefSeq Acc Id: XP_047298903   ⟸   XM_047442947
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054196172   ⟸   XM_054340197
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054196173   ⟸   XM_054340198
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054196174   ⟸   XM_054340199
- Peptide Label: isoform X3
Protein Domains
Saposin B-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22749-F1-model_v2 AlphaFold P22749 1-145 view protein structure

Promoters
RGD ID:6861100
Promoter ID:EPDNEW_H3624
Type:initiation region
Name:GNLY_1
Description:granulysin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38285,694,358 - 85,694,418EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4414 AgrOrtholog
COSMIC GNLY COSMIC
Ensembl Genes ENSG00000115523 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000263863 ENTREZGENE
  ENST00000263863.9 UniProtKB/Swiss-Prot
  ENST00000409696 ENTREZGENE
  ENST00000409696.7 UniProtKB/Swiss-Prot
  ENST00000524600 ENTREZGENE
Gene3D-CATH Saposin-like UniProtKB/Swiss-Prot
GTEx ENSG00000115523 GTEx
HGNC ID HGNC:4414 ENTREZGENE
Human Proteome Map GNLY Human Proteome Map
InterPro Granulysin-like UniProtKB/Swiss-Prot
  SapB_2 UniProtKB/Swiss-Prot
  Saposin-like UniProtKB/Swiss-Prot
  SaposinB_dom UniProtKB/Swiss-Prot
KEGG Report hsa:10578 UniProtKB/Swiss-Prot
NCBI Gene 10578 ENTREZGENE
OMIM 188855 OMIM
PANTHER GRANULYSIN UniProtKB/Swiss-Prot
  PTHR15541 UniProtKB/Swiss-Prot
Pfam SapB_2 UniProtKB/Swiss-Prot
PharmGKB PA28793 PharmGKB
PROSITE SAP_B UniProtKB/Swiss-Prot
SMART SapB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47862 UniProtKB/Swiss-Prot
UniProt B4DJJ4_HUMAN UniProtKB/TrEMBL
  B4E3H9 ENTREZGENE, UniProtKB/TrEMBL
  GNLY_HUMAN UniProtKB/Swiss-Prot
  H0YDW8_HUMAN UniProtKB/TrEMBL
  P09325 ENTREZGENE
  P22749 ENTREZGENE
  Q6GU08 ENTREZGENE
UniProt Secondary P09325 UniProtKB/Swiss-Prot
  Q6GU08 UniProtKB/Swiss-Prot