Serpinf1 (serine (or cysteine) peptidase inhibitor, clade F, member 1) - Rat Genome Database

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Gene: Serpinf1 (serine (or cysteine) peptidase inhibitor, clade F, member 1) Mus musculus
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Symbol: Serpinf1
Name: serine (or cysteine) peptidase inhibitor, clade F, member 1
RGD ID: 1332124
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in negative regulation of angiogenesis. Acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study osteogenesis imperfecta type 6. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); brain edema; eye disease (multiple); leukostasis; and metabolic dysfunction-associated steatohepatitis. Orthologous to human SERPINF1 (serpin family F member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI195227; alpha-2 antiplasmin; caspin; EPC-; EPC-1; Ped; Pedf; Pedfl; pigment epithelium derived factor; pigment epithelium-derived factor; pigment epithelium-derived factor-like; Sdf; SDF-3; Sdf3; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serine (or cysteine) proteinase inhibitor, clade F), member 1; serine (or cysteine) proteinase inhibitor, clade F, member 1; serpin F1; serpin-F1; stromal cell derived factor 3; stromal cell-derived factor 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,300,855 - 75,313,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,300,595 - 75,313,527 (-)EnsemblGRCm39 Ensembl
GRCm381175,410,029 - 75,422,623 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,409,769 - 75,422,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,223,531 - 75,236,125 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,225,964 - 75,238,707 (-)NCBIMGSCv36mm8
Celera1182,918,458 - 82,931,037 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
adenoid cystic carcinoma  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anogenital venereal wart  (ISO)
Arterial Thrombosis  (ISO)
brain edema  (ISO)
Brain Injuries  (ISO)
Carotid Artery Injuries  (ISO)
central retinal vein occlusion  (ISO)
Choroidal Neovascularization  (ISO)
chronic fatigue syndrome  (ISO)
colorectal cancer  (ISO)
corneal neovascularization  (ISO)
corneal ulcer  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (IEP,ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Endotoxin-Induced Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
hepatocellular carcinoma  (ISO)
hepatosplenic schistosomiasis  (ISO)
Hirschsprung's disease  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Keloid  (ISO)
kidney failure  (ISO)
leukostasis  (ISO)
lung non-small cell carcinoma  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melioidosis  (IMP,ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
middle cerebral artery infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
nephroblastoma  (ISO)
obesity  (ISO)
Olfaction Disorders  (ISO)
Osteoarthritis, Experimental  (IMP)
osteogenesis imperfecta  (ISO)
osteogenesis imperfecta type 3  (ISO)
osteogenesis imperfecta type 6  (IAGP,ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
ovarian hyperstimulation syndrome  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (ISO)
Peripheral Nerve Injuries  (ISO)
portal hypertension  (ISO)
proliferative diabetic retinopathy  (ISO)
Prostatic Neoplasms  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Retinal Neovascularization  (ISO)
retinal vein occlusion  (ISO)
retinitis pigmentosa  (ISO)
retinoblastoma  (ISO)
retinopathy of prematurity  (ISO)
Salivary Gland Neoplasms  (ISO)
sciatic neuropathy  (ISO)
Septic Peritonitis  (ISO)
Sickle Cell Retinopathy  (ISO)
Staphylococcal Skin Infections  (IMP)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveal melanoma  (IMP)
uveitis  (ISO)
venous tributary occlusion of retina  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Nornicotine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aconitine  (ISO)
acrolein  (ISO)
adrenaline  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
ceruletide  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (EXP)
cyproconazole  (ISO)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
fenamidone  (EXP)
flusilazole  (ISO)
fructose  (EXP)
furosemide  (ISO)
gefitinib  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
indometacin  (ISO)
mancozeb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (EXP)
methimazole  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nicotine  (EXP,ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentane-2,3-dione  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
pinostrobin  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propofol  (ISO)
propranolol  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
selenium atom  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Pigment epithelium-derived factor targets endothelial and epithelial cells in Wilms' tumor. Abramson LP, etal., J Pediatr Surg. 2006 Aug;41(8):1351-6.
2. Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization. Amaral J and Becerra SP, Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1318-26. doi: 10.1167/iovs.09-4455. Epub 2009 Oct 22.
3. Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury. Awad AS, etal., Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F891-900. doi: 10.1152/ajprenal.00149.2013. Epub 2013 Jul 24.
4. A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. Baraniuk JN, etal., BMC Neurol. 2005 Dec 1;5:22. doi: 10.1186/1471-2377-5-22.
5. Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Bhutto IA, etal., Exp Eye Res. 2006 Jan;82(1):99-110. Epub 2005 Jul 12.
6. Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injury. Calenda G, etal., BJU Int. 2012 May;109(10):1552-64. doi: 10.1111/j.1464-410X.2011.10705.x. Epub 2012 Feb 2.
7. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations. Cayouette M, etal., Neurobiol Dis. 1999 Dec;6(6):523-32.
8. Identification of pigment epithelium-derived factor as an adipocyte-derived inflammatory factor. Chavan SS, etal., Mol Med. 2012 Oct 24;18:1161-8. doi: 10.2119/molmed.2012.00156.
9. A physiological approach for treating endometriosis by recombinant pigment epithelium-derived factor (PEDF). Chuderland D, etal., Hum Reprod. 2013 Jun;28(6):1626-34. doi: 10.1093/humrep/det027. Epub 2013 Mar 6.
10. The role of pigment epithelium-derived factor in the pathophysiology and treatment of ovarian hyperstimulation syndrome in mice. Chuderland D, etal., J Clin Endocrinol Metab. 2013 Feb;98(2):E258-66. doi: 10.1210/jc.2012-3037. Epub 2013 Jan 7.
11. Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator. Chung C, etal., Gastroenterology. 2009 Jan;136(1):331-340.e2. Epub 2008 Oct 7.
12. Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy. Cohen MP, etal., Ophthalmic Res. 2008;40(1):5-9. Epub 2007 Nov 20.
13. Diabetes-independent increase of factor VII-activating protease activation in patients with Gram-negative sepsis (melioidosis). de Jong HK, etal., J Thromb Haemost. 2015 Jan;13(1):41-6. doi: 10.1111/jth.12776. Epub 2014 Dec 6.
14. Downregulation of pigment epithelium-derived factor in condyloma acuminatum. Dong YH, etal., J Int Med Res. 2013 Apr;41(2):365-70. doi: 10.1177/0300060513476584. Epub 2013 Mar 14.
15. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Duh EJ, etal., Am J Ophthalmol. 2004 Apr;137(4):668-74.
16. Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth. Duh EJ, etal., Invest Ophthalmol Vis Sci. 2002 Mar;43(3):821-9.
17. Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis. Ek ET, etal., Cancer Gene Ther. 2007 Jul;14(7):616-26. Epub 2007 May 4.
18. Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. Ek ET, etal., Clin Exp Metastasis. 2007;24(2):93-106. Epub 2007 Apr 18.
19. Hyperfibrinolysis in hepatosplenic schistosomiasis. el-Bassiouni NE, etal., J Clin Pathol. 1996 Dec;49(12):990-3. doi: 10.1136/jcp.49.12.990.
20. Pigment epithelium-derived factor (PEDF) attenuated capsaicin-induced neurotrophic keratouveitis. Feher J, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5173-80. doi: 10.1167/iovs.08-1852. Epub 2009 Jun 24.
21. Pigment epithelial-derived factor expression in endometriotic lesions in a rat model of endometriosis. Fu G, etal., Acta Histochem. 2013 May;115(4):301-7. doi: 10.1016/j.acthis.2012.08.006. Epub 2012 Sep 10.
22. Plasminogen concentrations and functional activities and concentrations of plasmin inhibitors in plasma samples from normal subjects and patients with septic shock. Gallimore MJ, etal., Thromb Res. 1980 Jun 1;18(5):601-8. doi: 10.1016/0049-3848(80)90214-5.
23. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium--derived factor in brown norway and sprague dawley rats contributing to different susceptibilities to retinal neovascularization. Gao G, etal., Diabetes. 2002 Apr;51(4):1218-25.
24. Decreased pigment epithelium-derived factor is associated with metastatic phenotype in human and rat prostate tumors. Halin S, etal., Cancer Res. 2004 Aug 15;64(16):5664-71.
25. Pigment epithelium-derived factor stimulates tumor macrophage recruitment and is downregulated by the prostate tumor microenvironment. Halin S, etal., Neoplasia. 2010 Apr;12(4):336-45.
26. Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Hartmann JS, etal., Mol Vis. 2011;17:1577-87. Epub 2011 Jun 10.
27. Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons. Houenou LJ, etal., J Comp Neurol. 1999 Sep 27;412(3):506-14.
28. Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy. Iizuka H, etal., Biochem Biophys Res Commun. 2007 Sep 21;361(2):421-6. Epub 2007 Jul 16.
29. Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Jenkins A, etal., Diabetes Res Clin Pract. 2008 Oct;82(1):e5-7. Epub 2008 Aug 19.
30. Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes. Jenkins AJ, etal., Diabet Med. 2007 Dec;24(12):1345-51. Epub 2007 Oct 29.
31. Prognostic role of serum AZGP1, PEDF and PRDX2 in colorectal cancer patients. Ji D, etal., Carcinogenesis. 2013 Jun;34(6):1265-72. doi: 10.1093/carcin/bgt056. Epub 2013 Feb 7.
32. Differential proteomic analysis of serum exosomes reveals alterations in progression of Parkinson disease. Jiang R, etal., Medicine (Baltimore). 2019 Oct;98(41):e17478. doi: 10.1097/MD.0000000000017478.
33. Pharmacodynamics of active site-inhibited factor VIIa in endotoxin-induced coagulation in humans. Jilma B, etal., Clin Pharmacol Ther. 2002 Oct;72(4):403-10. doi: 10.1067/mcp.2002.127740.
34. Administration of pigment epithelium-derived factor (PEDF) inhibits cold injury-induced brain edema in mice. Jinnouchi Y, etal., Brain Res. 2007 Sep 5;1167:92-100. Epub 2007 Jul 10.
35. Endogenous α2-antiplasmin is protective during severe gram-negative sepsis (melioidosis). Kager LM, etal., Am J Respir Crit Care Med. 2013 Oct 15;188(8):967-75. doi: 10.1164/rccm.201307-1344OC.
36. Increased serum pigment epithelium-derived factor levels in type 1 diabetic patients with diabetic retinopathy. Katakami N, etal., Diabetes Res Clin Pract. 2008 Jul;81(1):e4-7. Epub 2008 May 2.
37. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
38. Expression of pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in sickle cell retina and choroid. Kim SY, etal., Exp Eye Res. 2003 Oct;77(4):433-45.
39. Visceral obesity and hemostatic profile in patients with type 2 diabetes: the effect of gender and metabolic compensation. Kozek E, etal., Rev Diabet Stud. 2004 Fall;1(3):122-8. Epub 2004 Nov 10.
40. Pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis. Kozlowska J, etal., Saudi J Gastroenterol. 2016 Sep-Oct;22(5):375-379. doi: 10.4103/1319-3767.191143.
41. Proteases and protease inhibitors in taurocholate-induced acute pancreatitis in rats. Kruse P, etal., Int J Pancreatol. 1999 Apr;25(2):113-21.
42. Proteases and protease inhibitors in cerulein-induced acute pancreatitis in rats. Kruse P, etal., J Surg Res. 1999 Aug;85(2):294-300.
43. Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis. Kuncl RW, etal., J Neurochem. 2002 Apr;81(1):178-84.
44. Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis. Kuo CN, etal., Exp Eye Res. 2009 Nov;89(5):678-85. doi: 10.1016/j.exer.2009.06.021. Epub 2009 Jul 9.
45. Alzheimer's disease: Elevated pigment epithelium-derived factor in the cerebrospinal fluid is mostly of systemic origin. Lang V, etal., J Neurol Sci. 2017 Apr 15;375:123-128. doi: 10.1016/j.jns.2017.01.051. Epub 2017 Jan 17.
46. Host pigment epithelium-derived factor (PEDF) prevents progression of liver metastasis in a mouse model of uveal melanoma. Lattier JM, etal., Clin Exp Metastasis. 2013 Dec;30(8):969-76. doi: 10.1007/s10585-013-9596-3. Epub 2013 Jun 22.
47. A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Li H, etal., Exp Eye Res. 2006 Oct;83(4):824-33. Epub 2006 Jul 5.
48. Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats. Markovets AM, etal., Aging (Albany NY). 2011 Jan;3(1):44-54.
49. Pigment epithelium-derived factor improves metabolic derangements and ameliorates dysregulation of adipocytokines in obese type 2 diabetic rats. Matsui T, etal., Am J Pathol. 2014 Apr;184(4):1094-103. doi: 10.1016/j.ajpath.2013.12.032. Epub 2014 Feb 13.
50. High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes. Matsuoka M, etal., Exp Eye Res. 2006 Jan;82(1):172-8. Epub 2005 Jul 27.
51. Leukostasis and pigment epithelium-derived factor in rat models of diabetic retinopathy. Matsuoka M, etal., Mol Vis. 2007 Jun 29;13:1058-65.
52. Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy. Matsuyama K, etal., Mol Vis. 2008 May 28;14:992-6.
53. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
54. MGDs mouse GO annotations MGD data from the GO Consortium
55. MGD IEA MGD IEA
56. Synergistic neuroprotective effect via simian lentiviral vector-mediated simultaneous gene transfer of human pigment epithelium-derived factor and human fibroblast growth factor-2 in rodent models of retinitis pigmentosa. Miyazaki M, etal., J Gene Med. 2008 Dec;10(12):1273-81. doi: 10.1002/jgm.1257.
57. AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization. Mori K, etal., Invest Ophthalmol Vis Sci. 2002 Jun;43(6):1994-2000.
58. Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. Mori K, etal., J Cell Physiol. 2001 Aug;188(2):253-63.
59. Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with Sendai viral envelope proteins. Murakami Y, etal., Hum Gene Ther. 2010 Feb;21(2):199-209. doi: 10.1089/hum.2009.102.
60. Pigment Epithelium-Derived Factor (PEDF) mediates cartilage matrix loss in an age-dependent manner under inflammatory conditions. Nakamura DS, etal., BMC Musculoskelet Disord. 2017 Jan 25;18(1):39. doi: 10.1186/s12891-017-1410-y.
61. Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation. Nakamura K, etal., Am J Pathol. 2007 Jun;170(6):2159-70.
62. Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension. Nakamura K, etal., Int J Cardiol. 2008 Dec 13.
63. Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. Noma H, etal., Curr Eye Res. 2011 Mar;36(3):256-63. doi: 10.3109/02713683.2010.513090. Epub 2011 Jan 28.
64. Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema. Noma H, etal., Graefes Arch Clin Exp Ophthalmol. 2010 Nov;248(11):1559-65. doi: 10.1007/s00417-010-1486-7. Epub 2010 Aug 17.
65. Coagulation and fibrinolysis factors in dialysis patients with and without ischemic heart disease. Oda H, etal., Adv Perit Dial. 2000;16:152-5.
66. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
67. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
68. Propranolol Attenuates Proangiogenic Activity of Mononuclear Phagocytes: Implication in Choroidal Neovascularization. Omri S, etal., Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4632-4642. doi: 10.1167/iovs.18-25502.
69. Comparative proteomic analysis between normal skin and keloid scar. Ong CT, etal., Br J Dermatol. 2010 Jun;162(6):1302-15. doi: 10.1111/j.1365-2133.2010.09660.x. Epub 2010 Feb 1.
70. The expression of PEDF and VEGF in the gastric wall of prehepatic portal hypertensive rats. Pan WD, etal., Hepatogastroenterology. 2011 Nov-Dec;58(112):2152-5. doi: 10.5754/hge11227.
71. Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization. Park K, etal., Am J Pathol. 2011 Feb;178(2):688-98. doi: 10.1016/j.ajpath.2010.10.014.
72. Excess soluble urokinase-type plasminogen activator receptor in the plasma of dialysis patients correlates with increased fibrinolytic activity. Pawlak K, etal., Thromb Res. 2007;119(4):475-80. doi: 10.1016/j.thromres.2006.03.011. Epub 2006 Jul 7.
73. Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections. Peetermans M, etal., BMC Microbiol. 2014 Dec 17;14:310. doi: 10.1186/s12866-014-0310-7.
74. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
75. Mouse MP Annotation Import Pipeline RGD automated import pipeline
76. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
77. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
78. On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion. Rodríguez-Piñeiro AM, etal., J Proteomics. 2010 Jun 16;73(8):1511-22. doi: 10.1016/j.jprot.2010.03.005. Epub 2010 Mar 15.
79. A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013.
80. Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model. Sanagi T, etal., J Neurochem. 2008 Aug;106(4):1841-54. doi: 10.1111/j.1471-4159.2008.05529.x. Epub 2008 Jul 4.
81. Adenoviral gene delivery of pigment epithelium-derived factor protects striatal neurons from quinolinic acid-induced excitotoxicity. Sanagi T, etal., J Neuropathol Exp Neurol. 2010 Mar;69(3):224-33. doi: 10.1097/NEN.0b013e3181cfc46f.
82. Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat. Sanagi T, etal., Neurosci Lett. 2007 Aug 31;424(1):66-71. Epub 2007 Aug 1.
83. [Expression and signification of pigment epithelium-derived factor in experimental choroidal neovascularization of rat] Shi XH, etal., Zhonghua Yan Ke Za Zhi. 2004 Jun;40(6):404-8.
84. Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease. Spranger J, etal., Diabetes. 2001 Dec;50(12):2641-5.
85. Hexapeptides HLDF-6 and PEDF-6 restore memory in rats after chronic intracerebroventricular treatment with beta-amyloid peptide Abeta(25-35). Storozheva ZI, etal., Bull Exp Biol Med. 2006 Mar;141(3):319-22.
86. Pigment epithelium-derived factor (PEDF) administration inhibits occlusive thrombus formation in rats: a possible participation of reduced intraplatelet PEDF in thrombosis of acute coronary syndromes. Takenaka K, etal., Atherosclerosis. 2008 Mar;197(1):25-33. Epub 2007 Sep 11.
87. Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. Tong JP, etal., Am J Ophthalmol. 2006 Mar;141(3):456-62.
88. Components of the fibrinolytic system in the vitreous body in patients with vitreoretinal disorders. Ulrich JN, etal., Clin Exp Ophthalmol. 2008 Jul;36(5):431-6.
89. Epinephrine exerts anticoagulant effects during human endotoxemia. van der Poll T, etal., J Exp Med. 1997 Mar 17;185(6):1143-8.
90. Coagulation and fibrinolytic responses of human peritoneal fluid and plasma to bacterial peritonitis. van Goor H, etal., Br J Surg. 1996 Aug;83(8):1133-5. doi: 10.1002/bjs.1800830833.
91. Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy. Wang JJ, etal., Am J Physiol Renal Physiol. 2008 May;294(5):F1166-73. Epub 2008 Mar 5.
92. Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy. Wang JJ, etal., Diabetes 2005 Jan;54(1):243-50.
93. Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities. Wang JJ, etal., Diabetes. 2006 Jun;55(6):1678-85.
94. Modulation of thrombospondin 1 and pigment epithelium-derived factor levels in vitreous fluid of patients with diabetes. Wang S, etal., Arch Ophthalmol. 2009 Apr;127(4):507-13.
95. Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis. Yamagishi S, etal., Microvasc Res. 2006 Jul-Sep;72(1-2):86-90. Epub 2006 Jun 22.
96. Pigment epithelium-derived factor (PEDF) inhibits diabetes- or advanced glycation end product (AGE)-induced platelet CD40 ligand overexpression in rats. Yamagishi SI, etal., Int J Cardiol. 2009 Feb 21.
97. PEDF inhibits growth of retinoblastoma by anti-angiogenic activity. Yang H, etal., Cancer Sci. 2009 Dec;100(12):2419-25. doi: 10.1111/j.1349-7006.2009.01332.x. Epub 2009 Aug 27.
98. Combined Serum Biomarkers in Non-Invasive Diagnosis of Non-Alcoholic Steatohepatitis. Yang M, etal., PLoS One. 2015 Jun 29;10(6):e0131664. doi: 10.1371/journal.pone.0131664. eCollection 2015.
99. Rosiglitazone inhibits expression and secretion of PEDF in adipose tissue and liver of male SD rats via a PPAR-gamma independent mechanism. Yang S, etal., Endocrinology. 2014 Mar;155(3):941-50. doi: 10.1210/en.2013-1813. Epub 2014 Jan 1.
100. Metformin inhibits expression and secretion of PEDF in adipocyte and hepatocyte via promoting AMPK phosphorylation. Yang S, etal., Mediators Inflamm. 2013;2013:429207. doi: 10.1155/2013/429207. Epub 2013 Oct 31.
101. Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. Yoshida T, etal., Dig Dis Sci. 2017 Jun;62(6):1527-1536. doi: 10.1007/s10620-017-4550-x. Epub 2017 Apr 1.
102. Increased levels of pigment epithelium-derived factor in aqueous humor of patients with uveitis. Yoshida Y, etal., Br J Ophthalmol. 2007 Feb;91(2):149-50. Epub 2006 Sep 14.
103. Administration of pigment epithelium-derived factor delivered by adeno-associated virus inhibits blood-retinal barrier breakdown in diabetic rats. Yu H, etal., Mol Vis. 2010 Nov 15;16:2384-94.
104. Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor. Zhang SX, etal., FASEB J. 2006 Feb;20(2):323-5. Epub 2005 Dec 20.
105. [Pigment epithelium-derived factor expression in the retina in response to hypobaric hypoxia]. Zhang Y, etal., Zhonghua Yan Ke Za Zhi. 2007 Dec;43(12):1130-4.
106. The intrinsic PEDF is regulated by PPARgamma in permanent focal cerebral ischemia of rat. Zhu C, etal., Neurochem Res. 2012 Oct;37(10):2099-107. doi: 10.1007/s11064-012-0831-0. Epub 2012 Jun 20.
Additional References at PubMed
PMID:7814443   PMID:8938438   PMID:9565647   PMID:9614124   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11180952   PMID:12072560   PMID:12239160   PMID:12447163  
PMID:12477932   PMID:12632345   PMID:12641447   PMID:12740569   PMID:12912908   PMID:12941042   PMID:14681479   PMID:15020256   PMID:15051476   PMID:15489334   PMID:15549636   PMID:15713745  
PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16839360   PMID:18180304   PMID:18191271   PMID:18348263   PMID:18602915   PMID:19115638   PMID:19661223   PMID:19898467  
PMID:20185831   PMID:20709803   PMID:21236558   PMID:21267068   PMID:21386905   PMID:21576363   PMID:21652703   PMID:21677750   PMID:21846721   PMID:21873635   PMID:21964188   PMID:22171010  
PMID:22234980   PMID:22410737   PMID:22933798   PMID:23075882   PMID:23108227   PMID:23413146   PMID:23600479   PMID:23646899   PMID:23748041   PMID:23850519   PMID:23887690   PMID:24006456  
PMID:24172014   PMID:24194600   PMID:24318110   PMID:24456163   PMID:24583261   PMID:24664775   PMID:24760990   PMID:25003563   PMID:25054647   PMID:25095732   PMID:25368097   PMID:25562624  
PMID:25636741   PMID:25700221   PMID:26693895   PMID:26700654   PMID:27127101   PMID:27440994   PMID:27557659   PMID:27914705   PMID:28190640   PMID:28569772   PMID:28706437   PMID:28747334  
PMID:28860613   PMID:28911166   PMID:28972155   PMID:29075761   PMID:29259049   PMID:29294343   PMID:29351407   PMID:29438518   PMID:29449449   PMID:29736859   PMID:29752430   PMID:30042381  
PMID:30160348   PMID:30414426   PMID:30786278   PMID:31028961   PMID:31040226   PMID:31117965   PMID:31661672   PMID:31676463   PMID:31711388   PMID:31968655   PMID:32325033   PMID:32377760  
PMID:32385162   PMID:32427349   PMID:33008127   PMID:33412338   PMID:33498962   PMID:34132748   PMID:34321999   PMID:34774969   PMID:34965441   PMID:35125056   PMID:35258129   PMID:35364055  
PMID:35809620   PMID:35887093   PMID:36939278   PMID:37440564   PMID:37490993   PMID:38153666   PMID:38280375   PMID:38355793  


Genomics

Comparative Map Data
Serpinf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,300,855 - 75,313,449 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,300,595 - 75,313,527 (-)EnsemblGRCm39 Ensembl
GRCm381175,410,029 - 75,422,623 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,409,769 - 75,422,701 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,223,531 - 75,236,125 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,225,964 - 75,238,707 (-)NCBIMGSCv36mm8
Celera1182,918,458 - 82,931,037 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.87NCBI
SERPINF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,762,060 - 1,777,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,762,029 - 1,777,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37171,665,354 - 1,680,859 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,612,009 - 1,627,618 (+)NCBINCBI36Build 36hg18NCBI36
Build 34171,612,008 - 1,627,618NCBI
Celera171,681,796 - 1,697,412 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,562,622 - 1,578,251 (+)NCBIHuRef
CHM1_1171,673,331 - 1,688,930 (+)NCBICHM1_1
T2T-CHM13v2.0171,650,754 - 1,666,265 (+)NCBIT2T-CHM13v2.0
Serpinf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,748,504 - 60,760,898 (-)NCBIGRCr8
mRatBN7.21060,250,198 - 60,262,593 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,249,708 - 60,262,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,896,641 - 64,909,534 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,402,235 - 64,415,134 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,864,629 - 59,877,513 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,241,750 - 62,254,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,241,756 - 62,254,287 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,954,919 - 61,969,094 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,713,441 - 62,739,444 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,727,065 - 62,753,067 (-)NCBI
Celera1059,279,849 - 59,291,539 (-)NCBICelera
Cytogenetic Map10q24NCBI
Serpinf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,414,930 - 1,426,241 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,414,930 - 1,426,436 (-)NCBIChiLan1.0ChiLan1.0
SERPINF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,333,350 - 9,349,052 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,299,810 - 11,315,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,745,597 - 1,761,399 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,638,479 - 1,653,568 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,638,556 - 1,653,568 (+)Ensemblpanpan1.1panPan2
SERPINF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,891,368 - 45,902,768 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,891,410 - 45,902,765 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha945,042,116 - 45,052,600 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,718,522 - 46,730,219 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,718,590 - 46,730,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,488,488 - 45,499,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,782,914 - 45,794,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,837,469 - 45,848,807 (+)NCBIUU_Cfam_GSD_1.0
Serpinf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560245,008,093 - 45,020,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,885,475 - 7,899,113 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,885,816 - 7,898,308 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,948,510 - 47,959,470 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,949,004 - 47,959,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERPINF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,408,453 - 1,424,197 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605920,549,218 - 20,565,247 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,486,978 - 4,497,585 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,487,005 - 4,497,706 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Serpinf1
397 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1670
Count of miRNA genes:605
Interacting mature miRNAs:761
Transcripts:ENSMUST00000000769, ENSMUST00000125982, ENSMUST00000137103, ENSMUST00000138661, ENSMUST00000139403, ENSMUST00000155009, ENSMUST00000167281, ENSMUST00000168902
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301078Alcp2_malcohol preference locus 2 (mouse)Not determined117220979684731462Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
12903994Opfaq3_mopen field activity QTL 3 (mouse)117373754182069425Mouse

Markers in Region
AI195227  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381175,410,188 - 75,410,311UniSTSGRCm38
MGSCv371175,223,690 - 75,223,813UniSTSGRCm37
Celera1182,918,617 - 82,918,740UniSTS
Cytogenetic Map11B5UniSTS
Whitehead/MRC_RH11931.65UniSTS
Serpinf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B5UniSTS
cM Map11 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000000769   ⟹   ENSMUSP00000000769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,300,595 - 75,313,527 (-)Ensembl
GRCm38.p6 Ensembl1175,409,769 - 75,422,701 (-)Ensembl
Ensembl Acc Id: ENSMUST00000125982   ⟹   ENSMUSP00000126807
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,306,296 - 75,313,378 (-)Ensembl
GRCm38.p6 Ensembl1175,415,470 - 75,422,552 (-)Ensembl
Ensembl Acc Id: ENSMUST00000137103   ⟹   ENSMUSP00000114761
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,305,747 - 75,313,381 (-)Ensembl
GRCm38.p6 Ensembl1175,414,921 - 75,422,555 (-)Ensembl
Ensembl Acc Id: ENSMUST00000138661   ⟹   ENSMUSP00000121180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,304,740 - 75,313,412 (-)Ensembl
GRCm38.p6 Ensembl1175,413,914 - 75,422,586 (-)Ensembl
Ensembl Acc Id: ENSMUST00000139403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,304,799 - 75,306,021 (-)Ensembl
GRCm38.p6 Ensembl1175,413,973 - 75,415,195 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155009   ⟹   ENSMUSP00000131531
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,307,142 - 75,309,123 (-)Ensembl
GRCm38.p6 Ensembl1175,416,316 - 75,418,297 (-)Ensembl
Ensembl Acc Id: ENSMUST00000167281   ⟹   ENSMUSP00000133230
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,301,047 - 75,306,556 (-)Ensembl
GRCm38.p6 Ensembl1175,410,221 - 75,415,730 (-)Ensembl
Ensembl Acc Id: ENSMUST00000168902   ⟹   ENSMUSP00000131043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1175,300,890 - 75,308,822 (-)Ensembl
GRCm38.p6 Ensembl1175,410,064 - 75,417,996 (-)Ensembl
RefSeq Acc Id: NM_011340   ⟹   NP_035470
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391175,300,855 - 75,313,449 (-)NCBI
GRCm381175,410,029 - 75,422,623 (-)ENTREZGENE
MGSCv371175,223,531 - 75,236,125 (-)RGD
Celera1182,918,458 - 82,931,037 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035470   ⟸   NM_011340
- Peptide Label: precursor
- UniProtKB: O70629 (UniProtKB/Swiss-Prot),   O88691 (UniProtKB/Swiss-Prot),   P97298 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000126807   ⟸   ENSMUST00000125982
Ensembl Acc Id: ENSMUSP00000121180   ⟸   ENSMUST00000138661
Ensembl Acc Id: ENSMUSP00000000769   ⟸   ENSMUST00000000769
Ensembl Acc Id: ENSMUSP00000131043   ⟸   ENSMUST00000168902
Ensembl Acc Id: ENSMUSP00000133230   ⟸   ENSMUST00000167281
Ensembl Acc Id: ENSMUSP00000114761   ⟸   ENSMUST00000137103
Ensembl Acc Id: ENSMUSP00000131531   ⟸   ENSMUST00000155009
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97298-F1-model_v2 AlphaFold P97298 1-417 view protein structure

Promoters
RGD ID:6848599
Promoter ID:MM_TRO:1611
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:MTR001947.11.1643.2
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361175,229,586 - 75,230,086 (-)MPROMDB
RGD ID:6822062
Promoter ID:MM_KWN:8502
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000094022,   OTTMUST00000013988,   OTTMUST00000013989,   OTTMUST00000073520,   UC007KDQ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361175,235,799 - 75,236,299 (-)MPROMDB
RGD ID:8675534
Promoter ID:EPDNEW_M15798
Type:initiation region
Name:Serpinf1_1
Description:Mus musculus serine peptidase inhibitor, clade F, member 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381175,422,532 - 75,422,592EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108080 AgrOrtholog
Ensembl Genes ENSMUSG00000000753 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000769 ENTREZGENE
  ENSMUST00000000769.14 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
InterPro PEDF UniProtKB/Swiss-Prot
  Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report mmu:20317 UniProtKB/Swiss-Prot
MGD MGI:108080 ENTREZGENE
NCBI Gene 20317 ENTREZGENE
PANTHER PIGMENT EPITHELIUM-DERIVED FACTOR UniProtKB/Swiss-Prot
  PTHR11461 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpinf1 PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt B7ZC25_MOUSE UniProtKB/TrEMBL
  E9PWS2_MOUSE UniProtKB/TrEMBL
  E9PXR9_MOUSE UniProtKB/TrEMBL
  E9PZX2_MOUSE UniProtKB/TrEMBL
  F6S1M4_MOUSE UniProtKB/TrEMBL
  O70629 ENTREZGENE
  O88691 ENTREZGENE
  P97298 ENTREZGENE, UniProtKB/Swiss-Prot
  Q5ND37_MOUSE UniProtKB/TrEMBL
UniProt Secondary O70629 UniProtKB/Swiss-Prot
  O88691 UniProtKB/Swiss-Prot