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Gene: GRPEL2 (GrpE like 2, mitochondrial) Homo sapiens

Analyze

Symbol:

GRPEL2

Name:

GrpE like 2, mitochondrial

RGD ID:

1342740

HGNC Page

HGNC:21060

Description:

Predicted to enable adenyl-nucleotide exchange factor activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrion.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

DKFZp451C205; FLJ23713; FLJ33918; grpE protein homolog 2, mitochondrial; GrpE-like 2, mitochondrial; Mt-GrpE#2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Grpel2 (GrpE-like 2, mitochondrial)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Grpel2 (GrpE-like 2, mitochondrial)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Grpel2 (GrpE like 2, mitochondrial)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	GRPEL2 (GrpE like 2, mitochondrial)	NCBI	Ortholog
Canis lupus familiaris (dog):	GRPEL2 (GrpE like 2, mitochondrial)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grpel2 (GrpE like 2, mitochondrial)	NCBI	Ortholog
Sus scrofa (pig):	GRPEL2 (GrpE like 2, mitochondrial)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	GRPEL2 (GrpE like 2, mitochondrial)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Grpel2 (GrpE like 2, mitochondrial)	NCBI	Ortholog
Other homologs ²
Canis lupus familiaris (dog):	PCYOX1L (prenylcysteine oxidase 1 like)	HGNC	EggNOG
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Grpel2 (GrpE-like 2, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Grpel2 (GrpE-like 2, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grpel2 (GrpE-like 2, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	C34C12.8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MGE1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Roe1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	grpel2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	grpel2.L	Alliance	DIOPT (Xenbase)
Xenopus laevis (African clawed frog):	grpel2.S	Alliance	DIOPT (Xenbase)

Related Pseudogenes:

GRPEL2P1 GRPEL2P2 GRPEL2P3

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	149,345,499 - 149,354,583 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	149,345,430 - 149,354,583 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	148,725,062 - 148,734,146 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	148,705,170 - 148,714,339 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	148,705,284 - 148,714,338	NCBI
Celera	5	144,806,966 - 144,816,121 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	143,871,317 - 143,880,469 (+)	NCBI		HuRef
CHM1_1	5	148,157,397 - 148,166,568 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	149,880,331 - 149,889,398 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

familial adenomatous polyposis 1 (IAGP)

Hereditary Neoplastic Syndromes (IAGP)

Neurodevelopmental Disorders (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (ISO)

2-hydroxypropanoic acid (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (ISO)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (EXP)

antirheumatic drug (EXP)

arsenite(3-) (EXP)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (EXP)

beta-lapachone (EXP)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (ISO)

carbon nanotube (ISO)

CGP 52608 (EXP)

chloropicrin (EXP)

ciguatoxin CTX1B (ISO)

cisplatin (EXP)

clofibrate (ISO)

copper(II) sulfate (EXP)

dichloroacetic acid (ISO)

diquat (ISO)

doxorubicin (EXP)

enzyme inhibitor (EXP)

fenofibrate (ISO)

flutamide (ISO)

hydrogen peroxide (EXP)

inulin (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

N-methyl-4-phenylpyridinium (EXP)

N-methylformamide (ISO)

oxaliplatin (ISO)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (EXP,ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rac-lactic acid (EXP)

resveratrol (ISO)

rotenone (ISO)

sodium arsenite (EXP)

sunitinib (EXP)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thapsigargin (EXP)

topotecan (ISO)

triphenyl phosphate (EXP)

triticonazole (ISO)

tunicamycin (EXP)

urethane (EXP)

valdecoxib (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular protein transport (NAS)

protein folding (IEA)

protein import into mitochondrial matrix (IBA)

Cellular Component

mitochondrial inner membrane (NAS)

mitochondrial matrix (IEA)

mitochondrion (HTP,IDA,IEA)

PAM complex, Tim23 associated import motor (IBA)

TIM23 mitochondrial import inner membrane translocase complex (NAS)

Molecular Function

adenyl-nucleotide exchange factor activity (IBA,IEA)

protein binding (IPI)

protein homodimerization activity (IEA)

protein-folding chaperone binding (IEA)

unfolded protein binding (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

presequence pathway of mitochondrial protein import (TAS)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Unlocking the presequence import pathway.	Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.

Additional References at PubMed

PMID:9694873	PMID:10339406	PMID:12477932	PMID:14702039	PMID:15489334	PMID:17207965	PMID:18029348	PMID:19322201	PMID:20877624	PMID:21873635	PMID:26186194	PMID:28380382
PMID:28514442	PMID:28848044	PMID:29229926	PMID:30098457	PMID:31182584	PMID:33080218	PMID:33961781	PMID:34800366	PMID:34884508	PMID:35563538	PMID:35575683	PMID:35831314
PMID:36758106	PMID:39445986

Genomics

Comparative Map Data

GRPEL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	149,345,499 - 149,354,583 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	149,345,430 - 149,354,583 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	148,725,062 - 148,734,146 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	148,705,170 - 148,714,339 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	148,705,284 - 148,714,338	NCBI
Celera	5	144,806,966 - 144,816,121 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	143,871,317 - 143,880,469 (+)	NCBI		HuRef
CHM1_1	5	148,157,397 - 148,166,568 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	149,880,331 - 149,889,398 (+)	NCBI		T2T-CHM13v2.0

Grpel2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	61,845,495 - 61,860,068 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	61,845,495 - 61,859,396 (-)	Ensembl		GRCm39 Ensembl
GRCm38	18	61,712,424 - 61,726,358 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	61,712,424 - 61,726,325 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	61,872,078 - 61,885,985 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	61,837,793 - 61,851,700 (-)	NCBI		MGSCv36	mm8
Celera	18	62,997,997 - 63,011,843 (-)	NCBI		Celera
Cytogenetic Map	18	E1	NCBI
cM Map	18	34.69	NCBI

Grpel2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	57,438,168 - 57,450,408 (-)	NCBI		GRCr8
mRatBN7.2	18	55,167,831 - 55,180,073 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	55,168,209 - 55,180,180 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	57,261,339 - 57,273,589 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	57,975,976 - 57,988,238 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	55,791,694 - 55,803,936 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	57,037,995 - 57,050,234 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	57,036,877 - 57,050,408 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	56,266,330 - 56,278,569 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	57,691,610 - 57,703,850 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	18	53,316,882 - 53,329,122 (-)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI

Grpel2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955853	1,442 - 9,278 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955853	1,443 - 9,278 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRPEL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	144,575,752 - 144,585,237 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	142,715,494 - 142,724,786 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	144,771,261 - 144,780,987 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	150,781,671 - 150,791,377 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	150,781,671 - 150,791,377 (+)	Ensembl	panpan1.1		panPan2

GRPEL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	59,603,384 - 59,614,491 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	59,590,167 - 59,614,584 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	59,368,354 - 59,379,461 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	60,085,904 - 60,097,014 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	60,072,413 - 60,097,107 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	59,872,515 - 59,883,621 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	59,986,909 - 59,997,951 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	60,517,526 - 60,528,629 (-)	NCBI		UU_Cfam_GSD_1.0

Grpel2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	143,937,230 - 143,948,617 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	5,511,186 - 5,522,614 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	5,511,203 - 5,522,553 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRPEL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	150,511,178 - 150,520,462 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	150,510,520 - 150,520,013 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	157,276,628 - 157,283,071 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRPEL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	51,963,532 - 51,970,251 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666034	25,773,516 - 25,782,645 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grpel2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	8,702,969 - 8,715,502 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624774	8,702,833 - 8,713,901 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GRPEL2
20 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3	copy number gain	See cases [RCV000051193]	Chr5:130860928..155321811 [GRCh38] Chr5:130196621..154701371 [GRCh37] Chr5:130224520..154681564 [NCBI36] Chr5:5q23.3-33.2	pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1	copy number loss	See cases [RCV000053524]	Chr5:106619588..156124387 [GRCh38] Chr5:105955289..155551397 [GRCh37] Chr5:105983188..155483975 [NCBI36] Chr5:5q21.3-33.2	pathogenic
NM_152407.3(GRPEL2):c.77+800T>C	single nucleotide variant	Lung cancer [RCV000095380]	Chr5:149346416 [GRCh38] Chr5:148725979 [GRCh37] Chr5:5q32	uncertain significance
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3	copy number gain	See cases [RCV000138808]	Chr5:129847794..153353546 [GRCh38] Chr5:129183487..152733106 [GRCh37] Chr5:129211386..152713299 [NCBI36] Chr5:5q23.3-33.2	pathogenic
GRCh38/hg38 5q31.3-32(chr5:141089988-149530678)x3	copy number gain	See cases [RCV000139504]	Chr5:141089988..149530678 [GRCh38] Chr5:140469572..148910241 [GRCh37] Chr5:140449756..148890434 [NCBI36] Chr5:5q31.3-32	pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3	copy number gain	not provided [RCV000487658]	Chr5:94844077..178830410 [GRCh37] Chr5:5q15-35.3	likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3	copy number gain	See cases [RCV000449349]	Chr5:130125085..157574910 [GRCh37] Chr5:5q23.3-33.3	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)	copy number gain	See cases [RCV000510723]	Chr5:113577..180719789 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3	copy number gain	See cases [RCV000448245]	Chr5:106716357..180687338 [GRCh37] Chr5:5q21.3-35.3	pathogenic
GRCh37/hg19 5q31.3-32(chr5:141113273-149154835)x1	copy number loss	See cases [RCV000510497]	Chr5:141113273..149154835 [GRCh37] Chr5:5q31.3-32	pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del	deletion	Familial adenomatous polyposis 1 [RCV004561496]\|Hereditary cancer-predisposing syndrome [RCV000554476]	Chr5:86400000..154000000 [GRCh37] Chr5:5q14.3-33.2	pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1	copy number loss	See cases [RCV000511978]	Chr5:17628741..176575720 [GRCh37] Chr5:5p15.1-q35.2	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3	copy number gain	See cases [RCV000512039]	Chr5:113577..180719789 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3	copy number gain	not provided [RCV000744317]	Chr5:13648..180905029 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3	copy number gain	not provided [RCV000744323]	Chr5:25328..180693344 [GRCh37] Chr5:5p15.33-q35.3	pathogenic
Single allele	deletion	Neurodevelopmental disorder [RCV000787436]	Chr5:14685137..149511942 [GRCh37] Chr5:5p15.2-q32	uncertain significance
GRCh37/hg19 5q31.3-32(chr5:140424333-148985999)x3	copy number gain	not provided [RCV000848228]	Chr5:140424333..148985999 [GRCh37] Chr5:5q31.3-32	uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)	copy number gain	not specified [RCV002053526]	Chr5:130125085..157574910 [GRCh37] Chr5:5q23.3-33.3	pathogenic
NC_000005.9:g.(?_147774340)_(149681936_?)del	deletion	not provided [RCV003116332]	Chr5:147774340..149681936 [GRCh37] Chr5:5q32	uncertain significance
GRCh37/hg19 5q32(chr5:147164969-149315489)x1	copy number loss	not provided [RCV002473891]	Chr5:147164969..149315489 [GRCh37] Chr5:5q32	pathogenic
NM_152407.4(GRPEL2):c.199G>A (p.Val67Ile)	single nucleotide variant	not specified [RCV004147356]	Chr5:149348393 [GRCh38] Chr5:148727956 [GRCh37] Chr5:5q32	likely benign
NM_152407.4(GRPEL2):c.181G>A (p.Ala61Thr)	single nucleotide variant	not specified [RCV004109477]	Chr5:149348375 [GRCh38] Chr5:148727938 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.163C>G (p.Pro55Ala)	single nucleotide variant	not specified [RCV004228221]	Chr5:149348357 [GRCh38] Chr5:148727920 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.272G>A (p.Arg91Lys)	single nucleotide variant	not specified [RCV004122870]	Chr5:149349694 [GRCh38] Chr5:148729257 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.67T>C (p.Trp23Arg)	single nucleotide variant	not specified [RCV004238948]	Chr5:149345606 [GRCh38] Chr5:148725169 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.23C>T (p.Ala8Val)	single nucleotide variant	not specified [RCV004088776]	Chr5:149345562 [GRCh38] Chr5:148725125 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.324T>G (p.Ser108Arg)	single nucleotide variant	not specified [RCV004318222]	Chr5:149350928 [GRCh38] Chr5:148730491 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.86C>T (p.Pro29Leu)	single nucleotide variant	not specified [RCV004260816]	Chr5:149348280 [GRCh38] Chr5:148727843 [GRCh37] Chr5:5q32	likely benign
NM_152407.4(GRPEL2):c.44G>A (p.Arg15His)	single nucleotide variant	not specified [RCV004258444]	Chr5:149345583 [GRCh38] Chr5:148725146 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.134G>A (p.Arg45His)	single nucleotide variant	not specified [RCV004396119]	Chr5:149348328 [GRCh38] Chr5:148727891 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.245G>A (p.Arg82Lys)	single nucleotide variant	not specified [RCV004396120]	Chr5:149349667 [GRCh38] Chr5:148729230 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.163C>T (p.Pro55Ser)	single nucleotide variant	not specified [RCV004928426]	Chr5:149348357 [GRCh38] Chr5:148727920 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.325T>C (p.Phe109Leu)	single nucleotide variant	not specified [RCV004924806]	Chr5:149350929 [GRCh38] Chr5:148730492 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.617A>G (p.His206Arg)	single nucleotide variant	not specified [RCV004924803]	Chr5:149351221 [GRCh38] Chr5:148730784 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.133C>T (p.Arg45Cys)	single nucleotide variant	not specified [RCV004924804]	Chr5:149348327 [GRCh38] Chr5:148727890 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.392C>T (p.Ser131Leu)	single nucleotide variant	not specified [RCV004924805]	Chr5:149350996 [GRCh38] Chr5:148730559 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.612A>C (p.Lys204Asn)	single nucleotide variant	not specified [RCV004924807]	Chr5:149351216 [GRCh38] Chr5:148730779 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.373G>C (p.Glu125Gln)	single nucleotide variant	not specified [RCV004928424]	Chr5:149350977 [GRCh38] Chr5:148730540 [GRCh37] Chr5:5q32	uncertain significance
NM_152407.4(GRPEL2):c.379A>C (p.Ile127Leu)	single nucleotide variant	not specified [RCV004928425]	Chr5:149350983 [GRCh38] Chr5:148730546 [GRCh37] Chr5:5q32	uncertain significance

miRNA Target Status (No longer updated)

Confirmed Target Of

miRNA Gene	Mature miRNA	Method Name	Result Type	Data Type	Support Type	PMID
MIR21	hsa-miR-21-5p	Tarbase	external_info	Sequencing	POSITIVE

Predicted Target Of

	Summary Value
Count of predictions:	1675
Count of miRNA genes:	914
Interacting mature miRNAs:	1099
Transcripts:	ENST00000329271, ENST00000416916, ENST00000507562, ENST00000513661
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357314	AASTH54_H	Allergic/atopic asthma related QTL 54 (human)	3.56	0.0003	Reversible airflow obstruction	total serum IgE	5	135892246	150155845	Human

Markers in Region

STS-W61302

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	148,733,873 - 148,734,100	UniSTS	GRCh37
Build 36	5	148,714,066 - 148,714,293	RGD	NCBI36
Celera	5	144,815,848 - 144,816,075	RGD
Cytogenetic Map	5	q32	UniSTS
HuRef	5	143,880,196 - 143,880,423	UniSTS
GeneMap99-GB4 RH Map	5	570.45	UniSTS
NCBI RH Map	5	891.6	UniSTS

RH35851

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	148,733,873 - 148,734,000	UniSTS	GRCh37
Build 36	5	148,714,066 - 148,714,193	RGD	NCBI36
Celera	5	144,815,848 - 144,815,975	RGD
Cytogenetic Map	5	q32	UniSTS
HuRef	5	143,880,196 - 143,880,323	UniSTS
GeneMap99-GB4 RH Map	5	571.56	UniSTS
NCBI RH Map	5	891.6	UniSTS

WI-20933

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	5	148,733,770 - 148,734,047	UniSTS	GRCh37
GRCh37	X	63,908,515 - 63,908,797	UniSTS	GRCh37
Build 36	X	63,825,240 - 63,825,522	RGD	NCBI36
Celera	X	64,255,325 - 64,255,607	RGD
Celera	5	144,815,745 - 144,816,022	UniSTS
Cytogenetic Map	5	q32	UniSTS
HuRef	X	57,732,121 - 57,732,403	UniSTS
HuRef	5	143,880,093 - 143,880,370	UniSTS
GeneMap99-GB4 RH Map	5	571.66	UniSTS
Whitehead-RH Map	5	484.5	UniSTS
NCBI RH Map	5	891.6	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2253	4974	1726	2351	6	624	1951	465	2270	7306	6472	53	3734	1	852	1744	1617	175	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_152407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC131025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK074293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK091237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK096445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK294005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL704536	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL832325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC036678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000329271 ⟹ ENSP00000329558

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	149,345,499 - 149,354,583 (+)	Ensembl

Ensembl Acc Id:

ENST00000416916 ⟹ ENSP00000397302

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	149,345,502 - 149,351,654 (+)	Ensembl

Ensembl Acc Id:

ENST00000507562

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	149,345,619 - 149,354,583 (+)	Ensembl

Ensembl Acc Id:

ENST00000513661 ⟹ ENSP00000426331

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	5	149,345,430 - 149,349,858 (+)	Ensembl

RefSeq Acc Id:

NM_152407 ⟹ NP_689620

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	5	149,345,499 - 149,354,583 (+)	NCBI
GRCh37	5	148,724,364 - 148,734,146 (+)	NCBI
Build 36	5	148,705,170 - 148,714,339 (+)	NCBI Archive
Celera	5	144,806,966 - 144,816,121 (+)	RGD
HuRef	5	143,871,317 - 143,880,469 (+)	ENTREZGENE
CHM1_1	5	148,157,397 - 148,166,568 (+)	NCBI
T2T-CHM13v2.0	5	149,880,331 - 149,889,398 (+)	NCBI

Sequence:

show sequence

AGCAAGTGCGCGTGCGCTGCCTCTCAGCCCAAATTGGAAACATGGCCGTACGGTCGCTGTGGGC
GGGCCGGCTGCGGGTGCAGCGCCTACTGGCCTGGAGTGCCGCGTGGGAGAGCAAGGGATGGCCG
CTTCCATTCAGCACTGCCACCCAGAGAACTGCTGGTGAGGACTGCCGTTCTGAGGACCCTCCTG
ATGAGCTTGGGCCCCCTCTTGCTGAACGAGCCTTAAGGGTAAAAGCTGTTAAACTGGAGAAAGA
AGTCCAAGATTTAACAGTGAGATACCAGAGAGCTATAGCTGATTGTGAAAACATAAGGAGGCGA
ACCCAGAGATGTGTGGAAGACGCCAAGATATTTGGAATCCAGAGTTTCTGTAAGGACTTGGTGG
AGGTGGCTGACATTTTGGAGAAGACTACAGAGTGCATTTCTGAAGAATCGGAGCCTGAGGACCA
AAAGCTCACTCTGGAGAAGGTCTTCCGAGGGTTGTTGCTTTTAGAAGCAAAGCTGAAAAGTGTG
TTTGCCAAGCATGGCCTGGAGAAACTGACACCCATTGGTGACAAATATGACCCCCATGAGCATG
AACTCATCTGTCATGTGCCAGCTGGTGTTGGGGTGCAGCCTGGCACCGTGGCATTAGTAAGACA
AGATGGCTACAAACTTCATGGCCGCACCATTAGGCTTGCCCGAGTGGAAGTGGCAGTGGAGTCT
CAGAGAAGACTGTGAAGAGGCCATCAGGAACTGGATGTTCTCCCAGAGCGCAGTCACCTATGTT
TCTTTTATTTATTAAACTAGGTTTGTATTGTACATGAGGTACTTCATGTGATATGTTTTGGATT
TAGTCATATTGGCTTTATTTCTAAGATATTCTATTGATTTAATGTGACCTGTTTGGTCTCATCA
GAAGTCTTACCATTGGGCATTTGAACAGTGTGACAGGTGTTCCAATGGCCTTTATCAAAACATG
TTTAGGAAAATTGGTACTGTGATAAATTTGAATCCAAAATCCTTTTAACTATGGGTTTTCAACT
ACATGTTTCTTCCTAGCGGTCTCTATAACAGGAATTGTGTAGTATCTTGTATTTTGTGGAAAAA
GGAGATGGTAGGGATTGGTTCAACATTTGGGTACTTAGAGGATAAAGCTTCGTGGTCGTATAAA
TTTAGATCATTTGGATTGATTTTTATACACATAGATTTTCAGGACTTTACCTTTTGTTTTGTTT
TTTTCCTTTTAGCCATCTTTTGTTCTTGTAATCCCAACTAGATAGGCTTTATGCTCACATCATT
GTCCCATACCCACCCCTTTCTCATCCCCATTTGCAGGGGCTAAAGGTCTAGATGAGACTTGGAA
GGCAAGGAGCATCGAAATTTGAGATACCCAGGACCCTTTCAAGCAAGAATGGCCAAAAAGCCTT
GTGCTGTCTTTGCTCTTCAAATTATTTTCAGCCTCCTTGTCATATAATCATTTCAGGCAAACTG
AGGCAACACTAACAGCTAATGACCCAGATGGCTCTATTTGGGTAATTTACCTACAACTTATTCC
ACCAGCCTTTACTCCTCTGCCCTTTTGTCAATTTTACCTTATAATCCTTTATTAAATGATGGGA
GGTGGTGATCAGGACAAAAGTGTTAGGTTCCCATGATTTCTCATTTCATTTATTAATAGTTAAT
GCTGAATTTTTTTTTAAGTTTCCTCTGGCTCTATTTATGTTACTTTTTGCGATAAGAACACTTA
ACATAAGTATTCTCTCCTCTTGGCAATTTTTTTTTTTTTTCCTGTGTTGCCCAGGCTGACCTCC
AACTCCTGGGCCCAAGCAATCCTGCCTCAGCCTGCCAAGTAGCTAGGACTACAGGCGTTCACCA
CTGCGCCCGCAAAGTTTTTTTGTTGTTTTTTTTTTTAAGTTGGTACTCACAAATCACTACCTCT
GTTATATTGACAAGCTCTATTTCCTATTCTTTGTATCTGTTAAGTCACATCTGTGTAAACATTG
AGCTCACCTTTTATATATTAACCTCTAGAATTAATGGGCCTATGTGGTTTTTTTTCAGTCTTAT
AGCTGGTGTTCTGTAAAAGATTTGTCCAATAAACGACTTAATGAATGATACATCAGTCAGATTT
TAGGAAGGCAGTCAATTATGGATATTTTAATGTTGGAAGAGGCCTTAATGATCAAATCTCACCC
TTTCTGCTTCTGAAGTATGAAAATCTAGTCTTTTTAGGACTGGACACAAGGAAAATAATCTCTA
AACTATTGACTAAATTCCAGTGAGAGTATGAATGAAGAACAACTAGATATTAATGTCAATCATT
TAAGATTAATGGGCATGCAATTAAGTCTCCATTTAAGATTAATGGGCATGCAATGAAGTCTCCA
GCAGACAATCAGATGTTGTTGGATGTCTAGATTATATAGGTTTAGGTTGAAGTTATAAAATAAA
ATAAAATTCATTTTCCACTGGAACTCTATGACATTCAGTGGAGTGGTGGAAAGTTAACCTCTTA
TACATTATAGATAATTCTAAGACAGCACACAAACTTATCAATAAAGCCATCTCCTTGTGGGCCT
TACCATCTTCATCAGATTTAGACCCTTAAAAAACAAGTAAATATGCACTTTTAAAATGCAATCA
AAAGACTGGTGGTTAAGCTTGTAAAACCAGAACATCTTTTGGCATTCCACTAAGTATATATTGT
AAATTTAATGAACAATCAAGGTTCACAATAGGAAGTTGTCTTTTTTTGCCTTCCATTCTGTGAG
ATTTGACAGATGGTGACAATAAGAAAATGAGCTGATTGTAATTACTCTCTGTGTGTTTTTTTAT
TGCTAGCTATCATTACCAGTTAGAATTAACATTAATTACAATTAACAATAATTTTAGGTATGGA
ATGTTATGATTACCTAAAGAGATGTCTCTACCTAATGAGCTCAAGTGATCCTCCCACCTCAGCC
TACCAAGTAGCCAGGACCACAGGCAAGTGCACCACCATGACTGGCTAGTTTTGTTTTTTGGTTT
TTGGTTTTTGGTTTTTGGTTTTTTTTTTTTGGTTGGTTGGTTGTTTTTTACAGGCGGGGTCTCA
CTATATTGTCCAGGCTAGAAGAATTTTCTAATGGTCTATTACACCTCCCGTTTTGGCAAGTAAA
TTCAGAATAATTTTAGGTTCTTTTGTTATTCAGTAGTTTTGCAGACTTAAAAGTGTAAATTTAG
AATTAGAAGATGAAGCTATAGTAGTAAGAATCTCAAGCTGAAGGGCTTTGGGGAGCCAAAGCAG
CATATTAGAGCATAGGCTTGAACTTAAATCTCAGCTCAGTCACCTGCAGGACTTTAGGCACCAG
TGATTTCACCCTTCTGAGCCTGTTTCTTTATTCGTAAAATGATTATAATAATTCTTTCACAGCG
TTGTGAGGATTAAGTGAAATGTGTTAAATGCCTACTACAGTAGGTGCTCAGATATTTATTTTTA
TTTTTTTATTATGCACATTGTTTTTCCTGCCTTTTTATGGCTGTCTAAAGTCTAGGGAAAAGGG
AAGACTGGTTAATGATGAGTAGAAAAAACTTGTAAGCTAATCATTCACTGACTTATTTTCCTTC
CATTTTCTGGTTTTTAAAATTAGCCACACCACAGGAAACCCACATTTTTAGATGGAAAGAGCAA
GAAAATTGTGTCAGTGCTCTTAGTTATTTTCATCTTAATGGTATAGTGAAAAGACATTGACTTG
AGATGATACTAAGGAAGCTTTGGCTCACTCTCACTTGAAGAGGGGATCTTGGTGTTGTAGTACT
TGGACTGTACAAATGTTTTACTGACTTTTCTTACTGCTGTAAAGGAATCAGGCAGTTGGGTATT
GATATGTTATTTGGTGCTCTCATTCATGGCAAAGGATTTGATAAATAAAAGTTCTTTAAACACT
AAAGCAAAATCAAATGAGCAAAACTAAGGATGAAATGTAATATTCATCAGAACAAGGATCACTG
AGAAAAAATATTCAGAAACAACTTTAATAAAACCTGAATTGAAATAACTGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_689620	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH36678	(Get FASTA)	NCBI Sequence Viewer
	AAH70090	(Get FASTA)	NCBI Sequence Viewer
	BAB85040	(Get FASTA)	NCBI Sequence Viewer
	BAG57367	(Get FASTA)	NCBI Sequence Viewer
	CAD38619	(Get FASTA)	NCBI Sequence Viewer
	EAW61786	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000329558
	ENSP00000329558.3
	ENSP00000397302.2
GenBank Protein	Q8TAA5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_689620 ⟸ NM_152407
- Peptide Label:	precursor
- UniProtKB:	B4DFA6 (UniProtKB/Swiss-Prot), Q49AJ6 (UniProtKB/Swiss-Prot), Q8TAA5 (UniProtKB/Swiss-Prot), Q8N3S0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVRSLWAGRLRVQRLLAWSAAWESKGWPLPFSTATQRTAGEDCRSEDPPDELGPPLAERALRV KAVKLEKEVQDLTVRYQRAIADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTTECIS EESEPEDQKLTLEKVFRGLLLLEAKLKSVFAKHGLEKLTPIGDKYDPHEHELICHVPAGVGVQP GTVALVRQDGYKLHGRTIRLARVEVAVESQRRL hide sequence

Ensembl Acc Id:

ENSP00000397302 ⟸ ENST00000416916

Ensembl Acc Id:

ENSP00000329558 ⟸ ENST00000329271

Ensembl Acc Id:

ENSP00000426331 ⟸ ENST00000513661

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8TAA5-F1-model_v2	AlphaFold	Q8TAA5	1-225	view protein structure

Promoters

RGD ID:

6803235

Promoter ID:

HG_KWN:51483

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

NM_152407

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	5	148,704,596 - 148,705,257 (+)	MPROMDB

RGD ID:

6871304

Promoter ID:

EPDNEW_H8769

Type:

initiation region

Name:

GRPEL2_1

Description:

GrpE like 2, mitochondrial

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	5	149,345,519 - 149,345,579	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:21060	AgrOrtholog
COSMIC	GRPEL2	COSMIC
Ensembl Genes	ENSG00000164284	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000329271	ENTREZGENE
	ENST00000329271.8	UniProtKB/Swiss-Prot
	ENST00000416916.2	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.22.10	UniProtKB/Swiss-Prot
	3.90.20.20	UniProtKB/Swiss-Prot
GTEx	ENSG00000164284	GTEx
HGNC ID	HGNC:21060	ENTREZGENE
Human Proteome Map	GRPEL2	Human Proteome Map
InterPro	GrpE	UniProtKB/Swiss-Prot
	GrpE_coiled_coil	UniProtKB/Swiss-Prot
	GrpE_head	UniProtKB/Swiss-Prot
KEGG Report	hsa:134266	UniProtKB/Swiss-Prot
NCBI Gene	134266	ENTREZGENE
OMIM	618545	OMIM
PANTHER	GRPE PROTEIN HOMOLOG 2, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	PTHR21237	UniProtKB/Swiss-Prot
Pfam	GrpE	UniProtKB/Swiss-Prot
PharmGKB	PA134885090	PharmGKB
PRINTS	GRPEPROTEIN	UniProtKB/Swiss-Prot
PROSITE	GRPE	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51064	UniProtKB/Swiss-Prot
	SSF58014	UniProtKB/Swiss-Prot
UniProt	B4DFA6	ENTREZGENE
	D6RGI6_HUMAN	UniProtKB/TrEMBL
	GRPE2_HUMAN	UniProtKB/Swiss-Prot
	Q49AJ6	ENTREZGENE
	Q8N3S0	ENTREZGENE, UniProtKB/TrEMBL
	Q8TAA5	ENTREZGENE
UniProt Secondary	B4DFA6	UniProtKB/Swiss-Prot
	Q49AJ6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-26	GRPEL2	GrpE like 2, mitochondrial		GrpE-like 2, mitochondrial (E. coli)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations