Or4f7c (olfactory receptor family 4 subfamily F member 7C) - Rat Genome Database

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Gene: Or4f7c (olfactory receptor family 4 subfamily F member 7C) Rattus norvegicus
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Symbol: Or4f7c
Name: olfactory receptor family 4 subfamily F member 7C
RGD ID: 1333335
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to several human genes including OR4F21 (olfactory receptor family 4 subfamily F member 21); INTERACTS WITH bisphenol A; N-nitrosodiethylamine; thioacetamide.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 776; olfactory receptor gene Olr776; olfactory receptor Olr776; Olr776
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83118,913,402 - 118,914,340 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3118,913,402 - 118,914,340 (-)EnsemblGRCr8
mRatBN7.2398,458,889 - 98,459,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl398,457,871 - 98,464,794 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3102,034,716 - 102,035,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03110,633,720 - 110,634,658 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03108,381,463 - 108,382,401 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,065,454 - 103,066,392 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,065,454 - 103,066,392 (-)Ensemblrn6Rnor6.0
Rnor_5.03109,657,494 - 109,658,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4397,447,580 - 97,448,518 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera397,461,224 - 97,461,805 (-)NCBICelera
RGSC_v3.1397,344,007 - 97,344,946 (-)NCBI
Cytogenetic Map3q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or4f7c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83118,913,402 - 118,914,340 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3118,913,402 - 118,914,340 (-)EnsemblGRCr8
mRatBN7.2398,458,889 - 98,459,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl398,457,871 - 98,464,794 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3102,034,716 - 102,035,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03110,633,720 - 110,634,658 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03108,381,463 - 108,382,401 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03103,065,454 - 103,066,392 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,065,454 - 103,066,392 (-)Ensemblrn6Rnor6.0
Rnor_5.03109,657,494 - 109,658,432 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4397,447,580 - 97,448,518 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera397,461,224 - 97,461,805 (-)NCBICelera
RGSC_v3.1397,344,007 - 97,344,946 (-)NCBI
Cytogenetic Map3q34NCBI
OR4F21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388166,086 - 167,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8166,086 - 167,024 (-)Ensemblhg38GRCh38
GRCh378116,086 - 117,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368106,086 - 107,024 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348106,085 - 107,024NCBI
Cytogenetic Map8p23.3NCBI
CHM1_18115,901 - 116,839 (-)NCBICHM1_1
T2T-CHM13v2.011113,128 - 114,065 (-)NCBIT2T-CHM13v2.0
Or4f7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392111,644,131 - 111,645,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2111,642,592 - 111,650,685 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382111,813,786 - 111,814,724 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2111,812,247 - 111,820,340 (-)Ensemblmm10GRCm38
MGSCv372111,653,943 - 111,654,881 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362111,614,625 - 111,615,563 (-)NCBIMGSCv36mm8
Celera2112,985,955 - 112,986,893 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.75NCBI
LOC100156766
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1779,568,026 - 79,569,101 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2784,692,359 - 84,693,309 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Or4f7c
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:147
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000044181
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)3116582412122654872Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
1 1

Sequence


Ensembl Acc Id: ENSRNOT00000044181   ⟹   ENSRNOP00000047069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3103,065,454 - 103,066,392 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095304   ⟹   ENSRNOP00000089706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl398,457,871 - 98,464,794 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163238   ⟹   ENSRNOP00000101377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3118,913,402 - 118,914,340 (-)Ensembl
RefSeq Acc Id: NM_001000608   ⟹   NP_001000608
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83118,913,402 - 118,914,340 (-)NCBI
mRatBN7.2398,458,889 - 98,459,827 (-)NCBI
Rnor_6.03103,065,454 - 103,066,392 (-)NCBI
Rnor_5.03109,657,494 - 109,658,432 (-)NCBI
RGSC_v3.4397,447,580 - 97,448,518 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000608 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000089706.1
  ENSRNOP00000101377
RefSeq Acc Id: NP_001000608   ⟸   NM_001000608
- UniProtKB: A0A8I6ACG7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047069   ⟸   ENSRNOT00000044181
Ensembl Acc Id: ENSRNOP00000089706   ⟸   ENSRNOT00000095304
Ensembl Acc Id: ENSRNOP00000101377   ⟸   ENSRNOT00000163238
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0N4-F1-model_v2 AlphaFold D4A0N4 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333335 AgrOrtholog
BioCyc Gene G2FUF-48425 BioCyc
Ensembl Genes ENSRNOG00000047253 Ensembl
  ENSRNOG00000065372 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000076105 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000095304.1 UniProtKB/TrEMBL
  ENSRNOT00000163238 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
KEGG Report rno:404797 UniProtKB/TrEMBL
NCBI Gene 404797 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4f7c PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047253 RatGTEx
  ENSRNOG00000065372 RatGTEx
  ENSRNOG00000076105 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6ACG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4f7c  olfactory receptor family 4 subfamily F member 7C  Olr776  olfactory receptor 776  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr776  olfactory receptor 776   Olr776_predicted  olfactory receptor 776 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr776_predicted  olfactory receptor 776 (predicted)      Symbol and Name status set to approved 70820 APPROVED