Pomc (pro-opiomelanocortin-alpha) - Rat Genome Database

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Gene: Pomc (pro-opiomelanocortin-alpha) Mus musculus
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Symbol: Pomc
Name: pro-opiomelanocortin-alpha
RGD ID: 1331975
MGI Page MGI
Description: Enables hormone activity. Involved in positive regulation of cAMP-mediated signaling; positive regulation of oxytocin production; and response to melanocyte-stimulating hormone. Acts upstream of or within several processes, including glucose homeostasis; regulation of corticosterone secretion; and regulation of glycogen metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including alimentary system; nervous system; oviduct; skeletal musculature; and skin. Used to study obesity. Human ortholog(s) of this gene implicated in familial mediterranean fever; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ACT; ACTH; adrenal corticotropic hormone; adrenocorticotropic hormone; alp; alph; alpha-melanocyte stimulating hormone; alpha-MSH; alphaMSH; BE; beta-endorphin; Beta-LPH; beta-M; beta-melanocyte stimulating hormone; beta-MSH; Clip; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-; Gamma-LPH; gamma-melanocyte stimulating hormone; gamma-MSH; melanotropin gamma; met-enkephalin; Npp; PO; Pomc-1; Pomc1; pro-opiomelanocortin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Pomc-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ACTH Syndrome, Ectopic  (ISO)
acute kidney failure  (ISO)
acute kidney tubular necrosis  (ISO)
Acute Liver Failure  (ISO)
adrenal cortex disease  (ISO)
Adrenal Insufficiency  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
amnestic disorder  (ISO)
autistic disorder  (ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Bradycardia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Catalepsy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral palsy  (ISO)
cholestasis  (ISO)
chondrocalcinosis  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
Constipation  (ISO)
Cushing Syndrome  (ISO)
cystitis  (ISO)
depressive disorder  (ISO)
diabetes insipidus  (ISO)
diabetes mellitus  (ISO)
disease by infectious agent  (ISO)
disease of mental health  (ISO)
Edema  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (ISO)
Eye Pain  (ISO)
facial paralysis  (ISO)
familial mediterranean fever  (ISO)
Femur Head Necrosis  (ISO)
Fever  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
heroin dependence  (ISO)
Hirsutism  (ISO)
Hypercalciuria  (ISO)
Hypernatremia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypocalcemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
immune system disease  (ISO)
Inflammation  (IDA,IEP)
inflammatory bowel disease  (IDA,IMP)
Kidney Calculi  (ISO)
kidney disease  (ISO)
long QT syndrome  (ISO)
melanoma  (ISO)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
Myoclonic Epilepsies  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephrocalcinosis  (ISO)
Neurogenic Inflammation  (ISO)
Nociceptive Pain  (IEP)
obesity  (IAGP,ISO)
Oliguria  (ISO)
opioid abuse  (IEP)
Opsoclonus-Myoclonus Syndrome  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreas disease  (ISO)
penile disease  (ISO)
pituitary-dependent Cushing's disease  (ISO)
pneumonia  (ISO)
Postoperative Complications  (ISO)
Proopiomelanocortin Deficiency  (ISO)
proteinuria  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
restless legs syndrome  (ISO)
Rhabdomyoma  (ISO)
Sacroiliitis  (ISO)
severe acute respiratory syndrome  (ISO)
sick sinus syndrome  (ISO)
sleep disorder  (ISO)
steatotic liver disease  (ISO)
stress-related disorder  (ISO)
subvalvular aortic stenosis  (ISO)
synovitis  (ISO)
Tatton-Brown-Rahman syndrome  (ISO)
urinary tract infection  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
West syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-hex-3-en-1-ol  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
18-hydroxycortisol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hexenal  (ISO)
20-HETE  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-OH-DPAT  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinol  (ISO)
AM-251  (EXP,ISO)
ammonium chloride  (ISO)
apocynin  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Aroclor 1254  (ISO)
aspartame  (ISO)
astressin 2B  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
atropine  (ISO)
Aurothioglucose  (EXP)
benzo[a]pyrene  (ISO)
Benzylphosphonic acid  (EXP)
beta-hexachlorocyclohexane  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromocriptine  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
capsazepine  (EXP,ISO)
carbamazepine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
citalopram  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
cordycepin  (EXP)
corticosterone  (EXP,ISO)
cortisol  (ISO)
CP-96345(1+)  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deethylatrazine  (ISO)
dehydroepiandrosterone sulfate  (ISO)
deisopropylatrazine  (ISO)
dexamethasone  (ISO)
dichlorvos  (ISO)
diethyl hydrogen phosphate  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dinitrogen oxide  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
diprotium oxide  (ISO)
disodium cromoglycate  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
dodecane  (ISO)
dopachrome  (EXP)
dopamine  (EXP)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (ISO)
ether  (ISO)
eticlopride(1+)  (ISO)
fentanyl  (ISO)
finasteride  (ISO)
fludrocortisone  (ISO)
fluoxetine  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycerol  (ISO)
GTP  (EXP,ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (EXP,ISO)
halothane  (ISO)
herbicide  (ISO)
HET0016  (ISO)
imipramine  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
lansoprazole  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
loliolide  (EXP)
lycopene  (ISO)
magnesium atom  (ISO)
melanins  (EXP)
melatonin  (ISO)
metformin  (EXP)
methamidophos  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (ISO)
muscimol  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
naloxone  (ISO)
Naltrindole  (EXP)
naproxen  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nonane  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
olanzapine  (EXP,ISO)
Osajin  (ISO)
oxidopamine  (ISO)
paracetamol  (ISO)
Pentagastrin  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phentolamine  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
Pomiferin  (ISO)
potassium atom  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
progesterone  (EXP,ISO)
propazine  (ISO)
pyridoxal 5'-phosphate  (EXP)
quercetin  (EXP)
rabeprazole  (ISO)
reactive nitrogen species  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
Rosavin  (ISO)
ruthenium red  (EXP)
sarin  (ISO)
SB 203580  (ISO)
simazine  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP,ISO)
spironolactone  (ISO)
streptozocin  (ISO)
sufentanil  (ISO)
sumatriptan  (ISO)
superoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
theophylline  (ISO)
thimerosal  (EXP)
thioacetamide  (EXP,ISO)
toluene  (ISO)
triadimefon  (ISO)
triamcinolone  (ISO)
triclosan  (ISO)
trilostane  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
water  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
altered energy homeostasis pathway  (ISO)
altered melanocortin system pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway   (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
obesity pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alcohol consumption  (IAGP)
abnormal behavior  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal body weight  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal hair follicle pheomelanosome pheomelanin content  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal operant conditioning behavior  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spleen morphology  (IEA)
abnormal touch/ nociception  (IAGP)
absent adrenal gland  (IAGP)
decreased adrenal gland zona fasciculata size  (IAGP)
decreased adrenocorticotropin level  (IAGP)
decreased circulating adrenaline level  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased compensatory feeding amount  (IAGP)
decreased food intake  (IAGP)
decreased locomotor activity  (IAGP)
decreased oxygen consumption  (IAGP)
diluted coat color  (IAGP)
disorganized adrenal gland zona fasciculata  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged spleen  (IEA)
hepatic steatosis  (IAGP)
hyperactivity elicited by ethanol administration  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired glucose tolerance  (IAGP)
increased adrenal gland zona fasciculata size  (IAGP)
increased aggression towards mice  (IAGP)
increased alcohol consumption  (IAGP)
increased body fat mass  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased dopamine level  (IAGP)
increased fat cell size  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased lean body mass  (IAGP)
increased liver weight  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased renal fat pad weight  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to weight gain  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine adrenaline level  (IAGP)
insulin resistance  (IAGP)
obese  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polyphagia  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
small adrenal glands  (IAGP)
yellow coat color  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Bettenworth D, etal., Am J Pathol. 2011 Sep;179(3):1230-42. Epub 2011 Jul 8.
2. Opioid system genes in alcoholism: a case-control study in Croatian population. Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
3. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
4. Antiinflammatory activity of a COOH-terminal fragment of the neuropeptide alpha-MSH. Hiltz ME and Lipton JM, FASEB J. 1989 Sep;3(11):2282-4.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Spatial and temporal localization of the melanocortin 1 receptor and its ligand alpha-melanocyte-stimulating hormone during cutaneous wound repair. Muffley LA, etal., J Histochem Cytochem. 2011 Mar;59(3):278-88. Epub 2011 Jan 12.
9. Decreased immunoreactivity of the melanocortin neuropeptide alpha-melanocyte-stimulating hormone (alpha-MSH) after chronic ethanol exposure in Sprague-Dawley rats. Navarro M, etal., Alcohol Clin Exp Res. 2008 Feb;32(2):266-76. doi: 10.1111/j.1530-0277.2007.00578.x. Epub 2007 Dec 21.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. Pritchard LE, etal., J Endocrinol 2002 Mar;172(3):411-21.
14. alpha-MSH modulates experimental inflammatory bowel disease. Rajora N, etal., Peptides. 1997;18(3):381-5.
15. Mouse MP Annotation Import Pipeline RGD automated import pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. The critical role of the melanocortin system in the control of energy balance. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
19. Differential cross-tolerance development between single and repeated immobilization stress on the antinociceptive effect induced by beta-endorphin, 5-hydroxytryptamine, morphine, and WIN55,212-2 in the inflammatory mouse pain mode. Seo YJ, etal., Arch Pharm Res. 2011 Feb;34(2):269-80. Epub 2011 Mar 6.
20. Inhibition of cartilage damage by pro-opiomelanocortin prohormone overexpression in a rat model of osteoarthritis. Shen PC, etal., Exp Biol Med (Maywood). 2011 Mar 1;236(3):334-40. Epub 2011 Mar 4.
21. Neuroendocrine immune system in familial Mediterranean fever. Topaloglu R, etal., Turk J Pediatr. 2010 Nov-Dec;52(6):588-93.
22. Endocrine cells of the adenohypophysis in severe acute respiratory syndrome (SARS). Wei L, etal., Biochem Cell Biol. 2010 Aug;88(4):723-30. doi: 10.1139/O10-022.
23. Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis. Zhang Y, etal., Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.
24. Analgesic effect of different moxibustion durations in rheumatoid arthritis rats. Zheng B, etal., J Tradit Chin Med. 2014 Feb;34(1):90-5. doi: 10.1016/s0254-6272(14)60060-1.
Additional References at PubMed
PMID:221916   PMID:1329576   PMID:1378571   PMID:1482099   PMID:1508198   PMID:1673105   PMID:1689057   PMID:1769649   PMID:1922066   PMID:2536749   PMID:2575583   PMID:6129251  
PMID:6177687   PMID:6303853   PMID:6308009   PMID:7476975   PMID:7624521   PMID:7626792   PMID:7631421   PMID:7789336   PMID:7829983   PMID:7830793   PMID:7835908   PMID:7873877  
PMID:7984050   PMID:8027530   PMID:8051085   PMID:8093672   PMID:8130374   PMID:8143900   PMID:8185570   PMID:8284022   PMID:8309633   PMID:8389457   PMID:8392702   PMID:8397485  
PMID:8543156   PMID:8554527   PMID:8600981   PMID:8633004   PMID:8638120   PMID:8675014   PMID:8889548   PMID:8923471   PMID:8934515   PMID:8972488   PMID:8987796   PMID:9090387  
PMID:9105908   PMID:9118797   PMID:9140088   PMID:9229117   PMID:9441737   PMID:9463347   PMID:9519731   PMID:9573646   PMID:9620855   PMID:9677380   PMID:9726280   PMID:9746745  
PMID:9784500   PMID:9822156   PMID:9824688   PMID:9873204   PMID:10023025   PMID:10049363   PMID:10067870   PMID:10321434   PMID:10349636   PMID:10433800   PMID:10436066   PMID:10448196  
PMID:10451227   PMID:10465256   PMID:10470087   PMID:10498698   PMID:10499586   PMID:10546682   PMID:10559399   PMID:10588713   PMID:10623776   PMID:10628753   PMID:10861000   PMID:11042159  
PMID:11070424   PMID:11076861   PMID:11078460   PMID:11113319   PMID:11152636   PMID:11217851   PMID:11242080   PMID:11290323   PMID:11290325   PMID:11340336   PMID:11447259   PMID:11487609  
PMID:11687289   PMID:11731482   PMID:11807026   PMID:11852092   PMID:12130660   PMID:12142539   PMID:12153463   PMID:12183375   PMID:12223579   PMID:12438160   PMID:12443978   PMID:12458044  
PMID:12466851   PMID:12477932   PMID:12488365   PMID:12637208   PMID:12651892   PMID:12697680   PMID:12817018   PMID:12823859   PMID:12834911   PMID:12851316   PMID:12851317   PMID:12851327  
PMID:12859669   PMID:12907761   PMID:12914931   PMID:12970157   PMID:14578285   PMID:14580937   PMID:14644465   PMID:14645373   PMID:14681479   PMID:14711817   PMID:14722621   PMID:14732396  
PMID:15037319   PMID:15063754   PMID:15070780   PMID:15231703   PMID:15280541   PMID:15358786   PMID:15365214   PMID:15388297   PMID:15459176   PMID:15467755   PMID:15481808   PMID:15489334  
PMID:15564334   PMID:15591534   PMID:15661635   PMID:15666790   PMID:15701640   PMID:15718277   PMID:15731356   PMID:15761027   PMID:15798195   PMID:15813947   PMID:15841184   PMID:16043482  
PMID:16046291   PMID:16099070   PMID:16109736   PMID:16125819   PMID:16141072   PMID:16141073   PMID:16219686   PMID:16243970   PMID:16388118   PMID:16440060   PMID:16469766   PMID:16484322  
PMID:16556738   PMID:16601142   PMID:16602821   PMID:16678101   PMID:16840533   PMID:16840539   PMID:16887279   PMID:16899584   PMID:16914086   PMID:16920405   PMID:16931689   PMID:16959830  
PMID:17015435   PMID:17023536   PMID:17049174   PMID:17095588   PMID:17202473   PMID:17261674   PMID:17349749   PMID:17359964   PMID:17367776   PMID:17374695   PMID:17392792   PMID:17426285  
PMID:17467916   PMID:17592030   PMID:17632507   PMID:17652101   PMID:17698954   PMID:17717049   PMID:17717072   PMID:17728716   PMID:17873059   PMID:17909095   PMID:17989225   PMID:17991729  
PMID:17997230   PMID:18037398   PMID:18057101   PMID:18077674   PMID:18162515   PMID:18162531   PMID:18262361   PMID:18272476   PMID:18280051   PMID:18287559   PMID:18323674   PMID:18351662  
PMID:18359165   PMID:18382766   PMID:18388149   PMID:18396135   PMID:18439911   PMID:18495683   PMID:18550896   PMID:18559987   PMID:18775421   PMID:18849346   PMID:18930089   PMID:18996108  
PMID:19017526   PMID:19036902   PMID:19049975   PMID:19074037   PMID:19093031   PMID:19139274   PMID:19376143   PMID:19389708   PMID:19469902   PMID:19490636   PMID:19523439   PMID:19570576  
PMID:19733236   PMID:19737523   PMID:19809495   PMID:19864580   PMID:19889022   PMID:19900438   PMID:19923853   PMID:19934378   PMID:19994794   PMID:20008041   PMID:20032198   PMID:20071607  
PMID:20097762   PMID:20103739   PMID:20118198   PMID:20160350   PMID:20164094   PMID:20299824   PMID:20348924   PMID:20384608   PMID:20385224   PMID:20431921   PMID:20436479   PMID:20533364  
PMID:20593419   PMID:20805495   PMID:20807761   PMID:20934421   PMID:21050473   PMID:21074524   PMID:21084383   PMID:21184805   PMID:21193556   PMID:21195130   PMID:21247964   PMID:21262217  
PMID:21267068   PMID:21363936   PMID:21406615   PMID:21408198   PMID:21544212   PMID:21586695   PMID:21622576   PMID:21636786   PMID:21677750   PMID:21781958   PMID:21828248   PMID:21832120  
PMID:21846903   PMID:21873635   PMID:21876128   PMID:21895774   PMID:21972008   PMID:22008794   PMID:22166984   PMID:22201680   PMID:22210743   PMID:22319636   PMID:22326958   PMID:22421044  
PMID:22764240   PMID:22791713   PMID:22844247   PMID:22871966   PMID:22945632   PMID:22952458   PMID:22962254   PMID:23070814   PMID:23093774   PMID:23143598   PMID:23150495   PMID:23197713  
PMID:23274904   PMID:23283339   PMID:23284914   PMID:23288907   PMID:23337531   PMID:23341784   PMID:23370526   PMID:23386640   PMID:23430746   PMID:23493373   PMID:23503677   PMID:23640796  
PMID:23649822   PMID:23674600   PMID:23676213   PMID:23689030   PMID:23720397   PMID:23754801   PMID:23762150   PMID:23823479   PMID:23842677   PMID:23871693   PMID:23884446   PMID:24046867  
PMID:24134870   PMID:24205339   PMID:24227653   PMID:24376791   PMID:24412703   PMID:24477539   PMID:24506071   PMID:24673559   PMID:24797626   PMID:24829220   PMID:24855103   PMID:24949966  
PMID:24952961   PMID:25045707   PMID:25051442   PMID:25085924   PMID:25096581   PMID:25105693   PMID:25127258   PMID:25184992   PMID:25281401   PMID:25315894   PMID:25462585   PMID:25505333  
PMID:25510553   PMID:25585051   PMID:25594696   PMID:25605944   PMID:25671638   PMID:25825735   PMID:25855171   PMID:25864637   PMID:25907274   PMID:25936720   PMID:26075743   PMID:26358220  
PMID:26467632   PMID:26563310   PMID:26631960   PMID:26651607   PMID:26740662   PMID:26764381   PMID:26812162   PMID:26961412   PMID:26977396   PMID:27063791   PMID:27077912   PMID:27079169  
PMID:27080622   PMID:27093227   PMID:27184910   PMID:27209204   PMID:27212025   PMID:27226320   PMID:27564454   PMID:27578785   PMID:27616671   PMID:27626668   PMID:27631552   PMID:27689000  
PMID:27717825   PMID:27810956   PMID:27819350   PMID:27829153   PMID:27869800   PMID:27871073   PMID:28190775   PMID:28406939   PMID:28429261   PMID:28506993   PMID:28514752   PMID:28667175  
PMID:28706241   PMID:28807898   PMID:28821664   PMID:28904020   PMID:28911172   PMID:28911199   PMID:28928140   PMID:28938441   PMID:29031711   PMID:29031726   PMID:29040444   PMID:29180744  
PMID:29226825   PMID:29316344   PMID:29351427   PMID:29392534   PMID:29528284   PMID:29578405   PMID:29590552   PMID:29751050   PMID:29795232   PMID:29796621   PMID:29878108   PMID:29972793  
PMID:30040980   PMID:30063881   PMID:30085028   PMID:30146485   PMID:30283405   PMID:30291164   PMID:30307151   PMID:30307165   PMID:30311908   PMID:30535142   PMID:30541071   PMID:30673296  
PMID:30811539   PMID:30886014   PMID:30957016   PMID:30997487   PMID:31420539   PMID:31467425   PMID:31481663   PMID:31597102   PMID:31781038   PMID:31913463   PMID:32027603   PMID:32180559  
PMID:32213554   PMID:32244188   PMID:32302532   PMID:32311511   PMID:32313051   PMID:32315606   PMID:32325033   PMID:32453714   PMID:32585252   PMID:32694784   PMID:32722640   PMID:32803714  
PMID:33108146   PMID:33144604   PMID:33152456   PMID:33181265   PMID:33188191   PMID:33248443   PMID:33431871   PMID:33462216   PMID:33600763   PMID:33772537   PMID:33788980   PMID:33795686  
PMID:33887179   PMID:34072036   PMID:34288113   PMID:34324439   PMID:34329773   PMID:34564702   PMID:34626854   PMID:34644574   PMID:34730112   PMID:34905510   PMID:34971379   PMID:35044906  
PMID:35049495   PMID:35652338   PMID:35951005   PMID:36374777   PMID:36473997   PMID:36581316   PMID:36619565   PMID:36800350   PMID:36965574   PMID:37091593   PMID:37168577   PMID:37699899  
PMID:37741556   PMID:38224819  


Genomics

Comparative Map Data
Pomc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
POMC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,160,860 - 25,168,580 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,160,853 - 25,168,903 (-)EnsemblGRCh38hg38GRCh38
GRCh37225,383,729 - 25,391,449 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,237,226 - 25,245,063 (-)NCBINCBI36Build 36hg18NCBI36
Build 34225,295,438 - 25,303,103NCBI
Celera225,224,014 - 25,231,854 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,121,466 - 25,129,306 (-)NCBIHuRef
CHM1_1225,313,607 - 25,321,447 (-)NCBICHM1_1
T2T-CHM13v2.0225,195,313 - 25,203,034 (-)NCBIT2T-CHM13v2.0
Pomc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,659,137 - 32,665,175 (+)NCBIGRCr8
mRatBN7.2626,939,844 - 26,945,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,232,130 - 27,237,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,548,037 - 27,553,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,026,040 - 27,031,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,382,937 - 28,388,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,191,989 - 38,197,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,931,969 - 26,937,789 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,934,921 - 26,940,742 (+)NCBI
Celera626,415,706 - 26,421,526 (+)NCBICelera
RH 3.4 Map6117.99RGD
Cytogenetic Map6q14NCBI
Pomc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,217,363 - 7,220,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,217,233 - 7,220,401 (-)NCBIChiLan1.0ChiLan1.0
POMC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,353,171 - 101,357,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,357,136 - 101,361,068 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,161,668 - 25,165,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,258,768 - 25,266,806 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,258,768 - 25,262,706 (-)Ensemblpanpan1.1panPan2
POMC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,431,396 - 19,438,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,431,585 - 19,434,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,328,041 - 19,334,822 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,706,608 - 19,713,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,706,796 - 19,714,128 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,440,669 - 19,447,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,450,362 - 19,457,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,496,844 - 19,503,629 (-)NCBIUU_Cfam_GSD_1.0
Pomc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,774,289 - 63,781,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,061,587 - 7,065,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,060,747 - 7,065,276 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POMC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,661,004 - 113,670,418 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,766,352 - 120,772,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POMC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,491,296 - 82,499,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,494,323 - 82,499,447 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604529,662,185 - 29,670,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pomc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,442,292 - 7,445,020 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,442,223 - 7,448,513 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pomc
182 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:159
Interacting mature miRNAs:173
Transcripts:ENSMUST00000020990
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse

Markers in Region
RH130758  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,960,241 - 3,960,447UniSTSGRCm38
GRCm381915,362,539 - 15,362,745UniSTSGRCm38
MGSCv371915,437,029 - 15,437,235UniSTSGRCm37
MGSCv37123,960,241 - 3,960,447UniSTSGRCm37
Celera123,887,980 - 3,888,186UniSTS
Celera1916,019,701 - 16,019,907UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map12A1.1UniSTS
cM Map199.0UniSTS
Pomc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.1UniSTS
cM Map124.0UniSTS
Pomc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001278581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW120866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB022229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB022936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB025409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB026464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000020990   ⟹   ENSMUSP00000020990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,642 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218089   ⟹   ENSMUSP00000151367
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,618 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,618 (+)Ensembl
RefSeq Acc Id: ENSMUST00000218169   ⟹   ENSMUSP00000151769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,969 - 4,009,998 (+)Ensembl
GRCm38.p6 Ensembl123,954,969 - 3,959,998 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219543   ⟹   ENSMUSP00000151504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,573 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,573 (+)Ensembl
RefSeq Acc Id: ENSMUST00000220006   ⟹   ENSMUSP00000151450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,970 - 4,008,260 (+)Ensembl
GRCm38.p6 Ensembl123,954,970 - 3,958,260 (+)Ensembl
RefSeq Acc Id: NM_001278581   ⟹   NP_001265510
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278582   ⟹   NP_001265511
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278583   ⟹   NP_001265512
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278584   ⟹   NP_001265513
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008895   ⟹   NP_032921
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
MGSCv37123,954,951 - 3,960,618 (+)RGD
Celera123,882,688 - 3,888,382 (+)NCBI
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001265510 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265511 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265512 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265513 (Get FASTA)   NCBI Sequence Viewer  
  NP_032921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37169 (Get FASTA)   NCBI Sequence Viewer  
  AAB59729 (Get FASTA)   NCBI Sequence Viewer  
  AAH61215 (Get FASTA)   NCBI Sequence Viewer  
  BAB30771 (Get FASTA)   NCBI Sequence Viewer  
  BAB30818 (Get FASTA)   NCBI Sequence Viewer  
  BAC27095 (Get FASTA)   NCBI Sequence Viewer  
  BAC36795 (Get FASTA)   NCBI Sequence Viewer  
  BAE21739 (Get FASTA)   NCBI Sequence Viewer  
  BAE21764 (Get FASTA)   NCBI Sequence Viewer  
  BAE21815 (Get FASTA)   NCBI Sequence Viewer  
  BAE21833 (Get FASTA)   NCBI Sequence Viewer  
  BAE21850 (Get FASTA)   NCBI Sequence Viewer  
  CAA24769 (Get FASTA)   NCBI Sequence Viewer  
  CAA24770 (Get FASTA)   NCBI Sequence Viewer  
  EDL01382 (Get FASTA)   NCBI Sequence Viewer  
  EDL01383 (Get FASTA)   NCBI Sequence Viewer  
  EDL01384 (Get FASTA)   NCBI Sequence Viewer  
  EDL01385 (Get FASTA)   NCBI Sequence Viewer  
  EDL01386 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020990
  ENSMUSP00000020990.6
  ENSMUSP00000151367
  ENSMUSP00000151367.2
  ENSMUSP00000151450.2
  ENSMUSP00000151504
  ENSMUSP00000151504.2
  ENSMUSP00000151769.2
GenBank Protein P01193 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032921   ⟸   NM_008895
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265510   ⟸   NM_001278581
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265511   ⟸   NM_001278582
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265512   ⟸   NM_001278583
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265513   ⟸   NM_001278584
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000151769   ⟸   ENSMUST00000218169
RefSeq Acc Id: ENSMUSP00000151367   ⟸   ENSMUST00000218089
RefSeq Acc Id: ENSMUSP00000020990   ⟸   ENSMUST00000020990
RefSeq Acc Id: ENSMUSP00000151504   ⟸   ENSMUST00000219543
RefSeq Acc Id: ENSMUSP00000151450   ⟸   ENSMUST00000220006
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01193-F1-model_v2 AlphaFold P01193 1-235 view protein structure

Promoters
RGD ID:6849974
Promoter ID:EP25007
Type:single initiation site
Name:MM_COLI
Description:Proopiomelanocortin, adrenocorticotropic hormone/beta lipotropichormone, POMC or POMC1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 136; Mammalian POMC
Tissues & Cell Lines:CNS, pituitary
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA; experiments performed with; closely related gene
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37123,954,951 - 3,955,011EPD
MGSCv36123,954,951 - 3,955,011EPD
RGD ID:8677826
Promoter ID:EPDNEW_M16944
Type:multiple initiation site
Name:Pomc_1
Description:Mus musculus pro-opiomelanocortin-alpha , transcript variant5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38123,954,951 - 3,955,011EPDNEW
RGD ID:6849008
Promoter ID:MM_XEF:1440
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001011318,   NM_001031098,   NM_001032985,   NM_001087369,   NM_001163390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,959,836 - 3,960,336 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97742 AgrOrtholog
Ensembl Genes ENSMUSG00000020660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020990 ENTREZGENE
  ENSMUST00000020990.7 UniProtKB/Swiss-Prot
  ENSMUST00000218089 ENTREZGENE
  ENSMUST00000218089.2 UniProtKB/Swiss-Prot
  ENSMUST00000218169.2 UniProtKB/TrEMBL
  ENSMUST00000219543 ENTREZGENE
  ENSMUST00000219543.2 UniProtKB/Swiss-Prot
  ENSMUST00000220006.2 UniProtKB/TrEMBL
InterPro Mcrtin_ACTH_cent UniProtKB/Swiss-Prot
  Melanocortin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opioid_neuropept UniProtKB/Swiss-Prot
  PMOC UniProtKB/Swiss-Prot
KEGG Report mmu:18976 UniProtKB/Swiss-Prot
MGD MGI:97742 ENTREZGENE
NCBI Gene 18976 ENTREZGENE
PANTHER PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
  PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
  PRO-OPIOMELANOCORTIN UniProtKB/TrEMBL
  PRO-OPIOMELANOCORTIN UniProtKB/TrEMBL
Pfam ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Op_neuropeptide UniProtKB/Swiss-Prot
PharmGKB POMC RGD
PhenoGen Pomc PhenoGen
PRINTS MELANOCORTIN UniProtKB/Swiss-Prot
SMART ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Op_neuropeptide UniProtKB/Swiss-Prot
UniProt A0A1W2P724_MOUSE UniProtKB/TrEMBL
  A0A1W2P7R2_MOUSE UniProtKB/TrEMBL
  COLI_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P01200 ENTREZGENE
  Q544U4 ENTREZGENE
UniProt Secondary P01200 UniProtKB/Swiss-Prot
  Q544U4 UniProtKB/Swiss-Prot