Gulo (gulonolactone (L-) oxidase) - Rat Genome Database

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Gene: Gulo (gulonolactone (L-) oxidase) Mus musculus
Analyze
Symbol: Gulo
Name: gulonolactone (L-) oxidase
RGD ID: 1332224
MGI Page MGI
Description: Enables L-gulonolactone oxidase activity and flavin adenine dinucleotide binding activity. Involved in L-ascorbic acid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in several structures, including cranium; liver; nasal septum; nervous system; and pancreas. Orthologous to human GULOP (gulonolactone (L-) oxidase, pseudogene).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5730581M22; AU018375; BC028822; GLO; L-gulono-gamma-lactone oxidase; L-gulonolactone oxidase; LGO; MGC29968; MGC37793; MGC37880; sf; sfx; unh; unhip
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,224,235 - 66,246,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,224,235 - 66,246,656 (-)EnsemblGRCm39 Ensembl
GRCm381465,986,786 - 66,009,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,986,786 - 66,009,207 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,605,624 - 66,628,047 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,940,897 - 64,963,320 (-)NCBIMGSCv36mm8
Celera1451,257,847 - 51,259,334 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aorta elastic tissue morphology  (IAGP)
abnormal aorta endothelium morphology  (IAGP)
abnormal aorta smooth muscle morphology  (IAGP)
abnormal bone mineralization  (IEA)
abnormal eye morphology  (IEA)
abnormal gait  (IEA)
abnormal heart morphology  (IEA)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal optic disk morphology  (IEA)
abnormal osteoclast differentiation  (IAGP)
abnormal retina morphology  (IEA)
abnormal skeleton physiology  (IAGP)
abnormal spleen morphology  (IEA)
abnormal trabecular bone morphology  (IEA)
abnormal vertebral body morphology  (IAGP)
abnormal vitamin C level  (IAGP)
anemia  (IAGP)
anophthalmia  (IEA)
cataract  (IEA)
decreased body size  (IEA)
decreased bone mineral density  (IEA)
decreased bone mineral density of femur  (IAGP)
decreased chondrocyte number  (IAGP)
decreased circulating alkaline phosphatase level  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased lean body mass  (IEA)
decreased locomotor activity  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
disheveled coat  (IAGP)
enlarged heart  (IEA)
enlarged kidney  (IAGP)
enlarged spleen  (IEA)
femur fracture  (IEA)
fragile skeleton  (IAGP)
gastrointestinal hemorrhage  (IAGP)
hemarthrosis  (IAGP)
hemorrhage  (IAGP)
hindlimb paralysis  (IEA)
hyperactivity  (IEA)
increased brain size  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating HDL cholesterol level  (IEA)
increased vascular permeability  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
rachitic rosary  (IAGP)
rickets  (IEA)
slow postnatal weight gain  (IAGP)
small spleen  (IAGP)
small thymus  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:10349636   PMID:10606751   PMID:10639167   PMID:10922068   PMID:11042159   PMID:11062347   PMID:11076861   PMID:11217851   PMID:11914259   PMID:14681479   PMID:14962674   PMID:15489334  
PMID:15674730   PMID:16059632   PMID:16141072   PMID:16141073   PMID:16352673   PMID:16632110   PMID:16737683   PMID:16800296   PMID:16988135   PMID:17264304   PMID:17990318   PMID:18466336  
PMID:18554416   PMID:18764764   PMID:19690176   PMID:19941887   PMID:20410296   PMID:20558818   PMID:20570663   PMID:20599829   PMID:21267068   PMID:21346252   PMID:21873635   PMID:21878346  
PMID:22001929   PMID:22296218   PMID:22536166   PMID:23106783   PMID:23321552   PMID:23886864   PMID:24184603   PMID:24386598   PMID:24508240   PMID:24660109   PMID:26064792   PMID:27573077  
PMID:28106121   PMID:28652077   PMID:28705898   PMID:28825709   PMID:28851583   PMID:29180474   PMID:29452565   PMID:29987201   PMID:30025088   PMID:30172223   PMID:30219227   PMID:31390373  
PMID:31485074   PMID:32307537   PMID:32797675   PMID:32895473   PMID:32913121   PMID:33549889   PMID:34439814   PMID:34983833   PMID:35054942   PMID:35235785   PMID:36179436   PMID:36202795  


Genomics

Comparative Map Data
Gulo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,224,235 - 66,246,703 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,224,235 - 66,246,656 (-)EnsemblGRCm39 Ensembl
GRCm381465,986,786 - 66,009,254 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,986,786 - 66,009,207 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,605,624 - 66,628,047 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,940,897 - 64,963,320 (-)NCBIMGSCv36mm8
Celera1451,257,847 - 51,259,334 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
GULOP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,577,611 - 27,589,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,560,274 - 27,589,073 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,435,128 - 27,446,590 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,491,045 - 27,502,507 (+)NCBINCBI36Build 36hg18NCBI36
Celera826,395,229 - 26,406,690 (+)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef825,980,173 - 25,991,634 (+)NCBIHuRef
CHM1_1827,637,009 - 27,648,461 (+)NCBICHM1_1
T2T-CHM13v2.0827,854,954 - 27,866,415 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Gulo
732 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:245
Interacting mature miRNAs:273
Transcripts:ENSMUST00000059970
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
10043888Cia51_mcollagen induced arthritis QTL 51 (mouse)Not determined146610389368785736Mouse

Markers in Region
AU018375  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,986,950 - 65,987,045UniSTSGRCm38
MGSCv371466,605,787 - 66,605,882UniSTSGRCm37
Celera1451,259,076 - 51,259,171UniSTS
Cytogenetic Map14D1UniSTS
Whitehead/MRC_RH14748.18UniSTS
UniSTS:237216  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381465,986,848 - 65,987,097UniSTSGRCm38
MGSCv371466,605,685 - 66,605,934UniSTSGRCm37
Celera1451,259,024 - 51,259,273UniSTS
Cytogenetic Map14D1UniSTS
PMC15418P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381466,006,620 - 66,006,966UniSTSGRCm38
MGSCv371466,625,457 - 66,625,803UniSTSGRCm37
Celera1463,754,996 - 63,755,342UniSTS
Cytogenetic Map14D1UniSTS
Gulo  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D1UniSTS
cM Map1428.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000059970   ⟹   ENSMUSP00000060912
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1466,224,235 - 66,246,656 (-)Ensembl
GRCm38.p6 Ensembl1465,986,786 - 66,009,207 (-)Ensembl
RefSeq Acc Id: NM_178747   ⟹   NP_848862
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,224,236 - 66,246,659 (-)NCBI
GRCm381465,986,787 - 66,009,210 (-)NCBI
MGSCv371466,605,624 - 66,628,047 (-)RGD
Celera1451,257,847 - 51,259,334 (+)NCBI
Celera1463,738,693 - 63,757,584 (-)ENTREZGENE
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519066   ⟹   XP_006519129
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,224,235 - 66,246,703 (-)NCBI
GRCm381465,986,786 - 66,009,254 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001781125
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391466,224,235 - 66,246,703 (-)NCBI
GRCm381465,986,786 - 66,009,254 (-)NCBI
Sequence:
RefSeq Acc Id: NP_848862   ⟸   NM_178747
- UniProtKB: Q8K152 (UniProtKB/Swiss-Prot),   P58710 (UniProtKB/Swiss-Prot),   Q8K156 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519129   ⟸   XM_006519066
- Peptide Label: isoform X1
- UniProtKB: Q8K152 (UniProtKB/Swiss-Prot),   P58710 (UniProtKB/Swiss-Prot),   Q8K156 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000060912   ⟸   ENSMUST00000059970
Protein Domains
FAD-binding PCMH-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P58710-F1-model_v2 AlphaFold P58710 1-440 view protein structure

Promoters
RGD ID:8682782
Promoter ID:EPDNEW_M19422
Type:initiation region
Name:Gulo_1
Description:Mus musculus gulonolactone (L-) oxidase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381466,009,180 - 66,009,240EPDNEW
RGD ID:6825052
Promoter ID:MM_KWN:17268
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Liver
Transcripts:NM_178747
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361466,627,726 - 66,628,226 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353434 AgrOrtholog
Ensembl Genes ENSMUSG00000034450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000059970 ENTREZGENE
  ENSMUST00000059970.9 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.43.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.465.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.2520 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ALO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_PCMH_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_lactone_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxid_FAD_bind_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxy_OxRdtase_FAD_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sugar_lactone_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vanillyl_alc_oxidase_C-sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:268756 UniProtKB/Swiss-Prot
MGD MGI:1353434 ENTREZGENE
NCBI Gene 268756 ENTREZGENE
PANTHER L-GULONOLACTONE OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43762 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ALO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gulo PhenoGen
PIRSF LGO_GLO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FAD_PCMH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OX2_COVAL_FAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GGLO_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8JZZ1_MOUSE UniProtKB/TrEMBL
  Q8K152 ENTREZGENE
  Q8K156 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q8K152 UniProtKB/Swiss-Prot