Or4p22e (olfactory receptor family 4 subfamily P member 22E) - Rat Genome Database

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Gene: Or4p22e (olfactory receptor family 4 subfamily P member 22E) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Or4p22e
Name: olfactory receptor family 4 subfamily P member 22E
RGD ID: 1333305
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: LOC100910556; olfactory receptor 4P4-like; olfactory receptor 636; olfactory receptor gene Olr636; olfactory receptor Olr636; Olr636
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8394,603,450 - 94,604,391 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl394,603,450 - 94,604,391 (+)EnsemblGRCr8
mRatBN7.2374,147,245 - 74,148,186 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl374,147,245 - 74,148,186 (+)EnsemblmRatBN7.2
Rnor_6.0376,842,898 - 76,843,839 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl376,842,898 - 76,843,839 (+)Ensemblrn6Rnor6.0
Rnor_5.0383,999,376 - 84,000,317 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4372,454,365 - 72,455,306 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
RGSC_v3.1372,350,736 - 72,351,678 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Or4p22e
7 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)373376539118376539Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat


Expression

RNA-SEQ Expression

mesenchyme
renal system
2 2

Sequence


Ensembl Acc Id: ENSRNOT00000085537   ⟹   ENSRNOP00000072972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl394,603,450 - 94,604,391 (+)Ensembl
mRatBN7.2 Ensembl374,147,245 - 74,148,186 (+)Ensembl
Rnor_6.0 Ensembl376,842,898 - 76,843,839 (+)Ensembl
RefSeq Acc Id: NM_001000645   ⟹   NP_001000645
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8394,603,450 - 94,604,391 (+)NCBI
mRatBN7.2374,147,245 - 74,148,186 (+)NCBI
Rnor_6.0376,842,898 - 76,843,839 (+)NCBI
Rnor_5.0383,999,376 - 84,000,317 (+)NCBI
RGSC_v3.4372,454,365 - 72,455,306 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000645 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072972
  ENSRNOP00000072972.1
RefSeq Acc Id: NP_001000645   ⟸   NM_001000645
- UniProtKB: A0A0G2K4B1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072972   ⟸   ENSRNOT00000085537
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K4B1-F1-model_v2 AlphaFold A0A0G2K4B1 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333305 AgrOrtholog
BioCyc Gene G2FUF-48896 BioCyc
Ensembl Genes ENSRNOG00000051516 Ensembl
  ENSRNOG00000066089 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000074849 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000085537 ENTREZGENE
  ENSRNOT00000085537.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
KEGG Report rno:404841 UniProtKB/TrEMBL
NCBI Gene 404841 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4p22e PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051516 RatGTEx
  ENSRNOG00000066089 RatGTEx
  ENSRNOG00000074849 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A0G2K4B1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4p22e  olfactory receptor family 4 subfamily P member 22E  Olr636  olfactory receptor 636  Symbol and Name Changed 1299863 APPROVED
2022-06-02 Olr636  olfactory receptor 636  Olr636  olfactory receptor 636  Data merged from RGD:149736351 737654 PROVISIONAL
2021-08-09 Olr636  olfactory receptor 636      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-07-29 Olr636  olfactory receptor 636  LOC100910556  olfactory receptor 4P4-like  Data merged from RGD:6497992 737654 PROVISIONAL
2012-07-05 LOC100910556  olfactory receptor 4P4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Olr636  olfactory receptor 636   Olr636_predicted  olfactory receptor 636 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr636_predicted  olfactory receptor 636 (predicted)      Symbol and Name status set to approved 70820 APPROVED