Exoc6 (exocyst complex component 6) - Rat Genome Database

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Gene: Exoc6 (exocyst complex component 6) Mus musculus
Analyze
Symbol: Exoc6
Name: exocyst complex component 6
RGD ID: 1332295
MGI Page MGI
Description: Acts upstream of or within erythrocyte differentiation. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in central nervous system; dorsal root ganglion; foregut; genitourinary system; and liver lobe. Orthologous to human EXOC6 (exocyst complex component 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4833405E05Rik; AW413330; C430002C19; exocyst complex component Sec15A; hbd; msec1; msec15; Sec1; Sec15; SEC15 homolog; SEC15-like 1; SEC15-like protein 1; Sec15l1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,525,181 - 37,672,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,509,327 - 37,672,507 (+)EnsemblGRCm39 Ensembl
GRCm381937,536,763 - 37,684,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,520,879 - 37,684,059 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,624,908 - 37,757,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,615,562 - 37,748,397 (+)NCBIMGSCv36mm8
Celera1938,347,853 - 38,470,250 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IEA)
cytoplasm  (IEA)
exocyst  (IBA,NAS)
plasma membrane  (TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3960859   PMID:4596202   PMID:5405927   PMID:9292544   PMID:9680389   PMID:9923455   PMID:10349636   PMID:10597256   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851  
PMID:12477932   PMID:12520002   PMID:14610273   PMID:14662329   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16227995   PMID:16239432   PMID:16289749   PMID:16647565   PMID:17087999  
PMID:18480549   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22420621   PMID:23435566   PMID:24194600   PMID:26299925   PMID:28135344   PMID:31138677   PMID:32325033  


Genomics

Comparative Map Data
Exoc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,525,181 - 37,672,499 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,509,327 - 37,672,507 (+)EnsemblGRCm39 Ensembl
GRCm381937,536,763 - 37,684,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,520,879 - 37,684,059 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,624,908 - 37,757,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,615,562 - 37,748,397 (+)NCBIMGSCv36mm8
Celera1938,347,853 - 38,470,250 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.32NCBI
EXOC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,826,831 - 93,059,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1092,826,831 - 93,059,493 (+)EnsemblGRCh38hg38GRCh38
GRCh371094,586,588 - 94,819,247 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,584,450 - 94,809,241 (+)NCBINCBI36Build 36hg18NCBI36
Build 341094,598,248 - 94,809,240NCBI
Celera1088,335,925 - 88,560,454 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,221,556 - 88,446,771 (+)NCBIHuRef
CHM1_11094,877,294 - 95,101,961 (+)NCBICHM1_1
T2T-CHM13v2.01093,706,495 - 93,939,384 (+)NCBIT2T-CHM13v2.0
Exoc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,314,612 - 235,457,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,300,369 - 235,457,015 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,699,707 - 243,842,113 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01250,631,902 - 250,774,276 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01243,470,086 - 243,612,479 (+)NCBIRnor_WKY
Rnor_6.01256,211,879 - 256,369,318 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,226,179 - 256,368,813 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,708,969 - 263,850,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,964,047 - 242,008,416 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1232,405,767 - 232,549,626 (+)NCBICelera
Cytogenetic Map1q53NCBI
Exoc6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425389,940 - 601,304 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955425389,940 - 560,683 (-)NCBIChiLan1.0ChiLan1.0
EXOC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11093,060,721 - 93,316,030 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,088,914 - 93,316,030 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01089,569,961 - 89,803,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EXOC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,190,918 - 7,414,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,207,194 - 7,414,362 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,383,691 - 7,590,914 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,450,430 - 7,674,414 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,443,006 - 7,674,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,187,448 - 7,394,618 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,222,047 - 7,431,904 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,386,421 - 7,593,646 (+)NCBIUU_Cfam_GSD_1.0
Exoc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,201,688 - 40,392,331 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,831,165 - 1,975,872 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366011,835,469 - 1,976,735 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXOC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,326,827 - 104,549,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114104,326,943 - 104,549,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EXOC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,967,316 - 86,310,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,097,257 - 86,310,049 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,864,128 - 47,077,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exoc6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247374,055,685 - 4,310,478 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247374,043,672 - 4,311,147 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:69
Interacting mature miRNAs:76
Transcripts:ENSMUST00000066439
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1302123Tlsr8_mthymic lymphoma suppressor region 8 (mouse)Not determined192513600242388916Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
13504736Ifvrq6_minfluenza virus resistance QTL 6 (mouse)193690291044913949Mouse

Markers in Region
AW413330  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,683,750 - 37,683,846UniSTSGRCm38
MGSCv371937,758,240 - 37,758,336UniSTSGRCm37
Celera1938,470,747 - 38,470,843UniSTS
Cytogenetic Map19C2UniSTS
cM Map1926.0UniSTS
Whitehead/MRC_RH19357.47UniSTS
D19Mit101  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,659,224 - 37,659,346UniSTSGRCm38
MGSCv371937,733,714 - 37,733,836UniSTSGRCm37
Celera1938,446,250 - 38,446,372UniSTS
Cytogenetic Map19C2UniSTS
cM Map1926.0UniSTS
Whitehead Genetic1926.2UniSTS
Whitehead/MRC_RH19357.47UniSTS
Whitehead_YAC19 UniSTS
D19Dcr28  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381937,631,720 - 37,631,817UniSTSGRCm38
Celera1938,418,416 - 38,418,515UniSTS
Cytogenetic Map19C2UniSTS
cM Map19 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000066439   ⟹   ENSMUSP00000064332
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,538,866 - 37,672,507 (+)Ensembl
GRCm38.p6 Ensembl1937,550,418 - 37,684,059 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238817   ⟹   ENSMUSP00000159143
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,538,907 - 37,671,703 (+)Ensembl
GRCm38.p6 Ensembl1937,550,459 - 37,683,255 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238954   ⟹   ENSMUSP00000158866
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1937,509,327 - 37,672,507 (+)Ensembl
GRCm38.p6 Ensembl1937,520,879 - 37,684,059 (+)Ensembl
RefSeq Acc Id: NM_175353   ⟹   NP_780562
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,538,866 - 37,671,701 (+)NCBI
GRCm381937,550,418 - 37,683,253 (+)NCBI
MGSCv371937,624,908 - 37,757,743 (+)RGD
Celera1938,347,853 - 38,470,250 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017318044   ⟹   XP_017173533
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391937,525,181 - 37,672,499 (+)NCBI
GRCm381937,536,763 - 37,684,052 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_780562   ⟸   NM_175353
- UniProtKB: Q3U9D6 (UniProtKB/TrEMBL),   Q8C670 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017173533   ⟸   XM_017318044
- Peptide Label: isoform X1
- UniProtKB: A0A5F8MP92 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000064332   ⟸   ENSMUST00000066439
RefSeq Acc Id: ENSMUSP00000159143   ⟸   ENSMUST00000238817
RefSeq Acc Id: ENSMUSP00000158866   ⟸   ENSMUST00000238954
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R313-F1-model_v2 AlphaFold Q8R313 1-802 view protein structure

Promoters
RGD ID:13679390
Promoter ID:EPDNEW_M23844
Type:initiation region
Name:Exoc6_1
Description:Mus musculus exocyst complex component 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381937,550,452 - 37,550,512EPDNEW
RGD ID:6830018
Promoter ID:MM_KWN:26969
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:NM_175353,   UC008HIR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361937,624,861 - 37,625,361 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351611 AgrOrtholog
Ensembl Genes ENSMUSG00000053799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000064332 ENTREZGENE
  ENSMUSP00000064332.7 UniProtKB/TrEMBL
  ENSMUSP00000158866 ENTREZGENE
  ENSMUSP00000158866.2 UniProtKB/TrEMBL
  ENSMUSP00000159143.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000066439 ENTREZGENE
  ENSMUST00000066439.8 UniProtKB/TrEMBL
  ENSMUST00000238817.2 UniProtKB/TrEMBL
  ENSMUST00000238954 ENTREZGENE
  ENSMUST00000238954.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.357.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.670 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EXOC6/Sec15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EXOC6/Sec15_C_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EXOC6/Sec15_C_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec15_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:107371 UniProtKB/TrEMBL
MGD MGI:1351611 ENTREZGENE
NCBI Gene 107371 ENTREZGENE
PANTHER EXOCYST COMPLEX COMPONENT 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12702 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sec15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Exoc6 PhenoGen
PIRSF Sec15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F8MP92 ENTREZGENE, UniProtKB/TrEMBL
  A0A5F8MPW8_MOUSE UniProtKB/TrEMBL
  EXOC6_MOUSE UniProtKB/Swiss-Prot
  Q3U9D6 ENTREZGENE, UniProtKB/TrEMBL
  Q8C670 ENTREZGENE, UniProtKB/TrEMBL
  Q8R131_MOUSE UniProtKB/TrEMBL
  Q8R313 ENTREZGENE