Or1l8 (olfactory receptor family 1 subfamily L member 8) - Rat Genome Database

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Gene: Or1l8 (olfactory receptor family 1 subfamily L member 8) Rattus norvegicus
Analyze
Symbol: Or1l8
Name: olfactory receptor family 1 subfamily L member 8
RGD ID: 1333496
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in signal transduction. Predicted to be active in plasma membrane. Orthologous to human OR1L8 (olfactory receptor family 1 subfamily L member 8); INTERACTS WITH bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 1,2-dichloroethane (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 418; olfactory receptor gene Olr418; olfactory receptor Olr418; Olr418
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8340,863,247 - 40,864,179 (-)NCBIGRCr8
mRatBN7.2320,472,362 - 20,473,294 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl320,472,362 - 20,473,294 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx323,540,230 - 23,541,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0332,125,135 - 32,126,067 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0330,349,980 - 30,350,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0320,981,646 - 20,982,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl320,981,646 - 20,982,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0326,227,291 - 26,228,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4316,437,880 - 16,438,812 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1316,334,251 - 16,335,184 (-)NCBI
Celera315,143,355 - 15,144,287 (-)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or1l8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8340,863,247 - 40,864,179 (-)NCBIGRCr8
mRatBN7.2320,472,362 - 20,473,294 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl320,472,362 - 20,473,294 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx323,540,230 - 23,541,162 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0332,125,135 - 32,126,067 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0330,349,980 - 30,350,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0320,981,646 - 20,982,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl320,981,646 - 20,982,578 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0326,227,291 - 26,228,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4316,437,880 - 16,438,812 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1316,334,251 - 16,335,184 (-)NCBI
Celera315,143,355 - 15,144,287 (-)NCBICelera
Cytogenetic Map3p11NCBI
OR1L8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389122,546,271 - 122,583,384 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9122,567,117 - 122,583,384 (-)EnsemblGRCh38hg38GRCh38
GRCh379125,329,396 - 125,345,663 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369124,369,648 - 124,370,577 (-)NCBINCBI36Build 36hg18NCBI36
Build 349122,409,380 - 122,410,310NCBI
Celera995,978,150 - 95,979,079 (-)NCBICelera
Cytogenetic Map9q33.2NCBI
HuRef994,944,453 - 94,945,382 (-)NCBIHuRef
CHM1_19125,477,841 - 125,478,770 (-)NCBICHM1_1
T2T-CHM13v2.09134,764,443 - 134,780,693 (-)NCBIT2T-CHM13v2.0
Or1l8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39236,817,192 - 36,818,124 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl236,815,202 - 36,818,909 (-)EnsemblGRCm39 Ensembl
GRCm38236,927,180 - 36,928,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl236,925,190 - 36,928,897 (-)EnsemblGRCm38mm10GRCm38
MGSCv37236,782,700 - 36,783,632 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36236,749,189 - 36,750,121 (-)NCBIMGSCv36mm8
Celera236,621,710 - 36,622,642 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.19NCBI
LOC100995751
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,765,148 - 16,785,996 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1916,762,246 - 16,783,628 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0993,693,960 - 93,695,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19122,035,324 - 122,036,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9122,035,366 - 122,036,295 (-)Ensemblpanpan1.1panPan2
OR1L8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1960,118,039 - 60,118,983 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl960,118,039 - 60,118,968 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha959,313,429 - 59,314,373 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0961,034,732 - 61,035,676 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl961,034,732 - 61,035,661 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1959,793,641 - 59,794,583 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0960,109,218 - 60,110,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0960,198,891 - 60,199,835 (+)NCBIUU_Cfam_GSD_1.0
LOC100152475
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11262,510,617 - 262,511,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21294,808,827 - 294,809,792 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Or1l8
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:20
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000043676
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
634306Bp140Blood pressure QTL 1403.30.0013arterial blood pressure trait (VT:2000000)body weight (CMO:0000012)31737470335528639Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145428441896Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat


Expression

RNA-SEQ Expression

circulatory system
mesenchyme
mesoderm
3 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000043676   ⟹   ENSRNOP00000041074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl320,472,362 - 20,473,294 (-)Ensembl
Rnor_6.0 Ensembl320,981,646 - 20,982,578 (-)Ensembl
RefSeq Acc Id: NM_001000825   ⟹   NP_001000825
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8340,863,247 - 40,864,179 (-)NCBI
mRatBN7.2320,472,362 - 20,473,294 (-)NCBI
Rnor_6.0320,981,646 - 20,982,578 (-)NCBI
Rnor_5.0326,227,291 - 26,228,223 (-)NCBI
RGSC_v3.4316,437,880 - 16,438,812 (-)RGD
Celera315,143,355 - 15,144,287 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93112 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041074
  ENSRNOP00000041074.3
RefSeq Acc Id: NP_001000825   ⟸   NM_001000825
- UniProtKB: D3ZHU0 (UniProtKB/TrEMBL),   A6JUI5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041074   ⟸   ENSRNOT00000043676
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHU0-F1-model_v2 AlphaFold D3ZHU0 1-310 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333496 AgrOrtholog
BioCyc Gene G2FUF-49982 BioCyc
Ensembl Genes ENSRNOG00000029787 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043676 ENTREZGENE
  ENSRNOT00000043676.4 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:405114 UniProtKB/TrEMBL
NCBI Gene 405114 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or1l8 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029787 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A6JUI5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHU0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or1l8  olfactory receptor family 1 subfamily L member 8  Olr418  olfactory receptor 418  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr418  olfactory receptor 418   Olr418_predicted  olfactory receptor 418 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr418_predicted  olfactory receptor 418 (predicted)      Symbol and Name status set to approved 70820 APPROVED