Pomc (pro-opiomelanocortin-alpha) - Rat Genome Database

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Gene: Pomc (pro-opiomelanocortin-alpha) Mus musculus
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Symbol: Pomc
Name: pro-opiomelanocortin-alpha
RGD ID: 1331975
MGI Page MGI
Description: Enables hormone activity. Involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of oxytocin production; and response to melanocyte-stimulating hormone. Acts upstream of or within several processes, including glucose homeostasis; regulation of corticosterone secretion; and regulation of glycogen metabolic process. Located in extracellular space and secretory granule. Is expressed in several structures, including alimentary system; nervous system; oviduct; skeletal musculature; and skin. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ACT; ACTH; adrenal corticotropic hormone; adrenocorticotropic hormone; alp; alph; alpha-melanocyte stimulating hormone; alpha-MSH; alphaMSH; BE; beta-endorphin; Beta-LPH; beta-M; beta-melanocyte stimulating hormone; beta-MSH; Clip; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-; Gamma-LPH; gamma-melanocyte stimulating hormone; gamma-MSH; melanotropin gamma; met-enkephalin; Npp; PO; Pomc-1; Pomc1; pro-opiomelanocortin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Pomc-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)Ensemblmm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
ACTH Syndrome, Ectopic  (ISO)
acute kidney failure  (ISO)
acute kidney tubular necrosis  (ISO)
Acute Liver Failure  (ISO)
adrenal cortex disease  (ISO)
Adrenal Insufficiency  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (IEP,ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (ISO)
amnestic disorder  (ISO)
anxiety disorder  (ISO)
autistic disorder  (ISO)
Binge Drinking  (ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Bradycardia  (ISO)
Burns  (ISO)
calcinosis  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Catalepsy  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral palsy  (ISO)
cholestasis  (ISO)
chondrocalcinosis  (ISO)
Cocaine-Related Disorders  (ISO)
congestive heart failure  (ISO)
Constipation  (ISO)
Cushing Syndrome  (ISO)
cystitis  (ISO)
depressive disorder  (ISO)
diabetes insipidus  (ISO)
diabetes mellitus  (ISO)
disease by infectious agent  (ISO)
disease of mental health  (ISO)
Edema  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
eye disease  (ISO)
Eye Pain  (ISO)
facial paralysis  (ISO)
familial Mediterranean fever  (ISO)
Femur Head Necrosis  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
gastrointestinal system disease  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hematuria  (ISO)
Hemorrhage  (ISO)
heroin dependence  (ISO)
Hirsutism  (ISO)
human immunodeficiency virus infectious disease  (IEP)
Hyperalgesia  (ISO)
Hypercalciuria  (ISO)
Hypernatremia  (ISO)
Hyperphagia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypocalcemia  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
immune system disease  (ISO)
Inflammation  (IDA,IEP,ISO)
inflammatory bowel disease  (IDA,IMP)
Kidney Calculi  (ISO)
kidney disease  (ISO)
long QT syndrome  (ISO)
melanoma  (ISO)
morbid obesity  (ISO)
morphine dependence  (ISO)
morphine withdrawal syndrome  (ISO)
multiple sclerosis  (ISO)
myasthenia gravis  (ISO)
Myocardial Ischemia  (ISO)
Myoclonic Epilepsies  (ISO)
Nausea  (ISO)
Necrosis  (ISO)
nephrocalcinosis  (ISO)
Neuralgia  (ISO)
Neurogenic Inflammation  (ISO)
nicotine dependence  (ISO)
Nociceptive Pain  (IEP)
obesity  (IAGP,ISO)
Oliguria  (ISO)
opiate dependence  (ISO)
opioid abuse  (IEP)
Opsoclonus-Myoclonus Syndrome  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Pain  (ISO)
pancreas disease  (ISO)
penile disease  (ISO)
pituitary-dependent Cushing's disease  (ISO)
pneumonia  (ISO)
Postoperative Complications  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Proopiomelanocortin Deficiency  (ISO)
proteinuria  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
restless legs syndrome  (ISO)
Rhabdomyoma  (ISO)
Sacroiliitis  (ISO)
severe acute respiratory syndrome  (ISO)
sick sinus syndrome  (ISO)
Sleep Deprivation  (ISO)
sleep disorder  (ISO)
steatotic liver disease  (ISO)
stress-related disorder  (ISO)
subvalvular aortic stenosis  (ISO)
synovitis  (ISO)
type 2 diabetes mellitus  (ISO)
urinary tract infection  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
Wernicke-Korsakoff syndrome  (ISO)
West syndrome  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-20-hydroxypregn-4-en-3-one  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-hex-3-en-1-ol  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
11-deoxycorticosterone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
18-hydroxycortisol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9-hexadecafluorononanoic acid  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-hexenal  (ISO)
20-HETE  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-OH-DPAT  (ISO)
acetaldehyde  (ISO)
acetamide  (ISO)
acetylcholine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (ISO)
all-trans-retinol  (ISO)
alprenolol  (ISO)
AM-251  (EXP,ISO)
ammonium chloride  (ISO)
apocynin  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
Aroclor 1254  (ISO)
aspartame  (ISO)
astressin 2B  (ISO)
atorvastatin calcium  (ISO)
atrazine  (ISO)
atropine  (ISO)
Aurothioglucose  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzylphosphonic acid  (EXP)
beta-hexachlorocyclohexane  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bromocriptine  (ISO)
bucladesine  (ISO)
buspirone  (ISO)
Butylbenzyl phthalate  (EXP)
Butylparaben  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
capsaicin  (ISO)
capsazepine  (EXP,ISO)
carbamazepine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (EXP)
citalopram  (ISO)
clofibrate  (EXP)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
cordycepin  (EXP)
corticosterone  (EXP,ISO)
cortisol  (ISO)
CP-96345(1+)  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deethylatrazine  (ISO)
dehydroepiandrosterone sulfate  (ISO)
deisopropylatrazine  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dichlorvos  (ISO)
diethyl hydrogen phosphate  (EXP,ISO)
dimethyl sulfoxide  (EXP)
dinitrogen oxide  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (ISO)
diprotium oxide  (ISO)
disodium cromoglycate  (ISO)
disulfiram  (ISO)
dizocilpine maleate  (ISO)
dodecane  (ISO)
dopachrome  (EXP)
dopamine  (EXP)
endosulfan  (ISO)
enzacamene  (ISO)
ethanol  (ISO)
ether  (ISO)
eticlopride(1+)  (ISO)
fentanyl  (ISO)
finasteride  (ISO)
fludrocortisone  (ISO)
fluoxetine  (ISO)
fomepizole  (ISO)
formaldehyde  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glycerol  (ISO)
GSK-J4  (ISO)
GTP  (EXP,ISO)
guanosine 5'-[beta,gamma-imido]triphosphate  (EXP,ISO)
halothane  (ISO)
herbicide  (ISO)
HET0016  (ISO)
imipramine  (ISO)
imiquimod  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lansoprazole  (ISO)
lead(0)  (ISO)
lidocaine  (ISO)
linsidomine  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium hydride  (EXP,ISO)
loliolide  (EXP)
lycopene  (ISO)
magnesium atom  (ISO)
melanins  (EXP)
melatonin  (ISO)
metformin  (EXP)
methamidophos  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
metyrapone  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (EXP,ISO)
Morroniside  (ISO)
muscimol  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
naloxone  (ISO)
Naltrindole  (EXP)
naproxen  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nonane  (ISO)
Nonylphenol  (ISO)
NS-398  (ISO)
olanzapine  (EXP,ISO)
Osajin  (ISO)
oxidopamine  (ISO)
paracetamol  (ISO)
Pentagastrin  (ISO)
pentobarbital  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
Pervanadate  (ISO)
Phenoxybenzamine  (ISO)
phentolamine  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylephrine  (ISO)
phenylpropanolamine  (ISO)
Pomiferin  (ISO)
potassium atom  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
progesterone  (EXP,ISO)
propazine  (ISO)
propranolol  (ISO)
pyridoxal 5'-phosphate  (EXP)
quercetin  (EXP)
rabeprazole  (ISO)
reactive nitrogen species  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
Rosavin  (ISO)
ruthenium red  (EXP)
sarin  (ISO)
SB 203580  (ISO)
simazine  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP,ISO)
spironolactone  (ISO)
streptozocin  (ISO)
sufentanil  (ISO)
sumatriptan  (ISO)
superoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
theophylline  (ISO)
thimerosal  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (EXP)
toluene  (ISO)
triadimefon  (ISO)
triamcinolone  (ISO)
triclosan  (ISO)
trilostane  (EXP)
triphenyl phosphate  (EXP)
triphenylstannane  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
water  (ISO)
yohimbine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
calcium-mediated signaling  (IMP)
cell-cell signaling  (IEA,ISO,ISS)
cellular pigmentation  (IEA,ISO,ISS)
cortisol secretion  (ISO)
generation of precursor metabolites and energy  (IEA,ISO,ISS)
glucose homeostasis  (IMP)
killing of cells of another organism  (ISO)
modulation of process of another organism  (ISO)
motor behavior  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of eating behavior  (ISO)
negative regulation of immune response  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO,ISS)
neuropeptide signaling pathway  (IEA)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IDA)
positive regulation of cell population proliferation  (ISO)
positive regulation of melanin biosynthetic process  (ISO)
positive regulation of neutrophil mediated killing of fungus  (ISO)
positive regulation of oxytocin production  (IDA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
regulation of appetite  (IEA,ISO,ISS)
regulation of blood pressure  (IGI)
regulation of corticosterone secretion  (IBA,IMP)
regulation of glycogen catabolic process  (IMP)
response to ethanol  (ISO)
response to immobilization stress  (IEP)
response to lipopolysaccharide  (ISO)
response to melanocyte-stimulating hormone  (IDA)
signal transduction  (IEA,ISO,ISS)

Cellular Component
cytoplasm  (IDA)
extracellular region  (IEA,ISO,TAS)
extracellular space  (IBA,IDA,IEA,ISO,ISS)
neuronal cell body  (ISO)
peroxisomal matrix  (ISO)
peroxisome  (ISO)
secretory granule  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
altered energy homeostasis pathway  (ISO)
altered melanocortin system pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway   (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
obesity pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
syndecan signaling pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alcohol consumption  (IAGP)
abnormal behavior  (IAGP)
abnormal behavioral response to addictive substance  (IAGP)
abnormal corticosterone level  (IAGP)
abnormal hair follicle pheomelanosome pheomelanin content  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal operant conditioning behavior  (IAGP)
abnormal response/metabolism to endogenous compounds  (IAGP)
abnormal spleen morphology  (IEA)
abnormal touch/ nociception  (IAGP)
absent adrenal gland  (IAGP)
decreased adrenal gland zona fasciculata size  (IAGP)
decreased adrenocorticotropin level  (IAGP)
decreased circulating adrenaline level  (IAGP)
decreased circulating adrenocorticotropin level  (IAGP)
decreased circulating aldosterone level  (IAGP)
decreased circulating corticosterone level  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased oxygen consumption  (IAGP)
decreased response to leptin  (IAGP)
diluted coat color  (IAGP)
disorganized adrenal gland zona fasciculata  (IAGP)
enlarged adrenal glands  (IAGP)
enlarged spleen  (IEA)
hyperactivity elicited by ethanol administration  (IAGP)
impaired conditioned place preference behavior  (IAGP)
impaired glucose tolerance  (IAGP)
increased adrenal gland zona fasciculata size  (IAGP)
increased aggression towards mice  (IAGP)
increased alcohol consumption  (IAGP)
increased body fat mass  (IAGP)
increased body length  (IAGP)
increased body weight  (IAGP)
increased circulating adrenocorticotropin level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating leptin level  (IAGP)
increased dopamine level  (IAGP)
increased fat cell size  (IAGP)
increased food intake  (IAGP)
increased gonadal fat pad weight  (IAGP)
increased inguinal fat pad weight  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased renal fat pad weight  (IAGP)
increased retroperitoneal fat pad weight  (IAGP)
increased splenocyte proliferation  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased tumor necrosis factor secretion  (IAGP)
increased urine adrenaline level  (IAGP)
obese  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polyphagia  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
small adrenal glands  (IAGP)
yellow coat color  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring. Al-Yasari A, etal., Endocrinology. 2021 Jan 1;162(1):bqaa188. doi: 10.1210/endocr/bqaa188.
2. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Bettenworth D, etal., Am J Pathol. 2011 Sep;179(3):1230-42. Epub 2011 Jul 8.
3. Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. Cakir I, etal., J Biol Chem. 2013 Jun 14;288(24):17675-88. doi: 10.1074/jbc.M113.475343. Epub 2013 May 2.
4. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Calvino C, etal., Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.
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PMID:33788980   PMID:33795686   PMID:33887179   PMID:34072036   PMID:34288113   PMID:34324439   PMID:34329773   PMID:34564702   PMID:34585668   PMID:34626854   PMID:34644574   PMID:34730112  
PMID:34905510   PMID:34971379   PMID:35044906   PMID:35049495   PMID:35652338   PMID:35951005   PMID:36122808   PMID:36374777   PMID:36473997   PMID:36525492   PMID:36581316   PMID:36619565  
PMID:36800350   PMID:36965574   PMID:37091593   PMID:37168577   PMID:37495689   PMID:37589451   PMID:37699899   PMID:37741556   PMID:38224819   PMID:38355793   PMID:38652744   PMID:38744532  
PMID:38821928   PMID:38923438   PMID:39001875   PMID:39025297   PMID:39946455   PMID:40044116   PMID:40048253   PMID:40112816   PMID:40515561   PMID:40658750  


Genomics

Comparative Map Data
Pomc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)Ensemblmm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
POMC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,160,860 - 25,168,580 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,160,853 - 25,168,903 (-)Ensemblhg38GRCh38
GRCh37225,383,729 - 25,391,449 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,237,226 - 25,245,063 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34225,295,438 - 25,303,103NCBI
Celera225,224,014 - 25,231,854 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,121,466 - 25,129,306 (-)NCBIHuRef
CHM1_1225,313,607 - 25,321,447 (-)NCBICHM1_1
T2T-CHM13v2.0225,195,313 - 25,203,034 (-)NCBIT2T-CHM13v2.0
Pomc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,659,137 - 32,665,175 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl632,659,346 - 32,665,173 (+)EnsemblGRCr8
mRatBN7.2626,939,844 - 26,945,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx627,232,130 - 27,237,950 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,548,037 - 27,553,857 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,026,040 - 27,031,858 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,382,937 - 28,388,771 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)Ensemblrn6Rnor6.0
Rnor_5.0638,191,989 - 38,197,809 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4626,931,969 - 26,937,789 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera626,415,706 - 26,421,526 (+)NCBICelera
RGSC_v3.1626,934,921 - 26,940,742 (+)NCBI
RH 3.4 Map6117.99RGD
Cytogenetic Map6q14NCBI
Pomc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,217,363 - 7,220,386 (-)Ensembl
ChiLan1.0NW_0049554697,217,233 - 7,220,401 (-)NCBIChiLan1.0ChiLan1.0
POMC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,353,171 - 101,357,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,357,136 - 101,361,068 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,161,668 - 25,165,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,258,768 - 25,266,806 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,258,768 - 25,262,706 (-)EnsemblpanPan2panpan1.1
POMC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,431,396 - 19,438,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,431,585 - 19,434,440 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1719,328,041 - 19,334,822 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01719,706,608 - 19,713,398 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,706,796 - 19,714,128 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,440,669 - 19,447,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,450,362 - 19,457,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,496,844 - 19,503,629 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pomc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,774,289 - 63,781,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,061,587 - 7,065,109 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,060,747 - 7,065,276 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POMC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,661,004 - 113,670,418 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,766,352 - 120,772,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POMC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,491,296 - 82,499,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,494,323 - 82,499,447 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604529,662,185 - 29,670,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pomc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,442,292 - 7,445,020 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247387,442,223 - 7,448,513 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pomc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1724,626,609 - 24,629,270 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pomc
182 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:159
Interacting mature miRNAs:173
Transcripts:ENSMUST00000020990
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse

Markers in Region
RH130758  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38123,960,241 - 3,960,447UniSTSGRCm38
GRCm381915,362,539 - 15,362,745UniSTSGRCm38
MGSCv371915,437,029 - 15,437,235UniSTSGRCm37
MGSCv37123,960,241 - 3,960,447UniSTSGRCm37
Celera123,887,980 - 3,888,186UniSTS
Celera1916,019,701 - 16,019,907UniSTS
Cytogenetic Map19AUniSTS
Cytogenetic Map12A1.1UniSTS
cM Map199.0UniSTS
Pomc1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.1UniSTS
cM Map124.0UniSTS
Pomc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12A1.1UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001278581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001278584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK133800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW120866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB022229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB022936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB025409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB026464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V00831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020990   ⟹   ENSMUSP00000020990
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,642 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218089   ⟹   ENSMUSP00000151367
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,618 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,618 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218169   ⟹   ENSMUSP00000151769
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,969 - 4,009,998 (+)Ensembl
GRCm38.p6 Ensembl123,954,969 - 3,959,998 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219543   ⟹   ENSMUSP00000151504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,951 - 4,010,573 (+)Ensembl
GRCm38.p6 Ensembl123,954,951 - 3,960,573 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220006   ⟹   ENSMUSP00000151450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl124,004,970 - 4,008,260 (+)Ensembl
GRCm38.p6 Ensembl123,954,970 - 3,958,260 (+)Ensembl
RefSeq Acc Id: NM_001278581   ⟹   NP_001265510
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278582   ⟹   NP_001265511
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278583   ⟹   NP_001265512
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001278584   ⟹   NP_001265513
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
Celera123,882,688 - 3,888,382 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008895   ⟹   NP_032921
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39124,004,945 - 4,010,643 (+)NCBI
GRCm38123,954,945 - 3,960,643 (+)NCBI
MGSCv37123,954,951 - 3,960,618 (+)RGD
Celera123,882,688 - 3,888,382 (+)NCBI
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001265510 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265511 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265512 (Get FASTA)   NCBI Sequence Viewer  
  NP_001265513 (Get FASTA)   NCBI Sequence Viewer  
  NP_032921 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA37169 (Get FASTA)   NCBI Sequence Viewer  
  AAB59729 (Get FASTA)   NCBI Sequence Viewer  
  AAH61215 (Get FASTA)   NCBI Sequence Viewer  
  BAB30771 (Get FASTA)   NCBI Sequence Viewer  
  BAB30818 (Get FASTA)   NCBI Sequence Viewer  
  BAC27095 (Get FASTA)   NCBI Sequence Viewer  
  BAC36795 (Get FASTA)   NCBI Sequence Viewer  
  BAE21739 (Get FASTA)   NCBI Sequence Viewer  
  BAE21764 (Get FASTA)   NCBI Sequence Viewer  
  BAE21815 (Get FASTA)   NCBI Sequence Viewer  
  BAE21833 (Get FASTA)   NCBI Sequence Viewer  
  BAE21850 (Get FASTA)   NCBI Sequence Viewer  
  CAA24769 (Get FASTA)   NCBI Sequence Viewer  
  CAA24770 (Get FASTA)   NCBI Sequence Viewer  
  EDL01382 (Get FASTA)   NCBI Sequence Viewer  
  EDL01383 (Get FASTA)   NCBI Sequence Viewer  
  EDL01384 (Get FASTA)   NCBI Sequence Viewer  
  EDL01385 (Get FASTA)   NCBI Sequence Viewer  
  EDL01386 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020990
  ENSMUSP00000020990.6
  ENSMUSP00000151367
  ENSMUSP00000151367.2
  ENSMUSP00000151504
  ENSMUSP00000151504.2
GenBank Protein P01193 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032921   ⟸   NM_008895
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265510   ⟸   NM_001278581
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265511   ⟸   NM_001278582
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265512   ⟸   NM_001278583
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001265513   ⟸   NM_001278584
- Peptide Label: preproprotein
- UniProtKB: P01200 (UniProtKB/Swiss-Prot),   Q544U4 (UniProtKB/Swiss-Prot),   P01193 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000151769   ⟸   ENSMUST00000218169
Ensembl Acc Id: ENSMUSP00000151367   ⟸   ENSMUST00000218089
Ensembl Acc Id: ENSMUSP00000020990   ⟸   ENSMUST00000020990
Ensembl Acc Id: ENSMUSP00000151504   ⟸   ENSMUST00000219543
Ensembl Acc Id: ENSMUSP00000151450   ⟸   ENSMUST00000220006
Protein Domains
Pro-opiomelanocortin N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01193-F1-model_v2 AlphaFold P01193 1-235 view protein structure

Promoters
RGD ID:6849974
Promoter ID:EP25007
Type:single initiation site
Name:MM_COLI
Description:Proopiomelanocortin, adrenocorticotropic hormone/beta lipotropichormone, POMC or POMC1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 136; Mammalian POMC
Tissues & Cell Lines:CNS, pituitary
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA; experiments performed with; closely related gene
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv37123,954,951 - 3,955,011EPD
MGSCv36123,954,951 - 3,955,011EPD
RGD ID:8677826
Promoter ID:EPDNEW_M16944
Type:multiple initiation site
Name:Pomc_1
Description:Mus musculus pro-opiomelanocortin-alpha , transcript variant5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38123,954,951 - 3,955,011EPDNEW
RGD ID:6849008
Promoter ID:MM_XEF:1440
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_001011318,   NM_001031098,   NM_001032985,   NM_001087369,   NM_001163390
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36123,959,836 - 3,960,336 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97742 AgrOrtholog
Ensembl Genes ENSMUSG00000020660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020990 ENTREZGENE
  ENSMUST00000020990.7 UniProtKB/Swiss-Prot
  ENSMUST00000218089 ENTREZGENE
  ENSMUST00000218089.2 UniProtKB/Swiss-Prot
  ENSMUST00000219543 ENTREZGENE
  ENSMUST00000219543.2 UniProtKB/Swiss-Prot
InterPro Mcrtin_ACTH_cent UniProtKB/Swiss-Prot
  Melanocortin_N UniProtKB/Swiss-Prot
  Opioid_neuropept UniProtKB/Swiss-Prot
  PMOC UniProtKB/Swiss-Prot
  POMC-derived_peptides UniProtKB/Swiss-Prot
KEGG Report mmu:18976 UniProtKB/Swiss-Prot
MGD MGI:97742 ENTREZGENE
NCBI Gene 18976 ENTREZGENE
PANTHER PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
  PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
Pfam ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot
  Op_neuropeptide UniProtKB/Swiss-Prot
PharmGKB POMC RGD
PhenoGen Pomc PhenoGen
PRINTS MELANOCORTIN UniProtKB/Swiss-Prot
SMART ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot
  Op_neuropeptide UniProtKB/Swiss-Prot
UniProt A0A1W2P724_MOUSE UniProtKB/TrEMBL
  A0A1W2P7R2_MOUSE UniProtKB/TrEMBL
  COLI_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P01200 ENTREZGENE
  Q544U4 ENTREZGENE
UniProt Secondary P01200 UniProtKB/Swiss-Prot
  Q544U4 UniProtKB/Swiss-Prot