Ciao2b (cytosolic iron-sulfur assembly component 2B) - Rat Genome Database

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Gene: Ciao2b (cytosolic iron-sulfur assembly component 2B) Mus musculus
Analyze
Symbol: Ciao2b
Name: cytosolic iron-sulfur assembly component 2B
RGD ID: 1332407
MGI Page MGI
Description: Predicted to be involved in chromosome segregation; iron-sulfur cluster assembly; and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO2B (cytosolic iron-sulfur assembly component 2B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110019N10Rik; Fam96; Fam96b; family with sequence similarity 96, member B; mitotic spindle-associated MMXD complex subunit MIP18
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,366,471 - 105,368,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,366,470 - 105,368,597 (-)EnsemblGRCm39 Ensembl
GRCm388104,639,839 - 104,641,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,639,838 - 104,641,965 (-)EnsemblGRCm38mm10GRCm38
MGSCv378107,163,739 - 107,165,628 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,528,968 - 107,530,857 (-)NCBIMGSCv36mm8
Celera8108,872,435 - 108,874,324 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD and Lill R, Biochim Biophys Acta. 2015 Jun;1853(6):1528-39. doi: 10.1016/j.bbamcr.2014.12.018. Epub 2015 Jan 10.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15489334  
PMID:16141072   PMID:16141073   PMID:21873635   PMID:23150669   PMID:32325033   PMID:38355793  


Genomics

Comparative Map Data
Ciao2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,366,471 - 105,368,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8105,366,470 - 105,368,597 (-)EnsemblGRCm39 Ensembl
GRCm388104,639,839 - 104,641,728 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8104,639,838 - 104,641,965 (-)EnsemblGRCm38mm10GRCm38
MGSCv378107,163,739 - 107,165,628 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368107,528,968 - 107,530,857 (-)NCBIMGSCv36mm8
Celera8108,872,435 - 108,874,324 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
CIAO2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381666,932,065 - 66,934,402 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1666,932,065 - 66,934,423 (-)EnsemblGRCh38hg38GRCh38
GRCh371666,965,968 - 66,968,305 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,523,467 - 65,525,804 (-)NCBINCBI36Build 36hg18NCBI36
Celera1651,474,217 - 51,476,579 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1652,840,068 - 52,842,436 (-)NCBIHuRef
CHM1_11668,372,966 - 68,375,334 (-)NCBICHM1_1
T2T-CHM13v2.01672,726,365 - 72,728,702 (-)NCBIT2T-CHM13v2.0
Ciao2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr819350,644 - 352,518 (+)NCBIGRCr8
mRatBN7.219344,194 - 346,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl19344,203 - 346,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx19332,274 - 334,136 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0191,099,082 - 1,100,944 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.019374,277 - 376,139 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.019551,708 - 553,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19551,708 - 553,573 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.019545,968 - 547,833 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419262,410 - 264,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera19340,409 - 342,274 (+)NCBICelera
Cytogenetic Map19p14NCBI
Ciao2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543323,435,373 - 23,437,383 (-)NCBIChiLan1.0ChiLan1.0
CIAO2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21876,431,846 - 76,434,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,344,374 - 82,346,676 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,247,278 - 47,249,617 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11666,349,377 - 66,351,744 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,349,377 - 66,351,733 (-)Ensemblpanpan1.1panPan2
CIAO2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1582,384,719 - 82,386,655 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl582,384,756 - 82,386,540 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha582,373,423 - 82,375,356 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0582,821,338 - 82,823,270 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,821,370 - 82,823,154 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,644,528 - 82,646,461 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0582,331,365 - 82,333,201 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,970,292 - 82,972,228 (+)NCBIUU_Cfam_GSD_1.0
Ciao2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934942,404,843 - 42,407,348 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,181,536 - 17,184,271 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,181,766 - 17,184,266 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIAO2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,610,470 - 27,612,592 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,610,469 - 27,612,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CIAO2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1552,631,539 - 52,633,949 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl552,631,354 - 52,633,856 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604723,279,758 - 23,282,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ciao2b
37 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:484
Count of miRNA genes:310
Interacting mature miRNAs:340
Transcripts:ENSMUST00000093234, ENSMUST00000163140, ENSMUST00000164884
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8102486208111650036Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined876411976110412125Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined876411976110412125Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined876411976110412125Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined872122809106123021Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871829531105829637Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873929123107929226Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined876402145110402251Mouse

Markers in Region
RH124569  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388104,639,925 - 104,640,015UniSTSGRCm38
MGSCv378107,163,825 - 107,163,915UniSTSGRCm37
Celera8108,872,521 - 108,872,611UniSTS
Cytogenetic Map8D1UniSTS
RH125655  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388104,639,889 - 104,640,571UniSTSGRCm38
GRCm38742,952,058 - 42,952,307UniSTSGRCm38
MGSCv37750,207,428 - 50,207,677UniSTSGRCm37
MGSCv378107,163,789 - 107,164,471UniSTSGRCm37
Celera736,715,483 - 36,715,732UniSTS
Celera8108,872,485 - 108,873,167UniSTS
Cytogenetic Map8D1UniSTS
Cytogenetic Map7B4UniSTS
Whitehead/MRC_RH7538.65UniSTS
RH125925  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388104,639,862 - 104,640,085UniSTSGRCm38
GRCm38742,952,111 - 42,952,334UniSTSGRCm38
MGSCv37750,207,481 - 50,207,704UniSTSGRCm37
MGSCv378107,163,762 - 107,163,985UniSTSGRCm37
Celera8108,872,458 - 108,872,681UniSTS
Celera736,715,456 - 36,715,679UniSTS
Cytogenetic Map8D1UniSTS
Cytogenetic Map7B4UniSTS
Whitehead/MRC_RH16974.86UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000093234   ⟹   ENSMUSP00000090921
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,366,480 - 105,368,333 (-)Ensembl
GRCm38.p6 Ensembl8104,639,848 - 104,641,701 (-)Ensembl
Ensembl Acc Id: ENSMUST00000163140   ⟹   ENSMUSP00000148786
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,366,473 - 105,368,331 (-)Ensembl
GRCm38.p6 Ensembl8104,639,841 - 104,641,699 (-)Ensembl
Ensembl Acc Id: ENSMUST00000164884   ⟹   ENSMUSP00000132725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8105,366,470 - 105,368,597 (-)Ensembl
GRCm38.p6 Ensembl8104,639,838 - 104,641,965 (-)Ensembl
RefSeq Acc Id: NM_026753   ⟹   NP_081029
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398105,366,471 - 105,368,360 (-)NCBI
GRCm388104,639,839 - 104,641,728 (-)ENTREZGENE
MGSCv378107,163,739 - 107,165,628 (-)RGD
Celera8108,872,435 - 108,874,324 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_081029 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH55880 (Get FASTA)   NCBI Sequence Viewer  
  BAB23024 (Get FASTA)   NCBI Sequence Viewer  
  EDL11226 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000090921.5
  ENSMUSP00000132725
  ENSMUSP00000132725.2
  ENSMUSP00000148786.2
GenBank Protein Q9D187 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_081029   ⟸   NM_026753
- UniProtKB: Q9D187 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000132725   ⟸   ENSMUST00000164884
Ensembl Acc Id: ENSMUSP00000148786   ⟸   ENSMUST00000163140
Ensembl Acc Id: ENSMUSP00000090921   ⟸   ENSMUST00000093234

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D187-F1-model_v2 AlphaFold Q9D187 1-163 view protein structure

Promoters
RGD ID:8668031
Promoter ID:EPDNEW_M12047
Type:initiation region
Name:Fam96b_1
Description:Mus musculus family with sequence similarity 96, member B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388104,641,705 - 104,641,765EPDNEW
RGD ID:6843129
Promoter ID:MM_KWN:55498
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026753
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368107,165,456 - 107,165,956 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915773 AgrOrtholog
Ensembl Genes ENSMUSG00000031879 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000093234.5 UniProtKB/TrEMBL
  ENSMUST00000163140.2 UniProtKB/TrEMBL
  ENSMUST00000164884 ENTREZGENE
  ENSMUST00000164884.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.300.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1280 UniProtKB/Swiss-Prot
InterPro FSCA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP18-like UniProtKB/Swiss-Prot
KEGG Report mmu:68523 UniProtKB/Swiss-Prot
MGD MGI:1915773 ENTREZGENE
NCBI Gene 68523 ENTREZGENE
PANTHER CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12377 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FeS_assembly_P UniProtKB/Swiss-Prot
PhenoGen Ciao2b PhenoGen
Superfamily-SCOP SSF117916 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1D5RMI0_MOUSE UniProtKB/TrEMBL
  CIA2B_MOUSE UniProtKB/Swiss-Prot
  F8WHV1_MOUSE UniProtKB/TrEMBL
  Q9D187 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-14 Ciao2b  cytosolic iron-sulfur assembly component 2B  Fam96b  family with sequence similarity 96, member B  Symbol and/or name change 5135510 APPROVED