Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) - Rat Genome Database

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Gene: Ppargc1a (peroxisome proliferative activated receptor, gamma, coactivator 1 alpha) Mus musculus
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Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
RGD ID: 1332548
MGI Page MGI
Description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; nucleic acid binding activity; and transcription coactivator activity. Involved in several processes, including gluconeogenesis; positive regulation of cold-induced thermogenesis; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; response to dietary excess; and response to muscle activity. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; hindlimb digit mesenchyme; and sensory organ. Used to study Parkinson's disease; age related macular degeneration; cardiomyopathy; and congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A830037N07Rik; ENSMUSG00000079510; Gm11133; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma coactivator-1 alpha; Pgc; PGC-1; PGC-1-alpha; Pgc-1alpha; Pgc-1alphaa; PGC-1v; Pgc1; Pgco1; PPAR gamma coactivator variant form; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ppargc1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39551,611,591 - 52,273,316 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl551,611,592 - 51,725,068 (-)EnsemblGRCm39 Ensembl
GRCm38551,454,249 - 52,115,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl551,454,250 - 51,567,726 (-)EnsemblGRCm38mm10GRCm38
MGSCv37551,845,488 - 51,945,160 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36551,745,901 - 51,842,109 (-)NCBIMGSCv36mm8
Celera548,830,811 - 48,929,055 (-)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome  (ISO)
acute kidney failure  (IEP,IMP)
age related macular degeneration  (IAGP)
Albuminuria  (ISO)
Alzheimer's disease  (IDA,ISO)
amblyopia  (ISO)
amyotrophic lateral sclerosis  (IEP,ISO)
Bowen's Disease  (ISO)
Brain Injuries  (IEP,ISO)
Cardiomegaly  (IMP,ISO)
cardiomyopathy  (IAGP)
cardiovascular system disease  (ISO)
Carotid Artery Injuries  (IMP,ISO)
chronic kidney disease  (IDA)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
congenital hypothyroidism  (ISO)
congestive heart failure  (IAGP,IDA,IEP,ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Diseases of the Aged  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Fetal Growth Retardation  (ISO)
glucose intolerance  (IEP)
heart disease  (ISO)
Huntington's disease  (IDA,IEP,IMP,ISO)
hyperglycemia  (IDA,ISO)
hyperthyroidism  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Insulin Resistance  (ISO)
Kearns-Sayre syndrome  (IMP)
kidney cancer  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (IEP)
Lewy body dementia  (ISO)
macular degeneration  (ISO)
malignant fibrous histiocytoma  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA)
nephrotic syndrome  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (IDA,ISO)
Parkinson's disease  (IAGP,ISO)
Parkinsonism  (IDA,IEP,IMP)
placental insufficiency  (ISO)
Plaque, Atherosclerotic  (IEP)
prediabetes syndrome