Pomc (pro-opiomelanocortin-alpha) - Rat Genome Database

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Gene: Pomc (pro-opiomelanocortin-alpha) Mus musculus
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Symbol: Pomc
Name: pro-opiomelanocortin-alpha
RGD ID: 1331975
MGI Page MGI
Description: Enables hormone activity. Involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of oxytocin production; and response to melanocyte-stimulating hormone. Acts upstream of or within several processes, including glucose homeostasis; regulation of corticosterone secretion; and regulation of glycogen metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including alimentary system; nervous system; oviduct; skeletal musculature; and skin. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ACT; ACTH; adrenal corticotropic hormone; adrenocorticotropic hormone; alp; alph; alpha-melanocyte stimulating hormone; alpha-MSH; alphaMSH; BE; beta-endorphin; Beta-LPH; beta-M; beta-melanocyte stimulating hormone; beta-MSH; Clip; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-; Gamma-LPH; gamma-melanocyte stimulating hormone; gamma-MSH; melanotropin gamma; met-enkephalin; Npp; PO; Pomc-1; Pomc1; pro-opiomelanocortin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Pomc-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH Syndrome, Ectopic  (ISO)
acute kidney failure  (ISO)
acute kidney tubular necrosis  (ISO)
Acute Liver Failure  (ISO)
adrenal cortex disease  (ISO)
Adrenal Insufficiency  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (IEP,ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (ISO)
amnestic disorder  (ISO)
anxiety disorder  (ISO)
autistic disorder  (ISO)
Binge Drinking  (ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Bradycardia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Catalepsy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral palsy  (ISO)
cholestasis  (ISO)
chondrocalcinosis  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
Constipation  (ISO)
Cushing Syndrome  (ISO)
cystitis  (ISO)
depressive disorder  (ISO)
diabetes insipidus  (ISO)
diabetes mellitus  (ISO)
disease by infectious agent  (ISO)
disease of mental health  (ISO)
Edema  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (ISO)
Eye Pain  (ISO)
facial paralysis  (ISO)
familial Mediterranean fever  (ISO)
Femur Head Necrosis  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
heroin dependence  (ISO)
Hirsutism  (ISO)
human immunodeficiency virus infectious disease  (IEP)
Hyperalgesia  (ISO)
Hypercalciuria  (ISO)
Hypernatremia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypocalcemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
immune system disease  (ISO)
Inflammation  (IDA,IEP,ISO)
inflammatory bowel disease  (IDA,IMP)
Kidney Calculi  (ISO)
kidney disease  (ISO)
long QT syndrome  (ISO)
melanoma  (ISO)
morbid obesity  (ISO)
morphine dependence  (ISO)
morphine withdrawal syndrome  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
Myoclonic Epilepsies  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephrocalcinosis  (ISO)
Neuralgia  (ISO)
Neurogenic Inflammation  (ISO)
nicotine dependence  (ISO)
Nociceptive Pain  (IEP)
obesity  (IAGP,ISO)
Oliguria  (ISO)
opiate dependence  (ISO)
opioid abuse  (IEP)
Opsoclonus-Myoclonus Syndrome  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreas disease  (ISO)
penile disease  (ISO)
pituitary-dependent Cushing's disease  (ISO)
pneumonia  (ISO)
Postoperative Complications  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Proopiomelanocortin Deficiency  (ISO)
proteinuria  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
restless legs syndrome  (ISO)
Rhabdomyoma  (ISO)
Sacroiliitis  (ISO)
severe acute respiratory syndrome  (ISO)
sick sinus syndrome  (ISO)
Sleep Deprivation  (ISO)
sleep disorder  (ISO)
steatotic liver disease  (ISO)
stress-related disorder  (ISO)
subvalvular aortic stenosis  (ISO)
synovitis  (ISO)
Tatton-Brown-Rahman syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
Wernicke-Korsakoff syndrome  (ISO)
West syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-hex-3-en-1-ol  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
18-hydroxycortisol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hexenal  (ISO)
20-HETE  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-OH-DPAT  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinol  (ISO)
alprenolol  (ISO)
AM-251  (EXP,ISO)
ammonium chloride  (ISO)
apocynin  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Aroclor 1254  (ISO)
aspartame  (ISO)
astressin 2B  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
atropine  (ISO)
Aurothioglucose  (EXP)
benzo[a]pyrene  (ISO)
Benzylphosphonic acid  (EXP)
beta-hexachlorocyclohexane  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromocriptine  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
capsazepine  (EXP,ISO)
carbamazepine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
citalopram  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
cordycepin  (EXP)
corticosterone  (EXP,ISO)
cortisol  (ISO)
CP-96345(1+)  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deethylatrazine  (ISO)
dehydroepiandrosterone sulfate  (ISO)
deisopropylatrazine  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dichlorvos  (ISO)
diethyl hydrogen phosphate  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dinitrogen oxide  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
diprotium oxide  (ISO)
disodium cromoglycate  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
dodecane  (ISO)
dopachrome  (EXP)
dopamine  (EXP)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (ISO)
ether  (ISO)
eticlopride(1+)  (ISO)
fentanyl  (ISO)
finasteride  (ISO)
fludrocortisone  (ISO)
fluoxetine  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycerol  (ISO)
GTP  (EXP,ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (EXP,ISO)
halothane  (ISO)
herbicide  (ISO)
HET0016  (ISO)
imipramine  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
lansoprazole  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
loliolide  (EXP)
lycopene  (ISO)
magnesium atom  (ISO)
melanins  (EXP)
melatonin  (ISO)
metformin  (EXP)
methamidophos  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (ISO)
muscimol  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
naloxone  (ISO)
Naltrindole  (EXP)
naproxen  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nonane  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
olanzapine  (EXP,ISO)
Osajin  (ISO)
oxidopamine  (ISO)
paracetamol  (ISO)
Pentagastrin  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
Pomiferin  (ISO)
potassium atom  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
progesterone  (EXP,ISO)
propazine  (ISO)
propranolol  (ISO)
pyridoxal 5'-phosphate  (EXP)
quercetin  (EXP)
rabeprazole  (ISO)
reactive nitrogen species  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
Rosavin  (ISO)
ruthenium red  (EXP)
sarin  (ISO)
SB 203580  (ISO)
simazine  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP,ISO)
spironolactone  (ISO)
streptozocin  (ISO)
sufentanil  (ISO)
sumatriptan  (ISO)
superoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
theophylline  (ISO)
thimerosal  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP)
toluene  (ISO)
triadimefon  (ISO)
triamcinolone  (ISO)
triclosan  (ISO)
trilostane  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
water  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
altered energy homeostasis pathway  (ISO)
altered melanocortin system pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway   (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
obesity pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alcohol consumption  (IAGP)
abnormal behavior  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal body weight  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal hair follicle pheomelanosome pheomelanin content  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal operant conditioning behavior  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spleen morphology  (IEA)
abnormal touch/ nociception  (IAGP)
absent adrenal gland  (IAGP)
decreased adrenal gland zona fasciculata size  (IAGP)
decreased adrenocorticotropin level  (IAGP)
decreased circulating adrenaline level  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased compensatory feeding amount  (IAGP)
decreased food intake  (IAGP)
decreased locomotor activity  (IAGP)
decreased oxygen consumption  (IAGP)
decreased response to leptin  (IAGP)
diluted coat color  (IAGP)
disorganized adrenal gland zona fasciculata  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged spleen  (IEA)
hepatic steatosis  (IAGP)
hyperactivity elicited by ethanol administration  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired glucose tolerance  (IAGP)
increased adrenal gland zona fasciculata size  (IAGP)
increased aggression towards mice  (IAGP)
increased alcohol consumption  (IAGP)
increased body fat mass  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased dopamine level  (IAGP)
increased fat cell size  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased lean body mass  (IAGP)
increased liver weight  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased renal fat pad weight  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine adrenaline level  (IAGP)
insulin resistance  (IAGP)
obese  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polyphagia  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
small adrenal glands  (IAGP)
yellow coat color  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring. Al-Yasari A, etal., Endocrinology. 2021 Jan 1;162(1):bqaa188. doi: 10.1210/endocr/bqaa188.
2. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Bettenworth D, etal., Am J Pathol. 2011 Sep;179(3):1230-42. Epub 2011 Jul 8.
3. Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. Cakir I, etal., J Biol Chem. 2013 Jun 14;288(24):17675-88. doi: 10.1074/jbc.M113.475343. Epub 2013 May 2.
4. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Calvino C, etal., Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.
5. Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. Chen CP, etal., J Neurochem. 2004 Mar;88(6):1547-54. doi: 10.1046/j.1471-4159.2003.02300.x.
6. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Chen CP, etal., J Neurochem. 2006 May;97(4):1026-33. doi: 10.1111/j.1471-4159.2006.03839.x.
7. Opioid system genes in alcoholism: a case-control study in Croatian population. Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
8. Enhanced activity of the brain beta-endorphin system by free-choice ethanol drinking in C57BL/6 but not DBA/2 mice. De Waele JP and Gianoulakis C, Eur J Pharmacol. 1994 Jun 2;258(1-2):119-29. doi: 10.1016/0014-2999(94)90064-7.
9. Congenital vasopressin deficiency and acute and chronic opiate effects on hypothalamo-pituitary-adrenal axis activity in Brattleboro rats. Domokos A, etal., J Endocrinol. 2008 Jan;196(1):113-21. doi: 10.1677/JOE-07-0356.
10. Plasma levels of beta-endorphin, adrenocorticotropic hormone and cortisol during early and late alcohol withdrawal. Esel E, etal., Alcohol Alcohol. 2001 Nov-Dec;36(6):572-6. doi: 10.1093/alcalc/36.6.572.
11. Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons. Fitting S, etal., Am J Pathol. 2010 Sep;177(3):1397-410. doi: 10.2353/ajpath.2010.090945. Epub 2010 Jul 22.
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13. Transgenerational inheritance of fetal alcohol effects on proopiomelanocortin gene expression and methylation, cortisol response to stress, and anxiety-like behaviors in offspring for three generations in rats: Evidence for male germline transmission. Gangisetty O, etal., PLoS One. 2022 Feb 10;17(2):e0263340. doi: 10.1371/journal.pone.0263340. eCollection 2022.
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29. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
30. MGDs mouse GO annotations MGD data from the GO Consortium
31. MGD IEA MGD IEA
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37. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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46. Mouse MP Annotation Import Pipeline RGD automated import pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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68. Reduced hypothalamic POMC and anterior pituitary CRF1 receptor mRNA levels after acute, but not chronic, daily "binge" intragastric alcohol administration. Zhou Y, etal., Alcohol Clin Exp Res. 2000 Oct;24(10):1575-82.
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Genomics

Comparative Map Data
Pomc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
POMC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,160,860 - 25,168,580 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,160,853 - 25,168,903 (-)EnsemblGRCh38hg38GRCh38
GRCh37225,383,729 - 25,391,449 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,237,226 - 25,245,063 (-)NCBINCBI36Build 36hg18NCBI36
Build 34225,295,438 - 25,303,103NCBI
Celera225,224,014 - 25,231,854 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,121,466 - 25,129,306 (-)NCBIHuRef
CHM1_1225,313,607 - 25,321,447 (-)NCBICHM1_1
T2T-CHM13v2.0225,195,313 - 25,203,034 (-)NCBIT2T-CHM13v2.0
Pomc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,659,137 - 32,665,175 (+)NCBIGRCr8
mRatBN7.2626,939,844 - 26,945,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,232,130 - 27,237,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,548,037 - 27,553,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,026,040 - 27,031,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,382,937 - 28,388,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,191,989 - 38,197,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,931,969 - 26,937,789 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,934,921 - 26,940,742 (+)NCBI
Celera626,415,706 - 26,421,526 (+)NCBICelera
RH 3.4 Map6117.99RGD
Cytogenetic Map6q14NCBI
Pomc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,217,363 - 7,220,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,217,233 - 7,220,401 (-)NCBIChiLan1.0ChiLan1.0
POMC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,353,171 - 101,357,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,357,136 - 101,361,068 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,161,668 - 25,165,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,258,768 - 25,266,806 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,258,768 - 25,262,706 (-)Ensemblpanpan1.1panPan2
POMC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,431,396 - 19,438,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,431,585 - 19,434,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,328,041 - 19,334,822 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,706,608 - 19,713,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,706,796 - 19,714,128 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,440,669 - 19,447,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,450,362 - 19,457,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,496,844 - 19,503,629 (-)NCBIUU_Cfam_GSD_1.0
Pomc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,774,289 - 63,781,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,061,587 - 7,065,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,060,747 - 7,065,276 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POMC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,661,004 - 113,670,418 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,766,352 - 120,772,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POMC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,491,296 - 82,499,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,494,323 - 82,499,447 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604529,662,185 - 29,670,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pomc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,442,292 - 7,445,020 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,442,223 - 7,448,513 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pomc
182 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:159
Interacting mature miRNAs:173
Transcripts:ENSMUST00000020990
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse

Markers in Region
RH130758  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,960,241 - 3,960,447UniSTSGRCm38
GRCm381915,362,539 - 15,362,745UniSTSGRCm38
MGSCv371915,437,029 - 15,437,235UniSTSGRCm37
MGSCv37123,960,241 - 3,960,447UniSTSGRCm37
Celera123,887,980 - 3,888,186UniSTS
Celera1916,019,701 - 16,019,907UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map12A1.1UniSTS
cM Map199.0UniSTS
Pomc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.1UniSTS
cM Map124.0UniSTS
Pomc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001278581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW120866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB022229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB022936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB025409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB026464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020990   ⟹   ENSMUSP00000020990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,642 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218089   ⟹   ENSMUSP00000151367
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,618 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,618 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218169   ⟹   ENSMUSP00000151769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,969 - 4,009,998 (+)Ensembl
GRCm38.p6 Ensembl123,954,969 - 3,959,998 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219543   ⟹   ENSMUSP00000151504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,573 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,573 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220006   ⟹   ENSMUSP00000151450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,970 - 4,008,260 (+)Ensembl
GRCm38.p6 Ensembl123,954,970 - 3,958,260 (+)Ensembl
RefSeq Acc Id: NM_001278581   ⟹   NP_001265510
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278582   ⟹   NP_001265511
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278583   ⟹   NP_001265512
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278584   ⟹   NP_001265513
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008895   ⟹   NP_032921
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
MGSCv37123,954,951 - 3,960,618 (+)RGD
Celera123,882,688 - 3,888,382 (+)NCBI
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001265510 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265511 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265512 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265513 (Get FASTA)   NCBI Sequence Viewer  
  NP_032921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37169 (Get FASTA)   NCBI Sequence Viewer  
  AAB59729 (Get FASTA)   NCBI Sequence Viewer  
  AAH61215 (Get FASTA)   NCBI Sequence Viewer  
  BAB30771 (Get FASTA)   NCBI Sequence Viewer  
  BAB30818 (Get FASTA)   NCBI Sequence Viewer  
  BAC27095 (Get FASTA)   NCBI Sequence Viewer  
  BAC36795 (Get FASTA)   NCBI Sequence Viewer  
  BAE21739 (Get FASTA)   NCBI Sequence Viewer  
  BAE21764 (Get FASTA)   NCBI Sequence Viewer  
  BAE21815 (Get FASTA)   NCBI Sequence Viewer  
  BAE21833 (Get FASTA)   NCBI Sequence Viewer  
  BAE21850 (Get FASTA)   NCBI Sequence Viewer  
  CAA24769 (Get FASTA)   NCBI Sequence Viewer  
  CAA24770 (Get FASTA)   NCBI Sequence Viewer  
  EDL01382 (Get FASTA)   NCBI Sequence Viewer  
  EDL01383 (Get FASTA)   NCBI Sequence Viewer  
  EDL01384 (Get FASTA)   NCBI Sequence Viewer  
  EDL01385 (Get FASTA)   NCBI Sequence Viewer  
  EDL01386 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020990
  ENSMUSP00000020990.6
  ENSMUSP00000151367
  ENSMUSP00000151367.2
  ENSMUSP00000151450.2
  ENSMUSP00000151504
  ENSMUSP00000151504.2
  ENSMUSP00000151769.2
GenBank Protein P01193 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032921   ⟸   NM_008895
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265510   ⟸   NM_001278581
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265511   ⟸   NM_001278582
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265512   ⟸   NM_001278583
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265513   ⟸   NM_001278584
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000151769   ⟸   ENSMUST00000218169
Ensembl Acc Id: ENSMUSP00000151367   ⟸   ENSMUST00000218089
Ensembl Acc Id: ENSMUSP00000020990   ⟸   ENSMUST00000020990
Ensembl Acc Id: ENSMUSP00000151504   ⟸   ENSMUST00000219543
Ensembl Acc Id: ENSMUSP00000151450   ⟸   ENSMUST00000220006
Protein Domains
Pro-opiomelanocortin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01193-F1-model_v2 AlphaFold P01193 1-235 view protein structure

Promoters
RGD ID:6849974
Promoter ID:EP25007
Type:single initiation site
Name:MM_COLI
Description:Proopiomelanocortin, adrenocorticotropic hormone/beta lipotropichormone, POMC or POMC1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 136; Mammalian POMC
Tissues & Cell Lines:CNS, pituitary
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA; experiments performed with; closely related gene
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37123,954,951 - 3,955,011EPD
MGSCv36123,954,951 - 3,955,011EPD
RGD ID:8677826
Promoter ID:EPDNEW_M16944
Type:multiple initiation site
Name:Pomc_1
Description:Mus musculus pro-opiomelanocortin-alpha , transcript variant5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38123,954,951 - 3,955,011EPDNEW
RGD ID:6849008
Promoter ID:MM_XEF:1440
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001011318,   NM_001031098,   NM_001032985,   NM_001087369,   NM_001163390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,959,836 - 3,960,336 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97742 AgrOrtholog
Ensembl Genes ENSMUSG00000020660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020990 ENTREZGENE
  ENSMUST00000020990.7 UniProtKB/Swiss-Prot
  ENSMUST00000218089 ENTREZGENE
  ENSMUST00000218089.2 UniProtKB/Swiss-Prot
  ENSMUST00000218169.2 UniProtKB/TrEMBL
  ENSMUST00000219543 ENTREZGENE
  ENSMUST00000219543.2 UniProtKB/Swiss-Prot
  ENSMUST00000220006.2 UniProtKB/TrEMBL
InterPro Mcrtin_ACTH_cent UniProtKB/Swiss-Prot
  Melanocortin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opioid_neuropept UniProtKB/Swiss-Prot
  PMOC UniProtKB/Swiss-Prot
  POMC-derived_peptides UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18976 UniProtKB/Swiss-Prot
MGD MGI:97742 ENTREZGENE
NCBI Gene 18976 ENTREZGENE
PANTHER PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
  PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
  PRO-OPIOMELANOCORTIN UniProtKB/TrEMBL
  PRO-OPIOMELANOCORTIN UniProtKB/TrEMBL
Pfam ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Op_neuropeptide UniProtKB/Swiss-Prot
PharmGKB POMC RGD
PhenoGen Pomc PhenoGen
PRINTS MELANOCORTIN UniProtKB/Swiss-Prot
SMART ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Op_neuropeptide UniProtKB/Swiss-Prot
UniProt A0A1W2P724_MOUSE UniProtKB/TrEMBL
  A0A1W2P7R2_MOUSE UniProtKB/TrEMBL
  COLI_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P01200 ENTREZGENE
  Q544U4 ENTREZGENE
UniProt Secondary P01200 UniProtKB/Swiss-Prot
  Q544U4 UniProtKB/Swiss-Prot