Gja10 (gap junction protein, alpha 10) - Rat Genome Database

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Gene: Gja10 (gap junction protein, alpha 10) Mus musculus
Analyze
Symbol: Gja10
Name: gap junction protein, alpha 10
RGD ID: 1332573
MGI Page MGI
Description: Enables gap junction channel activity. Acts upstream of or within detection of light stimulus involved in visual perception; gamete generation; and synapse assembly. Located in gap junction. Is expressed in several structures, including eye; gonad; intestine; liver; and sciatic nerve. Orthologous to human GJA10 (gap junction protein alpha 10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: connex; connexin n; connexin-57; Cx-57; cx57; Cx59; Cxnn; gap junction alpha-10 protein; gap junction membrane channel protein alpha 10
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39432,594,595 - 32,607,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl432,596,960 - 32,602,760 (-)EnsemblGRCm39 Ensembl
GRCm38432,600,865 - 32,602,382 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl432,596,960 - 32,602,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv37432,687,840 - 32,689,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36432,929,478 - 32,930,995 (-)NCBIMGSCv36mm8
Celera432,348,089 - 32,349,606 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
connexin complex  (IBA,IEA)
gap junction  (IDA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10329667   PMID:11967204   PMID:12477932   PMID:14681012   PMID:15081111   PMID:15147297   PMID:15466892   PMID:16820008   PMID:17681699   PMID:18320035   PMID:18829945   PMID:19177557  
PMID:19433576   PMID:20849935   PMID:20966351   PMID:20979653   PMID:21267068   PMID:21840349   PMID:21873635   PMID:22855819   PMID:24349437   PMID:25823610   PMID:26420868   PMID:27022629  
PMID:29174891   PMID:29217689   PMID:29352045   PMID:30093671   PMID:30933967   PMID:31122676   PMID:31619966   PMID:32290105   PMID:32795398   PMID:32822477   PMID:33535040   PMID:34061953  
PMID:34122012   PMID:35169021   PMID:38355793   PMID:39307290  


Genomics

Comparative Map Data
Gja10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39432,594,595 - 32,607,382 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl432,596,960 - 32,602,760 (-)EnsemblGRCm39 Ensembl
GRCm38432,600,865 - 32,602,382 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl432,596,960 - 32,602,760 (-)EnsemblGRCm38mm10GRCm38
MGSCv37432,687,840 - 32,689,357 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36432,929,478 - 32,930,995 (-)NCBIMGSCv36mm8
Celera432,348,089 - 32,349,606 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map414.25NCBI
GJA10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38689,894,469 - 89,896,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl689,894,469 - 89,921,760 (+)EnsemblGRCh38hg38GRCh38
GRCh37690,604,188 - 90,605,839 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36690,660,909 - 90,662,540 (+)NCBINCBI36Build 36hg18NCBI36
Celera691,024,729 - 91,026,360 (+)NCBICelera
Cytogenetic Map6q15NCBI
HuRef687,823,568 - 87,825,199 (+)NCBIHuRef
CHM1_1690,701,849 - 90,703,480 (+)NCBICHM1_1
T2T-CHM13v2.0691,106,163 - 91,107,814 (+)NCBIT2T-CHM13v2.0
Gja10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8551,787,407 - 51,799,827 (-)NCBIGRCr8
mRatBN7.2546,991,051 - 47,002,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl546,992,946 - 46,996,570 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx549,137,140 - 49,138,660 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0550,736,302 - 50,737,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0550,681,456 - 50,682,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0547,819,484 - 47,841,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,835,066 - 47,836,586 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0552,423,308 - 52,434,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,900,601 - 48,902,121 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1548,900,779 - 48,920,511 (-)NCBI
Celera545,756,256 - 45,757,776 (-)NCBICelera
Cytogenetic Map5q21NCBI
Gja10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541116,593,576 - 16,595,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541116,586,673 - 16,601,999 (+)NCBIChiLan1.0ChiLan1.0
GJA10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25109,979,746 - 109,981,397 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16107,880,882 - 107,882,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0687,774,889 - 87,776,520 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1691,046,601 - 91,048,232 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl691,046,601 - 91,072,335 (+)Ensemblpanpan1.1panPan2
GJA10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11249,075,169 - 49,099,146 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1249,092,747 - 49,097,743 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1248,881,931 - 48,905,866 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01249,884,482 - 49,908,390 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1249,902,078 - 49,907,050 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11249,199,389 - 49,223,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01249,100,131 - 49,124,052 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01249,292,484 - 49,316,411 (+)NCBIUU_Cfam_GSD_1.0
Gja10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494684,077,686 - 84,079,313 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365102,379,892 - 2,395,851 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365102,380,114 - 2,395,781 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl157,868,387 - 57,893,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1157,879,740 - 57,881,395 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2164,826,657 - 64,828,312 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11314,646,091 - 14,716,787 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1314,651,295 - 14,652,926 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040191,033,170 - 191,041,842 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247994,278,097 - 4,279,588 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gja10
391 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSMUST00000056517
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301203Alcp8_malcohol preference locus 8 (mouse)Not determined41739516051395290Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
10401115Pgia35_mproteoglycan induced arthritis 35 (mouse)Not determined41256237746562509Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1558992Ses8_msalmonella enteritidis susceptibility 8 (mouse)Not determined4868324042683429Mouse
4141302Ssrq5_mstress response QTL 5 (mouse)Not determined868324042683430Mouse
4141555Nbwa2_mNZB and NZW autoimmunity 2 (mouse)Not determined41789251551892635Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
12880405Jcdq1_mjoint cartilage degeneration QTL 1 (mouse)41256237746562509Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
1301697Sluc18_msusceptibility to lung cancer 18 (mouse)Not determined42237344856373612Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
25440481Moaq1_mmodifier of alien QTL 1 (mouse)41950000046000000Mouse
1301237Alcp7_malcohol preference locus 7 (mouse)Not determined41739516051395290Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
1302075Bdln6_mbody length 6 (mouse)Not determined42237344856373612Mouse
1302010Wta1_mweight adult 1 (mouse)Not determined4868324042683429Mouse
1301437Scon1_msucrose consumption 1 (mouse)Not determined42237344856373612Mouse
10401905Sicd3_mseizure-induced cell death 3 (mouse)Not determined4939552543760862Mouse
1301473Triglq1_mtriglyceride QTL 1 (mouse)Not determined4868324042683429Mouse
1300769Pcyts2_mplasmacytoma susceptibility 2 (mouse)Not determined42211194456112145Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1302058Hrtfm3_mheart failure modifier 3 (mouse)Not determined42211194456112145Mouse
1302184Aaom1_mautoimmune aoritis in MRL mice 1 (mouse)Not determined42432229946332776Mouse
1302125Lxw1_mlupus BXSB x NZW 1 (mouse)Not determined4868324042683429Mouse
12903995Opfaq2_mopen field activity QTL 2 (mouse)43034341933824057Mouse

Markers in Region
Gja10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,600,931 - 32,601,308UniSTSGRCm38
MGSCv37432,687,906 - 32,688,283UniSTSGRCm37
Celera432,348,155 - 32,348,532UniSTS
Cytogenetic Map4A5UniSTS
cM Map416.1UniSTS
UniSTS:484878  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38432,600,865 - 32,602,382UniSTSGRCm38
MGSCv37432,687,840 - 32,689,357UniSTSGRCm37
Celera432,348,089 - 32,349,606UniSTS
Cytogenetic Map4A5UniSTS
cM Map416.1UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000056517   ⟹   ENSMUSP00000061742
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl432,600,644 - 32,602,760 (-)Ensembl
GRCm38.p6 Ensembl432,600,644 - 32,602,760 (-)Ensembl
Ensembl Acc Id: ENSMUST00000219644   ⟹   ENSMUSP00000151323
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl432,596,960 - 32,602,760 (-)Ensembl
GRCm38.p6 Ensembl432,596,960 - 32,602,760 (-)Ensembl
RefSeq Acc Id: NM_001411853   ⟹   NP_001398782
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39432,594,595 - 32,607,382 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001398782 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAB40358 (Get FASTA)   NCBI Sequence Viewer  
  EDL05506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061742.3
  ENSMUSP00000151323
  ENSMUSP00000151323.2
GenBank Protein Q9WUS4 (Get FASTA)   NCBI Sequence Viewer  
  VZP20186 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSMUSP00000151323   ⟸   ENSMUST00000219644
Ensembl Acc Id: ENSMUSP00000061742   ⟸   ENSMUST00000056517
RefSeq Acc Id: NP_001398782   ⟸   NM_001411853
- Peptide Label: precursor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUS4-F1-model_v2 AlphaFold Q9WUS4 1-505 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339969 AgrOrtholog
Ensembl Genes ENSMUSG00000051056 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056517.3 UniProtKB/Swiss-Prot
  ENSMUST00000219644 ENTREZGENE
  ENSMUST00000219644.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot
InterPro Connexin UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
  Connexin_CS UniProtKB/Swiss-Prot
  Connexin_N UniProtKB/Swiss-Prot
  Connexin_N_sf UniProtKB/Swiss-Prot
MGD MGI:1339969 ENTREZGENE
NCBI Gene 14610 ENTREZGENE
PANTHER GAP JUNCTION ALPHA-10 PROTEIN UniProtKB/Swiss-Prot
  PTHR11984 UniProtKB/Swiss-Prot
Pfam Connexin UniProtKB/Swiss-Prot
PhenoGen Gja10 PhenoGen
PRINTS CONNEXIN UniProtKB/Swiss-Prot
PROSITE CONNEXINS_1 UniProtKB/Swiss-Prot
  CONNEXINS_2 UniProtKB/Swiss-Prot
SMART CNX UniProtKB/Swiss-Prot
  Connexin_CCC UniProtKB/Swiss-Prot
UniProt CXA10_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2ANV0 UniProtKB/Swiss-Prot